Nature Communications
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2025
·Vol. 16
·期 1
·1-9
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IF 15.7
Cai Jinghan,Lan Shun,Wei Bin,Qi Junlei,Nan Ce-Wen,Lin Yuan-Hua
Dielectrics with high permittivity, low dielectric loss, and good temperature stability are crucial for electronic components to meet the ever-increasing application demands. However, challenges remain in further optimizing dielectric properties due to the correlation between these parameters. Here, we propose a chemical bonding engineering strategy in high-entropy CaTiO 3 ceramics and realize colossal permittivity with low loss and excellent stability. Our results reveal that the high-concentration oxygen vacancy ( \({{{\rm{V}}}}_{{{\rm{O}}}}^{\cdot \cdot }\) )-related defects and the decreased activation energy of grain/grain boundary led to a colossal permittivity dielectric behavior, which should be ascribed to the weakened chemical bonding and the reduced formation energy of defects confirmed by our first-principles calculation. Consequently, in the high-entropy CaTiO 3 ceramic, a permittivity of 2.37 × 10 5 , low loss of 0.005, and good temperature stability (<± 15%) in -50–250 °C are simultaneously achieved. This finding implies that chemical bonding engineering may be a promising strategy for designing colossal permittivity materials and provides a broad opportunity for the development of other defect-dependent functional materials.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Sun Yu,Xie Yong,Chen Xiaoxuan,Wu Jing,Liu Pengfei,Wang Xin,Tian Zhen,Zheng Wenhao,Jiang Zhouyu,Kang Zhuo,Zhang Yue
Unveiling structure-activity correlations at the sub-nanoscale remains an essential challenge in catalysis science. During electrocatalysis, dynamic structural evolution drives the ambiguous entanglement of crystals and electrons degrees of freedom that obscure the activity origin. Here, we track the structural evolution of Ni-based model pre-catalysts (Ni(OH) 2 , NiS 2 , NiSe 2 , NiTe), detailing their catalytically active state during water oxidation via operando techniques and theoretical calculations. We reveal the sub-nanometric structural difference of NiO 6 unit with a regular distortion in the reconstructed active phase NiOOH, codetermined by the geometric (bond lengths) and electronic (covalency) structure of the pre-catalysts on both spatial and temporal scales. The symmetry-broken active units induce the delicate balance of the p and d orbitals in NiOOH, further steering the modulation of catalytic intermediate configurations and mechanisms, with improved performance. This work recognizes the fine structural differences of the active phases from the sub-nanometer scale, and quantitatively explains their influence on activity. Our findings provide a more intuitive design framework for high-efficiency materials through targeted symmetry engineering of active units.
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ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
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2025
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IF 2.9
Liu Zaizhi,Liao Haibin,Li Hualan,Zou Zhengrong
Cinnamomum camphora chvar. Borneol essential oil (CBEO), a potential antibacterial ingredient, faces challenges in widespread use for food preservation due to its high volatility and low stability. This study aimed to enhance the stability and release properties of CBEO by preparing CBEO/β-cyclodextrin microcapsules. The ultrasound-assisted complexation (UACP) method has been developed to fabricate microcapsules containing CBEO , with β -cyclodextrin used as the wall material. The UACP process was optimized using the Box–Behnken response surface methodology. Under optimal conditions—a wall–core ratio of 4.09, ultrasound time of 52 min, ultrasound power of 617 W, and embedding temperature of 32 °C—the maximum microcapsule yield (84.93 ± 2.21%) and encapsulation efficiency (60.20 ± 1.56%) were achieved. Analysis through scanning electron microscopy, Fourier transform infrared spectroscopy, particle size distribution analysis, thermogravimetric analysis, and X-ray diffraction revealed the effective encapsulation of CBEO by UACP method. Furthermore, CBEO microcapsules exhibited favorable thermal stability and a slow-release effect. This study presents a promising approach to microencapsulation technology for the preparation of plant essential oil microcapsules.
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BRAZILIAN JOURNAL OF MICROBIOLOGY
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2025
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IF 1.9
Lv Jianhua,Gu Xiangnan,Hui Minmin,Luo Yingjie,Luo Wenbo,Zhao Huiting,Yin Shuqin,Feng Yan,Xue Zhiquan
Phenol hydroxylase (PH) plays a central role in phenol biodegradation pathways. In this study, the enzymatic activity of PH in Candida tropicalis GY8 was evaluated following phenol-induced cultivation, and oxidation products were analyzed via high-performance liquid chromatography (HPLC). Two phenol hydroxylase genes, CtPHE1 and CtPHE2 , were identified, and their expression patterns were examined using RT-qPCR. Functional analysis of the corresponding proteins was conducted by cloning and expressing the genes in Escherichia coli BL21(DE3). Enzymatic activity reached its maximum after 15 h of cultivation ( p < 0.01), and phenol conversion to catechol was verified by HPLC. RT-qPCR results indicated peak transcript levels at 10 h, with CtPHE2 showing consistently higher expression than CtPHE1 at 5, 10, and 15 h ( p < 0.01). Both recombinant proteins were capable of phenol degradation, with CtPHE2 exhibiting greater catalytic activity. These findings provide essential molecular information for advancing the understanding of phenol biodegradation mechanisms.
