JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Qiang Zhang,Xu Li,Jinxiang Dong
Despite significant breakthroughs that have been made in the application performance of traditionally distributed Guerbet alcohol ethoxylates (GAEO), research on the characteristics of their narrow distribution products remains relatively limited. Herein, a series of hydrophilic and hydrophobic nonionic surfactants have been synthesized via the ethoxylation of 2-butyl-octanol with ethylene oxide. Ca(OAc) 2 was employed as a narrow distribution (NRD) catalyst, while KOH served as a broad distribution (BRD) catalyst. The synthesized products were characterized using Fourier-transform infrared (FT-IR), 1 H and 13 C nuclear magnetic resonance ( 1 H, 13 C NMR) spectroscopy. In addition, a comprehensive assessment of the physicochemical and surface properties of the NRD GAEO surfactants was conducted through systematic investigations. The results were then compared to conventionally distributed GAEO surfactants. The study has demonstrated that NRD GAEO surfactants exhibited lower critical micelle concentration (CMC) values, which have the higher efficiency of the surfactant application. In addition, the NRD products have superior wettability performance, reduced foaming capacity in foam properties, and improved rapid defoaming capacities. In regarding their other properties, they closely mirrored the performance of BRD products. These findings will contribute to a comprehensive understanding of the properties of NRD ethoxylates and have substantial practical implications in optimizing personal care and household cleaning products.
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CHEMISTRY & BIODIVERSITY
·
2024
·Vol. 21
·期 7
·e202400929
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IF 2.3
Yuee Tian,Shiyue Ma,Yibo Liu,Yan Li,Genqiang Chen,Zhiping Che
In order to explore novel natural product-based insecticidal agent, two important intermediates ( 2 and 3 ) and 4-acyloxy-2′-bromo-6′-chloropodophyllotoxin derivatives ( 4 a – f and 5 a – f ) were designed and prepared, and their structures were confirmed by 1 H-NMR, 13 C NMR, HRMS, ESI-MS, optical rotation and melting point (mp). The stereochemical configuration of compound 4 b was unambiguously confirmed by single-crystal X-ray diffraction. Moreover, we evaluated the insecticidal activity of target compounds 4 a – f and 5 a – f against a serious agricultural pest of Mythimna separata by using the leaf-dipping method. Among all tested compounds, compounds 4 d , 5 d and 5 f exhibited stronger insecticidal activity with a final mortality rate exceeding 60 %. Especially compound 5 d exhibited the best insecticidal activity, with a final mortality rate of 74.1 %. It has been proven that introducing bromine or chlorine atoms at the C-2′, C-2′ and C-6′ positions of the E ring of podophyllotoxin can produce more potent compounds. In addition, the configuration of the C-4 position is important for insecticidal activity, and 4β-configuration is optimal. This will pave the way for further design, structural modification, and development of derivatives of podophyllotoxin as insecticidal agents. Graphical
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DALTON TRANSACTIONS
·
2024
·
IF 3.5
Xiaoyu Chu,Xinrui Wang,Shuo Tian,Yongkuo Zhao,Shikai Liu,Hong Yan,Yan Shang
Modulating the photogenerated electrons of CeO2 to activate O2 and efficiently photocatalytic degradation of chlorophenols is a highly desired goal. Herein, we have successfully fabricated FePc/CeO2 heterojunction through H-bond induced assembly. The photocatalytic degradation of 2, 4-DCP by the amount-optimized FePc/CeO2 nanocomposite was improved by 3 times compared with pure CeO2. By means of electron paramagnetic resonance (EPR) and single wavelength photocurrent spectroscopy, it is confirmed that the excellent photocatalytic performance is mainly attributed to the formation of Z-scheme heterojunction, which promotes charge separation and transfer, and the introduction of FePc broadens the visible light absorption range of heterojunction. Moreover, O2 temperature-programmed-desorbed curves and electrochemical O2 reduction measurements results demonstrate that the single Fe-N4(II) site in FePc is more conducive to promoting O2 activation than that of other metal phthalocyanines. Based on in situ FT-IR and liquid chromatography-tandem mass spectrometry (LC-MS), a possible reaction pathway of 2, 4-DCP degradation was proposed. This study provides a novel strategy to prepare CeO2 based Z-scheme heterojunctions with abundant monoatomic sites for pollutant degradation.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Kunfeng Zhang,Jinxia Liang,Sainan Yang,Fangfei Song,Hongxia Chen,Baozhong Zhang,Bo Peng,Hanyu Chen,Hongxing Dai
Constructing an S-scheme heterojunction presents an effective strategy to enhance photocatalytic efficiency via accelerating photoexcited charge separation while preserving strong redox potentials. Herein, amorphous Ni(OH) 2 (a-NH) was in-situ integrated with crystalline Bi 12 O 17 Br 2 (BOB) nanosheets to form an amorphous/crystalline a-NH/BOB S-scheme heterojunction. The as-synthesized a-NH/BOB-0.5 photocatalyst exhibited superior bisphenol A (BPA) degradation efficiency, achieving 48.7 and 3.7-fold enhancements compared to individual a-NH and BOB, respectively. Comprehensive investigations revealed that the improved photocatalytic activity originated from the synergistic effects of enhanced light-harvesting ability and the formation of strong interfacial electric field at the amorphous/crystalline interface. Moreover, the influences of solution pH, coexisting anions, and water matrices on BPA degradation efficiency were also investigated. Reaction mechanism and toxicity assessment demonstrated that BPA could be gradually transformed into small molecules with low toxicity. This work demonstrates an efficient approach for the design of high-performance photocatalysts for environmental remediation by constructing amorphous/crystalline interface and S-scheme charge transfer mechanism.
