ENERGY & FUELS
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2024
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IF 5.2
Guangjie Chen,Guangying Chen,Miao Fa,Yuxian Yang,Yu Wang,Fei Li,Li Sze Lai,Swee Pin Yeap
In order to reduce the regeneration energy consumption of CO2 capture in the postcombustion capture process and explore the regulatory characteristics of phase separation, a series of 1-amino-2-propanol (MIPA)/sulfolane biphasic solutions were proposed to capture CO2. The effects of the molar ratio on the phase separation behavior, CO2 equilibrium absorption, and desorption performances of MIPA/solfolane biphasic absorbents as well as three ternary solutions with the extra addition of ethanolamine (MEA) were investigated comprehensively in experiments. The results showed that the 4M/5M MIPA/sulfolane biphasic solution exhibited excellent performance with higher CO2 loadings in the phase separation point for a CO2-rich liquid (0.4530 mol/mol), better desorption efficiency (85.53%), and relatively low regeneration energy consumption (32% lower than 30 wt % MEA). Besides, MEA has a positive effect on promoting the phase separation of the MIPA/sulfolane solution and reducing the desorption energy consumption. Furthermore, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy was used to explore the reaction and phase separation mechanisms. The results indicated that generated carbamate salts can increase the ionic strength of the aqueous solution, leading to the accumulation of reacted MIPA or MEA in the water phase and the exclusion of sulfolane from water to form a new liquid phase. The results of this work can provide theoretical support for the future industrial application of MIPA/sulfolane biphasic absorbents and offer some guidance for the mechanism exploration of other biphasic solvent systems.
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JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Qiang Zhang,Xu Li,Jinxiang Dong
Despite significant breakthroughs that have been made in the application performance of traditionally distributed Guerbet alcohol ethoxylates (GAEO), research on the characteristics of their narrow distribution products remains relatively limited. Herein, a series of hydrophilic and hydrophobic nonionic surfactants have been synthesized via the ethoxylation of 2-butyl-octanol with ethylene oxide. Ca(OAc) 2 was employed as a narrow distribution (NRD) catalyst, while KOH served as a broad distribution (BRD) catalyst. The synthesized products were characterized using Fourier-transform infrared (FT-IR), 1 H and 13 C nuclear magnetic resonance ( 1 H, 13 C NMR) spectroscopy. In addition, a comprehensive assessment of the physicochemical and surface properties of the NRD GAEO surfactants was conducted through systematic investigations. The results were then compared to conventionally distributed GAEO surfactants. The study has demonstrated that NRD GAEO surfactants exhibited lower critical micelle concentration (CMC) values, which have the higher efficiency of the surfactant application. In addition, the NRD products have superior wettability performance, reduced foaming capacity in foam properties, and improved rapid defoaming capacities. In regarding their other properties, they closely mirrored the performance of BRD products. These findings will contribute to a comprehensive understanding of the properties of NRD ethoxylates and have substantial practical implications in optimizing personal care and household cleaning products.
