Environmental Earth Sciences
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2025
·Vol. 84
·期 12
·1-12
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IF 2.8
Jiang Chengchen,Zhou Shuai,Shu Xiaohua,Yu Guo,Zeng Honghu,Zhu Zongqiang,Yang Chen,Dang Zhi
Composite pollution poses a significant challenge for soil remediation. This study simulated arsenic and PAH-contaminated soil in karst regions to evaluate the effectiveness of electro-bioremediation under varying soil conditions. Results showed that Alcaligenes faecalis subsp. faecalis exhibited strong PAH degradation and moderate As(V) reduction capabilities. PAH removal efficiency was maximized (55.93%), while arsenic removal efficiency declined as pH increased. Higher soil organic carbon and available nitrogen reduced arsenic removal, whereas increased available phosphorus enhanced it. Under optimized conditions (35 g/kg organic carbon, 150 mg/kg nitrogen, 50 mg/kg phosphorus), residual arsenic was minimized (118.80 mg/kg), and PAH removal peaked at 45.47%. These findings underscore the pivotal role of soil parameters in remediation efficiency, offering practical insights for optimizing electro-bioremediation strategies for soil contaminated by arsenic and PAH.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 11
·1-22
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IF 2.8
Liu Gang,Zhang Aoyang,Ahmed Shams Forruque,Ma Weiwu
In the current study, nitrogen and oxygen (N/O)-co-doped porous carbon for supercapacitors was successfully synthesized from sunflower discs through activation modification with potassium citrate and urea. Material characterization and electrochemical performance testing in three-electrode and two-electrode systems demonstrated that the porous carbon (SDU-900), prepared under activation conditions at 900 \(^{\circ }\) C exhibited an interconnected pore structure and excellent electrochemical properties. In a three-electrode system (6 M KOH as the electrolyte, current density of 0.5 A/g), SDU-900 demonstrated a high specific capacitance of 294.2 F/g. Moreover, the symmetric device based on SDU-900 exhibits an excellent energy density of 20.05 Wh/kg at a power density of 495 W/kg. After 15,000 galvanostatic charge–discharge (GCD) cycles at 5 A/g, the initial specific capacitance was retained at 93.89%, indicating remarkable cycling stability. Notably, the activation process utilized sunflower discs discarded from agricultural production as precursors, replacing the highly corrosive alkali activators with potassium citrate, a benign salt. This approach provides an environmentally friendly method for synthesizing porous carbon for supercapacitor applications.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Yuan Jiashuai,Jian Chuanyong,Shang Zhihui,Yao Yu,Wang Bicheng,Li Yixiang,Wang Rutao,Fu Zhipeng,Li Meng,Hong Wenting,He Xu,Cai Qian,Liu Wei
Two-dimensional (2D) materials have been identified as promising candidates for future electronic devices. However, high dielectric constant (κ) materials, which can be integrated with 2D semiconductors, are still rare. Here, we report a hydrate-assisted thinning chemical vapor deposition (CVD) technique to grow manganese oxide (Mn 3 O 4 ) single crystal nanosheets, enabled by a strategy to minimize the substrate lattice mismatch and control the growth kinetics. The material demonstrated a dielectric constant up to 135, an equivalent oxide thickness (EOT) as low as 0.8 nm, and a breakdown field strength ( E bd ) exceeding 10 MV/cm. MoS 2 field-effect transistors (FETs) integrated with Mn 3 O 4 thin films through mechanical stacking method operate under low voltages (<1 V), achieving a near 10 8 I on /I off ratio and a subthreshold swing (SS) as low as 84 mV/dec. The MoS 2 FET exhibit nearly zero hysteresis (<2 mV/MV cm⁻¹) and a low drain-induced barrier lowering (~20 mV/V). This work further expands the family of 2D high- κ dielectric materials and provides a feasible exploration for the epitaxial growth of single-crystal thin films of non-layered materials.
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Journal of Analysis and Testing
·
2025
·
IF 7
Wang Shuaishuai,Shen Chen,Wei Yuqing,Zhao Hongwei,Chen Jia,Zhang Bo,Qiu Hongdeng
Ion exchange chromatography (IEC) is one of the essential methods to separate rare earth elements (REEs), which relies on the stationary phase. In this study, a novel aromatic sulfonic acid-modified silica stationary phase (SCX-Tol) was synthesized by grafting aromatic sulfonic acid groups onto silica surfaces using 2-(4-chlorosulfonylphenyl)ethyl trichlorosilane as the functionalizing agent in toluene. The successful modification was confirmed by scanning electron microscopy (SEM), elemental analysis, X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR). The chromatographic performance of SCX-Tol was systematically evaluated and compared with two commercial ion-exchange columns. The results demonstrated the superior separation efficiency of SCX-Tol, particularly in the challenging separation of dysprosium (Dy) and yttrium (Y), which are traditionally difficult to resolve using chromatographic methods. The separation efficiency improved with an increasing density of sulfonic acid groups on the stationary phase surface. These findings indicate that SCX-Tol is a promising stationary phase for both the separation and quantification of REEs, offering the potential applications in separating and detecting REEs.
