ACTA PHARMACOLOGICA SINICA
·
2025
·
IF 8.4
Yan Meng-qi,Qiu Xiao-yun,Zhang Shuo,Yu Xue-min,Sun Min-juan,Yang Yuan-zhi,Gong Yi-wei,Zou Shuang,Li Meng-han,Fei Fan,Du Yu,Wang Yi,Tang Ying-ying,Chen Zhong,Xu Ceng-lin
Pharmacoresistance remains intractable in epilepsy, necessitating in-depth mechanism investigations. Cumulative data have pointed to active neuroinflammation in pharmacoresistant epilepsy, but the process between neuroinflammation and pharmacoresistance remains unknown. In this study we investigated how severe neuroinflammation altered anti-seizure drugs (ASMs) pharmacology. Hippocampal kindling or kainic acid-induced temporal lobe epilepsy (TLE) models were established in mice that had received intra-hippocampal LPS injection. Acute hippocampal slices were prepared; current-clamp recording was made in hippocampal pyramidal neurons to assess the impact of ASMs on neuronal excitability and sodium channels. We showed that intra-hippocampal LPS injection resulted in higher inflammatory cytokine levels in the hippocampus. LPS induced-neuroinflammation significantly decreased the antiseizure efficacy of phenytoin (PHT), carbamazepine (CBZ) and rufinamide (RUF), all the ASMs tested were unable to alleviate the seizure severities. We observed the “off-target” phenomena of ASMs, i.e. ASMs’ loss of ability to suppress the firing of action potentials and the amplitudes of sodium currents in hippocampal pyramidal neurons from LPS-treated mice. We demonstrated that LPS induced-neuroinflammation promoted the degradation of spermine, an essential polyamine linked with ASM performance on sodium channels, through upregulating the catabolic enzyme spermidine/spermine N (1)-acetyltransferase (SSAT). Intra-hippocampal injection of SSAT agonist DENSPM mimicked LPS-induced “off-target” phenomena of ASMs, whereas injection of SSAT antagonist diminazene aceturate into hippocampus reversed the “off-target” phenomenon of ASMs in LPS-treated mice. Finally, intrahippocampal injection of spermine restored the efficacy of ASMs on action potential firings and sodium currents, resulting in the reversal of pharmacoresistance in LPS-treated TLE models. These results provide new evidence that neuroinflammation causes pharmacoresistance in TLE via promoting spermine degradation, and highlight spermine supplementation as a promising therapy for pharmacoresistant TLE.
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JOURNAL OF POROUS MATERIALS
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2025
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IF 3.2
Yan Xuemei,Gou Zenian,Chang Weichun,Liu Ruixiang,Su Jikai,Su Dong,Li Xiaolei
The inherent brittleness of pure SiO 2 aerogels due to the fragile Si–O–Si bonding connection at the neck greatly limits their applications. The limitations in mechanical properties of SiO 2 aerogels can be effectively overcome through the recent advancements in organic–inorganic hybrid systems. In this paper, resorcinol- formaldehyde (RF) reinforced silica aerogels (RSA) were synthesized using tetraethyl orthosilicate (TEOS) as the silicon precursor through a two-step sol–gel approach coupled with an ethanol supercritical drying process. The structural evolution and properties of aerogels during RSA's preparation were studied in relation to RF sol properties, gelation catalysts, and the doping content of RF sol. In particular, the aerogels crosslinked with γ-aminopropyltriethoxysilane (APTES), exhibit multifunctional properties including a high specific surface area of 802 m 2 /g, a low density of 0.208 g/cm 3 , a low thermal conductivity of 0.0230 W/(m·K), good hydrophobicity (a water contact angle of 141.5°) and compressive strength (0.58 MPa at 10% strain). The thermally insulating, hydrophobic and robust resorcinol–formaldehyde modified silica aerogel materials have positive significance in expanding the applications of silica aerogels.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2025
·Vol. 36
·期 1
·1-12
·
IF 4.5
Chi Menghui,Zhang Leyuan,Deng Bing,Lin Jing,Wang Qian,Zhang Lina,Yin Min,Gu Lingwen,Li Daohao,Zhao Guiqiu,Li Cui
The blindness rate of fungal keratitis is high, however, traditional therapy, like eye drops, has poor bioavailability. To make the traditional treatment more effective, new drug-loading system was explored, which can attach to the ocular surface to prolong the release time of natamycin (NATA). Sodium alginate (SA) has attractive properties of biocompatibility, biodegradability, which have been exploited to be natural-origin polymer of drug release. Because of special egg box structure of SA, the sodium ions in the structure can be exchanged with divalent cations through crosslinking, which could control the pore size inside the material and release rate of the loaded drug. Here, we utilized the composite of sodium alginate and polyethylene oxide (PEO) with natamycin loaded through crosslinking with calcium ion ethanol aqueous solution to delay drug release and treat fungal keratitis. The results from experiments proved that the membrane with the slowest rate of drug release was the group with the ratio of ethanol to water 2:1, and the 1% natamycin-loaded films could effectively inhibit the growth of Aspergillus fumigatus . SA-PEO membranes could reduce the inflammatory response. Conclusively, NATA-SA-PEO films could be considered a useful approach to prolong ocular natamycin maintenance and improve the outcome of fungal keratitis. Graphical