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CHEMISTRY & BIODIVERSITY
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2024
·Vol. 21
·期 7
·e202400929
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IF 2.3
Yuee Tian,Shiyue Ma,Yibo Liu,Yan Li,Genqiang Chen,Zhiping Che
In order to explore novel natural product-based insecticidal agent, two important intermediates ( 2 and 3 ) and 4-acyloxy-2′-bromo-6′-chloropodophyllotoxin derivatives ( 4 a – f and 5 a – f ) were designed and prepared, and their structures were confirmed by 1 H-NMR, 13 C NMR, HRMS, ESI-MS, optical rotation and melting point (mp). The stereochemical configuration of compound 4 b was unambiguously confirmed by single-crystal X-ray diffraction. Moreover, we evaluated the insecticidal activity of target compounds 4 a – f and 5 a – f against a serious agricultural pest of Mythimna separata by using the leaf-dipping method. Among all tested compounds, compounds 4 d , 5 d and 5 f exhibited stronger insecticidal activity with a final mortality rate exceeding 60 %. Especially compound 5 d exhibited the best insecticidal activity, with a final mortality rate of 74.1 %. It has been proven that introducing bromine or chlorine atoms at the C-2′, C-2′ and C-6′ positions of the E ring of podophyllotoxin can produce more potent compounds. In addition, the configuration of the C-4 position is important for insecticidal activity, and 4β-configuration is optimal. This will pave the way for further design, structural modification, and development of derivatives of podophyllotoxin as insecticidal agents. Graphical
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Advanced Science
·
2024
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IF 14.3
Jin Li,Qiuling Jiang,Xiujing Xing,Cuilian Sun,Ying Wang,Zhijian Wu,Wei Xiong,Hao Li
Electrochemical conversion of nitrate (NO 3 − ) to ammonia (NH 3 ) is a potential way to produce green NH 3 and remediate the nitrogen cycle. In this paper, an efficient catalyst of spherical CuO made by stacking small particles with oxygen-rich vacancies is reported. The NH 3 yield and Faraday efficiency are 15.53 mg h −1 mg cat −1 and 90.69%, respectively, in a neutral electrolyte at a voltage of -0.80 V (vs. reversible hydrogen electrode). The high activity of the electrodes results from changes in the phase and structure during electrochemical reduction. Structurally, there is a shift from a spherical structure with dense accumulation of small particles to a layered network structure with uniform distribution of small particles stacked on top of each other, thus exposing more active sites. Furthermore, in terms of phase, the electrode transitions from CuO to Cu/Cu(OH) 2 . Density functional theory calculations showed that Cu(OH) 2 formation enhances NO 3 - adsorption. Meanwhile, the Cu(OH) 2 can inhibit the competing hydrogen evolution reaction, while the formation of Cu (111) crystal surfaces facilitates the hydrogenation reaction. The synergistic effect between the two promotes the NO 3 - to NH 3 . Therefore, this study provides a new idea and direction for Cu-based oxides in electrocatalytic NH 3 production.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2025
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IF 3.5
Yan-Xia Li,He Ma,Le Shi,Zhong-Fei Zhang,Yu-Meng Wu,Chao Yan,Yan Chen,Yong-Ming Lu
BACKGROUND Polysaccharides from Pleurotus citrinopileatus exhibit diverse bioactivities, yet their efficacy against ultraviolet B (UVB)-induced photoaging remains unexplored. This study aimed to purify and characterize a specific PCP and assess its protective effects using a UVB-induced zebrafish model. RESULTS A polysaccharide, designated as PCP-2, was isolated from P. citrinopileatus through hot-water extraction, ultrafiltration and chromatography. PCP-2 is a galactoglucan with a molecular weight of 1.52 × 10 6 Da, predominantly composed of 1,4-linked glucopyranosyl and 1,4,6-linked galactopyranosyl residues. In UVB-exposed zebrafish, PCP-2 administration resulted in a significant reduction of reactive oxygen species and malondialdehyde levels, alongside enhanced activities of antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase. Additionally, PCP-2 