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AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 5
·1-12
·
IF 4
Liu Xiaoqing,Dong Xiaoling,Peng Zhen,Wang Cuihong,Wan Jianwei,Chen Min,Zheng Chunli
In this study, a quercetin-loaded liposome system modified with collagenase was developed to increase QU penetration in the ECM and improve IPF treatment. Quercetin-loaded long circulation liposome (QU-LP) and quercetin-loaded liposome modified with collagenase type I (QU-CLP) were prepared, followed by characterization of the encapsulation efficiency, particle size, morphology, and in vitro drug release. Their effect on the cytotoxicity of A549 cells was detected by the Cell Counting Kit-8, and the cellular uptake was investigated using cellular fluorescence imaging and flow cytometry. TGF-β1 induced A549 cell model was established to mimic pulmonary fibrosis to explore further the anti-pulmonary fibrosis effect of QU-CLP by CCK8 experiment. QU-CLP significantly improves the solubility and bioavailability of QU by encapsulating it in the internal cavity with a high encapsulation efficiency (EE%) of 92.86 ± 1.03%. Liposomes alleviate the influence of QU on normal A549 cell growth. Enhanced fluorescence intensity was observed in A549 cells treated with coumarin 6-labeled and collagenase-modified nanoliposomes (C6-CLP) after 4 h of incubation on the collagen matrix, confirming that collagenase-loaded liposomes could penetrate the collagen barrier and cells internalized more hydrophobic drug. The mean fluorescence intensity (MFI) of the C6-CLP group was 2.88 times that of the C6-labeled nanoliposomes (C6-LP). Moreover, QU-CLP significantly (** P < 0.01) inhibited the proliferation of A549 cells stimulated by TGF-β1. QU-CLP has excellent potential for delivering QU with enhanced bioavailability, high cellular uptake efficiency, and improved therapeutic efficacy in IPF. Graphical abstract
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MARINE BIOTECHNOLOGY
·
2025
·Vol. 27
·期 3
·1-9
·
IF 2.8
Li Jinling,Zhou Zhiyan,Feng Fangjian,Yuan Wei,Zhang Yawen,Wang Jiaxing,Zhang Bin,Jin Haixiao,He Shan,Ding Lijian
Epilepsy is a serious brain disease that urgently needs new drugs to treat it. In this study, three new α -pyrone derivatives, nocardipones A − C ( 1 − 3 ), were isolated from the sponge-associated actinomycete Nocardiopsis sp. NBUDK19 guided by anti-epileptic bioactivity using an in vivo zebrafish model. Compounds 1 − 3 were isolated and purified by silica gel column chromatography combined with semi-preparative HPLC. The structures of 1 − 3 were elucidated by UV, HRESIMS, NMR spectroscopic analysis, optical rotation, and computational chemical calculations. Our pharmacological study showed that compounds 1 − 3 exhibited notable reductions in seizure-like locomotor activity at 5 μg/mL. The qPCR analysis showed that compounds 1 − 3 significantly regulated the mRNA expression levels of c-fos and genes associated with GABAergic-glutamatergic signaling, including gria1b and gat1 . The molecular docking revealed that compounds 1 − 3 strongly binding to 4-aminobutyric acid transaminase, with binding energies of − 7.3, − 7.8, and − 7.3 kcal/mol, respectively. This work enriches bioactive drug discovery to treat epilepsy and illustrates an underlying pharmacological and molecular mechanism of these natural α -pyrones.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Chen Binmeng,Wang Meng,Manzano Hegoi,Zhao Yuyang,Li Yunjian
Silane coupling agents are widely recognized to retard early hydration when incorporated into fresh cement paste, yet the atomic-level mechanisms underlying their effects on clinker dissolution, such as adsorption of silane monomer onto reactive surface sites and modification of ion detachment pathways, remain unexplored. Here we show dissolution behavior of tricalcium silicate (Ca 3 SiO 5 ) under 3-aminopropyl triethoxysilane impact using ab initio metadynamics, with experimental validation of the retardation effects in silane-treated pastes. The shielding effect of silane induces shifts in free energy changes of stepwise calcium dissolution from negative to positive and alters the most stable Ca coordination state during dissolution, resulting in the transition of dissolution from spontaneous to non-spontaneous. Specifically, hydrolyzed silane adsorbs dissociatively onto the Ca 3 SiO 5 surface by forming ionic Ca-O bonds, thereby occupying reactive sites and introducing steric hindrance. This, in turn, impedes coordination interactions between calcium ions and water molecules. Experimental results further corroborate these interactions, as evidenced by reduced calcium concentrations in silane-treated pastes, which in turn slowed the hydration process. These findings offer nanoscale insights into the role of SCAs in cement hydration and provide a foundation for future research into the complex interactions within organic/cement systems.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-23
