Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Li Wen,Shi Zhiyuan,Jing Huaqing,Dou Yunsheng,Liu Xinyi,Zhang Mengyao,Qiu Zitong,Heger Zbynek,Li Nan
Dysregulation of extracellular matrix (ECM) homeostasis plays a pivotal role in the accelerated degradation of cartilage, presenting a notable challenge for effective osteoarthritis (OA) treatment and cartilage regeneration. In this study, we introduced an injectable hydrogel based on streamlined-zinc oxide (ZnO), which is responsive to matrix metallopeptidase (MMP), for the delivery of miR-17-5p. This approach aimed to address cartilage damage by regulating ECM homeostasis. The ZnO/miR-17-5p composite functions by releasing zinc ions to attract native bone marrow mesenchymal stem cells, thereby fostering ECM synthesis through the proliferation of new chondrocytes. Concurrently, sustained delivery of miR-17-5p targets enzymes responsible for matrix degradation, thereby mitigating the catabolic process. Notably, the unique structure of the streamlined ZnO nanoparticles is distinct from their conventional spherical counterparts, which not only optimizes the rheological and mechanical properties of the hydrogels, but also enhances the efficiency of miR-17-5p transfection. Our male rat model demonstrated that the combination of streamlined ZnO, MMP-responsive hydrogels, and miRNA-based therapy effectively managed the equilibrium between catabolism and anabolism within the ECM, presenting a fresh perspective in the realm of OA treatment.
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高影响因子
BIOTECHNOLOGY LETTERS
·
2012
·Vol. 34
·期 9
·1673-1678
·
IF 1.683
Chen Lei,Hu Ying-Dan,Li Ning,Zong Min-Hua
Cross-linked enzyme aggregates (CLEAs) of β -glucosidase were prepared and characterized. Under the optimum conditions, the activity recovery of CLEAs reached 84 %. The reduction by NaBH 4 resulted in slightly lower activities of CLEAs, while their thermostability was enhanced. CLEAs were more thermally stable than free enzyme (half lives, 973 vs. 518 min at 50 °C), while less stable than seed meal (half life, 1,090 min). In 90 % (v/v) t -butanol, the half lives of CLEAs and free enzyme were 53 and 6.7 h, respectively. Besides, the catalytic efficiency ( V
max / K
m ) of CLEAs was comparable to free enzyme (0.42 vs. 0.47 min −1 mg −1 ). This carrier-free immobilized enzyme had a network structure with multiple layers. The productivity of salidroside using CLEAs reached 150 g/l g catalyst, while being 6.3 g/l g with seed meal.
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高影响因子
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
·
2021
·Vol. 135
·期 2
·431-440
·
IF 2.686
Jiang Bowei,He Wei,Jin Chuan,Liu Ying,Wen Dan,Wang Chudong,ZEYE Moutanou Modeste Judes,Li Jienan,Zha Lagabaiyila
Genotyping of short tandem repeat (STR) markers is the basic method of forensic science. Enhanced technologies are needed to meet the requirements of databasing and casework samples. The STRscan-17LC kit is a 6 Dye STR kit which amplifies 16 STR loci: D3S1358, TPOX, D16S539, vWA, D2S1338, CSF1PO, D19S433, D7S820, FGA, D8S1179, D5S818, D13S317, D18S51, TH01, D12S391, and D21S11 and the sex-determinant locus amelogenin. This kit is designed for better tolerance to PCR inhibitors and analysis of mildly degraded samples with all fragments smaller than 330 bases. In this study, the STRscan-17LC kit is validated according to the SWGDAM (Scientific Working Group on DNA Analysis Methods) guidelines, including PCR-based studies, sensitivity, precision and accuracy, inhibitors, species specificity, DNA mixture studies, population, and concordance studies. The validation results suggest that the STRscan-17LC kit is a useful tool for forensic application.