inhibited apoptosis by upregulating Bcl-2 expression and downregulating caspase-3. It also attenuated cellular senescence, as indicated by decreased β -galactosidase activity and increased telomerase activity. Moreover, PCP-2 promoted the synthesis of type I and III collagen by suppressing matrix metalloproteinases MMP-1 and MMP-3 and reduced melanin production through the downregulation of tyrosinase expression. Mechanistic studies suggested that these protective effects are mediated via activation of the Nrf2/HO-1 signaling pathway. CONCLUSION PCP-2 from P. citrinopileatus effectively mitigates UVB-induced photoaging, primarily by activating the Nrf2/HO-1 pathway. These findings suggest PCP-2's potential as an anti-photoaging agent in both food and pharmaceutical industries. © 2025 Society of Chemical Industry.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yue Lu,Jiahui Lei,Haoran Dong,Linrui Zhong,Qiqi Fu,Qingqing Xie,Long Li,Fangyi Liang
Chlorophenols (CPs) pose potential threat to the environment and public health due to their persistence and high toxicity. Zero-valent iron coupled with microorganisms have been applied for the degradation of halogenated organic matter, which is considered as a remediation technology of increasing interest. However, few studies have attempted to investigate the effects of this coupled system on CPs degradation and to comprehensively unveil the governing mechanisms. In this study, we systematically compared the effects of the composite system of microscale zero-valent iron (mZVI) with different particle sizes and Desulfitobacterium hafniense DCB-2 (i.e. 3 μm mZVI + DCB-2, 5 μm mZVI + DCB-2, and 10 μm mZVI + DCB-2) on the process of bioreductive dechlorination of 2,3-dichlorophenol (2,3-DCP). Interestingly, the lower particle sizes of mZVI (3 μm and 5 μm) were more favorable for rapid 2,3-DCP bio-dechlorination due to the fact that mZVI with smaller particle size were less likely to agglomerate with strain DCB-2, which facilitated the transfer of electrons from strain DCB-2 to 2,3-DCP. Besides, the optimal particle size of mZVI (3 μm) was selected from the above experimental results to further explore the percentage generation of reduction products and the dechlorination pathway of 2,3-DCP in composite system. The results showed that the low toxicity product 2-chlorophenol (2-CP) accounted for 31.76 % of the composite system, while in the pure bacteria treatment this value was only 20.42 %. The mZVI and DCB-2 coupling strategy might provide a new idea and feasible solution for the green reduction of chlorinated phenols.
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DALTON TRANSACTIONS
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2024
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IF 3.5
Xiaoyu Chu,Xinrui Wang,Shuo Tian,Yongkuo Zhao,Shikai Liu,Hong Yan,Yan Shang
Modulating the photogenerated electrons of CeO2 to activate O2 and efficiently photocatalytic degradation of chlorophenols is a highly desired goal. Herein, we have successfully fabricated FePc/CeO2 heterojunction through H-bond induced assembly. The photocatalytic degradation of 2, 4-DCP by the amount-optimized FePc/CeO2 nanocomposite was improved by 3 times compared with pure CeO2. By means of electron paramagnetic resonance (EPR) and single wavelength photocurrent spectroscopy, it is confirmed that the excellent photocatalytic performance is mainly attributed to the formation of Z-scheme heterojunction, which promotes charge separation and transfer, and the introduction of FePc broadens the visible light absorption range of heterojunction. Moreover, O2 temperature-programmed-desorbed curves and electrochemical O2 reduction measurements results demonstrate that the single Fe-N4(II) site in FePc is more conducive to promoting O2 activation than that of other metal phthalocyanines. Based on in situ FT-IR and liquid chromatography-tandem mass spectrometry (LC-MS), a possible reaction pathway of 2, 4-DCP degradation was proposed. This study provides a novel strategy to prepare CeO2 based Z-scheme heterojunctions with abundant monoatomic sites for pollutant degradation.
