CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Meng-Han Yan,Zhi-Fei Zhang,Hai-Hua Huang,Zi-Liang Li,Peng Li,Ji-Gong Hao,Wei Li,Juan Du,Mahesh Kumar Joshi,Peng Fu
In this work, a series of x Sm 2 O 3 -(1- x ) CaCu 3 Ti 4 O 12 ( x Sm 2 O 3 -(1- x )CCTO, x = 0.00–0.05) negative temperature coefficient (NTC) ceramics were prepared by a solid-state method. The influence of Sm 2 O 3 content on electrical properties was examined using microstructural, band gap, morphological, Direct Current (DC) resistivity, and impedance spectroscopy analysis. The increase in Sm 2 O 3 content resulted in a gradual decrease of the resistivities ( ρ 25 ), thermal constants ( B 25/75 ), activation energies for electrical conduction ( E a ) and activation energies of the relaxation process ( E relax ) from 1.16 × 10 7 Ω cm, 6387 K, 0.5456 eV and 0.5592 eV to 3.43 × 10 5 Ω cm, 4149 K, 0.4088 eV and 0.4115 eV respectively. First-principles calculations revealed a reduction in the band gap by adding Sm 2 O 3 , partially explaining the decrease in electrical resistivity. In-situ XPS analysis elucidated a relationship between conduction mechanism of Sm 2 O 3 -doped CCTO ceramics and electron hopping. Impedance analyses showed that both grains and grain boundaries contributed to the NTC effect of ceramics. The electrical inhomogeneity arose from grains and grain boundaries, while local relaxation was due to the short-range motion of charge carriers.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Yajie Wang,Ziyi Zhang,Jie Li,Ying Tang,Liang Fang
Excellent spinel microwave dielectric ceramics (1- x )Zn 2 TiO 4 - x Li 2 MgTi 3 O 8 (ZTLMT x , x = 1/3 and 2/3) were prepared at relatively low densification temperatures of 1100 °C and 1080 °C, respectively. A disordered cubic phase with space group Fd -3 m was formed at x = 1/3, whereas an ordered cubic phase with space group P 4 3 32 was formed at x = 2/3. The ceramics at x = 1/3 and 2/3 exhibited promising microwave dielectric properties of ɛ r = 18.27 and 22.96, Q × f = 91,877 GHz and 75,186 GHz, and τ f = −42.3 ppm/°C and −21.05 ppm/°C, respectively. The large deviation between the experimental ԑ r and theoretical ε th of 1/3 and 2/3 ceramics were 18.3 % and 57 %, respectively, due to the underestimation of the ionic polarizability of Ti 4+ . The difference in their ɛ r , Q × f , and τ f were discussed by the structure, FWHM of A 1g , lattice energy and bond energy in detail.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Meichen Liu,Meichen Gao,Xu Shi,Yilin Yin,Huanyi Liu,Ruirui Xie,Chenxi Huang,Wenwen Zhang,Shiwen Xu
With the increasing development of the society, silicon dioxide (SiO 2 ) has been used in various fields, such as agriculture, food industry, etc., and its residues can pose a potential health threat to organisms. Quercetin (Que) is a potent free radical scavenger commonly found in plants. C57BL/6 mice were chosen to established a mouse model of SiO 2 exposure and Que antagonism to investigate the mechanism of action of Que in rescuing the toxic damage of SiO 2 on mouse cerebellum tissue. The results showed that cytoplasmic vacuolization, and inflammatory cell infiltration caused by SiO 2 were alleviated by the addition of Que, and reduced oxidative stress in mouse cerebellum, alleviated the activation of TLR4 pathway induced by SiO 2 , and substantially reduced the occurrence of ZBP-1-mediated PANoptosis induced by SiO 2 exposure in mouse cerebellum. In NS20Y cells, the oxidative stress activator (Elesclomol) and inhibitor N-acetyl cysteine (NAC), and the NF-κB activator 2 (NA2) were added. Elesclomol and NAC confirm the involvement of ROS in regulating the TLR4/NF-κB pathway, the TLR4/NF-κB pathway regulated ZBP-1-mediated PANoptosis in cerebellum and NS20Y cells induced by SiO 2 exposure. In conclusion, the present experimental data suggest that Que mitigates the onset of ZBP-1-mediated PANoptosis in neuronal cells induced by SiO 2 through the ROS/TLR4/NF-κB pathway. The present experimental findings help to understand the detoxification effect of Que in more tissues and provide an important reference for the rescue of organisms in long-term SiO 2 environment.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
An Hanwen,Li Menglu,Liu Qingsong,Song Yajie,Liu Jiaxuan,Yu Zhihang,Liu Xingjiang,Deng Biao,Wang Jiajun
Polyethylene oxide (PEO) based electrolytes critically govern the security and energy density of solid-state batteries, but typically suffer from poor oxidation resistance at high voltages, which limits the energy density of batteries. Here, we report a Lewis-acid coordinated strategy to significantly improve the cyclic stability of 4.8 V-class PEO-based battery. The introduced Mg 2+ and Al 3+ with strong electron-withdrawing capability weaken the electron density of ether oxygen (EO) chains via chelation in the coordination structure, resulting in a locally limited interaction between the EO chains and the surface of cathodes at high state of charge. The batteries using Lewis-acid coordinated electrolytes and Ni-rich cathodes achieve high voltage stability of 4.8 V over 300 cycles. Further, the realization of industrial-scale electrolyte membranes, and Ah-level pouch cells over 586 Wh kg ‒1 with good cyclic stability, suggests the potential of our strategy in practical applications of all-solid-state batteries.
