INTERNATIONAL IMMUNOPHARMACOLOGY
·
2023
·
IF 5.6
Na Li,Fanghan He,Yunxiao Shang
Obese asthma is a form of refractory asthma with inflammation as the underlying mechanism. The specific mechanism of action of anti-inflammatory growth differentiation factor 15 (GDF15) in obese asthma is unclear. The purpose of this study was to explore the effect of GDF15 on cell pyroptosis in obese asthma and to determine its mechanism of airway protection. Male C57BL6/J mice were fed with a high-fat diet, sensitized, and challenged with ovalbumin. Recombinant human (rh)GDF15 was administered 1 h before the challenge. GDF15 treatment significantly reduced airway inflammatory cell infiltration, mucus hypersecretion and airway resistant, and decreased cell counts and inflammatory factors in bronchoalveolar lavage fluid. Serum inflammatory factors decreased, and the increased levels of NLR family pyrin domain containing 3 (NLRP3), caspase-1, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and gasdermin-D (GSDMD-N) in obese asthmatic mice were inhibited. Furthermore, the suppressed phosphoinositide 3-kinase (PI3K)/AKT signal pathway was activated after rhGDF15 treatment. The same result was obtained by overexpression of GDF15 in human bronchial epithelial cells induced by lipopolysaccharide (LPS) in vitro, and the effect of GDF15 was reversed after the application of a PI3K pathway inhibitor. Thus, GDF15 could protect the airway by inhibiting cell pyroptosis in obese asthmatic mice through the PI3K/AKT signaling pathway.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Chemical Neuroscience
·
2023
·
IF 5
Yu-Qing Liu,Chu-Qiao Liang,Zhi-Wei Chen,Jun Hu,Jin-Jian Hu,Yun-Yi Luo,Yong-Xiang Chen,Yan-Mei Li
Tau plays a major role in Alzheimer’s disease (AD) and several other neurodegenerative diseases. Tau undergoing liquid–liquid phase separation (LLPS) performs specific physiological functions, induces pathological processes, and contributes to neurodegeneration. Regulating Tau phase separation helps maintain physiological functions of Tau and inhibits pathological aggregation. Here, we show that the 14-3-3 zeta isoform (14-3-3ζ) participates in Tau LLPS. 14-3-3ζ can undergo co-phase separation with WT Tau, participate in and stabilize Tau droplets, and inhibit Tau droplet-driven tubulin assembly. On the other hand, 14-3-3ζ disrupts the LLPS of phosphorylated and glycated Tau, thereby inhibiting the amyloid aggregation initiated by LLPS.
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2023
·
IF 13.3
Yue Wu,Tianzhe Zhao,Xiao Shao,Junyu Chen,Tianyong Zhang,Bin Li,Shuang Jiang
Chiral inorganic quasi-2D perovskites are prepared by self-assembling 3D perovskites in solution for the first time. The quasi-2D perovskite synthesized is a pure-phase perovskite with < n > = 3 and is periodically arranged, which is a big breakthrough in quasi-2D inorganic perovskites. With the individual chiral CsPbBr 3 nanocrystals (NCs) assemble into quasi-2D perovskite, the g-factor significantly improved (≈5 × 10 −3 ). In addition, the chiroptical activity of quasi-2D perovskites is explored to be improved with the lateral size increasing. In the first stage of assembly, chiral optical activity is increased due to the lateral size-dependent optical activity, while the changes in the later stages are attributable to the chiral morphology. Interestingly, chirality inversion is found to be correlated to the number of ligands. It is believed that different conformers of chiral ligands caused by steric hindrance of the original ligand oleylamine result in opposite circular dichroism (CD) polarities. The chirality inversion phenomenon is universal, regardless of the choice of ligands. This work opens up a new path for the synthesis of quasi-2D perovskites and provides more opportunities for the modulation of chiral optical activity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Fungal Biology
·
2023
·
IF 2.5
Jiaxin Liu,Canying Li,Chenyang Zhang,Rui Huang,Linhong Qu,Yonghong Ge
Black spot rot caused by Alternaria alternata is one of the major postharvest disease of apple fruit during logistic. This study evaluated in vitro inhibitory effect of 2-hydroxy-3-phenylpropanoic acid (PLA) at various concentrations on A. alternata and the possible mechanisms involved in its action. Results showed that different concentrations of PLA inhibited conidia germination and mycelial growth of A. alternata in vitro, and 1.0 g L −1 was the lowest effective concentration to suppress A. alternata growth. Moreover, PLA significantly reduced relative conductivity and increased malondialdehyde and soluble protein contents. PLA also increased H 2 O 2 and dehydroascorbic acid contents, but reduced ascorbic acid content. Additionally, PLA treatment inhibited catalase , ascorbate peroxidase , monodehydroascorbate acid reductase, dehydroascorbic acid reductase and glutathione reductase activities, whereas promoted superoxide dismutase activity. All these findings suggest that the possible mechanisms involved in the inhibitory effect of PLA on A. alternata included damaging the cell membrane integrity to cause electrolyte leakage and destroying reactive oxygen species balance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2023