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2025
·
IF 3.3
Wang Xiang,Zhang Di,Li Charlie,Zhang Junwei,Tong Cailing,Sun Yilan,Pang Jie
Pure konjac glucomannan (KGM) film has certain limitations in mechanical properties, antioxidant activity, and preservation ability. To solve these limitations, osmanthus powder (OP) was innovatively added to KGM film-forming solution to prepare KGM-based film by casting method.The effect of varying amounts of OP on the rheological properties of film-forming solution, the structure, physicochemical, functional properties of KGM edible film were evaluated. The results showed that the addition of different amounts of OP variously affects the performance of the KGM film. The addition of OP enhanced the mechanical properties, antioxidant, antibacterial, UV blocking, and degradation ability of the film. Furthermore, when the addition amount of OP was 0.25%, the KGM edible film containing osmanthus aroma exhibited optimal overall performance. The film showed good mechanical properties, antioxidant, UV blocking, and had preservation effects for fresh-cut apples. Additionally, the addition of OP improved the sensory evaluation of edible films, imparting them with a unique osmanthus aroma, thus providing a new method to improve edible film packaging.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-17
·
IF 3.9
Zhao Yuliang,Sun Tingting,Zhang Huawei,Lian Chao,Zhao Zhongpeng,Jiang Yongqiang,Duan Huiqi,Ren Yuhao,Sun Xuyang,Zhan Zhikun,Qu Mingyue,Chen Shaolong
Staphylococcal enterotoxin B (SEB) holds critical importance in disease diagnosis, food safety, and public health due to its high toxicity and potent pathogenicity. Traditional immunoassay methods for detecting SEB often exhibit insufficient accuracy and robustness. This study leverages machine learning technology to integrate the quantitative measurement advantages of electrochemical methods with the strong specificity of immunoassays, achieving high-precision coupled electrochemical immunodetection of SEB. Firstly, an electrochemical immunosensing system was developed to capture the target analyte SEB by immobilizing specific antibodies on the electrode surface. Cyclic voltammetry (CV) was utilized to accurately characterize the immune response process. Secondly, feature selection methodologies within machine learning are utilized to identify eight key parameters from CV curves that are highly related to SEB concentration. This enhancement significantly improves both the accuracy and interpretability of SEB measurement data. Lastly, a multivariate linear regression algorithm is employed to effectively train and fit the extracted feature data. This approach successfully mitigates noise introduced by variations in electrode batches, experimental conditions, and operational techniques-thereby enabling robust quantitative measurements of SEB concentration with high precision. The entire detection process requires only 20 μL sample and is accomplished in just two minutes. This method can detect antigen concentrations at both ng/mL and μg/mL levels, with a detection limit of 1 ng/mL. The \(R^2\) score for predicting SEB antigen concentration is approximately 0.999, accompanied by a mean absolute percentage error (MAPE) of 6.09% This approach achieves high precision, robustness, and specificity in SEB detection, offering extensive detection range, rapid response time, and cost-effectiveness, presenting new opportunities for identifying various pathogenic toxins.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Bai Yizhuo,Zhang Shiyu,Zhang Kaifan,Li Jiali,Zhang Jiehe,Hao Mingxu,Tao Haisheng
Nitro-functionalized NO 2 -MIL-53(Fe) was synthesized by modifying MIL-53(Fe) to enhance persulfate activation for the degradation of tetracycline (TCN). Comparative studies with NH 2 -MIL-53(Fe) and pristine MIL-53(Fe), it was found that NO 2 -MIL-53(Fe) is categorized as an ideal type I isotherm, without observable hysteresis loop. The introduction of nitro-group incorporation significantly increased specific surface area clocking in at 298.3 m 2 /g and an average pore diameter of 3.3 nm, created uniform micropores, and improved adsorption capacity. Structural characterization confirmed Fe(II) generation and electron transfer in NO 2 -MIL-53(Fe), enabling 82.1% TCN removal within 30 min. Radical (SO 4 ·− , ·OH, O 2 ·⁻ ) and non-radical ( 1 O 2 , charge transfer) pathways synergistically drove degradation, as evidenced by quenching experiments and EPR analysis. ESI-Q-TOF MS identified key intermediates, proposing plausible TCN degradation pathways. This study highlights the potential of nitro-functionalized metal-organic frameworks (MOFs) in advanced oxidation processes, emphasizing their enhanced catalytic activity and performance mechanisms, and provides new ideas for the remediation of pollutants in water bodies. Graphical abstract