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ELECTROCHIMICA ACTA
·
2011
·
IF 3.65
Xiaofang Shen,Yan Cui,Yuehong Pang,He Qian
1-Hydroxypyrene (1-OHP) is a ubiquitous metabolite of polycyclic aromatic hydrocarbons (PAHs) and has been widely used as a biomarker for evaluation of human exposure to PAHs. In this paper, an electrochemical sensor consisted of graphene oxide nanoribbon (GON)/octa(3-aminopropyl)octasilae quioxane octahydrochloride (OA-POSS) framework films (GON/OA-POSS) modified electrode for pre-concentrating and sensing of 1-OHP was described. The GON/OA-POSS composite films were prepared by hierarchically layer-by-layer assembly via electrostatic interactions. GON, which has higher electrical conductivity than that of graphene oxide, offers residual π-conjugated systems for adsorption of 1-OHP via π–π stacking interaction. Meanwhile, OA-POSS nanocages make the GON layers frameworked to enhance contacting between GON and 1-OHP. When 1-OHP was pre-concentrated on GON/OA-POSS frameworks modified electrode, the response signal and adsorption stability was enhanced significantly. Differential pulse voltammetry was used for direct determination of 1-OHP. The electrochemical sensor calibration curve had a range of 0.1–12.55 μM ( R = 0.995) with a detection limit of 0.04 μM. The results showed that the GON/OA-POSS framework films modified electrode established a new way for simple and sensitive analysis of 1-OHP.
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Korean Journal of Pain
·
2024
·
IF 3.4
Kaiwen Lin,Datian Fu,Zhongtao Wang,Xueer Zhang,Canyang Zhu
Background Galangin, commonly employed in traditional Chinese medicine for its diverse medicinal properties, exhibits potential in treating inflammatory pain. Nevertheless, its mechanism of action remains unclear. Methods Mice were randomly divided into 4 groups for 7 days a normal control group, a galangin-treated (25 and 50 mg/kg), and a positive control celecoxib (20 mg/kg). Analgesic and anti-inflammatory effects were evaluated using a hot plate test, acetic acid-induced writhing test, acetic acid-induced vascular permeability test, formalin-induced paw licking test, and carrageenan-induced paw swelling test. The interplay between galangin, transient receptor potential vanilloid 1 (TRPV1), NF-κB, COX-2, and TNF-α proteins was evaluated via molecular docking. COX-2, PGE2, IL-1β, IL-6, and TNF-α levels in serum were measured using ELISA after capsaicin administration (200 nmol/L). TRPV1 expression in the dorsal root ganglion was analyzed by Western blot. The quantities of substance P (SP) and calcitonin gene-related peptide (CGRP) were assessed using qPCR. Results Galangin reduced hot plate-induced licking latency, acetic acid-induced contortions, carrageenan-triggered foot inflammation, and capillary permeability in mice. It exhibited favorable affinity towards TRPV1, NF-κB, COX-2, and TNF-α, resulting in decreased levels of COX-2, PGE2, IL-1β, IL-6, and TNF-α in serum following capsaicin stimulation. Galangin effectively suppressed the upregulation of TRPV1 protein and associated receptor neuropeptides CGRP and SP mRNA, while concurrently inhibiting the expression of NF-κB, TNF-α, COX-2, and PGE2 mRNA. Conclusions Galangin exerts its anti-inflammatory pain effects by inhibiting TRPV1 activation and regulating COX-2, NF-κB/TNF-α expression, providing evidence for the use of galangin in the management of inflammatory pain.
