JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.7
Ziyue Ju,Ruichan Lv,Ji Zhang,Delong Shi,Yitong Chen,Anees A. Ansari
Conventional techniques such as screen printing and hand-brushing, though scalable, often compromise on patterning resolution and material waste. In contrast, advanced inkjet printing offers a promising route for high-resolution and efficient manufacturing. In this study, a flexible electrode based on Ni-MOF material used high-precision scalable inkjet printing was developed for glucose sensing in human body fluids for wearable devices. Initially, Ni-MOF material with a high specific surface area and porous structure was synthesized via a hydrothermal method, and its potential for electrochemical detection was investigated. Experimental results demonstrated that the material exhibited high sensitivity and a broad detection range for glucose. Importantly, graphite and carbon nanotubes were incorporated to construct a Ni-MOF composite material with the composition ratio optimized to enhance conductivity and mechanical stability, for further application in flexible electrodes. Typically, a cost-effective, high-efficiency, and scalable fabrication process was achieved through high-precision inkjet printing technology, which enables 1200 dpi resolution while supporting ultra-large-scale printing up to 1200 × 1200 mm. Simutaneously, simulation-based optimization was conducted to determine the most effective electrode shape. As a result, the detection range of the inkjet-printed flexible electrode was extended to 0.005–2.63 mM, with an improved sensitivity of 12.2 μA·μM −1 ·cm −2 . Moreover, excellent mechanical stability and long-term durability were achieved, enabling precise differentiation of glucose fluctuations in low-concentration simulated sweat. Finally, a microfluidic channel to provide environment for the reaction was designed, thereby establishing a fundamental foundation for applying the flexible electrode in wearable devices.
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Molecular Catalysis
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2026
·
IF 4.9
Hui-Li Wu,Jia-Wei Liu,Chang-Long Tan,Zi-Rong Tang
Selective photocatalytic dehydrogenation of saturated N-heterocycles represents a sustainable photoredox route for synthesizing valuable nitrogen-containing unsaturated heteroaromatic organics. Herein, we report a Ni-decorated 3D sea urchin-like CdS composite (Ni/CdS) as a dual-functional photocatalyst for the efficient and selective semi-dehydrogenation of 1,2,3,4-tetrahydroisoquinoline (THIQ) to 3,4-dihydroisoquinoline (DHIQ) coupled with H 2 evolution under visible light irradiation. The surface-decorated Ni nanoparticles significantly enhance the separation and transfer of photogenerated electron–hole pairs over Ni/CdS, and act as reactive sites for proton reduction to H 2 , thereby leading to the improved dual-functional photoredox catalysis. Mechanistic studies identify the carbon-centered radical (•CH(NH)C 8 H 8 ) as a pivotal intermediate in the photocatalytic semi-dehydrogenation of THIQ. This study establishes an effective strategy for designing noble-metal-free photocatalytic systems that integrate selective organic transformations with H 2 evolution in a cooperative manner.
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Materials Today Bio
·
2026
·
IF 10.2
Tingting Liu,Wenyan She,Ruili Du,Yali Bao,Zhibin Guo,Qichao Gao,Hanping Li,Pengfei Suo,Yi Liu,Yujiao Liu
It is important yet challenging to enhance immunotherapy responses using biosafe agents due to the immunosuppressive tumor microenvironment. To address this challenge, BD3PP was constructed by encapsulating black phosphorus quantum dots (BPQDs), a synthesized thioredoxin reductase inhibitor 3c, and Dir (the fluorescent dye) into PLGA nanoparticles, followed by conjugation with a PDL1 antagonist for synergistic multimodal therapy and imaging. The mechanism and efficiency of BD3PP were investigated through density functional theory (DFT) calculations, molecular docking, and in vitro and in vivo experiments. The PDL1 antagonist served as a targeting moiety that binds PDL1 on the tumor cell surface, enabling the controlled intracellular release of the three therapeutic agents. Self-passivated bilayer BPQDs converted optical energy into heat for photothermal therapy and generated singlet oxygen ( 1 O 2 ) from O 2 for type Ⅱ photodynamic therapy, showing far superior