JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2025
·
IF 4.1
Qianqian Song,Yang Chen,Yongjian Xu,Yatao Yan,Qianhui Wu,Fang Guo,Ming Chen,Guowang Diao
Hydrogen energy represents a form of green energy, and the electrolysis of water for hydrogen production is recognized as an efficient method. Current research is primarily focused on the development of catalysts that are both efficient and stable, particularly those capable of functioning consistently across the entire pH spectrum. In this work, Co 9 S 8 /NC co doped with N and P was successfully synthesized through a series of sulfurization, calcination, and phosphating operations using dual ligand Co-ZIF as the precursor. By coating a carbon layer and co doping with nitrogen and phosphorus, the catalytic performance and stability of hydrogen evolution reaction (HER) were significantly improved over the entire pH range. At a fixed current density of 10 mA cm −2 , the overpotential of HER was measured at voltages of 136, 96, and 194 mV in three different pH solutions. Furthermore, the electrocatalyst exhibits remarkable electrochemical stability over extended periods. After 20 h or 2000 cycles of testing, the catalytic activity did not show a significant decrease across the entire pH range, but rather exhibited a relatively sustained constant.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Ziyan Pu,Zengquan Zhu,Xiao-Jun Lv,Yueming Li
Conventional lithium-ion batteries (LIBs) are nearing their theoretical capacity limit, and there is an urgent need to develop energy storage devices with higher energy densities and cycling stabilities. In this work, a hybrid electrode design, which combines the traditional “rocking chair” mechanism and “anion intercalation” mechanism to improve energy density is reported. The hybrid electrode is composed of LiMn 2 O 4 and N,P-doped graphite (NPG) to use both anion and cation storage mechanisms. This design enhances the electrochemical potential windows and the energy density of the fabricated cell. Electrochemical results show that the fabricated cell not only shows a 44.1 % higher capacity than conventional LIBs. It displays a stable cycle life across a wide climate temperature range from − 20 to 25 °C, with a capacity retention rate of 86 % after 600 cycles at 100 mA g −1 . This study demonstrates the critical role of doping graphite with N and P to improve the electrochemical performance of graphite in deep charge/discharge, providing a valuable strategy for developing cathode materials in dual-ion batteries.
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NEW CARBON MATERIALS
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2024
·
IF 6.5
Tan Yi,Jun-long Huang,Zong-heng Cen,Yi-wei Ji,Shao-hong Liu
Carbon-based catalysts are promising materials for the electrochemical extraction of uranium from seawater. However, their practical application is often limited by high cost and low catalytic activity. Using low-cost polystyrene sulfonic acid resin and melamine as raw materials, a class of nitrogen and sulfur co-doped carbon nanosheets (CNSs) with high catalytic activity has been developed by a low-temperature hydrothermal treatment and high-temperature carbonization. Because of their high conductivity and high catalytic activity, CNS-based electrodes can catalyze uranyl ions in seawater into easily recoverable Na 2 O(UO 3 ·H 2 O) x precipitates at −2 V, and achieve an extraction capacity of up to 3 923.7 mg g −1 with a uranium removal of 98.1% in uranium-spiked seawater (1×10 3 mg L −1 ). In situ Raman spectroscopy showed that a large number of uranium compounds appeared on the surface of the composite electrode within 40 min of extraction. The electrode also recovered 72.7% of the uranium in natural seawater, demonstrating excellent prospects for this application. This work provides a new approach into the design of low-cost, metal-free electrocatalysts for the efficient uranium extraction from natural seawater.