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Journal of Food Measurement and Characterization
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2025
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IF 3.3
Liu Lujie,Huang Lixin,Wang Chengzhang,Zhang Caihong,Xie Pujun,Deng Yejun,Wang Xiang,Liu Yong
Starch nanocrystals (SNCs) are a desirable stabilizer for Pickering emulsion, and ginkgo starch (GS) is a potential resource to prepare SNCs. However, the formation mechanism and application of GS-SNCs are not fully elucidated. To address the problem, ginkgo SNCs were prepared using sulfuric acid hydrolysis and the formation mechanism was revealed by molecular structure and morphology changes. The stability of hydrolyzed products in the Pickering emulsions was assessed. The results from hydrolysis kinetics showed a rapid hydrolysis stage in 1–3 days and a slow hydrolysis stage in 4–7 days. The process of forming SNCs exhibited an exo-corrosion, including molecular chain breakage and granule disintegration. SNCs were present in the acid hydrolysis process and comprised of low molecular weight amylopectin, with mean particles of 168 nm for 7-day-formed SNCs. The acid hydrolysis gave a significant increase from 32 to 42% in the relative crystallinity and decrease from 2407406 g/mol to 5136 g/mol on the molecular weight, and the molecular weight change occurred mainly on the first day of hydrolysis. The oil-in-water (O/W) Pickering emulsion was prepared by acid hydrolyzed starch via ultrasonication. The products of acid hydrolysis for 6 and 7 days, AGS-6 and AGS-7 emulsified Pickering emulsions exhibited good stability for 4 months. The size and molecular weight were the important factors that influence the stability of Pickering emulsion. This study provides practical support for the use of Ginkgo SNCs in Pickering emulsions.
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-19
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IF 3.9
Liu Huijuan,Cheng Zhifei,Wu Xianliang,Xie Jiao
Metformin, a typical pharmaceutical and personal care product (PPCPs), has a significant role in protecting brain cognitive function and delaying multiple organs aging, as well as causes seriously endocrine and reproductive interference to aquatic organisms due to drug abuse. Graphene that is of stable structure, flexible connection between carbon atoms, and the conjugated large pi bonds has been used to wastewater treatment, while Graphene-based materials used to remove PPCPs are rarely reported. Therefore, two graphene oxide (GO) based materials, including silane coupling agent modified product (CTOS-mGO) and Pyracantha fortuneana proanthocyanidin extract reduced product (PFPA-rGO), were used for metformin removal from aqueous solution as well as revealed the mechanism in this adsorption process. The results showed that metformin could be quickly and effectively removed by GO, CTOS-mGO and PFPA-rGO, of which the best material of adsorption effects was CTOS-mGO. The pseudo-second-order kinetic could effectively describe their adsorption process, and they achieved more than 80% removal rate within 15 to 20 min. Metformin adsorption by GO, CTOS-mGO and PFPA-rGO were all spontaneous and exothermic. CTOS-mGO was of the largest adsorption capacity and recycling utilization for metformin removal in comparison with GO and PFPA-rGO. The optimal adsorption temperature and pH for the GO and CTOS-mGO, PFPA-rGO adsorbents were 293 K and pH 6.0, 293 K and pH 7.0, 303 K and pH 6.0, respectively. Our results suggested that the aromatic rings and the abundant oxygen-containing functional groups distributed on the surface of the sheets endowed them with the characteristics of π-electron acceptors or donors, and metformin with dissociative properties could serve as a stabilizer for this π–π interaction. In addition, the electrostatic interaction between the positively charged metformin and the negatively charged GO and CTOS-mGO were also important contributors to the adsorption reaction. Our results emphasized that the GO based materials might be an effective method for alleviating metformin and other PPCPs pollution, which also provided a reference for environmental remediation of similar pollutants.