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DRUG AND CHEMICAL TOXICOLOGY
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2025
·
IF 1.9
Yongxiao Huang,Caina Jiang,Fangyao Li,Xianli Ma
As a commonly used flame retardant in numerous products, it is inevitable that tris(2-chloroethyl)phosphate (TCEP) is released into the surrounding environment during its use. This process gives rise to potential environmental concerns that must be addressed. In recent years, there has been significant interest in the role of TCEP in the development of hyperuricemia (HUA). However, the specific mechanisms by which TCEP contributes to this condition remain to be fully elucidated. In this study, we have employed a combination of network toxicology and in vitro experiments to investigate the potential effects of TCEP on HUA and its mechanism of action. Through systematic analysis of GeneCards, OMIM, Swiss Target Prediction, and CHEMBL databases, a total of 242 TCEP-induced HUA targets were identified. Utilizing the STRING and DAVID databases further elucidated the core targets and associated signaling pathways of TCEP in relation to HUA. The molecular docking assay results demonstrated that TCEP exhibits binding activity with the selected targets. In vitro, our findings revealed that TCEP exacerbates HUA by amplifying the inflammatory response and upregulating the mRNA expression levels of GLUT9 and URAT1. The present study provides a new perspective and theoretical basis for the in-depth understanding of the molecular mechanism of TCEP affecting HUA, and helps to further understand the pathogenesis of HUA and the role of environmental factors.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
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IF 6.3
Yuchi Dong,Yalan Liang,Haoyu Gao,Xianyu Jiang,Linbo Zhang,Liangjun Yin,Le Yuan,Xin Wang,Guo Jing
Magnetic metal absorbers will inevitably suffer from corrosion and aging failure in actual application environments (air, salt spray, acid/alkali, etc.), resulting in serious deterioration of their performance. Using inert, densified materials to modify absorber surface is an effective and feasible solution. Herein, a core-shell structure carbonyl iron composite absorbent (CIP@2-MI/MBI/EP) was prepared by in-situ polymerization with 2-methylimidazole (2-MI), 2-mercaptobenzimidazole (MBI), epoxy resin (EP) as the precursor, and carbonyl iron powder (CIP) as the core. The core-shell structure has enhanced both of corrosion resistance and microwave absorbing performance due to the effect of alleviating the intrusion of corrosive media and low dielectric characteristics of the corrosion inhibitors MBI and EP. The results of electromagnetic parameter test exhibited the minimum reflection loss(RL) of the modified absorbent at 13.78 GHz is -69.57 dB, and the thickness is only 1.65 mm. Electrochemical tests revealed the corrosion potential (E corr )of the composite powder shifted positively from -0.680 V to -0.012 V compared to original CIP. The corrosion current (i corr ) decreased from 59.1 μA/cm 2 to 0.1562 μA/cm 2 , and the annual corrosion rate (CR) decreased by 2 orders of magnitude to 0.0223 mil/year. These results attest to the exceptional corrosion resistance of the composites. In addition, the results of salt spray experiments revealed that the morphology and composition of CIP@2-MI/MBI/EP absorbers remained largely unchanged after 720 H salt spray test. Meanwhile, the acid resistance test (PH=1) further demonstrated the outstanding anti-corrosion performance of the composites. The research offers a new option for the development and design of high-efficiency microwave absorbent with robust corrosion resistance.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xin Wang,Yiyang Bi,Chengqian Wang,Ke Li,Yu Zhang,Qun Liu
In this research, we report a simple and cost-effective method for the preparation of two-dimensional (2D) Ni 2 P-Ni(PO 3 ) 2 derived from metal-organic frameworks (MOFs) via a one-step thermal phosphorization strategy. The resulting material is employed to significantly enhance the photocatalytic hydrogen evolution performance of zero-dimensional (0D) CdS nanoparticles. Through an ultrasonic-assisted strategy, the CdS nanoparticles are uniformly dispersed on the surface of Ni 2 P-Ni(PO 3 ) 2 , leading to the successful fabrication of a Ni 2 P-Ni(PO 3 ) 2 /CdS composite with substantially enhanced photocatalytic performance. Under visible light irradiation (λ ≥ 420 nm) using Na 2 S-Na 2 SO 3 as sacrificial agents, the 3 wt% Ni 2 P-Ni(PO 3 ) 2 /CdS composite demonstrated a remarkable photocatalytic hydrogen evolution rate of 2235 µmol g −1 h −1 , which is approximately 7.5 times higher than that of pristine CdS (297 µmol g −1 h −1 ). Over a 20 h cycling experiment, the composite catalyst demonstrated remarkable stability, maintaining around 78 % of its initial hydrogen generation efficiency. The enhanced performance of the composite is ascribed to the role of Ni 2 P-Ni(PO 3 ) 2 in facilitating the separation of photoinduced charge carriers from CdS and improving electrical conductivity. A possible electron-hole transfer mechanism is proposed based on the experimental findings. This work is expected to be helpful in fabricating efficient CdS photocatalysts.