to non-passivated bilayer BPQDs or bulk BP. Meanwhile, 3c selectively inhibited thioredoxin reductase, leading to the production of · and H 2 O 2 . These effects synergistically induced immunogenic cell death (ICD), promoted macrophage polarization toward the M1 phenotype, and remodeled the tumor microenvironment to facilitate tumor clearance. The near-infrared fluorescent dye Dir enabled real-time imaging both in vitro and in vivo . DFT calculation revealed that BPQDs were ultimately degraded into biocompatible phosphoric acid. Along with the other biocompatible components in BD3PP, biosafety was guaranteed. This research introduces an efficient and biosafe nanoplatform based on self-passivated bilayer BPQDs, which exhibits prolonged blood circulation and enhanced multimodal real-time photothermal and near-infrared imaging. Importantly, this nanoplatform enables integrated photothermal, photodynamic, and targeted therapies, demonstrating promising potential for anti-tumor preclinical and clinical applications.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19
Cong-Yi Sheng,Yu-Hua Huang,Yu-Chuang Fang,Su-Yan Zou,Wei Wei,Dong-Dong Huang,Dai-Bin Kuang,Xu-Dong Wang
Halide perovskite thick films have emerged as promising candidates for X-ray detection and imaging. However, the residual strain arising from soft lattice, lattice mismatch, and weak interfacial bonding causes cracks and delamination, hindering the integration of perovskite film with thin film transistor (TFT). Here, a multifunctional natural molecule (digallic acid, DA) is introduced into the ultrasonic spraying perovskite film to achieve efficient and stable fully air-processed X-ray detectors. Results demonstrate that DA's abundant functional groups not only enhance adhesion between perovskite films and substrates to improve the integrability with TFT, but also effectively passivate defects. Furthermore, this approach modulates the perovskite's Fermi level, creating an interfacial barrier that significantly reduces dark current. Consequently, DA modification enables the device to obtain a high sensitivity of 3.1 × 10 5 µC Gy air −1 cm −2 and a low detection limit of 39.8 nGy air s −1 , simultaneously greatly enhances the tolerance to irradiation, remaining stable after 140 Gy air X-ray irradiation. The flat-panel detector, integrating DA-modified perovskite film with TFT backplane, successfully achieved rapid X-ray imaging under low dose rate (92 ms/frame, 27.2 µGy air s −1 , tolal dose of 2.5 µGy air ). This work highlights DA's potential as a versatile molecular tool for developing low-dose, high-performance X-ray imaging systems.
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CERAMICS INTERNATIONAL
·
2026
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IF 5.6
Jialong Wu,Zhen Li,Weidong Gu,Xinyan Niu,Yunbo Wang,Ding Huang,Shuangshuang Jiang,Manhong Huang,Jun Li,Guanghui Li
Densification of silicon carbide (SiC) ceramic membrane typically requires sintering temperatures above 2000 °C, resulting in high energy consumption and substantial fabrication costs, and conventional SiC membrane exhibit limited removal efficiency for small molecules. To address these challenges, a co-sintering method was employed to fabricate cobaltic oxide (Co 2 O 3 ) loaded SiC catalytic membrane, with the Co 2 O 3 content systematically optimized. Co 2 O 3 functions as both a sintering temperature-lowering aid and an active site for catalytic ozonation of pollutants. Compared to pure SiC membrane (water permeability: 1200 L m −2 h −1 bar −1 ; flexural strength: 10.5 MPa), the Co@SiC membrane demonstrated significant improvements in both water permeability (1400 L m −2 h −1 bar −1 ) and mechanical strength (13.0 MPa). Numerical simulation further elucidated the neck formation dynamics. Moreover, Co@SiC membrane effectively degrades 95 % Congo red within 20 min, attributed to the generation of superoxide radicals (•O 2 − ). Density functional theory (DFT) calculations illustrated Co sites can effectively absorb ozone molecules and break O-O bond in ozone to generate •O 2 − . Fukui index analysis further indicated •O 2 − tend to attack N=N double bonds in dye molecules. This study proposes a comprehensive understanding of low-temperature sintering behavior and catalytic ozonation performance of Co 2 O 3 modified composite membrane, offering a sustainable strategy for membrane fabrication and wastewater treatment.