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CANCER SCIENCE
·
2024
·
IF 4.5
Luhaoran Sun,Zeyu Li,Peng Shu,Min Lu
High expression of truncated O-glycans Tn antigen predicts adverse clinical outcome in patients with clear cell renal cell carcinoma (ccRCC). To understand the biosynthetic underpinnings of Tn antigen changes in ccRCC, we focused on N-acetylgalactosaminyltransferases (GALNTs, also known as GalNAcTs) known to be involved in Tn antigen synthesis. Data from GSE15641 profile and local cohort showed that GALNT6 was significantly upregulated in ccRCC tissues. The current study aimed to determine the role of GALNT6 in ccRCC, and whether GALNT6-mediated O-glycosylation aggravates malignant behaviors. Gain- and loss-of-function experiments showed that overexpression of GALNT6 accelerated ccRCC cell proliferation, migration, and invasion, as well as promoted ccRCC-derived xenograft tumor growth and lung metastasis. In line with this, silencing of GALNT6 yielded the opposite results. Mechanically, high expression of GALNT6 led to the accumulation of Tn antigen in ccRCC cells. By undertaking immunoprecipitation coupled with liquid chromatography/mass spectrometry, vicia villosa agglutinin blot, and site-directed mutagenesis assays, we found that O-glycosylation of prohibitin 2 (PHB2) at Ser161 was required for the GALNT6-induced ccRCC cell proliferation, migration, and invasion. Additionally, we identified lens epithelium-derived growth factor (LEDGF) as a key regulator of GALNT6 transcriptional induction in ccRCC growth and an upstream contributor to ccRCC aggressive behavior. Collectively, our findings indicate that GALNT6-mediated abnormal O-glycosylation promotes ccRCC progression, which provides a potential therapeutic target in ccRCC development.
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Cell Death Discovery
·
2024
·Vol. 10
·期 1
·1-16
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IF 6.1
Liu Zhaohong,Xiang Peng,Zeng Shengmei,Weng Ping,Wen Yilin,Zhang Wanping,Hu Hui,Zhao Dezhang,Ma Limei,Yu Chao
Vascular endothelial injury initiates atherosclerosis (AS) progression. N -Acetylneuraminic acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage. And GLS2-associated glutaminolysis disorder contributed to mitochondrial dysfunction. However, mechanisms underlying Neu5Ac-associated mitochondrial dysfunction as well as its association with GLS2 remains unclear. In this study, we constructed GLS2 −/− ApoE −/− mice by using HBLV-GLS2 shRNA injection. And methods like immunofluorescence, western blotting, transmission electron microscopy were applied to detect profiles of endothelial injury and AS progression both in vivo and in vitro. We demonstrated that Neu5Ac accumulation increased GLS2 expression and promoted glutaminolysis disorder, which further induced endothelial mitochondrial dysfunction via a pyroptosis-dependent pathway in vivo and in vitro. Mechanically, Neu5Ac interacted with SIRT3 and led to FOXO3a deacetylation and phosphorylation, further facilitated c-Myc antagonism and ultimately increased GLS2 levels. Inhibition of GLS2 could improve mitochondrial function and mitigate pyroptosis process. In addition, blocking Neu5Ac production using neuraminidases (NEUs) inhibitor could rescue endothelial damage and alleviate AS development in ApoE −/− mice. These findings proposed that Neu5Ac induced GLS2-mediated glutaminolysis disorder and then promoted mitochondrial dysfunction in a pyroptosis-dependent pathway. Targeting GLS2 or inhibiting Neu5Ac production could prevent AS progression.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
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IF 8.1
Jinsong Shi,Jianguo Xu,Hongmin Cui,Nanfu Yan,Runhan Yan,Yaqing Weng
Porous carbon is a very promising type of CO 2 adsorbent due to its excellent stability, low cost, and tunable physicochemical properties. In the current work, N-doped hierarchically porous carbon was synthesized with the assistance of NaCl template and KHCO 3 activation. A series of carbons with three dimensional and interconnected micro- meso -macroporous structure were successfully prepared. Effects of synthesis conditions on textural properties and N-doping were analyzed and discussed with details. The carbons also exhibited high surface area (725–2423 m 2 /g) and N content (1.49–7.93 wt%). CO 2 adsorption properties were studied with a combined experimental and theoretical approach. At 25 °C and 1 bar, the carbons exhibited CO 2 uptake up to 4.22 mmol/g and CO 2 /N 2 selectivity up to 25.6. Grand canonical Monte Carlo (GCMC) simulation was employed to further elucidate the different roles played by N-doping and textural properties during CO 2 adsorption. Effects of various N-functionalities located in pores with different sizes on CO 2 adsorption were thus revealed. The present study presents a novel strategy for controlled synthesis of porous carbons, and provides helpful insights into their CO 2 adsorption behaviors.
