INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Haiyan Li,Zekun Jin,Nengguo Tao
This study aimed to develop food-grade ethyl cellulose/agarose aerogels for the controlled release of plant essential oils to extend the shelf life of fresh rice noodles. The antibacterial efficacy of ten unsaturated aldehyde essential oils was evaluated against primary spoilage bacteria, including Leuconostoc lactis , Lactococcus lactis , Acinetobacter johnsonii , Exiguobacterium indicum , and Enterobacter sichuanensis . Based on its superior antimicrobial performance, (E)-2-hexenal was selected for encapsulation within ethyl cellulose/agarose aerogels to achieve controlled release and extend the shelf life of fresh rice noodles. Increasing the ethyl cellulose concentration resulted in a more uniform pore size distribution, enhanced mechanical properties and hydrophobicity, and improved controlled release of (E)-2-hexenal in the aerogels. The optimized aerogel, loaded with 0.20 μL/mL of (E)-2-hexenal, exhibited significant antimicrobial activity, effectively inhibiting bacterial growth for 72 h. Moreover, the aerogel formulation effectively preserved the quality of fresh rice noodles by mitigating changes in total plate count, pH, water content, water activity, cooking properties, color, and texture, ultimately extending the product's shelf life by 4 days at 25 °C. These findings highlight the potential of ethyl cellulose/agarose aerogels loaded with (E)-2-hexenal as an innovative preservation strategy for fresh rice noodles, providing a promising method for enhancing food quality and longevity.
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BMC INFECTIOUS DISEASES
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2025
·Vol. 25
·期 1
·1-9
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IF 3
Ma Ying-Chao,Yang Xiu-Ling,Gu Jian-Jun
ObjectiveTo evaluate the effects of different SARS-CoV-2 inactivation methods on the blood concentration of colistin sulfate.Methods A colistin sulfate reference substance, a quality control plasma sample, and a clinically measured sample were transferred and heated in a 56 °C water batch for 30 min or irradiated under an ultraviolet (UV) lamp for 60 min to examine the stability of the reference solution and quality control plasma sample. Statistical analysis was conducted for the concentration of the clinically measured sample before and after inactivation with the intraclass correlation coefficient (ICC) method, the Passing–Bablok regression, and the Bland–Altman analysis.Results The reference substance of colistin sulfate was unstable under UV inactivation. Under moist heat inactivation, the reference substance and quality control plasma sample of colistin sulfate were stable. The ICC of the concentration results of 27 clinical blood samples with and without moist heat inactivation was 0.995 (P < 0.001). The Passing–Bablok regression equation was Y = 0.01347 + 0.9861X (R2 = 0.994, n = 27). Finally, 96.30% (26/27) of test data was within the 95% limit of agreement. The results obtained with the three statistical analysis methods all showed a high correlation and agreement between the plasma concentration results of samples not inactivated and inactivated with moist heat inactivation.Conclusion The clinical plasma concentration test samples for colistin sulfate can be processed with the moist heat virus inactivation method to reduce the risk of virus infection of medical staff.