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Mengchen Li,Bo Li,Binbin Long,Leibin Li,Yang Chen,Mingye Peng,Mengzhou Zhou
Lactobacillus plantarum R is the predominant bacterium widely used in food fermentation. However, it has a low tolerance to ethanol during fermentation, which restricts its broader application in the food industry. Although biofilm formation enhances bacterial resistance to various stresses, regulating biofilm formation in L. plantarum R remains challenging. In this study, we established a pathway for producing autoinducer 2 (AI-2), a quorum-sensing (QS) signaling molecule, by heterologously expressing pfs and LuxS in L. plantarum R. This approach aimed to modulate cell membrane structure and improve bacterial ethanol resistance. The findings showed that exogenous AI-2 significantly enhanced the growth of L. plantarum R under high-ethanol concentration and improved its biofilm formation at different ethanol concentrations. Furthermore, a multi-omics analysis revealed potential mechanisms by which AI-2 improved the tolerance of L. plantarum R to ethanol. Notably, the upregulation of the crr gene, a component of the phosphotransferase system (PTS), enhanced biofilm formation in response to ethanol stress. In addition, differential metabolites enriched in cysteine and methionine metabolic pathways further supported the role of QS in enhancing the tolerance of L. plantarum R to ethanol. These findings lay the groundwork for enhancing the fermentation performance of strains applied in the food fermentation industry, presenting a novel method for expanding the utilization of L. plantarum R in high-ethanol fermentation.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Zhen-yan Song,Wen-jing Yu,Yi-jie Jin,Meng-fen Zhou,Chun-xiang He,Ze Li,Jia-wei He,Qi Chen,Ping Li,Yaqiao Yi,Shao-wu Cheng
Ethnopharmacological relevance Derived from the plant Scutellaria baicalensis Georgi, baicalin is a naturally occurring flavonoid, has demonstrated anti-inflammatory, neuroprotective, hypoglycemic, and lipid-lowering properties. While its effects on Alzheimer's disease (AD) or type 2 diabetes mellitus (T2DM) have been studied individually, its therapeutic role in AD comorbid with T2DM remains unclear. Aim of the study This study aims to explore the potential therapeutic mechanisms associated with baicalin through a rat model featuring AD combined with T2DM. Materials and methods A dual-pathology rat model was developed using a streptozotocin (STZ) and a high-fat dietary regimen injections to induce T2DM, followed by intracerebroventricular STZ to induce AD pathology. Behavioral tests, biochemical assays, histological analyses, qPCR, and Western blotting were used to evaluate baicalin's effects. Untargeted metabolomics was applied to profile metabolic alterations, while network pharmacology and molecular docking were integrated to predict key targets and pathways. Finally, cellular thermal shift assay (CETSA) was conducted to validate the direct binding of baicalin to core proteins. Results Baicalin significantly improved cognitive performance, ameliorated glucose and lipid metabolism, and suppressed neuroinflammation in AD-T2DM rats. Metabolomics identified disruptions in energy metabolism, amino acid metabolism, and purine metabolism pathways. Network pharmacology analysis revealed ALDH2, NOS2, GOT1, GPT, and XDH as key targets associated with these metabolic disturbances. Molecular docking demonstrated strong binding affinities between baicalin and the identified targets. qPCR confirmed the regulation of ALDH2 and NOS2 gene expression by baicalin, and CETSA experiments further validated the thermal stabilization of these proteins, supporting direct interactions in vivo. Conclusions Baicalin exerts therapeutic effects by targeting ALDH2 and NOS2 to modulate arginine and proline metabolism and regulate key metabolites such as GABA and L-arginine. This mechanism improves neuronal function and insulin sensitivity, highlighting baicalin as a promising multi-target treatment for AD with T2DM.
