INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 1
·349
·
IF 4.9
Hongying Zhang,Yulong Liu,Yukun Huang,Kaiwen Zhao,Tingting Yu,Youjuan Wu,Zijia Yin,Meifeng Li,Dongming Li,Lihua Fan,Xiaowen Xu,Chengyu Hu,Shanghong Wang
Abamectin is an insecticide, miticide and nematicide that has been extensively used in agriculture for many years. The excessive use of abamectin inevitably pollutes water and soil and might even cause adverse effects on aquatic biota. However, it is currently unclear how abamectin exposure causes neurotoxicity in aquatic organisms. Herein, the early neural system development was assessed in zebrafish embryos following abamectin exposure. After treatment with a concentration gradient of abamectin (0.055, 0.0825, 0.11 mg/L), the survival rate, average heart rate, pericardial edema area and yolk sac edema were all documented in zebrafish embryos (96 hpf). It was found that after abamectin exposure, embryonic brain development was impaired, and motor behaviors were also affected. The fluorescence intensity was reduced in the transgenic embryos (Eno2: GFP). The activities of acetylcholinesterase (AChE) and ATPase were decreased, and the expression of neurodevelopment-related genes, such assox10,gap43,grin1b,abat,gad1b,grin2b,nestinandglsa, were all inhibited in zebrafish embryo treatment with abamectin. Furthermore, the reactive oxygen species (ROS) were triggered upon exposure to abamectin in zebrafish embryos along with the accumulation of ROS, eventually resulting in neuroapoptosis in the developing embryonic brain. In conclusion, neurodevelopmental toxicity was caused by oxidative stress-induced apoptosis in zebrafish embryos following abamectin exposure.
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MACROMOLECULES
·
2016
·
IF 5.554
Kaiyi Zhou,Hui Cao,Pan Gao,Zhigang Cui,Yi Ding,Yuanli Cai
Autocatalytic self-sorting in the biomimetic poly(cystamine methacrylamide hydrochloride) (PCysMA) is presented, whose units comprise lysine-mimetic alkylammonium ions and cystine-mimetic alkyl disulfide spacers. The block copolymer with poly(2-hydroxypropylmethacrylamide) was synthesized directly by RAFT in acidic water under visible light irradiation at 25 °C. Disulfide exchange can be initiated by the terminal thiolates as generated by alkalization-induced aminolysis. 65–67% CysMA units sort into hydrophobic polymer disulfides and water-soluble cystamine at pH 10.5. Moreover, intermediate reactions occur in the presence of copper ions, i.e., Cu(II)–NH2 coordination, aminolysis, NH2-to-SH substitution, and cupric-to-cuprous reduction in metal centers, thus autocatalytic self-sorting with essentially 100% conversion at pH 8.8. UV–vis spectroscopy, 1H NMR, atomic absorption spectroscopy, and elemental analysis confirmed this ideal self-sorting. Dynamic light scattering and atomic force microscopy identified supramolecular-to-supracolloidal self-assembly with concomitant release of cystamine molecules and intermediate cuprous complexes. Such a self-sorting underlines an amazing prospect for the use of a single polymer to achieve artificial reaction complexity, hierarchy, and metabolic process, with minimal synthetic efforts.