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INORGANIC CHEMISTRY
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2024
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IF 4.3
Ya-Lan Deng,Chun-Li Hu,Jiang-Gao Mao
The π-conjugated [C3H6+xN6]x+ (x = 0–3) cations are good functional groups, which are widely employed in the preparations of nonlinear optical (NLO) and birefringent materials due to their high hyperpolarizability and optical anisotropy. In this paper, the first melamine hydroxyborate [C3H7N6]3[B3O5(OH)2] (MelBO-I) was synthesized by the boric acid melting method under the molar ratio of H3BO3:C3H6N6 = 1:1. MelBO-I (P21/c) exhibits a two-dimensional (2D) {[C3H7N6]3[B3O5(OH)2]}∞ layer composed of [C3H7N6]+ cations and [B3O5(OH)2]3– anions interconnected via hydrogen bonds. MelBO-I exhibits significant birefringence (Δn = 0.286@546 nm). Under the molar ratio of H3BO3/C3H6N6 = 3:1, [C3H8N6]4[B12O19(OH)6] (MelBO-II) was isolated. In MelBO-II (P21), highly polymerized [B12O19(OH)6]8– groups form a 3D network through hydrogen bonding, featuring 1D tunnels of 8-membered and 16-membered rings filled by [C3H8N6]2+ cations. MelBO-II is the first noncentrosymmetric (NCS) bifunctional melamine borate with a moderate SHG response (0.4 × KDP) and large birefringence (Δn = 0.285@546 nm). The results indicate that incorporating [C3H6+xN6]x+ (x = 0–3) cations into borate can effectively induce birefringence. A high concentration of boric acid promotes the formation of large boric acid cluster anions and facilitates the transformation from the CS to NCS structure.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Liangyun Yu,Yingzhuo Shen,Lu Chen,Qi Zhang,Xiaoya Hu,Qin Xu
Herein, a novel ultrasensitive cholesterol photoelectrochemical (PEC) sensor was designed based on fluorinated molecularly imprinted polymers (FMIPs) functionalized CH 3 NH 3 PbI 3 @carbon nanodots (CH 3 NH 3 PbI 3 @CNDs) platform. 2-(Perfluorooctyl) ethyl acrylate (PFEA), a functional monomer, was chosen not only to endow CH 3 NH 3 PbI 3 good selectivity but also improve its aqueous stability because of the fluorine containing long hydrophobic chain. Furthermore, the FMIPs can inhibit the recombination of electron holes and prolonged the carrier life time, and dramatically enhance the charge transfer efficiency by the reduction of defect density through the polymer passivation of grain boundaries of perovskite. The morphology, the enhanced hydrophobicity and photoelectric properties of FMIPs@CH 3 NH 3 PbI 3 @CNDs interface was characterized by transmission electron microscopy, Fourier transform infrared spectrum, scanning electron microscope, contact angle, photoluminescence spectrum and intensity modulated photovoltage spectrum, respectively. Under the optimized conditions, the linear range of the designed PEC sensor for cholesterol detection was 1.0 × 10 −13 –1.0 × 10 −9 mol/L, and the detection limit was down to 8.9 × 10 −14 mol/L. The new PEC sensor exhibited specific selectivity, good stability and hypersensitivity, and was successfully applied to cholesterol detection in human serum samples. This work extended the development of the MIPs based sensor and the high-performance perovskite.
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Bioactive Materials
·
2024
·
IF 18
Daping Xie,Congwei Han,Chonghao Chen,Zhencheng Liao,Senio Campos de Souza,Yiming Niu,João F. Mano,Lei Dong,Chunming Wang
Cancer vaccination holds great promise for cancer treatment, but its effectiveness is hindered by suboptimal activation of CD8 + cytotoxic T lymphocytes, which are potent effectors to mediate anti-tumor immune responses. A possible solution is to switch antigen-presenting cells to present tumor antigens via the major histocompatibility complex class I (MHC-I) to CD8 + T cells – a process known as cross-presentation. To achieve this goal, we develop a three-dimensional (3D) scaffold vaccine to promote antigen cross-presentation by persisted toll-like receptor-2 (TLR2) activation after one injection. This vaccine comprises polysaccharide frameworks that “hook” TLR2 agonist (acGM) via tunable hydrophobic interactions and forms a 3D macroporous scaffold via click chemistry upon subcutaneous injection. Its retention-and-release of acGM enables sustained TLR2 activation in abundantly recruited dendritic cells in situ , inducing intracellular production of reactive oxygen species (ROS) in optimal kinetics that crucially promotes efficient antigen cross-presentation. The scaffold loaded with model antigen ovalbumin (OVA) or tumor specific antigen can generate potent immune responses against lung metastasis in B16-OVA-innoculated wild-type mice or spontaneous colorectal cancer in transgenic Apc Min/+ mice, respectively. Notably, it requires neither additional adjuvants nor external stimulation to function and can be adjusted to accommodate different antigens. The developed scaffold vaccine may represent a new, competent tool for next-generation personalized cancer vaccination.