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JOURNAL OF MOLECULAR LIQUIDS
·
2025
·
IF 5.2
Yue Wang,Wenxiu Li,Tao Zhang
The separation of 2-methylfuran (2-MF) and methanol (MeOH) azeotropes presents a critical challenge in biofuel production due to the efficiency and sustainability limitations of conventional methods. In this study, three ionic liquids (ILs)—1-ethyl-3-methylimidazolium hydrogen sulfate ([EMIM][HSO 4 ]), 1-ethyl-3-methylimidazolium thiocyanate ([EMIM][SCN]), and 1-ethyl-3-methylimidazolium dicyanamide ([EMIM][DCA])—were selected as green extractants for 2-MF – MeOH azeotropic separation. Ternary liquid-liquid equilibrium (LLE) data for the system 2-MF (1) + MeOH (2) + IL (3) were experimentally determined at 303.15 K and 101.325 kPa. The order of both distribution coefficient and selectivity is [EMIM][HSO 4 ] > [EMIM][SCN] > [EMIM][DCA]. Then, the NRTL model was subsequently employed to regress the experimental data, and the accuracy of the NRTL binary parameters was verified through the “GMcal_TieLinesLL” tool. Further mechanistic investigation integrated theoretical approaches (ESP, IGMH, RDF, and MSD analysis) with experimental validation via FT-IR spectroscopy. This combined methodology conclusively elucidates the pivotal role of hydrogen bonding in the extraction and separation process.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Guangjie Chen,Guangying Chen,Ge Gao,Li Sze Lai,Swee Pin Yeap,Wee Horng Tay,Helei Liu
The utilization of biphasic absorbents for CO2 capture can substantially reduce energy consumption. This study investigated the mass transfer kinetics and thermodynamics of the phase separation absorption process using 1-amino-2-propanol (MIPA)/sulfolane (TMS) biphasic solvents. 13C NMR spectroscopy was employed to analyze the species in different CO2-loaded solutions. The direction and extent of species transfer during the absorption process were elucidated and the phase separation mechanism was explored. CO2 absorption kinetics were studied in a wetted-wall column, and the physicochemical properties and the absorption reaction kinetics data under different experimental conditions were obtained. Results showed the overall mass transfer coefficient (KG) was 1.6 times higher than 30 wt % MEA and twice that of DETA/TMS solution. NMR and kinetic data analysis revealed that phase separation is mainly contributing to the deterioration of the mass transfer process in biphasic solution, reducing the liquid-film mass transfer coefficient (KL) by 63.2% during the phase separation stage. Furthermore, the desorption heats of different biphasic solvents with identical amine concentrations were measured using a microcalorimeter. Findings indicated that TMS did not alter the thermodynamic properties of the solution. Since only the CO2-rich phase is regenerated, the energy consumption is significantly reduced compared to that of MEA.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Yanpei Xu,Silong Li,Shuxian Gao,Fudong Jia,Liang Guo,Jiangrong Hou,Shaowei Ma,Heya Zheng,Chuxiao Sun,Qi Wang
Prostate-specific antigen (PSA) detection is vital for early prostate cancer diagnosis, yet conventional methods suffer from sensitivity and label-dependent limitations. This study presents a surface plasmon resonance (SPR) biosensor enhanced by Ni(OH) 2 /Ti 3 C 2 T x MXene nanocomposites (NTC) for sensitive detection of total PSA (tPSA) in serum. The NTC architecture synergizes carboxyl-functionalized MXene, amplifying localized electric fields and antibody-binding sites, with Ni(OH) 2 nanoflowers that prevent MXene stacking and enhance refractive index (RI) sensitivity. Optimized via finite element modeling (50-nm Au film, 72.4 ° incident angle), the Au-NTC architecture achieved a 39.34% improvement in RI sensitivity (3064.86 nm/RIU) compared to pristine Au. Through the dual signal amplification mechanism of synergistic enhancement by nanomaterials and sandwich method with gold nanoparticles, enabled detection of tPSA in 20% serum across a wide dynamic range (0.2–160 ng/mL), fully covering the clinical risk threshold (4–10 ng/mL). The platform demonstrated an ultralow limit of detection (LOD) of 0.0361 ng/mL (0.5157 pM) and high specificity against interferons. Kinetic analysis revealed strong antigen-antibody affinity (equilibrium dissociation constant K D = 4 . 26 × 1 0 − 10 M), while batch-producible sensor chips and integrated microfluidics underscored practical applicability. This work advances label-free SPR biosensing for precision prostate cancer diagnostics, offering significant potential in point-of-care testing and early intervention strategies.
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