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JOURNAL OF CHROMATOGRAPHY A
·
2019
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IF 3.858
Junyu Lu,Jingyi Luan,Yijun Li,Xiwen He,Langxing Chen,Yukui Zhang
Biomedical sciences, and in particular disease biomarker research, demand highly selective and efficient glycoproteins/peptides enrichment platforms. In this work, a facile strategy to prepare hydrophilic maltose-functionalized magnetic metal-organic framework loaded with Au nanoparticles (denoted as [email protected] ) for highly efficient enrichment of N-linked glycopeptides. In brief, carboxyl-functional Fe 3 O 4 nanospheres were firstly coated with a Zr-based MOF shell, the resulting MOF was then loaded with Au nanoparticles in situ and then modified with thiol-functional maltose via Au− S bonds to obtain [email protected] with core-shell structure. The physical property and adsorption of [email protected] to glycopeptides were investigated. The results showed [email protected] possessing the outstanding performance in glycopeptides enrichment with high selectivity (1:200, mass ratio of horseradish peroxidase to bovine serum albumin digest), a low limit of detection (10 fmol), a high recovery (over 83.3%), and a large binding capacity (83 μg•mg −1 ). The [email protected] nanocomposite can enrich 24 and 32 glycopeptides from tryptic HRP and human IgG digests, respectively. Moreover, the nanocomposite was applied to the selective enrichment of glycopeptides from the complex biological samples and a total of 123 unique N-glycosylation sites were identified from 113 glycopeptides in 1 μL of human serum, which were assigned to 46 different glycoproteins. These results showed the promising application of [email protected] in the detection and identification of low-abundance N-linked glycopeptides in complex biological samples.
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CARBOHYDRATE POLYMERS
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2015
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IF 4.074
Wuxia Zhang,Feifei Sun,Hong Niu,Qingjie Wang,Jinyou Duan
As a major component in extracellular matrix of the tissue, chondroitin sulfate A (CS-A) has been shown to exhibit either pro- or anti-inflammatory immune response which was largely dependent on its molecular size and cell types. In this study, we determined the signaling pathway involved in immune response of CS and its N -deacetylated derivative (dCS). Our data indicated that both CS and dCS could activate the NF-κB transcription factor in antigen presenting cells and induce TNF-α production through the TLR/MyD88 pathway. Further studies demonstrated that both CS and dCS had a potential in promoting the proliferation of spleen lymphocytes, and promoting the cytokines secretion by OVA-sensitized splenocytes. Thus, our finding provided a mechanistic insight into the understanding of cellular immunity of CS and dCS, which might be helpful to develop CS-based immune modulators against chronic inflammatory conditions, autoimmunity, infectious diseases, allergies and asthmatic conditions.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiaoxiao Li,Yu Yan,Xiaonan Zheng,Yuan Yao,Yang Liu
Single atom catalysts (SACs) exhibit impressive catalytic activity for various reactions due to low coordination environment and tunable electronic structures, attracting increasing attention. However, it is big challenge to develop transition-metal-based SACs for oxygen reduction reaction (ORR) with high stability. Bioinspired by the structure and mechanism of vanadium-dependent haloperoxidase, we herein demonstrate that saturated coordination could boost ORR activity of atomically dispersed V-N-C catalyst combining DFT prediction and experimental verification. Spontaneous axial OH coordination to V-N-C catalyst in alkaline electrolyte not only optimizes the adsorption interaction for key intermediates to boost ORR activity, but also keeps vanadium atom at the highest valence against Fenton activity to improve the stability. The as-designed catalyst exhibits half-wave potential of 0.858 V vs . RHE for ORR, comparable to the commercial Pt/C benchmark. This work provides a proof-of-concept design of SACs and broadens the horizon of its potential applications.