·
IF 3.7
Yantao Dong,Wei Xu,Xue Lan,Hongsheng Mo,Xiaozheng Lan,Jiandang Liu,Bangjiao Ye,Hongjun Zhang
Organic ionic plastic crystals (OIPCs) are promising solid electrolytes. To observe the effect of defects and a mixed OIPC matrix on ionic conductivity, lithium-ion transfer and chloride-ion transfer in chiral and racemic (+/±)-3-hydroxyquinuclidinium perchlorate plastic crystals were studied. The pure chiral material and racemic mixture and their corresponding doped mixtures showed different thermal behaviors. Powder X-ray diffraction revealed that the cubic crystal structure appeared in both the high-temperature phase of the pure chiral material and the whole temperature range for the racemic system. Solid-state nuclear magnetic resonance spectra indicated the possible ion mobility of the two undoped matrices. The lithium-ion conductivity in the chiral material (above −10 °C) and racemic mixture (in the whole temperature region) increased 2.5–3 orders of magnitude, while the chloride-ion conductivity in the chiral material only increased obviously above 50 °C. Positron annihilation lifetime spectroscopy demonstrated the dependence of ionic conductivity on defect volumes of the pure chiral material and its doped mixtures, and the defects of the doped mixtures expanded largely. The ionic conductivity and defect volume of the doped mixtures containing lithium ions and chloride ions qualitatively obeyed the Cohen–Turnbull free volume theory.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2023
·Vol. 103
·期 6
·3129-3138
·
IF 4.1
Zonghan Wang,Chao Guo,Deyang Li,Dayong Zhou,Donghong Liu,Beiwei Zhu
BACKGROUND Epigallocatechin-3-gallate (EGCG) is well known for excellent chain-breaking antioxidant capability. However, browning by oxidation and aggregation of EGCG is a non-negligible defect that hinders its applications as an antioxidant in various foodstuffs. Therefore, how to eliminate or mitigate browning efficiently, while retaining functionalities as food additive is a challenge in the food industry. RESULTS Our results demonstrated that EGCG could be anchored within the internal cavity of γ-cyclodextrin (γ-CD) to form an inclusion structure, where hydrophobic interaction, hydrogen bonding, and π-stacking were identified to be the primary drivers. The interplay between two molecules and the steric hindrance from γ-CD could restrict the motion and aggregation of EGCG efficiently, thus alleviating the browning effect. In addition, the conformational adaption of EGCG within the inclusions would result in general decreases in hydrogen-bond dissociation enthalpies for the pyrogallol-type structure on the b ring, thus enhancing the antioxidant capability. In practical application, the nanoscale γ-CD/EGCG inclusion complexes were validated preliminarily as efficient additives in the preservation of shrimp surimi, presenting significant effects on prolonging the shelf-life of products. CONCLUSION Here, nanoscale γ-CD/EGCG inclusion complexes as alternatives to EGCG were tailored as food antioxidants for the preservation of shrimp surimi products, exerting antioxidant effects while mitigating the browning effects of EGCG on products. Through self-assembly, EGCG would be anchored with the cavity of γ-CD, which could regulate the release modes and restrict the aggregation of EGCG. This facile strategy has great potential in food preservation. © 2023 Society of Chemical Industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Li-Shu Zhou,Yan-Shu Xiong,Ran Jia,Ming-Xing Li,Bo-Huan Fan,Jia-Yi Tang,Wen Li,Hai-Qin Lu,Yu-Wei Lan,Kai Li
The crucial need for quality refined sugar has led to the development of advanced adsorbents, with a focus on the decolorization of remelt syrup. In this study, (3-chloro-2-hydroxypropyl) trimethylammonium chloride and polyethyleneimine co-modified pomelo peel cellulose-derived aerogel (CP-PPA) was fabricated, and synthetic melanoidins were used as model colorants of remelt syrup to evaluate the validity and practicality of CP-PPA for eliminating colored impurities. Integrating abundant amine-functionalized groups (quaternary ammonium and protonated amine) within the pomelo peel-derived aerogel directionally captured electronegative melanoidins via electrostatic interactions. Furthermore, the active sites, types, and relative strength of the weak interactions between CP-PPA and melanoidins were determined using density functional theory simulations. CP-PPA exhibited an excellent equilibration adsorbing capacity for capturing melanoidins of 749.51 mg/g, and a removal efficiency of 93.69 %. Additionally, the adsorption mechanism was thoroughly examined in an effort to improve the economy of the sugar refinement industry.