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MOLECULES
·
2024
·Vol. 29
·期 16
·3846
·
IF 4.2
Lei Huang,Jian Qian,Shijian Sun,Zheng Li,Dechuan Li
A novel method for synthesizing dumbbell-shaped (Gd1−xTbx)2O(CO3)2·H2O (GOC:xTb3+) phosphors using sodium carbonate was investigated. An amount of 1 mmol of stable fluorescent powder can be widely prepared using 3–11 mmol of Na2CO3at a pH value of 8.5–10.5 in the reaction solution. The optimal reaction conditions for the phosphors were determined to be 7 mmol for the amount of sodium carbonate and a pH of 9.5 in the solution. Mapping analysis of the elements confirmed uniform distribution of Gd3+and Tb3+elements in GOC:xTb3+. The analysis of fluorescence intensity shows that an optimal excitation wavelength of 273 nm is observed when the concentration of Tb3+is between 0.005 and 0.3. The highest emission intensity was observed for GOC:0.05Tb3+with a 57.5% maximum quantum efficiency. The chromaticity coordinates show that the color of GOC:Tb3+is stable and suitable for fluorescence recognition. Latent fingerprint visualization reveals distinctive features like whorls, hooks, and bifurcations. Therefore, the sodium carbonate method offers an effective alternative to traditional urea chemical reaction conditions for preparing GOC:Tb3+.
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JOURNAL OF MATERIALS CHEMISTRY
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2012
·Vol. 22
·期 8
·3404-3410
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IF 5.968
Xiao-lei Huang,Jia Chai,Tao Jiang,Ying-Jin Wei,Gang Chen,Wan-qiang Liu,Dongxue Han,Li Niu,Limin Wang,Xin-bo Zhang
Large-area Co(OH)2 nanosheets have been successfully coated with ionic liquid modified graphenevia a general strategy. The advantageous combination of graphene and the 2D structure of the Co(OH)2 nanosheets endows the obtained heterostructures with a remarkable lithium-storage performance, including high reversible capacity and superior cyclic and rate performance.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2012
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IF 2.422
Yao Chen,Hui Wang,Yanyan Tang,Jun Zeng
Ternary (liquid + liquid) equilibria date for the (water + 2-propanol + α -pinene, or β -pinene) systems were measured at T = (293.15, 298.15, 303.15, and 308.15) K under atmospheric pressure. The experimental results were correlated using the extended and modified UNIQUAC models. The calculated results obtained from the modified UNIQUAC model successfully represent the experimental tie-line data. The temperature influence on liquid-phase equilibria was studied.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
·
IF 2.323
Fang Zhang,Yanqing Zhu,Yi Yu,Li Xu,Guoji Liu
The solid–liquid equilibria (SLE) in the ternary system of 2-methyl-1,4-naphthoquinone (2-MNQ) + phthalic anhydride (PA) + 1,4-dioxane were determined experimentally by using the isothermal dissolution equilibriam method within temperatures 283.15, 293.15, and 303.15 K, respectively. The ternary phase diagram could be helpful in the separation of 2-MNQ and PA. On the basis of the experimental data on solubilities the phase diagrams of the system were plotted. Two pure solid phases were formed at 283.15, 293.15 and 303.15 K, including pure PA and pure 2-MNQ, which were confirmed and determined by Schreinemakers’ wet residue method. The phase diagram at 283.15 K is similar to those at 293.15 and 303.15 K and the crystalline regions of 2-MNQ and PA decrease with increasing temperature. NRTL and Wilson model were employed to correlate and calculate the solubility data for the ternary system. A comparison between the two models shows that the NRTL model agrees better with the experimental data than those with the Wilson model. In addition, the densities of equilibrium liquid phase were obtained at the corresponding temperatures versus composition in the system.