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PubMed
高影响因子
Postepy Dermatologii i Alergologii
·
2025
·Vol. 42
·期 4
·398-406
·
IF 1.7
Bei Zhao,Yinghua Liu,Xuemei Tang,Shi Cheng
Introduction:The effectiveness of chemotherapy in treating melanoma is limited due to drug resistance. Previous studies have shown that SENP1 (Sentrin/SUMO-specific protease 1) is related to the tumour hypoxic microenvironment, tumorigenesis and metastasis.Aim:This study aimed to investigate its roles in drug resistance of melanoma.Material and methods:Originally, a concentration of 2 µg/ml dacarbazine (DTIC) was employed in the treatment of A375 and M14 cell lines for a duration of 24 h. Subsequently, the cells were transferred to fresh medium and allowed to proliferate until reaching 80% of their maximum density. This treatment cycle was then repeated for a total of 10 days, following which the DTIC concentration was doubled. The establishment of drug-resistant cell lines for both A375 and M14 occurred after 8 months of sustained and continuous treatment. The expression level of SENP1 was monitored monthly using real-time reverse transcriptase-polymerase chain reaction (RT-qPCR), with a fold change above 1.5 compared to the untreated condition considered as significant.Results:Finally, the study found that SENP1 was up-regulated by about 2.2-1.7 times in the drug-resistant cells. In addition, overexpression of SENP1 in normal A375 cells improved cell viability against DTIC. The study also found that Yes-associated protein (YAP) could form protein condensates in the cytoplasm while its expression was enhanced by SENP1-mediated deSUMOylation.Conclusions:This study suggests that there is a positive correlation between the ubiquitin-specific protease SENP1 and drug resistance in melanoma. Its up-regulation may lead to changes in the deSUMOylation of YAP, activate the Hippo signalling pathway, and increase the resistance of melanoma to DTIC.
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PubMed
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Nano Research
·
2023
·Vol. 16
·期 12
·13366-13374
·
IF 9.9
Lin Chaoxin,Kim Kumchol,Wang Zuochao,Yan Zhuang,Tang Zhiyong,Liu Yaling
Integration and synergy of the unique functions of different components have been developed into one of the most convenient and effective ways to construct the composite advanced materials with collective properties and improved performances. In this work, the mace-like tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ)/HKUST-1 composite structures with single single-crystalline TTF-TCNQ submicrorods covered by ordered HKUST-1 nanosheet arrays were successfully constructed by an efficient TTF-TCNQ seed-mediated growth approach. Impressively, thanks to the synergetic and complementary effects between TTF-TCNQ and HKUST-1, the sensors based on such mace-like TTF-TCNQ/HKUST-1 composite structures not only displayed an experimental detection limit of 10 part per billion (ppb) for NO 2 detection, but also exhibited outstanding selectivity even if the concentration of the interfering gases was 10 times that of NO 2 . Meanwhile, good reproducibility and rapid response were also achieved. This work opens the avenue for creation of novel high-performance sensing materials for application in gas sensing.
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COMBUSTION AND FLAME
·
2025
·
IF 6.2
Zhongkai Liu,Mengqi Wu,Zhaohan Chu,Xiaoqing Wu,Jiabin Huang,Jiuzhong Yang,Bin Yang,Feng Zhang
In this work, we conducted a combined experimental and theoretical investigation into the reactivity of naphthylmethyl radical (1-A2CH 2 , C 11 H 9 ) with allene (aC 3 H 4 ) and propyne (pC 3 H 4 ). Co-pyrolysis experiments of 1-(chloromethyl)naphthalene (1-A2CH 2 Cl) with aC 3 H 4 or pC 3 H 4 were studied using a flash pyrolysis microreactor coupled with synchrotron vacuum ultraviolet photoionization mass spectrometry. Significant signals at m/z = 39 (C 3 H 3 ), attributed to the rapid H-abstraction and/or pyrolysis of C 3 H 4 molecules, were detected in both experiments, indicating concurrent radical-radical (1-A2CH 2 + C 3 H 3 ) and radical-molecule (1-A2CH 2 + aC 3 H 4 /pC 3 H 4 ) reactions. Theoretical calculations reveal that the radical-radical reaction is kinetically favored under experimental conditions compared to the radical-molecule reaction, dominantly forming two C 14 H 12 adducts, 1-(1,2-butadiene-4-yl)naphthalene (1-W1) and 1-(but‑yn-3-yl)naphthalene (1-W2), along with minor amounts of other C 14 H 12 isomers and C 14 H 11 + H products. The computed rate coefficients and branching ratios of various reaction channels expand the analysis to broader temperature and pressure ranges. The radical-radical products (1-W1 and 1-W2) dominate at atmospheric-to-high pressures (>1 atm) or relatively lower temperatures (<1500 K). At higher temperatures and low pressures, competition arises between radical-radical and radical-molecule pathways. Furthermore, the structures of bimolecular products differ significantly between the 1-A2CH 2 + aC 3 H 4 and 1-A2CH 2 + pC 3 H 4 reaction systems, with implications for the formation of larger polycyclic aromatic hydrocarbons.