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JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
·
2015
·Vol. 38
·期 5
·508-512
·
IF 1.189
M. Zhao,K.-Z. Xie,H.-S. Guo,A.-H. Li,X. Xie,G.-X. Zhang,G.-J. Dai,J.-Y. Wang
A residue depletion study of ampicillin (AMP) was performed after oral dosing (60.0 mg/kg and 120.0 mg/kg body weight once a day for 5 days) to laying hens, through the use of reversed-phase high-performance liquid chromatography with fluorescence detection (RP-HPLC-FLD) to achieve detection of ampicillin residue in eggs. Limit of detection was 0.5 ng/g, and limit of quantitation was 1.2 ng/g for ampicillin. Extraction recoveries of ampicillin from samples fortified at 5.0–125.0 ng/g levels ranged from 77.5% to 84.6% in albumen, 77.9% to 87.5% in yolk, and 77.9% to 88.6% in whole egg, with coefficients of variation ≤9.3%. The maximum concentrations of ampicillin in albumen, yolk, and whole egg were detected at 1, 2, and 1 day after the last administration of ampicillin, respectively. Ampicillin was not detectable in albumen at day 9 of withdrawal time, at day 10 and 11 in yolk, and day 9 and 11 in whole egg at each of those 2 dose levels. The theoretical withdrawal time of AMP in whole egg was 6.730 and 7.296 days for 60 and 120 mg/kg oral dosage, respectively. This method also proved to be suitable as a rapid and reliable method for the determination of ampicillin in other poultry eggs.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Tang Si,Liu Yaqing,Zhu Jianming,Cheng Xueyu,Liu Lu,Hammerschmidt Katrin,Zhou Jin,Cai Zhonghua
Understanding how organisms have adapted to persist in unpredictable environments is a fundamental goal in biology. Bet hedging, an evolutionary adaptation observed from microbes to humans, facilitates reproduction and population persistence in randomly fluctuating environments. Despite its prevalence, empirical evidence in microalgae, crucial primary producers and carbon sinks, is lacking. Here, we report a bet-hedging strategy in the unicellular microalga Haematococcus pluvialis . We show that isogenic populations reversibly diversify into heterophenotypic mobile and non-mobile cells independently of environmental conditions, likely driven by stochastic gene expression. Mobile cells grow faster but are stress-sensitive, while non-mobile cells prioritise stress resistance over growth. This is due to shifts from growth-promoting activities (cell division, photosynthesis) to resilience-promoting processes (thickened cell wall, cell enlargement, aggregation, accumulation of antioxidant and energy-storing compounds). Our results provide empirical evidence for bet hedging in a microalga, indicating the potential for adaptation to current and future environmental conditions and consequently conservation of ecosystem functions.
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ADVANCED MATERIALS
·
2021
·Vol. 33
·期 31
·2008586
·
IF 30.849
Weizhuang Zhuo,Bin Lei,Shuang Wu,Fanghang Yu,Changsheng Zhu,Jianhua Cui,Zeliang Sun,Donghui Ma,Mengzhu Shi,Honghui Wang,Wenxiang Wang,Tao Wu,Jianjun Ying,Shiwei Wu,Zhenyu Wang,Xianhui Chen
The discovery of magnetism in 2D materials offers new opportunities for exploring novel quantum states and developing spintronic devices. In this work, using field-effect transistors with solid ion conductors as the gate dielectric (SIC-FETs), we have observed a significant enhancement of ferromagnetism associated with magnetic easy-axis switching in few-layered Cr 2 Ge 2 Te 6 . The easy axis of the magnetization, inferred from the anisotropic magnetoresistance, can be uniformly tuned from the out-of-plane direction to an in-plane direction by electric field in the few-layered Cr 2 Ge 2 Te 6 . Additionally, the Curie temperature, obtained from both the Hall resistance and magnetoresistance measurements, increases from 65 to 180 K in the few-layered sample by electric gating. Moreover, the surface of the sample is fully exposed in the SIC-FET device configuration, making further heterostructure-engineering possible. This work offers an excellent platform for realizing electrically controlled quantum phenomena in a single device.
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WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2014
·Vol. 30
·期 12
·3245-3250
·
IF 1.353
Guo Xuena,Liu Wei,Bai Xuejing,He Xiuping,Zhang Borun
High-performance liquid chromatography was used to separate Cr(III) and Cr(VI) in samples with detection by inductively coupled plasma mass spectrometry(ICP-MS). The separation was achieved on a weak anion exchange column. The mobile phase was pH 7.0 ammonium nitrate solution. The redox reaction between Cr(III) and Cr(VI) was avoided during separation and determination. This separation method could be used to separate the samples with large concentration differences between Cr(III) and Cr(VI). The alkaline digestion was used to extract chromium in solid sample, which had no effect on the retention time and the peak area of the Cr(VI). However, the conversion of Cr(VI) from Cr(III) was observed during alkaline digestion, which displayed positive relation with the ratio of Cr(III) and Cr(VI) in samples. Both Cr(III) and Cr(VI) contents of chromium yeasts cultured in media with different chromium additions were determined. The spike recoveries of Cr(VI) for chromium yeasts were in the range of 95–108 %.