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Polymers
·
2025
·Vol. 17
·期 5
·679
·
IF 4.9
Gege Bao,Lu He,Xiaofeng Zhang,Xi Yu,Jingpeng Li,Daochun Qin
Bamboo, recognized as a nutrient-dense biomass material, exhibits a high susceptibility to mold infestations, which can result in discoloration and a notable decrease in longevity, thereby posing potential health risks to humans. In this study, melamine-formaldehyde resin (MFR) was utilized to load 3-iodo-2-propargyl-butyl-carbamate (IPBC) via in situ polymerization, resulting in the preparation of microcapsules suitable for anti-mold protection of bamboo. The mold resistance ofAspergillus niger,Trichoderma viride, andPenicillium citrinumwere evaluated. A scanning electron microscope (SEM), transmission electron microscope (TEM), Fourier-transform infrared spectrometer (FTIR), and thermogravimetric analysis (TG) were used to characterize and analyze the formation process, surface morphology, structural composition, and thermal stability of the microcapsules. The effects of different surfactants (Span 80, Tween 80, SDBS, SDS, GA) on the microscopic morphology of the anti-mold microcapsules were investigated. The results show that microcapsules prepared with Tween 80 as the surfactant exhibited good mold resistance. After coating MFR with IPBC, the drug loading of I-MFR is 20%, with an encapsulation efficiency of 80%, demonstrating excellent anti-mold performance. The microcapsules show favorable anti-mold performance and have broad application prospects in bamboo protection.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2024
·
IF 6.2
Jiaqi Ding,Wanyu He,Wanxiao Sha,Guoqiang Shan,Lingyan Zhu,Lin Zhu,Jianfeng Feng
Exposure routes are important for health risk assessment of chemical risks. The application of physiologically based toxicokinetic (PBTK) models to predict concentrations in vivo can determine the effects of harmful substances and tissue accumulation on the premise of saving experimental costs. In this study, Tri(2-chloroethyl) phosphate (TCEP), an organophosphate ester (OPE), was used as an example to study the PBTK model of mice exposed to different exposure doses by multiple routes. Different routes of exposure (gavage and intradermal injection) can cause differences in the concentration of chemicals in the organs. TCEP that enters the body through the mouth is mainly concentrated in the gastrointestinal tract and liver. However, the concentrations of chemicals that enter the skin into the mice are higher in skin, rest of body, and blood. In addition, TCEP was absorbed and accumulated very rapidly in mice, within half an hour after a single exposure. We have successfully established a mouse PBTK model of the TCEP accounting for multiple exposure Routes and obtained a series of kinetic parameters. The model includes blood, liver, kidney, stomach, intestine, skin, and rest of body compartments. Oral and dermal exposure route was considered for PBTK model. The PBTK model established in this study has a good predictive ability. More than 70% of the predicted values deviated from the measured values by less than 5-fold. In addition, we extrapolated the model to humans. A human PBTK model is built. We performed a health risk assessment for world populations based on human PBTK model. The risk of TCEP in dust is greater through mouth than through skin. The risk of TCEP in food of Chinese population is greater than dust.
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TALANTA
·
2024
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IF 5.6
Meixiang Xue,Shuangxi Cai,Ye Deng,Fang Luo,Jianhui Huang,Zhenyu Lin
T-2 toxin, a hazardous mycotoxin often present in cereals and products based on cereals, poses a substantial risk to humans and animals due to its high toxicity. The development of uncomplicated, quick and highly sensitive methods for detecting T-2 toxin is imperative. In this work, a portable sensing system was constructed using water column height as a readout device in combination with a controlled release system, which allows for an accurate quantitative analysis of T-2 toxin without the need for expensive instrumentation or skilled technicians. Hyaluronic acid (HA) hydrogel was constructed by double cross-linked DNA/aptamer hybrids with polyethyleneimine (PEI) and embedded with platinum nanoparticles (Pt NPs). The aptamer specifically bound to T-2 toxin in its presence, resulting in the disruption of the hydrogel and subsequent release of the Pt NPs. These Pt NPs were later mixed with a solution of H 2 O 2 in a confined reaction flask, leading to the decomposition of H 2 O 2 into O 2 . A glass capillary tube containing a column of red water had been inserted into the cap of the reaction flask, and the low solubility of O 2 led to an increase in pressure within the reaction unit, causing the red water column to rise. There is a good linear correlation between the height of the capillary liquid level and the T-2 toxin concentration in the range of 20 ng/mL to 6 μg/mL. The system has been successfully used to detect T-2 toxin in samples of barley tea and corn.
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