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 17
·6344
·
IF 4.6
Shuanghui Wang,Chuhong Chen,Yan Lu
Cadmium (Cd), a harmful heavy metal that has no biological purpose, can harm healthy fetal and child development. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in tea, has been shown to increase cell viability under Cd exposure and ameliorate Cd-induced kidney injury in adult male rats. Using theCaenorhabditis elegans(C. elegans) model, we demonstrated that EGCG mitigated Cd-induced body size developmental toxicity through a mechanism that did not involve chelation with EGCG and was not associated with Cd accumulation and efflux. Our research indicated that the beneficial effects of EGCG on Cd-induced body size developmental toxicity were associated with the mitigation of endoplasmic reticulum stress. Furthermore, our observations indicate that EGCG reduced Cd-induced developmental toxicity inC. elegansvia the PEK-1/eIF-2α/ATF-4 pathway. Our results provide important evidence for the potential benefits of consuming tea as a detoxification agent.Keywords:tea;EGCG;cadmium;Caenorhabditis elegans;developmental toxicity;endoplasmic reticulum stress
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RARE METALS
·
2023
·Vol. 42
·期 10
·3387-3398
·
IF 8.8
Dai Jing,Jing Jian,Yang Jian-Ping,Zhang Wen,Liu Shao-Xiong,Wang Qian-Fu,Wen Jia-Xing,Hu Hai,Li Hui-Fang,Liu Li
Na superionic conductor (NASICON)-type La 0.33 Ti 2 (PO 4 ) 3 (LaTP) is firstly proposed as sodium/potassium storage materials. The density functional theory (DFT) calculations show that LaTP has good electronic character and low Na + /K + migration barriers. The flexible La 0.33 Ti 2 (PO 4 ) 3 /C nanofiber film is synthesized via electrostatic spinning and investigated as free-standing electrode applied to sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) in this work. The low band gap and Na + /K + migration barriers of LaTP, unique morphology, and complete conductive carbon net allow the La 0.33 Ti 2 (PO 4 ) 3 /C nanofibers film to deliver high capacity (296.3 mAh·g −1 for SIBs and 235.8 mAh·g −1 for PIBs), excellent rate performance (142.5 mAh·g −1 for SIBs and 50.5 mAh·g −1 for PIBs at 1.00 A·g −1 ), and superior cyclability above 1000 cycles. The full-cell tests show that the material has a good application prospect, indicating a promising flexible anode material for SIBs and PIBs. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2023
·
IF 4.3
Zhengchao Shen,Kexin Tian,Muhammad Mujahid Ali,Sifan Mei,Xin Ma,Jiang Liang,Feng Pan,Jianwen Li,Haixia Sui,Zhenxia Du
3-monochloropropane-1,2-diol esters (3-MCPDEs) and glycidyl esters (GEs) are food contaminants and have arisen continuous attention due to their toxicity, especially towards infants. Current risk assessment of these contaminants was mostly employing deterministic approaches, lacking quantitative characterization of the likelihood, incidence, or severity of the risks involved. Herein, 3-MCPDE and GE levels in 46 representative infant formulas (IFs) from Chinese market were determined by GC-MS/MS. Then, combining the occurrence data and consumption data from China National Food Consumption Survey, the Monte Carlo simulation-based probabilistic model for risk assessment of 3-MCPDEs and GEs in IFs from Chinese market was established. The results showed that all P90 (90th percentiles) hazard quotient values were below 1, demonstrating 3-MCPDEs didn't pose health risks to most populations aged 0–36 months old. However, for 0–12 months old groups, P10 (10th percentiles) margin of exposure values were all below 25000, indicating GEs may pose potential risks to 10% of this group. Uncertainty analysis revealed that the probabilistic model had considered uncertainties of model input and distribution, and realized refined assessment. This study is the first report on probabilistic assessment of 3-MCPDEs and GEs in IFs, which also provided references for the formulation of related regulatory limits in China.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Jun Cong,Shao-hua Luo,Peng-yu Li,Kun Li,Peng-wei Li,Sheng-xue Yan