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Nature Catalysis
·
2021
·Vol. 4
·期 11
·959-967
·
IF 41.813
Wang Qianru,Pan Jaysree,Guo Jianping,Hansen Heine Anton,Xie Hua,Jiang Ling,Hua Lei,Li Haiyang,Guan Yeqin,Wang Peikun,Gao Wenbo,Liu Lin,Cao Hujun,Xiong Zhitao,Vegge Tejs,Chen Ping
Ammonia is the feedstock for nitrogen fertilizers and a potential carbon-free energy carrier; however, its production is highly energy intensive. Conventional heterogeneous catalysts based on metallic iron or ruthenium mediate dinitrogen dissociation and hydrogenation through a relatively energy-expensive pathway. Here we report the ternary ruthenium complex hydrides Li 4 RuH 6 and Ba 2 RuH 6 as an alternative class of catalysts, composed of electron- and hydrogen-rich [RuH 6 ] anionic centres, for non-dissociative dinitrogen reduction, where hydridic hydrogen transports electrons and protons between the centres, and the Li/Ba cations stabilize N x H y ( x = 0–2, y = 0–3) intermediates. The dynamic and synergistic involvement of all the components of the ternary complex hydrides facilitates an associative reaction mechanism with a narrow energy span and perfectly balanced kinetic barriers for the multistep process, leading to ammonia production from N 2 + H 2 with superior kinetics under mild conditions.
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Biochar
·
2026
·Vol. 8
·期 1
·48
·
IF 15.1
Zhang Xiangyu,Zhang Peng,Jiao Le,Zhang Yanwei,Sun Hongwen,Liu Chenglan
Agricultural herbicide contamination in soil poses a significant challenge to global food security and ecosystem health. However, conventional remediation strategies often neglect the co-control of parent compounds and their more mobile transformation products, thereby increasing the risks of crop uptake and incomplete detoxification. Here, we have developed a novel nitrogen-doped biochar-modified zero-valent iron nanocomposite (NC-ZVI) that enables multi-interface regulation of pollutants in soil–plant systems, simultaneously promoting soil remediation and safeguarding crop health. Engineering of atomic Fe–C and Fe–N coordination along with N-doped active sites modulated the electronic structure of ZVI, enhancing the surface reactivity and electron capability in NC-ZVI. This enabled rapid removal of approximately 90% of acetochlor in soil within 7 d by reinforced interfacial catalytic degradation. NC-ZVI also promoted the release of iron ions, driving the formation of iron plaques on maize root surfaces. These plaques established a dynamic protective barrier that reduced the total concentrations of acetochlor and its degradation products in maize by 81.2% while maintaining iron nutrient uptake. The multi-interface interaction strategy not only restored maize productivity, increasing its aboveground biomass by 208.4%, but also preserved soil microbial diversity, all at a cost-competitive level. Overall, this work advances the understanding of the interactions between biochar-based materials and pollutants in soil–plant systems, providing a powerful tool to tackle soil pollution and enhance food safety.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2026
·
IF 4.7
Hailong Feng,Hongtao Luo,Xiugeng Li,Yang Jiang,Baihui He
Ferroptosis is a novel anticancer therapeutic approach that effectively circumvents the apoptotic cell death mechanism. Nonetheless, enhancing the catalytic effectiveness of the Fe 2+ -mediated Fenton reaction and effectively inducing ferroptosis present significant challenges. In this study, motivated by the kinetics of hyperthermia-improved Fenton reactions, we initially developed Quercetin (QT)-Curcumin (CUR)-Iron (Fe)-coordinated nanochelates for photothermal-improved ferroptosis in anticancer therapy. We precisely adjusted the appropriate feeding rate of polyvinylpyrrolidone (PVP), QT, CUR, and Fe to develop unique nanofibrous QT-CUR-Fe chelates, referred to as QCFs. The differences in size and structure made QCFs more practical for colorectal cancer therapy than ultrasmall QT-Fe (QFs). Under NIR laser exposure, QCFs can continuously enhance the formation of depleted excessive GSH and toxic hydroxyl radicals (•OH), leading to increased lipid peroxidation (LPO) accumulation and subsequently activating the ferroptosis pathway in vitro. Furthermore, the incorporation of CUR may suppress prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2) in conjunction with PTT-improved ferroptosis colorectal therapy to facilitate dendritic cell (DC) maturation, elicit immunogenic cell death (ICD), and enhance synergistic antitumor immunotherapy. Overall, this study proposed a way to integrate small-molecule immunomodulators into QFs nanocoordination to overcome its limitations, thereby fostering a novel design concept for colorectal cancer therapy.