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RARE METALS
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2025
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IF 11
Zhou Luo-Ting,Zhang Qian-Qian,Yuan Hua-Dong,Fang Ru-Yi,Luo Jian-Min,Huang Hui,Gan Yong-Ping,Xia Yang,Zhang Jun,Xia Xin-Hui,He Xin-Ping,Jin Cheng-Bin,Zhang Wen-Kui
Lithium (Li) metal anodes (LMAs) that employ three-dimensional lithiophilic frameworks are among the most promising options for constructing high-energy-density rechargeable batteries. Herein, hollow ZnS nanosheets with the coating of N-doped carbon are modified on the surface of carbon cloth (NCHZS@CC) to serve as the host material for Li metal. It is revealed that the high surface area of NCHZS@CC can significantly reduce local current density and mitigate volume change during cycling. More importantly, the lithiated product of ZnS, confined within the carbon cage, facilitates the uniform deposition of Li metal on carbon fibers and promotes the formation of a stable solid electrolyte interphase enriched with Li 2 S, thereby improving long-term performance as the cycling progresses. Consequently, the LMAs based on NCHZS@CC demonstrate an impressive cycle life beyond 560 h with an ultralow overpotential of 38 mV at a current density of 5 mA cm −2 with a capacity of 1 mAh cm −2 in the symmetric cell. In addition, when matched with a high mass loading cathode of LiFePO 4 (11.5 mg cm −2 ), the assembled full cell displays outstanding performance, achieving 900 cycles at a rate of 2C. Graphical abstract
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EUROPEAN JOURNAL OF MEDICAL RESEARCH
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2025
·Vol. 30
·期 1
·1-14
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IF 3.4
Wang Xiu,Du Wentao,Wang Yunyun,Khan Ahsan Riaz,Zhang Haijun
Objective This study aims to design and fabricate a leadless pacemaker (LPM) electrode loaded with rapamycin (RAPA)–poly(lactic-co-glycolic acid) (PLGA) drug sustained-release system to reduce the local fibrous tissue proliferation after LPM implantation, reduce local bioelectrical impedance, and facilitate the safe extraction of LPM after use. Methods We fabricated an LPM electrode loaded with the RAPA-PLGA drug-sustained-release system and carried out in vitro and in vivo experiments to verify its effect. Results A scanning electron microscope showed that the LPM electrode cavity was loaded with the RAPA-PLGA drug’s sustained-release system. The energy-dispersive spectrometer showed that the LPM electrode had RAPA and PLGA-related elements. The average drug loading rate of the drug sustained-release system was (51.02% ± 2.66) %, and the encapsulation rate was (85.04% ± 4.43%). The RAPA loaded in the electrode chamber was about (337.83 ± 53.66)μg. In vitro release results show that the LPM electrode loaded with RAPA–PLGA can continue to release for 44 days. In vitro cell inhibition experiments showed that the drug-loaded electrode group had an obvious inhibitory effect on fibroblasts, and the difference between the groups was significant ( p < 0.05). In vivo experiments showed that the local bioelectrical impedance of the drug-loaded electrode group is lower than that of the control group, with a difference between groups with statistical significance ( p < 0.05). The histopathological analysis of tissue sections from the site of (LPM electrode implantation revealed reduced fibrous tissue hyperplasia in the drug-loaded electrode group compared to the control group. Additionally, H&E staining indicated that the implantation of drug-loaded electrodes did not induce abnormal alterations in the liver, heart, spleen, lung, or kidney tissues. Conclusion The LPM electrode loaded with RAPA–PLGA demonstrates significant, sustained drug release and anti-proliferative effects in vitro. This drug-loaded electrode has been deemed safe for implantation in animal models. It can effectively inhibit local fibrous tissue proliferation and reduce local bioelectrical impedance, offering a technical strategy to prolong the in vivo functionality of LPMs and enhance clinical procedures.