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高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 51
·期 9
·5032-5041
·
IF 2.047
Li Zhenhui,Chen Jianwen,Wen An,Guo Fang,Hu Dengyan,Zhu Wenbo,Chen Wenjun
Temperature-sensitive and flexible nanocomposite films are prepared by doping a poly(vinylidene fluoride) (PVDF) matrix with cobalt oxide (Co 3 O 4 ) nanoparticles. The structural and morphological characterization, dielectric properties, and conductivity of the Co 3 O 4 /PVDF nanocomposites are then systematically investigated. The nanocomposite film loaded with 10 wt.% Co 3 O 4 displays dielectric permittivity of 37 at 1 kHz, which is about 274% higher than that of pristine PVDF (13.5 at 1 kHz). The dielectric constant of the 10 wt.% Co 3 O 4 /PVDF nanocomposite as a function of absolute temperature can be fitted as \( T = 26.62 \times \ln \left( {(\varepsilon_{r} - 40.595)/1.335 \times 10^{ - 5} } \right)\) over a range of 300–423 K at 1 kHz. This fitting formula may provide important reference values for the design of flexible temperature sensors. The temperature coefficient of the dielectric constant (at 1 kHz) for the 10 wt.% Co 3 O 4 /PVDF nanocomposite film is 0.94% K −1 within a range of 350–423 K, and conductivity of about 5.78 × 10 −5 S / cm is achieved at 383 K, which is four orders of magnitude larger than that for the pristine PVDF (3.9 × 10 −9 S / cm). These results show that the addition of Co 3 O 4 nanoparticles in PVDF matrix significantly improves the dielectric constant and temperature sensitivity of the composites. Thus, the Co 3 O 4 /PVDF nanocomposites show potential application prospects in miniaturized and flexible temperature sensors.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 18
·17310-17320
·
IF 2.8
Pu Shengyan,Xue Shengyang,Yang Zeng,Hou Yaqi,Zhu Rongxin,Chu Wei
A superparamagnetic graphene oxide (GO)/Fe 3 O 4 nanocomposite (MGO) was prepared by a facile in situ co-precipitation strategy, resulting in a prospective material for the application of graphene oxide in wastewater treatment. MGO was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The prepared adsorbent showed a high adsorption efficiency relevant to the purification of dye-contaminated wastewater and could be readily magnetically separated. The maximum adsorption capacity was ca. 546.45 mg g −1 for the common cationic dye methylene blue (MB) and ca. 628.93 mg g −1 for the anionic dye Congo red (CR). The adsorption processes fit the pseudo-second-order kinetic model well, which revealed that these processes may involve the chemical interaction between adsorbate and adsorbent. The thermodynamic parameters indicated that the adsorption reaction was an endothermic and spontaneous process. Furthermore, the prepared magnetic adsorbent had a wide effective pH range from 5 to 11 and showed good stability after five reuse cycles. The synthetic MGO showed great potential as a promising adsorbent for organic contaminant removal in wastewater treatment.
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高影响因子
ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY
·
2016
·Vol. 23
·期 1
·73-85
·
IF 1.87
Hu Hangbiao,Zhang Tao,Yuan Shaojun,Tang Shengwei
Abstract The adsorption performance of multi-walled carbon nanotubes (MWCNTs) towards CO 2 gas was enhanced by covalently grafting of phenylenediamine (PDA) via an activation-grafting process. Different loading amounts were achieved by changing the activation time and the dosage of activating agent. The so-synthesized adsorbents were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, Thermogravimetry analysis, Transmission electron microscope, Raman spectroscopy and Nitrogen adsorption–desorption analysis. The CO 2 adsorption properties were studied via static volumetric method. The results indicated that the modification process did not alter the crystal structure, whilst the quantity of defect sites and amorphous structures increased greatly. Moreover, the average pore size after functionalization increased from 9.68 to 23.80 nm. 0.59 mmol·g −1 of CO 2 were captured by aminated MWCNTs at 303.15 K and 200 kPa, while the adsorption capacity of the raw materials was only 0.17 mmol·g −1 under the same conditions. Adsorption–regeneration cycles exhibited the stability of the PDA modified MWCNTs during the prolonged cyclic operations. We found that the adsorption of CO 2 on MWCNTs belonged to physical adsorption and the adsorption behavior of CO 2 on PDA modified MWCNTs was a chemical adsorption. The effective enhancement of the CO 2 capture ability was attributed to the increased number of active sites, which offered stronger interactions with CO 2 after PDA grafting.