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高影响因子
CHEMICAL PHYSICS
·
2025
·
IF 2.4
Mengyu Lin,Jiumei Chu,Dianjun Dong,Xue Yang,Dianquan Dong
Spinel-type titanium-based lithium-ion sieve H 4 Ti 5 O 12 has excellent theoretical adsorption capacity and selectivity. Still, spinel-type lithium adsorbents prepared in existing studies have poor adsorption, poor recyclability, and difficulty in recovery. To solve the above problems, composite mesoporous ion sieves, Polyvinyl Butyral-H 4 Ti 5 O 12 –1 (PVB-HTO-1) modified with dual surfactants, were synthesized for the first time in this paper. Hydrophilic lithium-ion sieve HTO-1 with a mesoporous structure was synthesized by adding two surfactants, CTAB and F127. Then the modified ion sieve was composited with PVB to make a fine rod-like composite material, PVB-HTO-1, with a diameter of no more than 0.5 mm, to solve the limitation of the industrial application that the recycling of powdered ion sieve is difficult. The bi-component surfactant-derived ion sieve, PVB-HTO-1, exhibits superior hydrophilicity and possesses a porous mesoporous framework that facilitates ion exchange processes, achieving adsorption equilibrium within a timeframe of three hours. It demonstrates a remarkable maximum adsorption capacity of 53.25 mg/g. Even after undergoing five cycles of adsorption and desorption, the material's adsorption capacity remains at over 90 % of its initial value, indicative of its robust cyclic stability. The uptake of Li + ions by PVB-HTO-1 aligns with the pseudo-second-order kinetic model and conforms to the Langmuir isothermal adsorption model.
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ANALYST
·
2019
·Vol. 144
·期 9
·3072-3079
·
IF 4.019
Yuhuan Wang,Ruyan Wang,Lei Wang,Licheng Wang,Yong Guo,Xiaojing Liang,Shuai Wang
Au nanoparticle-hybridized silica (Au@sil) spheres were synthesized in one step as a liquid chromatographic stationary phase for the first time. The hybridized stationary phase showed good separation performances in reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography even without bonding with any organic groups. Compared with the bare silica stationary phase, the Au@sil stationary phase showed better separation performance under the same conditions in RPLC and HILIC modes. The effects of acetonitrile content, buffer concentration, and the pH of the mobile phase on analyte retention were further investigated. The results showed that the Au@sil stationary phase had a complex retention mechanism of electrostatic and partitioning interactions. By comparing Au solution (solAu) with different proportion volumes in silica sol, the optimum hybridized stationary phase was found to comprise 33 vol% solAu. Au@sil was further modified with 1-octadecanethiol by self-assembly and used to separate alkylbenzenes and polycyclic aromatic hydrocarbons by RPLC. The separation efficiency of the 1-octadecanethiol self-assembled modified Au@sil (C18-Au@sil) column was much better than that of Au@sil. Overall, the successful hybridization of Au nanoparticles provided a new method to prepare a stationary phase in a simple and environmentally friendly way.
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PubMed
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BIOORGANIC CHEMISTRY
·
2024
·
IF 4.5
Linlin Han,Hongyan Tan,Jungjoon Lee,Peng Wang,Yuqing Zhao
Based on the significant biological activities and the remarkable physical and chemical properties of 1 H -1,2,3-triazole pharmacophore, we herein adopted the strategy of click chemistry to combine the triazole fragment and the unique scaffold of 25-OCH 3 -PPD ( AD-1 ) to design a series of potent compounds inducing apoptosis and DNA damage. The anti-proliferative effect was verified by MTT assay and colony formation assay. DNA double-stand breaks (DSBs) were obtained by observing the nuclear focus formation and the protein expression of γ-H2AX. Cell cycle arrest was evaluated by the cycle-related proteins such as CDK2, CDK4, CDK6, Cyclin D1 and P 21. Apoptosis was assessed by flow cytometry, mitochondrial membrane potential (MMP) detection and the expression of apoptosis-related proteins. Reactive oxygen species (ROS) generation was measured with 2′, 7′-dichlorofluorescein diacetate (DCFH-DA) staining. According to SAR analysis, the most potent compound 6a exhibited great inhibitory effect against A549 cells, which IC 50 value of 2.84 ± 0.68 μM. Furthermore, 6a remarkably induced DNA damage, cell cycle arrest and apoptosis in A549 cells. 6a treatment increased the levels of ROS. Network pharmacology and molecular docking predicted the potential signaling pathways and ligand-receptor interactions, and the results of western blotting showed that 6a inhibited the PI3K/Akt/Bcl-2 signaling pathway by decreasing PI3K and Bcl-2 and total level of Akt expression, while Bax and Cyt c were increasing in 6a -treated A549 cells. As mentioned above, 6a has a potent inhibitory effect in A549 cells through induction of DNA damage, apoptosis via ROS generation and modulation of PI3K/Akt/Bcl-2 signaling pathway.
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高影响因子
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