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IF 12.6
Su Yanguo,Chen Rui,Wang Bingjie,Wang Teng,Tao Jiaojiao,Diao Qijie,Jiang Tianze,Zhao Xia
Activation of cGAS-STING signaling pathway and accumulation of reactive oxygen and nitrogen species (RONS) are important issues facing the treatment of rheumatoid arthritis (RA). Here, we report a biomimetic nano-Chinese medicine (HA-RM-Cel-BR) for RA immunotherapy based on STING inhibition of celastrol (Cel) and RONS clearance of bilirubin (BR). HA-RM-Cel-BR is constructed by the carrier-free self-assembly of active ingredients Cel and BR from traditional Chinese medicine, and then camouflaged by hyaluronic acid (HA)-modified red blood cell membranes (RM). HA-RM-Cel-BR prolongs circulation time through RM camouflage, targets inflamed joints by HA modification, and remodels the joint immune microenvironment by STING inhibition and RONS clearance. More importantly, HA-RM-Cel-BR shows excellent therapeutic effects on RA rat model, and significantly reduces hepatotoxicity associated with Cel. Our work provides a new strategy for RA immunotherapy with traditional Chinese medicine ingredients.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Deng Qiyu,Zhu Hengjia,Zhao Zhipeng,Li Hegeng,Yang Ling,Wu Xinya,Zhang Yiyuan,Yu Peng,Tang Xin,Li Wei,Yin Xiaobo,Wang Liqiu
Adjusting magnetization orienting and conformal assembling of high-coercivity micro-magnets at the microscale remains challenging, despite long-standing demand for space-resolved magnetic modulation in various applications. Local magnetic modulation, including remagnetization or reassembly, typically requires high fields and temperatures to overcome the coercivity and stringent conditions while suffering from low assembly efficiency or poor spatial resolution. Here, we report a linear magnet composed of a hydrogel (alginate) matrix and precisely discrete phase-change-material (PCM, eicosane) cells containing micro-magnetic particles (NdFeB, ~5 µm). Moderate local laser heating (~40 °C) reversibly switches PCM from solid to fluid state thus relaxing particles’ interfacial constraints inside the hydrogel matrix, overcoming the high-coercivity of magnetic assembly and allowing particles in cells to reorient under mild fields (≤30 mT). The linear magnet shows excellent discrete magnetization programmability (~150 µm) and stretchability (strain ~80%), enabling versatile functionalities such as conformal and patterned field generation, soft robotic actuation, flexible sensing, and interactive wearables with dynamically coded information.
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ACTA PHARMACOLOGICA SINICA
·
2025
·
IF 8.4
Xia Ling-yan,Yu Nai-rong,Huang Su-ling,Qu Hui,Qin Li,Zhao Qin-shi,Leng Ying
Non-alcoholic steatohepatitis (NASH) has emerged as a prevalent chronic liver disease with a huge unmet clinical need. A few studies have reported the beneficial effects of Poria cocos Wolf ( P. cocos ) extract on NASH mice, but the active components were still unknown. In this study we investigated the therapeutic effects of dehydrotrametenolic acid methyl ester (ZQS5029-1), a lanosterol-7,9(11)-diene triterpenes in P. cocos , in a high-fat diet plus CCl 4 induced murine NASH model and a GAN diet induced ob/ob murine NASH model. The NASH mice were treated with ZQS5029-1 (75 mg·kg –1 ·d –1 , i.g.) for 6 and 8 weeks, respectively. We showed that ZQS5029-1 treatment markedly relieved liver injury, inflammation and fibrosis in both the murine NASH models. We found that ZQS5029-1 treatment significantly suppressed hepatic NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in both the NASH murine models, and blocked lipopolysaccharides (LPS)+adenosine 5’-triphosphate (ATP)/Nigericin-induced NLRP3 inflammasome activation in bone marrow-derived macrophages (BMDMs) and Kupffer cells in vitro. We demonstrated that ZQS5029-1 directly bound to the H236 residue of mouse Caspase-1, thereby inhibiting NLRP3 inflammasome activation. The effects of ZQS5029-1 on macrophage-hepatocyte/HSC crosstalk were analyzed using the supernatants from macrophages preconditioned with LPS + ATP introduced into hepatocytes and hepatic stellate cells (HSCs). We found that the conditioned medium from the BMDMs induced injury and death, as well as lipid accumulation in hepatocytes, and activation of HSCs; these effects were blocked by conditioned medium from BMDMs treated with ZQS5029-1. Moreover, the protective effects of ZQS5029-1 on hepatocytes and HSCs were eliminated by H236A-mutation of Caspase-1. We conclude that ZQS5029-1 is a promising lead compound for the treatment of NASH by inhibiting NLRP3 inflammasome activation through targeting Caspase-1 and regulating the macrophage-hepatocyte/HSC crosstalk.