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Scientific Reports
·
2019
·Vol. 9
·期 1
·1-11
·
IF 4.011
Li Junchao,Li Xuhua,Han Jindong,Meng Fansheng,Jiang Jinyuan,Li Jiao,Xu Chunlian,Li Yun
Mesoporous bimetallic Fe/Co was prepared as a Fenton-like catalyst to degrade the tetracycline hydrochlorides (TC). The nanocasting strategy with KIT-6 as a hard template was carried out to synthesize the mesoporous bimetallic catalyst. The mesoporous bimetallic Fe/Co catalyst was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen adsorption-desorption isotherms, and Brunauer-Emmett-Teller (BET) method. The results showed that the catalyst has significant nanofeatures; the surface area, pore size, and particle size were 113.8 m 2 g −1 , 4 nm, and 10 nm, respectively. In addition, the effects of the operating parameters, such as the iron-to-cobalt ratio, pH, H 2 O 2 , and initial TC concentrations on its catalytic performance were investigated. The best operating parameters were as follows: iron-to-cobalt ratio = 2:1 to 1:1, pH = 5–9, H 2 O 2 : 30 mmol, initial TC less than 30 mg/L. Furthermore, the mesoporous bimetallic Fe/Co showed a good performance for degrading TC, achieving a removal rate of 86% of TC after 3 h under the reaction conditions of H 2 O 2 = 30 mmol, mesoporous bimetallic Fe/Co = 0.6 g/L, TC = 30 mg/L, pH = 7.0, and temperature = 25.5 °C. The mesoporous bimetallic Fe/Co catalyst shows good stability and reusability. This work demonstrated that mesoporous bimetallic Fe/Co has excellent catalytic efficiency, smaller amounts of leached ions, and wider pH range, which enhance its potential applications.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2015
·Vol. 293
·期 6
·1767-1779
·
IF 1.865
Luo Yingwu,Wang An-Ni,Gao Xiang
Poly high internal phase emulsion (PolyHIPE) monolith has attracted many attentions for easy preparation, precise control on its porous structure, and excellent properties. In many applications, however, post-modification is needed to introduce functional groups onto their surfaces in order to achieve specific separation ability, reactivity or absorptivity, etc. In the current work, we proposed one-pot interfacial polymerization method to achieve composite PolyHIPEs with functional surface in one pot. It was realized by three strategies in preparing typical polystyrene PolyHIPEs from water-in-oil (W/O) HIPE: (1) introducing water-soluble initiator of potassium persulfate (KPS) and monomer of acryl acid (AA) into aqueous phase under conventional HIPE polymerization, (2) introducing KPS and AA into aqueous phase under high internal phase emulsions via reversible addition-fragmentation chain transfer (HIPE RAFT) living radical polymerization, and (3) employing reactive amphipathic MacroRAFT agent as surfactant. All these three strategies proved to be effective to generate a composite structure with different surface and bulk compositions. AA enrichment on the surface was verified by X-ray photoelectric energy spectrum (XPS) etching. Their effects on the morphology and mechanical properties were also studied.
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高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 4
·1-9
·
IF 5.705
Song Jinyi,Yang Chengcheng,Ma Jiao,Han Qian,Ran Peiyao,Fu Yingzi
An electrochemical chiral multilayer nanocomposite was prepared by modifying a glassy carbon electrode (GCE) via opposite-charge adsorption of amino-modified β-cyclodextrin (NH 2 -β-CD), gold-platinum core-shell microspheres (Au@Pts), polyethyleneimine (PEI), and multi-walled carbon nanotubes (MWCNTs). The modified GCE was applied to the enantioselective voltammetric determination of tryprophan (Trp). The Au@Pts enable an effective immobilization of the chiral selector (NH 2 -β-CD) and enhance the electrochemical performance. Scanning electron microscopy, transmission electron microscopy, UV-vis spectroscopy, FTIR and electrochemical methods were used to characterize the nanocomposite. Trp enantiomers were then determined by differential pulse voltammetry (DPV) (with a peak potential of +0.7 V vs. Ag/AgCl). The recognition efficiency was expressed by an increase in peak height by about 32% for DPV determinations of L-Trp compared to D-Trp in case of a 5 mM Trp solution of pH 7.0. Response was linear in the 10 μM to 5.0 mM concentration range, and the limits of detection were 4.3 μM and 5.6 μM with electrochemical sensitivity of 43.5 μA·μM −1 ·cm −2 and 34.6 μA·μM −1 ·cm −2 for L-Trp and D-Trp, respectively (at S/ N = 3).