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CHEMICAL ENGINEERING SCIENCE
·
2026
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IF 4.3
Mengdi Zhang,Sheng Liu,Hongwei Zhao,Zhilong Liu,Mingyang Chen,Mingxuan Li,Dandan Han,Junbo Gong
Customized production of high-end functional sugars is greatly limited due to the lack of quantitative correlation between the content of homologous impurities in impure syrup and the optimized crystallization operating profiles. Using α-Anhydrous Glucose as the model substance, this work presents a crystallization size control model considering the presence of impurity, aiming to generate an optimized cooling trajectory to achieve the design of custom-sized sugar crystals. Validation and comparison experiments showed that the glucose of target size with an advantage in anti-compression and anti-caking during the storage and transport process can be obtained through cooling trajectory generated by the proposed model. This model-based control strategy can provide an opportunity to find optimal cooling trajectory by balancing the relationship between cooling time and seed loading to meet demands of both product functionality and human manufacturability.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.1
Chao Lu,Zhuxuan Shi,Fengna Xi,Yucheng Zhou
Sensitive tumor biomarker detection is vital to early cancer diagnosis, therapy monitoring, and prognosis. Herein, a signal-off electrochemiluminescence (ECL) immunosensing platform was developed by combining enzyme-loaded immunogold nanoprobes, magnetic bead-based sandwich recognition, and nanochannel modified electrode, that enables sensitive detection of carcinoembryonic antigen (CEA) as proof-of-concept demonstration. Functionalization of low-cost ITO electrode with silica nanochannel film (SNF) produced nanochannel electrode, which enabled the electrostatic enrichment of the cationic tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ ) emitter and resulted in a 119-fold ECL enhancement over bare ITO. Gold nanoparticles (AuNPs) were used to co-load multiple glucose oxidase (GOD) together with detection antibody (dAb), yielding GOD/dAb@Au nanoprobes. In the presence of CEA, magnetic beads functionalized with capture antibody (cAb) selectively bound the target and subsequently associated with the GOD/dAb@Au probes to form an enzyme-bearing sandwich immunocomplex. Application of an external magnetic field enabled rapid separation of the immunocomplex from sample matrix. Using the SNF/ITO electrode and a Ru(bpy) 3 2+ /tripropylamine (TPrA) solution containing glucose (Glu), the GOD-mediated production of H 2 O 2 acted as a quencher, decreasing the ECL signal in a CEA-dependent manner. The immunosensor demonstrated a linear detection range for CEA from 10 fg/mL to 100 ng/mL, with a limit of detection (LOD) as low as 5.3 fg/mL. CEA detection in fetal bovine serum was realized. Additionally, the SNF/ITO electrode could be regenerated and reused.
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RSC Advances
·
2026
·Vol. 16
·期 5
·4640-4654
·
IF 4.6
Yanping Zhang,Hong Xi,Dongyuan Qin,Ping Cao,Shuo Yang,Jing Yin,Tianliang Li,Lili Ding
Inflammatory bowel disease (IBD) is characterized by chronic gastrointestinal inflammation driven by oxidative stress and immune dysregulation. This study develops a novel oral nanozyme composite drug delivery system (MXene/CBN@GelMA, MCG) designed for targeted therapy of IBD. The composite integrates antioxidative MXene nanosheets and anti-inflammatory columbianadin (CBN) into a gelatin methacryloyl (GelMA) hydrogel, enabling targeted delivery and therapy. MCG efficiently scavenges reactive oxygen species (ROS) and generates oxygen (O2) through a superoxide dismutase (SOD)-catalase (CAT) cascade reaction, thereby alleviating oxidative stress and mitigating hypoxia in the inflamed tissues. In a dextran sulfate sodium (DSS)-induced IBD model, MCG treatment significantly reduced disease activity, restored colon length, preserved mucosal integrity, and suppressed pro-inflammatory pathways. Transcriptomic analysis revealed that MCG reversed IBD-associated gene expression dysregulation and modulated immune-related pathways. The system demonstrated high biocompatibility and effective targeting, providing a synergistic therapeutic strategy for IBD through antioxidative and anti-inflammatory mechanisms.
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Materials Today Bio
·
2026
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IF 10.2
Chen Chen,Na Zhang,Fructueux Modeste Amona,Xiaolei Han,Qi Tang,Lanxin Geng,Guangfu Liao,Jie Zhang,Tushuai Li
Chronic wounds infected with multidrug-resistant bacteria pose a significant challenge to global health, as traditional monotherapies often fail to eradicate pathogens and restore the damaged wound microenvironment. Engineering innovative nanocomposites that integrate synergistic therapeutics and controlled release is a pivotal strategy for advanced wound management. Here, we developed a novel multi-drug metal-organic framework (MOF) nanocomposite, BBR + FA@UiO, by covalently grafting ferulic acid (FA) onto UiO-66-NH 2 and physically loading berberine (BBR). Drawing from "Jun–Chen–Zuo–[ Shi ]" hierarchy of Traditional Chinese Medicine (TCM), this design used the MOF as a robust porous carrier “[ Shi ]” for the antibacterial drug "Jun" (BBR) and antioxidant drug "Chen/Zuo" (FA). BBR + FA@UiO exhibits potent, synergistic antibacterial and antibiofilm activity against critical clinical pathogens like MRSA and Pseudomonas aeruginosa, through a pH/ROS-responsive release mechanism in the infected site. Functionally, BBR + FA@UiO activates the Nrf2/Keap1 pathway in macrophages, thereby mitigating oxidative stress and enhancing mitochondrial function. Consequently, proliferation and migration of Human Umbilical Vein Endothelial Cells (HUVECs) are restored through promoting angiogenesis. In vivo, BBR + FA@UiO significantly accelerates healing by eradicating bacteria, enhancing collagen deposition, and improving vascularization, driven by the coordinated activation of the Nrf2/HO-1 antioxidant axis and pro-regenerative Wnt/β-catenin and TGF-β signaling pathways. Demonstrating excellent biocompatibility and no systemic toxicity, this work establishes BBR + FA@UiO as a new therapeutic approach that merges TCM with advanced MOFs for comprehensive wound care.