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Bioresources and Bioprocessing
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2025
·Vol. 12
·期 1
·1-16
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IF 5.1
Deng Jie,Zheng Jia,Li Xing,Huang Dan,Ye Guangbin,Luo Huibo
Qu -aroma is a critical quality indicator for medium–high temperature Daqu (MT- Daqu ). Due to the differences in regional and environmental conditions, these differences are likely to cause variations in the Qu -aroma of MT- Daqu . Despite this, comprehensive research on the variations in Qu -aroma across different regions has been lacking. This study aims to address this gap to analyze the differences in Qu -aroma characteristics of MT- Daqu from seven distinct production areas. Sensory analysis identified seven broad aroma categories and 25 specific aromas characterizing the Qu -aroma of MT- Daqu samples. Chen aroma and roasted aroma were notably more prevalent in MT- Daqu samples from Sichuan compared to those from other regions ( P < 0.05 ). In total, 123 volatile compounds were detected in MT- Daqu , with 42 classified as aroma-active compounds. Among these, 21 aroma-active compounds were identified as markers distinguishing Sichuan MT- Daqu from those produced in non-Sichuan regions, showing significant differences in their concentrations ( P < 0.05 ). Additionally, six major aroma-active compounds were found to significantly contribute to the aroma differences between Sichuan and non-Sichuan MT- Daqu . This study delineates the distinct Qu -aroma characteristics of MT- Daqu from various SAB production areas. The insights gained from this research offer valuable guidance for optimizing flavor profiles in MT- Daqu production. Graphical
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International Journal of Minerals Metallurgy and Materials
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2025
·Vol. 32
·期 5
·1056-1067
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IF 7.2
Guan Zhenhao,Zhang Ying,Wen Shuming,Zuo Qi,Wu Yu,Li Xiaokang
This study investigated the effect of konjac glucomannan (KGM) on the flotation separation of calcite and scheelite. Microflotation tests showed that under the action of 50 mg/L KGM, the floatability of calcite notably decreased, while the impact on scheelite was negligible, resulting in a recovery difference of 82.53%. Fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) analyses indicated the selective adsorption of KGM on the calcite surface. Test results of the zeta potential and UV-visible absorption spectroscopy revealed that KGM prevented the adsorption of sodium oleate on the calcite surface. X-ray photoelectron spectroscopy (XPS) analysis further confirmed the chemical adsorption of KGM on the calcite surface and the formation of Ca(OH) 2 . The density functional theory (DFT) simulation results were consistent with the flotation tests, demonstrating the strong adsorption performance of KGM on the calcite surface. This study offers a pathway for highly sustainable and cost-effective mineral processing by utilizing the unique properties of biopolymers such as KGM to separate valuable minerals from gangue minerals.
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EXPERIMENTAL AND MOLECULAR MEDICINE
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2025
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IF 12.9
Wu Jin,Guo Zixiang,Wang Long,Shen Yue,Li Xiang,Zhang Zhewei,Han Xiao,Zhang Jianlan,Cai Kunzhan,Tang Chunbo
Periodontitis is an oral immunoinflammatory disease, and macrophages play a crucial role in its pathophysiology. However, macrophage death during antibacterial activities will exacerbate inflammation and tissue damage. Porphyromonas gingivalis is a major constituent of subgingival biofilm plaques in periodontitis, but the effects and precise molecular mechanisms by which it triggers macrophage death remain unknown. Here we found that P. gingivalis infection notably activated multiple death pathways in bone-marrow-derived macrophages, including pyroptosis, apoptosis and necrosis. Furthermore, using RNA sequencing, we identified that P. gingivalis infection markedly increased the expression of Z-DNA binding protein 1 (Zbp1) in bone-marrow-derived macrophages. Initially identified as an interferon-induced tumor-associated protein, Zbp1 serves as an upstream sensor that regulates cell death by activating PANoptosis. Mechanistically, P. gingivalis induced a mitochondrial stress response, prompting the release of mitochondrial DNA. This mitochondrial DNA then interacted with Zbp1, consequently augmenting its downstream PANoptosis signals. In addition, P. gingivalis stimulated macrophage Zbp1 expression through the Tlr2/4–JNK–Stat3/5 pathway, exacerbating macrophage death. Importantly, blocking the biosynthesis of endogenous Zbp1 by pharmacological delivery with microneedles improved the survival of P. gingivalis -infected macrophages and inhibited periodontal tissue destruction. These findings highlight Zbp1 as a potential therapeutic target for P. gingivalis -induced periodontitis.
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Nature Communications
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2025
·Vol. 16
·期 1
·1-15
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IF 15.7
Liu Zhen,Wu Jiacai,Wang Ning,Lin Yongqi,Song Ruiteng,Zhang Min,Li Bin
Despite remarkable progress in designing RNA delivery systems, endosomal escape remains a recognized challenge for efficient RNA delivery. In this study, we develop a robust mRNA delivery platform termed endosomolytic chloroquine-like optimized lipid nanoparticles (ecoLNPs) for versatile mRNA delivery in vitro and in vivo via integrating the signature scaffold extracted from endosomolytic chloroquine into ionizable lipids. RNase-resistant ecoLNPs are capable of delivering a broad variety of mRNA payloads to diverse cell types, even hard-to-transfect 3D cells, with an efficiency of up to 18.9-fold higher than that of commercial transfection reagents. The pH-responsive endosomolytic activity of ecoLNPs can be largely attributed to the proton sponge effect and saposin B-promoted membrane disruption. In vivo, ecoLNPs enable potent local and systemic mRNA delivery and exhibit comparable potency to the clinically approved mRNA vaccine carrier, but strong tropism for lymph nodes following intramuscular injection. Furthermore, ecoLNPs are able to retain in vivo delivery potency for at least one week under non-frozen conditions and induce efficient genome editing in transgenic mice. Overall, the structure-guided integration strategy provides a pathway for de novo design of endosomolytic mRNA delivery systems.
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