Schematic of an electrochemical chiral multilayer nanocomposite composed of multi-walled carbon nanotubes (MWCNTs), polyethyleneimine (PEI), gold-platinum core-shell microspheres (Au@Pt) and amino-modified β-cyclodextrin (NH 2 -β-CD). It was prepared by modifying a glassy carbon electrode (GCE) for enantioselective voltammetric determination of tryptophan (Trp) enantiomers.
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高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 9
·1-9
·
IF 6.232
Song Yiju,Qiao Jingwen,Li Wenjun,Ma Chaoyun,Chen Siyu,Li Hongling,Hong Chenglin
A molybdenum disulfide based graphite phase carbon nitride (MoS 2 /g-C 3 N 4 ) which is supported by a platinum-copper nanoparticle (PtCu) Z-type catalyst was created in this study. The catalyst exploits optoelectronic synergistic effect with large surface area, good catalysis, and biocompatibility to amplify the signal. The electrode impedance of the synthesized MoS 2 /g-C 3 N 4 -PtCu was reduced five times in visible light compared with dark conditions, thereby improving the detection of carcinoembryonic antigen (CEA). At a voltage of − 0.4 V, the immunoprobe constructed with this material is used for CEA detection. A linear relationship between 100 fg mL −1 and 80 ng mL −1 concentrations was achieved with a minimum detection limit of 33 fg mL −1 (S/ N = 3). The recovery rate was 103–104%, and the relative standard deviation was 2.9–3.8%. This implies that the sandwich immunosensors have good reproducibility, selectivity, and stability and can be used in various applications.
Graphical Abstract
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高影响因子
Frontiers of Environmental Science & Engineering
·
2021
·Vol. 16
·期 3
·1-16
·
IF 4.357
Zhao Shuangyang,Chen Chengxin,Ding Jie,Yang Shanshan,Zang Yani,Ren Nanqi
Fabrication of easily recyclable photocatalyst with excellent photocatalytic activity for degradation of organic pollutants in wastewater is highly desirable for practical application. In this study, a novel ternary magnetic photocatalyst BiVO 4 /Fe 3 O 4 /reduced graphene oxide (BiVO 4 /Fe 3 O 4 /rGO) was synthesized via a facile hydrothermal strategy. The BiVO 4 /Fe 3 O 4 with 0.5 wt% of rGO (BiVO 4 /Fe 3 O 4 /0.5% rGO) exhibited superior activity, degrading greater than 99% Rhodamine B (RhB) after 120 min solar light radiation. The surface morphology and chemical composition of BiVO 4 /Fe 3 O 4 /rGO were studied by scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, UV visible diffuse reflectance spectroscopy, Fourier transform infrared spectroscopy, and Raman spectroscopy. The free radicals scavenging experiments demonstrated that hole (h + ) and superoxide radical (O 2 •− ) were the dominant species for RhB degradation over BiVO 4 /Fe 3 O 4 /rGO under solar light. The reusability of this composite catalyst was also investigated after five successive runs under an external magnetic field. The BiVO 4 /Fe 3 O 4 /rGO composite was easily separated, and the recycled catalyst retained high photocatalytic activity. This study demonstrates that catalyst BiVO 4 /Fe 3 O 4 /rGO possessed high dye removal efficiency in water treatment with excellent recyclability from water after use. The current study provides a possibility for more practical and sustainable photocatalytic process.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 10
·13941-13947
·
IF 2.478
Liu Ying,Cao Bo,Zhang Xu,Luo Rong,Luo Chunhua,Lin Hechun,Peng Hui
Layered Co(OH) 2 has been regarded as a potential candidate for pseudocapacitor electrode material, but it is limited by its poor conductivity and low surface area. Herein, carbonated multi-walled carbon nanotubes (MWCNTs-COOH) were used to improve the conductivity of α-Co(OH) 2 nanocomposites. α-Co(OH) 2 nanoflowers were successfully grown and tangled with MWCNTs-COOH to form a randomly oriented network structure mediated by ammonia using water-methanol as co-solvent at room temperature. The capacitance performances of the obtained α-Co(OH) 2 @MWCNT-COOH composites were investigated to find that MWCNT-COOH improved the specific capacitance efficiently. Especially, in the presence of 20% in mole of MWCNT-COOH, the composite gave rise to the high specific capacitance of 1027 F/g at the current density of 2 A/g with good cycle stability, whose specific capacitance remained 78% of its original even after 5000 cycles at 30 A/g current. The large surface area and strengthening the conductivity of the composites lead to the improvement of efficiency in charge/discharge process.
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