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Discover Oncology
·
2025
·Vol. 16
·期 1
·1-13
·
IF 2.9
Huang Hai-yi,Lin Lisa Zong Yong,Lu Xin-yi,Jiang Ying
Triple negative breast cancer (TNBC) refers to a molecular subtype of breast cancers (BC) with high rate of distant metastases and poor prognosis. Epirubicin (EPI) is widely used for the therapy of TNBC but it’s limited in clinical use due to cardiotoxicity and chemotherapy resistance. We previously identified F-α-DDB-derivative, a novel synthetic of bifendate, as a potential agent to improve the therapeutic efficacy of TNBC in combination with EPI since F-α-DDB-derivative inhibited MDA-MB-468, but not as much as EPI. In this study, we investigated the antitumor activity of F-α-DDB-derivative in combination with EPI against TNBC in vitro and in vivo and whether co-treatment would induce additional cardiotoxicity. In human TNBC MDA-MB-468 cells, application of F-α-DDB-derivative (11.5, 23.0, 46.0 μg/ml) in combination with EPI (1.5, 3.0, 6.0 μg/ml) exhibited great inhibition on cell viability and cell proliferation. Additionally, F-α-DDB-derivative (5.75, 11.5, 23.0, 46.0 μg/ml) interacted with EPI (0.75, 1.5, 3.0, 6.0 μg/ml) synergistically to induce apoptosis in MDA-MB-468 cells. This suggests that F-α-DDB-derivative may be more sensitive to apoptotic pathways. Furthermore, we revealed that co-administration of EPI and F-α-DDB-derivative (ip, once every other day for 14 days) significantly increased the therapeutic efficacy of EPI (2.0 mg/kg) or F-α-DDB-derivative (20.0 mg/kg) in mice harboring MDA-MB-468 cell xenografts without additional cardiotoxicity compared to that in EPI monotherapy group. These results implicate that co-treatment of EPI and F-α-DDB-derivative may be a potential therapeutic approach for the treatment of TNBC.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Zhu Zijie,Liu Yiwen,Qin Yuanbin,Gu Fangchao,Zhuang Lei,Yu Hulei,Chu Yanhui
Developing bioinspired all-ceramics with plastic phases is considered one of the most effective ways to simultaneously achieve enhanced strength and toughness in ceramic materials for high-temperature applications. Here we explore tough and strong bioinspired high-entropy all-ceramics with a contiguous network structure that are able to serve up to 1300 °C. Specifically, we develop the high-entropy all-ceramics, featuring a unique contiguous network distribution of the Cr 7 C 3 plastic phase within the predominant high-entropy carbide (HEC) hard phase, through a high-entropy composition-engineering strategy. The resulting materials exhibit impressive fracture initiation toughness of 12.5 ± 1.5 MPa·m 1/2 and flexural strength of 613 ± 52 MPa at room temperature, as well as ~97% strength retention up to 1300 °C due to their good high-temperature stability, surpassing the performance of most other reported bioinspired ceramics. Further experimental and theoretical investigations demonstrate that the Cr 7 C 3 phase can undergo plastic deformation by forming nanoscale shear bands with significant crystal defects, resulting in multiple toughening mechanisms involving crack-bridging of unfractured Cr 7 C 3 ligaments and crack deflection in the HEC/Cr 7 C 3 all-ceramics. This work successfully develops tough and strong bioinspired high-entropy all-ceramics capable of serving up to 1300 °C, offering an innovative strategy that facilitates further design of bioinspired ceramics applicable at higher temperatures.
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