Na 3 V 2 (PO 4 ) 3 is particularly suitable as cathode materials for sodium ion batteries (SIBs). Its NASICON structure is not only conducive to the rapid migration of Na + , but also has less volume deformation during Na + deintercalation, and the main frame mechanism remains unchanged. However, owing to its own structure, the electronic conductivity is limited, which limits its practical application. Here, on the basis of carbon coating to enhance the electronic conductivity, the effect of sodium site doping of K + on the structure and properties of Na 3 V 2 (PO 4 ) 3 /C is deeply explored by comparing series Na 3-x K x V 2 (PO 4 ) 3 /C (x = 0, 0.05, 0.1, 0.15, 0.2). The initial discharge capacity of Na 2.9 K 0.1 V 2 (PO 4 ) 3 /C is 107.7 mAh·g −1 in the potential range of 2.5–3.8 V at 0.2C, and the capacity remains 95 % after 300 cycles. The excellent performance of Na 2.9 K 0.1 V 2 (PO 4 ) 3 /C benefits from the large radius of K + as functional support ions, which lightly relieves the deformation pressure of Na + during the deintercalation process, thereby stabilizing the crystal structure. Moreover, the doping of K + plays a critical role in improving the diffusion coefficient of Na + . Density functional theory (DFT) calculations demonstrate that the Na-site doping of K + can enhance the electronic conductivity of the material, which in turn brings excellent electrochemical performance. Prime novelty statement • On the basis of carbon coating, Na 2.9 K 0.1 V 2 (PO 4 ) 3 /C cathode materials with excellent electrochemical performance are obtained by doping K at theNa-site. • The effect of Na-site doping of K + on the structure and properties of Na 3 V 2 (PO 4 ) 3 /C is deeply explored by comparing series Na 3-x K x V 2 (PO 4 ) 3 /C (x = 0, 0.05, 0.1, 0.15, 0.2). • The mechanism of excellent electrochemical performance and structural stability caused by Na-site doping of K + is revealed theoretically by DFT calculation.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2023
·
IF 7
Xinrui Wang,Mengxian Yu,Qingzhu Jia,Fangyou Yan,Qiang Wang
Ionic liquids (ILs) have high chemical stability and resistance to biodegradation, and their highly efficient removal from the water environment is imminent due to their potential ecotoxicity and environmental risks. Yet, current degradation methods are inefficient for ionic liquids even if activation of persulfate (PS) is enhanced by vis with the presence of catalysts. In this study, a simple and high-efficient simulated solar to activate PS was conducted for the degradation of 1-ethyl-3-methylimidazolium chloride (C 2 mimCl). The results revealed that over 99 % of C 2 mimCl was degraded by solar activated PS within 4 h at 25 °C. The degradation of the C 2 mimCl still exhibited excellent performance under natural sunlight activated PS, providing the practical application value. Based on density function theory (DFT) calculation and major intermediates determined by ultra-high-performance liquid chromatography triple quadrupole mass spectrometry (UHPLC-TQ-MS), the first major sites of C 2 mimCl to be attacked were the C atoms on imidazolium ring, followed by the alkyl side chain, and the degradation of C 2 mimCl was mainly carried out by imidazolium ring oxidation , C–N bond breakage and elimination reactions. Consequently, the findings of this work may provide new insight on the degradation of ILs by solar activated PS with excellent practical application.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）