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MATERIALS & DESIGN
·
2026
·
IF 8.2
Jinhuan Li,Ling Cai,Zhen Fu,Xiaodong Zhu,Yanqiang Huang,Yuan Wu,Jin Chen
Due to the spatiotemporal specificity and high efficacy, tumor microenvironment (TME)-responsive nanozyme catalytic therapy has attracted considerable attentions. Nevertheless, it remained challenging to remodel TME for improving therapeutic benefits. Here, a TME-responsive nanozyme termed p-GOx-MnO 2 -ICG (p-GMI) was synthesized via biomimetic mineralization using ε-poly-L-lysine (EPL) as the template. The obtained p-GMI comprised glucose oxidase (GOx), MnO 2 nanoparticles, and photosensitizer indocyanine green (ICG), which exhibited prominent triple-enzyme activities (glucose oxidase, catalase-like, and peroxidase-like) enabling multimodal therapy. Specifically, starvation therapy (ST) was initiated through glutathione peroxidase-mediated glucose depletion. The released Mn 2+ in TME utilized the produced H 2 O 2 and gluconic acid to initiate Fenton-like reaction, enhancing chemodynamic therapy (CDT) efficacy. Meanwhile, the generated O 2 by catalase-like nanozyme can not only activate GOx but serve as the photodynamic therapy (PDT) substrate, leading to synergistically improved ST and PDT outcomes. Both in vitro and in vivo experiments indicated p-GMI nanozyme enabled fluorescence imaging/magnetic resonance imaging-guided ST/CDT/PDT combinational therapy, while also exhibiting favorable biosafety in the CAL-27 xenograft mouse model. Therefore, the built TME-responsive and dual-modal imaging guided p-GMI nanozymes as integrated cascade nanosystem held potentials in dealing with oral cancer.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Quan-Shui Wang,Sen Pang,Xiao-Yi Tong,Du-Qiang Luo,Jian Wang,Fei Cao
Alternaria alternata causes serious postharvest diseases in tomatoes, threatening shelf life and food safety. In this study, a natural and eco-friendly strategy was developed using Ligusticum jeholense essential oil (LEO), extracted via optimized enzymatic–deep eutectic solvent microwave-assisted method (EDP–MAHD), which achieved a 3.38-fold higher yield than conventional extraction. GC–MS analysis confirmed consistent chemical composition across production batches. In vitro , LEO exhibited potent antifungal activity against A. alternata (IC₅₀, 0.0718 μL/mL), while in vivo experiments on tomato fruit showed it significantly inhibited lesion expansion and suppressed the accumulation of mycotoxins, alternariol (AOH) and tenuazonic acid (TeA). SEM, TEM, proteomic, and physiological analyses revealed that LEO disrupted membrane integrity, interfered with energy metabolism, and induced oxidative stress, suggesting multi-target antifungal mechanisms. Acute toxicity in mice confirmed its safety. These findings support the application of LEO as a promising natural preservative for postharvest disease and toxin control in tomatoes.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 2
·124
·
IF 5.4
Li Zhe,Gao Zhaodong,Chen Zhijiao,Liu Yuanan,Wang Xiaohui
A dual-mode ratiometric fluorescent nanosensor was developed for ultrasensitive detection of glucose via simultaneous measuring pH and O 2 changes during enzymatic oxidation. The nanosensor integrates pH-sensitive fluorescent probe FITC and O 2 -sensitive probe RuDP into hybrid nanoparticle core, with glucose oxidase (GOx) immobilized poly-L-lysine shell. During GOx-catalyzed reaction with glucose, the nanosensor gives rise of a decrease in pH-sensitive fluorescence due to acidification and an increase in O 2 -sensitive fluorescence owing to oxygen depletion, enabling a dual-mode readout under single-excitation wavelength. The emission ratio between O 2 -sensitive peak and pH-sensitive peak, employs signal amplification and results in high sensitivity, compared to single O 2 and pH testing. The ratiometric fluorescent signal exhibits a strong linear response in the 0–1 mM glucose range with a detection limit of 7.3 µM. The sensor shows robust performance and high reproducibility in DMEM and human sweat. In vivo imaging of zebrafish further confirms the photostability, and sensitivity of nanosensor, highlighting their utility for glucose detection. This study presents the first ratiometric fluorescence amplification strategy employing dual pH/O 2 testing for real-time glucose detection. The proposed nanosensor promotes non-invasive glucose detection in biomedical research and dual-mode ratiometric amplification strategies for monitoring metabolic targets. Graphical abstract
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危险品化学品经营许可证（带存储）