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高影响因子
MATERIALS SCIENCE FORUM
·
2015
·
IF 0
Wang Fa Xu,Fa Meng Sun,Jing Bo Liu,Xiao Fang Li,Fa Ai Zhang
A series of porous poly(styrene-divinylbenzene) monoliths (polyHIPE) was synthesized by high internal phase emulsions (HIPE). The effects of the ethanol contents on the microstructure of the polyHIPE were characterized by scanning electron microscopy and mercury intrusion porosimeter. The adsorption and release behaviors of the polyHIPE for a monomer mixture consisting of dicyclopentadiene (DCPD) /styrene (St) (DS, mass ratio of 9/1) were investigated. The polymerization of the mixture DS within pores of the polyHIPE was studied. The results showed that the microstructure of the polyHIPE was significantly influenced by the ethanol content. The increase of ethanol in the HIPE increased the internal pore diameter and decreased the pore volume of the polyHIPE, thus decreased the DS absorption and increased the release rate. The DS monomer can enter the pores(cavities, windows) and fill the original holes after the polymerization. Compared with conventional polymerization of DCPD/St, the poly(DCPD/St) (pDS) obtained from confined spaces possess higher molecular weight, broader molecular weight distribution, and higher Tg. As the pore diameter increased, the effect of space confinement reduced, and the performances of pDS were closed to that prepared by conventional polymerization.
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Soft Matter
·
2023
·Vol. 19
·期 34
·6468-6479
·
IF 3.4
Hongyue Wu,Bolun Zhang,Xiaochen Liu,Yuzhou Liu,Jing Cui,Zhongyi Chu
Microstructure adhesive pads can effectively manipulate objects in underwater environments. Current adhesive pads can achieve adhesion and separation with rigid substrates underwater; however, challenges remain in the control of adhesion and detachment of flexible materials. Additionally, underwater object manipulation necessitates considerable pre-pressure and is sensitive to water temperature fluctuations, potentially causing object damage and complicating adhesion and detachment processes. Thus, we present a novel, controllable adhesive pad inspired by the functional attributes of microwedge adhesive pads, combined with a mussel-inspired copolymer (MAPMC). In the context of underwater applications for flexible materials, the use of a microstructure adhesion pad with microwedge characteristics (MAPMCs) is a proficient approach to adhesion and detachment operations. This innovative method relies on the precise manipulation of the microwedge structure's collapse and recovery during its operation, which serves as the foundation for its efficacy in such environments. MAPMCs exhibit self-recovering elasticity, water flow interaction, and tunable underwater adhesion and detachment. Numerical simulations elucidate the synergistic effects of MAPMCs, highlighting the advantages of the microwedge structure for controllable, non-damaging adhesion and separation processes. The integration of MAPMCs into a gripping mechanism allows for the handling of diverse objects in underwater environments. Furthermore, by merging MAPMCs and a gripper within a linked system, our approach enables automatic, non-damaging adhesion, manipulation, and release of a soft jellyfish model. The experimental results indicate the potential applicability of MACMPs in underwater operations.