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Journal of Oleo Science
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2021
·
IF 1.601
Xiumei Wang,Xiaoxu Zhao,Xiaoli Qin,Zexin Zhao,Bo Yang,Yonghua Wang
n-3 polyunsaturated fatty acids (PUFA)-rich triacylglycerols (TAG) with many beneficial effects are still difficult to be synthesized efficiently and rapidly by current synthetic techniques. This study reports the fatty acid specificity of immobilized MAS1 lipase and its efficient synthesis of n-3 PUFA-rich TAG by esterification of glycerol with n-3 PUFA in natural deep eutectic solvents (NADES) systems. Immobilized MAS1 lipase showed the highest preference for capric acid [C10:0, the highest specificity constant (1/α)=1] whereas it discriminated strongly against docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) due to their lowest specificity constants (1/α=0.19 and 0.2). Moreover, the highest n-3 PUFA-rich TAG content (55.8%) with similar n-3 PUFA composition to the substrate was obtained in choline chloride/glycerol (CG) system. There was a 1.38-fold increase of TAG content in CG system compared with that in the solvent-free system. Interestingly, immobilized MAS1 lipase exhibited no regiospecificity in the solvent-free and various NADES systems. Besides, the potential reaction mechanism of immobilized MAS1 lipase-catalyzed esterification of glycerol with n-3 PUFA in NADES systems was described. It was found that the use of NADES as solvents could greatly enhance TAG content, and make it easy to separate the product. These results indicated that immobilized MAS1 lipase is a promising biocatalyst for the efficient synthesis of n-3 PUFA-rich TAG by esterification of glycerol with n-3 PUFA in NADES systems.
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Nanomaterials
·
2024
·Vol. 14
·期 21
·1690
·
IF 4.4
Shihao Cui,Dejian Xu,Zhiyuan Wang,Libo Wang,Yikun Zhao,Wei Deng,Qingshan Zhao,Mingbo Wu
Palladium (Pd) catalysts play a crucial role in facilitating Suzuki cross-coupling reactions for the synthesis of valuable organic compounds. However, conventional heterogeneous Pd catalysts often encounter challenges such as leaching and deactivation during reactions, leading to reduced catalytic efficiency. In this study, we employed an innovative intercalation templating strategy to prepare two-dimensional carbon nanosheets with high nitrogen doping derived from petroleum asphalt, which were utilized as a versatile support for immobilizing Pd nanoparticles (Pd/N-CNS) in efficient Suzuki cross-coupling reactions. The results indicate that the anchoring effect of high-pyridinic N species on the two-dimensional carbon nanosheets enhances interactions between Pd and the support, effectively improving both the dispersibility and stability of the Pd nanoparticles. Notably, the Pd/N-CNS catalyst achieved an overall turnover frequency (TOF) of 2390 h−1for the Suzuki cross-coupling reaction under mild conditions, representing approximately a nine-fold increase in activity compared to commercial Pd/C catalysts. Furthermore, this catalyst maintained an overall TOF of 2294 h−1even after five reaction cycles, demonstrating excellent stability. Theoretical calculations corroborate these observed enhancements in catalytic performance by attributing them to improved electron transfer from Pd to the support facilitated by abundant pyridinic N species. This work provides valuable insights into feasible strategies for developing efficient catalysts aimed at sustainable production of biaromatic compounds.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Gong Cheng,Li Haiyun,Wang Huaxin,Zhang Cong,Zhuang Qixin,Wang Awen,Xu Zhiyuan,Cai Wensi,Li Ru,Li Xiong,Zang Zhigang
The bidirectional migration of halides and silver causes irreversible chemical corrosion to the electrodes and perovskite layer, affecting long-term operation stability of perovskite solar cells. Here we propose a silver coordination-induced n-doping of [6,6]-phenyl-C 61 -butyric acid methyl ester strategy to safeguard Ag electrode against corrosion and impede the migration of iodine within the PSCs. Meanwhile, the coordination between DCBP and silver induces n-doping in the PCBM layer, accelerating electron extraction from the perovskite layer. The resultant PSCs demonstrate an efficiency of 26.03% (certified 25.51%) with a minimal non-radiative voltage loss of 126 mV. The PCE of resulting devices retain 95% of their initial value after 2500 h of continuous maximum power point tracking under one-sun irradiation, and > 90% of their initial value even after 1500 h of accelerated aging at 85 °C and 85% relative humidity.
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