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ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Lin Jia,Ruichun Luo,Xiaoyu Zheng,Xiaotao Zhang,Ping Wang,Lu Lv,Longyi Fu,Weikang Dong,Chunyu Zhao,Dian Li,Tong Zhu,Yingjie Wang,Minghui Li,Jing Li,Yang Yang,Denan Kong,Jijian Liu,Qingmei Hu,Yang Zhao,Yan Xiong,Wu Zhou,Jiadong Zhou,Yao Zhou
Mixing entropy engineering is a promising strategy to tune the physical and chemical properties of materials. Although high-entropy in van der Waals bulk solids have been reported, entropy engineering in 2D monolayers remains unconquered. In this work, the epitaxial growth of a 2-inch 1T″ hexanary medium-entropy alloy monolayer (Re a W b Mo c In d S x Se y ) is reported via the chemical vapor deposition method. The atomic structure and chemical composition are confirmed by X-ray photoelectron spectroscopy, scanning transmission electron microscopy, energy dispersive X-ray spectroscopy and electron energy loss spectroscopy, illustrating the uniform distribution of the six elements. The hexanary medium-entropy alloy photodetectors show an ultrawide photo-response from visible to near-infrared wavelengths with a responsivity of 100.2 A W −1 under 520 nm laser illumination. Meanwhile, the hexanary medium-entropy alloy monolayer exhibits excellent electrocatalytic hydrogen production with an overpotential of 176.6 mV in dark. Importantly, an overpotential of 43.7 mV at 10 mA cm −2 with a lowered Tafel slope of 51.9 mV dec −1 under 520 nm laser irradiation is obtained due to the excellent conductivity. The work opens a new way to design mixing = entropy alloys and enables the application of transition metal dichalcogenides in photo-enhanced electrocatalytic hydrogen production.
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Reaction Chemistry & Engineering
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2024
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IF 3.4
Qifeng Yang,Liping Liang,Ning Xu,Yang Li,Zhihui Wang,Dadong Shen,Yiming Mo
Electroorganic synthesis has received significant attention due to its environmentally friendly nature, offering the potential to replace traditional hazardous chemical production routes. However, an in-depth technoeconomic analysis (TEA) of electrosynthesis technology is still necessary to objectively assess the economic viability of this technology as an alternative to the traditional chemical synthesis. In this study, we used the cerium-mediated electrosynthesis of 2-methyl-1,4-naphthoquinone (2-MNQ, also known as vitamin K3) as a case study. The process development was conducted in both small-scale and large-scale electrochemical flow cells with 6.25 cm2 and 208 cm2 electrode sizes, respectively, to investigate the process scalability. Under the optimal conditions, a 66% yield was achieved for 2-MNQ with 90% Faradaic efficiency at 50 mA/cm2 current density. We performed a comprehensive TEA on the key factors influencing electroorganic synthesis, including current density, electrode cost and lifespan, membranes, and electricity price. Furthermore, considering ongoing technological advancements in electrodes, membranes, and renewable electricity generation, we analyzed the trend of future projected cost reductions for electrosynthesis processes.
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RENAL FAILURE
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2024
·
IF 3
Yushi Peng,Yingchun Zheng,Fu Xiong,Mingming Zhang,Yuchen Wang,Jia Luo,Wenli Zeng,Jialiang Hui,Wenfeng Deng,Jian Xu,Yun Miao,Renfei Xia,Yiling Fang
Background Primary hyperoxaluria type 2 (PH2) is a rare disorder caused by GRHPR mutations. Research on the mutation spectrum and pedigree of PH2 helps in comprehending its pathogenesis and clinical outcomes, guiding clinical diagnosis and treatment.Methods We report a case of PH2 with a three-generational pedigree. The GRHPR genotypes of the family members were confirmed by Sanger sequencing. Urine and blood samples were collected for biochemical analysis. Computational analysis was performed to assess the pathogenicity of the mutations. Cellular experiments based on site-directed mutagenesis were conducted to confirm the effect of mutations on GRHPR expression, activity, and subcellular localization.Results The proband underwent her first kidney transplantation in 2015, and experienced recurrent urinary tract infections and urolithiasis postoperatively. Graft failure occurred in 2018. Whole exome sequencing identified compound heterozygous GRHPR mutations p.G160E/p.P203Rfs*7. The patient underwent a second kidney transplantation in 2019 and maintained good graft function with