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JOURNAL OF FLUORESCENCE
·
2026
·
IF 3.4
Su Qian,Huang Li,Zhang Youjin,Yang Zhiyong
Carbon dots (CDs) have been broadly employed in many fields due to their excellent fluorescence property, especially in pharmaceutical analysis. Herein, we developed a simple and rapid method to prepare the phosphorus-nitrogen (P, N) co-doped carbon dots via a 3-minute 50-second microwave-assisted synthesis, using N-butyldiethanolamine as the carbon source with phosphoric acid accelerating the CDs formation reaction. The prepared CDs (termed CD1) were characterized by TEM, FT-IR, XPS, XRD and fluorescence spectroscopy. P, N co-doped CDs exhibited notable water solubility, a quantum yield of 19.7% and good photobleaching resistance. Taking advantage of their superior fluorescence, these CDs served as a bright-blue probe for tigecycline detection through fluorescence quenching. The sensor displayed excellent selectivity and anti-interference ability against common coexisting drugs (e.g., voriconazole, ceftazidime, amikacin). Under optimized conditions, a wide linear range (1-936 µM) between F 0 / F and Tigecycline concentration was established, with a correlation coefficient (R) of 0.984, and the detection limit (LOD) was calculated to be 1.10 µM. Furthermore, we clarified the fluorescence quenching mechanism of CD1 toward tigecycline, which was attributed to the internal filtration effect (IFE). Thus, this work demonstrated a novel P, N co-doped CD-based sensing strategy for rapid tigecycline monitoring.
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Food Analytical Methods
·
2026
·Vol. 19
·期 2
·112
·
IF 3
Tang Tingting,Chen Ziyi,Chen Shu,Zhang Peisheng,Zeng Rongjin,Hao Yuanqiang
This study developed and validated a photoelectrochemical (PEC) platform for hydrogen sulfide (H 2 S) analysis in alcoholic beverages by electrodepositing/annealing dense BiFeO 3 films on FTO and converting them in situ into BiFeO 3 /Bi 2 S 3 heterojunctions. Phase formation and elemental redistribution were verified by XRD, SEM/EDS, and XPS; UV–vis/Tauc and Mott–Schottky supported broadened visible absorption and a direct Z-scheme alignment, while EIS revealed a markedly lowered interfacial charge-transfer resistance. Under optimized conditions, the sensor delivered a linear range of 0.1‒100 μM with an LOD of 36 nM, along with good selectivity against common anions and thiol-bearing interferents and excellent cycling photostability. In real matrices, standard additions achieved recoveries of 99.2%‒103.5% in water; beer and red wine contained 1–2 μmol·L ‒1 H 2 S with 94.5%‒106.5% recoveries. These results demonstrated that in situ chemical conversion coupled with Z-scheme interfacial engineering offers a simple, robust, and general route to rapid, sensitive, and matrix-tolerant PEC monitoring of H 2 S in complex fermented beverages.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Xu Qian-Yue,Xie Si-Yu,Wang Hai-Bo
Herein, a colorimetric and smartphone dual-channel sensor has been constructed for the sensitive detection of acetone based on a chemically driven redox-cycling reactive system. In the redox-cycling system, o -phenylenediamine (OPD) acted as the colorimetric substrate. Initially, colorless OPD was oxidized by Cu 2+ ions to generate Cu + ions and light yellow 2,3-diaminophenazine (DAP). The Fenton-like reaction between hydrogen peroxide (H 2 O 2 ) and generated Cu + ions initiated the production of Cu 2+ ions and hydroxyl radicals (·OH). The resulting ·OH and reproduced Cu 2+ ions could further catalyze other OPD molecules, leading to the formation of more light yellow DAP molecules, with a distinct ultraviolet absorption peak appearing at 440 nm. And this process continued until all OPD was completely consumed in the cycling reaction system. Interestingly, acetone was introduced into the redox-cycling system, leading to a colorless solution and a reduction of absorbance intensity at 440 nm. Based on this phenomenon, a colorimetric sensor with excellent sensitivity and selectivity has been designed for the visual detection of acetone. The sensor exhibited a linear correlation with acetone concentrations within the range of 2 μM to 5 mM, achieving a detection limit of 0.5 μM. Notably, RGB color space analysis was performed for the quantitative detection of acetone with the assistance of a smartphone. The results were in good agreement with the data obtained via UV-visible absorption spectroscopy. Furthermore, the strategy realized the rapid detection of acetone in real tap water, river water, and lake water samples. Graphical abstract
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危险品化学品经营许可证（带存储）