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Advanced Science
·
2024
·Vol. 12
·期 6
·2411861
·
IF 14.3
Xu Feng,Guanfeng Gao,Quanhua Lin,Yongkang Yang,Jiajia Tan,Ziang Liu,Jianrong Qiu,Xiaofang Jiang,Shifeng Zhou
The entropy mediated temperature-structure evolution has attracted significant interest, which is used for the development of functional alloys and ceramics. But such strategy has not yet been demonstrated for development of non-metallic glasses. Herein, the successful application of the entropy engineering concept to non-metallic glass to manipulate its in situ crystallization process is demonstrated. The comparison of the entropy concept in alloys, ceramics, and non-metallic glass is discussed. As a typical example, the activation and preservation of the entropy stabilized effect of a typical niobosilicate glass system at different temperatures are studied. The relation between the micro-configurations and the entropic property is analyzed. Via the entropy engineering strategy, the crystallization of the niobosilicate glass can be manipulated. As a result, the LiNbO 3 nanocrystal-in-glass (NiG) composite with high crystallinity is developed, which exhibits 8 times higher nonlinearity compared with the β -BBO crystal. The developed NiG composite is demonstrated for practical application in precise measurement of the duration and phase of ultra-short femtosecond pulse.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-9
·
IF 14.919
Cheng Erjian,Xia Wei,Shi Xianbiao,Fang Hongwei,Wang Chengwei,Xi Chuanying,Xu Shaowen,Peets Darren C.,Wang Linshu,Su Hao,Pi Li,Ren Wei,Wang Xia,Yu Na,Chen Yulin,Zhao Weiwei,Liu Zhongkai,Guo Yanfeng,Li Shiyan
The nature of the interaction between magnetism and topology in magnetic topological semimetals remains mysterious, but may be expected to lead to a variety of novel physics. We systematically studied the magnetic semimetal EuAs 3 , demonstrating a magnetism-induced topological transition from a topological nodal-line semimetal in the paramagnetic or the spin-polarized state to a topological massive Dirac metal in the antiferromagnetic ground state at low temperature. The topological nature in the antiferromagnetic state and the spin-polarized state has been verified by electrical transport measurements. An unsaturated and extremely large magnetoresistance of ~2 × 10 5 % at 1.8 K and 28.3 T is observed. In the paramagnetic states, the topological nodal-line structure at the Y point is proven by angle-resolved photoemission spectroscopy. Moreover, a temperature-induced Lifshitz transition accompanied by the emergence of a new band below 3 K is revealed. These results indicate that magnetic EuAs 3 provides a rich platform to explore exotic physics arising from the interaction of magnetism with topology.
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BME Frontiers
·
2025
·
IF 7.7
Liyun Wang,Jialiang Zhou,Shengjie Jiang,Xiaoling Deng,Wenbin Zhang,Kaili Lin
Objective: This study aims to investigate the regulatory effects of piezoelectricity on the inflammatory microenvironment in osteoporosis treatment. Impact Statement: Recent studies have extensively explored the impact of piezoelectric materials on macrophage polarization and cytokine secretion. However, the effects of piezoelectricity on macrophages for the regulation of immune osteogenesis in osteoporosis remain poorly understood. This study provides novel insights into the regulatory role of piezoelectricity in macrophage modulation within osteoporotic diseases. Introduction: The overexpression of various inflammatory factors in osteoporosis exacerbates bone metabolism imbalance. Macrophage polarization plays a pivotal role in inflammation regulation and tissue repair. Therefore, investigating the regulatory effects of piezoelectricity on macrophage polarization is crucial for improving the inflammatory microenvironment and fostering an immune environment conducive to osteoporotic bone regeneration. Methods: This study fabricated polarized potassium sodium niobate ceramic (PKNN) piezoelectric bioceramics using solid-phase sintering and high-pressure polarization techniques, and investigated their regulatory effects on macrophage polarization, anti-inflammatory factor expression, and osteogenic differentiation bone marrow mesenchymal stem cells derived from ovariectomized rats (rBMSCs-OVX). Results: PKNN substantially promotes M2 macrophage polarization and enhances anti-inflammatory factor expression, effectively suppressing inflammatory responses. Further studies demonstrate that PKNN, by modulating macrophages, indirectly regulates osteoblast gene expression, improving the inhibitory effects of the pathological microenvironment on osteogenic differentiation of rBMSCs-OVX. Conclusion: This research provides important theoretical evidence for the development of immunomodulatory osteoporotic bone regeneration materials driven by piezoelectricity.
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Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Lijia Zhou,Xiangjiang Dong,Qiang Li,Xianran Xing
We systematically investigated the superconducting properties of 2H-PtxTaS2 (0 ≤ x ≤ 0.08). As the platinum (Pt) content increases, the charge density wave (CDW) in 2H-TaS2, which appears at approximately 75 K, is progressively suppressed and completely disappears in Pt0.06TaS2. Meanwhile, the superconducting transition temperature (Tc) first increases and then decreases, reaching its maximum value of approximately 4.85 K at x = 0.06. This phenomenon suggests a competitive interplay between CDW and superconductivity (SC) in this system. Further measurements of the superconducting parameters of Pt0.06TaS2 indicate that the enhancement of Tc is primarily attributed to an increase in the density of states at the Fermi level.
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