urine dilution measures. Notably, her brother and sister carried the same mutations; however, only the proband progressed to renal failure. Computational analysis suggested that p.G160E reduced the affinity of GRHPR for coenzymes. Cellular experiments indicated that p.G160E reduced GRHPR activity (p < 0.001), whereas p.P203Rfs*7 not only suppressed expression (p < 0.001) and reduced activity (p < 0.001), but also facilitated protein aggregation. Based on our results, the variant p.G160E was classified as ‘pathogenic’ according to ACMG guidelines.Conclusions Our findings suggest that treatment strategies for the long-term prevention of oxalate nephropathy should be developed for patients with PH2 receiving isolated kidney transplantation. Moreover, the pathogenicity of the compound heterozygous GRHPR mutations p.G160E/p.P203Rfs*7 was also validated.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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2025
·Vol. 29
·期 15
·e70778
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IF 4.2
Hong Tang,Qi Dai,Ziyan Zhao,Weiye Ge,Danlei Li,Zelin Chang,Penglai Pi,Jia Li,Zheng Sun
Glioblastoma (GBM) is an aggressive and highly malignant primary brain tumour, accounting for a significant proportion of adult brain tumours. It is associated with a poor prognosis and high recurrence rates. Although temozolomide (TMZ) remains the standard first-line chemotherapy for GBM, its clinical efficacy is often limited by the development of drug resistance and toxic effects on normal tissues. Melatonin (Mel), a natural indoleamine synthesised by the pineal gland, has demonstrated synergistic anti-tumour effects when combined with various chemotherapy agents in multiple studies. This study investigates the synergistic potential of Mel to enhance TMZ's therapeutic efficacy against GBM. The results demonstrate that the combination of Mel and TMZ significantly inhibits glioblastoma cell proliferation, migration, and invasion. Mechanistically, this synergistic effect is mediated through the NF-κB/COX-2 signalling pathway. Mel enhances TMZ's anti-tumour activity by inhibiting IκBα phosphorylation, suppressing NF-κB activation, and downregulating COX-2 expression. Additionally, the combination treatment induced apoptosis via activation of the Caspase-3 pathway. These results suggest that Mel can potentiate the therapeutic efficacy of TMZ in glioblastoma treatment, offering a promising strategy to overcome TMZ resistance while reducing its associated toxicity.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2025
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IF 3.1
Liqing Wang,Menghan Chen,Hanxue Wang,Qihui Sun,Sujuan Zheng,Xiaoyun Liu,Yong Yang,Rong Rong
Clinical studies have demonstrated that many traditional Chinese medicines (TCM) exhibit not only antiviral effects but also efficacy in alleviating clinical symptoms of Coronavirus Disease 2019 (COVID-19). However, the pharmacologically active constituents responsible for their anti-COVID-19 efficacy remain unclear. This study aimed to establish a novel strategy for identifying active ingredients from herbs clinically used for COVID-19. An integrated approach combining data mining with Affinity Ultrafiltration (AUF) was developed. Initially, using a data mining strategy, high-frequency herbs were selected from the herbs clinically used in COVID-19. Furthermore, AUF technology was used to screen for potential bioactive components from the high-frequency herbs. The anti-COVID-19 potential of active compounds was assessed through enzyme activity assays and molecular docking, followed by validation in cellular and animal models. Data mining revealed that Glycyrrhiza uralensis Fisch., Lonicera japonica Thunb. and Forsythia suspensa (Thunb.) Vahl were the high-frequency herbs used in COVID-19. Five potential 3-Chymotrypsin-like protease (3CL pro ) inhibitors were screened from three herbs via AUF and identified using high-resolution mass spectrometry. Further enzymatic and cellular assays demonstrated that Licochalcone C (LCC) and Forsythiaside A (FTA) inhibited Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication at micromolar concentrations. Notably, FTA treatment significantly suppressed the elevation of pulmonary parameters and inflammatory mediators induced by SARS-CoV-2 nucleocapsid protein in mice. In summary, this study proposes a novel strategy integrating data mining with AUF to discover active compounds from TCM. Two components, LCC and FTA, were identified as dose-dependent inhibitors of SARS-CoV-2 Omicron strain replication in vitro.
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