Frontiers in Chemistry
·
2022
·
IF 5.545
Zhao Benhui,Deng Yueqing,Cao Lei,Zhu Jichun,Zhou Zhengji
Kesterite-structured Cu2ZnSn(S,Se)4 (CZTSSe) thin film photovoltaics have attracted considerable attention in recent years because of its low-cost and eco-friendly raw material, as well as high theoretical conversion efficiency. However, its photovoltaic performance is hindered by large open-circuit voltage (VOC) deficiency due to the presence of intrinsic defects and defect clusters in the bulk of CZTSSe absorber films. The doping of extrinsic cation to the CZTSSe matrix was adopted as an effective strategy to ameliorate defect properties of the solar cell absorbers. Herein, a novel Se&Sb2Se3 co-selenization process was employed to introduce Sb into CZTSSe crystal lattice. The results reveal that Sb-doping plays an active role in the crystallization and grain growth of CZTSSe absorber layer. More importantly, one of the most seriously detrimental SnZn deep defect is effectively passivated, resulting in significantly reduced deep-level traps and band-tail states compared to Sb free devices. As a result, the power conversion efficiency of CZTSSe solar cell is increased significantly from 9.17% to 11.75%, with a VOC especially enlarged to 505 mV from 449 mV. This insight provides a deeper understanding for engineering the harmful Sn-related deep defects for future high-efficiency CZTSSe photovoltaic devices.
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JOURNAL OF BIOTECHNOLOGY
·
2015
·
IF 2.871
Yu-Cai He,Zhi-Cheng Tao,Yun Ding,Dan-Ping Zhang,Yin-Qin Wu,Yun Lu,Feng Liu,Yu-Feng Xue,Cheng Wang,Jian-He Xu
To avoid adding NAD + and effectively transform ethyl 4-chloro-3-oxobutanoate, the mixture of l -glutamine (200 mM) and d -xylose (250 mM) was added into in n -butyl acetate–water (10:90, v/v) biphasic system instead of NAD + for increasing the biocatalytic efficiency. To further improve the synthesis of optically pure ethyl ( R )-4-chloro-3-hydroxybutanoate (>99% ee ), β-cyclodextrin was also added into this reaction media, and ethyl ( R )-4-chloro-3-hydroxybutanoate (>99% ee ) could be effectively synthesized from 800 mM ethyl 4-chloro-3-oxobutanoate in the yield of 100% by whole-cells of recombinant E. coli CCZU-A13. Finally, the possible mechanism for improving the reductase activity by supplementation of l -glutamine, d -xylose and β-CD was proposed. In conclusion, this strategy has high potential for the effective biosynthesis of ethyl ( R )-4-chloro-3-hydroxybutanoate (>99% ee ).
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JOURNAL OF CHROMATOGRAPHY A
·
2012
·
IF 4.531
Zian Lin,Hui Huang,Xiaobo Sun,Yao Lin,Lan Zhang,Guonan Chen
A new polymer monolith with three modes of reverse-phase, hydrophilic and cation-exchange interaction was synthesized in 100 μm i.d. fused-silica capillary by in situ polymerization procedure. The pre-polymerization mixture consisted of glycidyl methacrylate (GMA) and 4-vinylphenylboronic acid (VPBA) as bifunctional monomers, ethylene dimethacrylate (EDMA) as crosslinker, 1,4-butanediol (BDO) and diethylene glycol (DEG) as binary porogenic solvents, and azobisisobutyronitrile (AIBN) as initiator. The resulting poly(GMA-co-VPBA-co-EDMA) monolith showed a relatively homogeneous monolithic structure, good permeability and mechanical stability. Different ratios of monomers and porogens were used for optimizing the properties of monolithic column. The column performance was assessed by the separation of a series of neutral solutes, charge solutes, phenols and anilines. Compared with poly(GMA-co-EDMA) monolith, the proposed monolith exhibited more flexible adjustment of selectivity in terms of hydrophobic, hydrophilic, as well as cation-exchange interaction in the same chromatographic conditions. High column efficiencies for benzene derivatives with 70,000–102,000 theoretical plates/m could be obtained at a linear velocity of 0.265 mm/s. The run-to-run, column-to-column, and batch-to-batch repeatabilities of the retention times were less than 8.23%. Additionally, the purposed monolith was also applied to efficient separation of alkaloids and proteins for demonstrating its potential in biomolecule separation.
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DIAMOND AND RELATED MATERIALS
·
2021
·
IF 3.315
Wei Jiang,Pinghua Chen,Xueqin Li,Guanghui Wu,Huitao Zheng,Chenxuan Li,Lei Fang,Hualin Jiang
Electrochemical analysis using specifically designed electrodes represents a promising strategy to detect organic pollutants, such as 4-nitrophenol (4-NP), in the environment. Towards this goal, a metal-free composite of phenanthroline doped graphitic carbon nitride (g-C 3 N 4 -PD) was synthesized, characterized, and applied as the electrode materials for electrochemical detection of 4-NP in water. The phenanthroline doping simultaneously extends the π-conjugation system of g-C 3 N 4 , and creates defect sites in g-C 3 N 4 , leading to better conductivity, higher 4-NP adsorption, and significantly enhanced electrocatalytic activity . Electrochemical sensors were fabricated by using g-C 3 N 4 -PD-modified carbon electrode. They showed a broad detection concentration range of 2.854–1117 μM and a low detection limit of 39 nM for 4-NP, with high reproducibility, stability and selectivity . Reliable and accurate measurements of 4-NP in real-life water samples have been demonstrated using these electrodes.
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高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2018
·Vol. 28
·期 2
·133-142
·
IF 1.607
Feng Yu,Teng Xingxing,Gu Jinhua,Yu Bangwei,Luo Yan,Ye Lianbao
In the previous research, our group designed and synthesized 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b] indoles, which showed high anti-tumor activity. In this study, a series of novel 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b] indole derivatives were designed by introducing an alkyl or aralkyl and a sulfonyl group, which are considered as the pharmacophores of some antitumor drugs based on the combination principles, and synthesized. The antiproliferative activity of all the target compounds were evaluated against Hela, A549, HepG2, and MCF-7 cell lines using the MTT assay in vitro. The results were represented by IC 50 values. All compounds showed moderate to excellent antiproliferative activity with IC 50 values between 0 μM and 100 μM against cancer cells. The proliferations of Hela, A549, HepG2, and MCF-7 cell lines were inhibited in a dose-dependent manner, and the cytolytic activity was markedly inhibited at the same time. The IC 50 values of intermediate 3 inhibited against Hela, A549, HepG2, and MCF-7 cell lines were 52.75, 50.30, 60.31, and 54.39 μM, respectively, which were higher than the new compounds that we expected. The compounds 4a – 4d bearing sulfonyl, substituted by electron donating group, showed moderate to significant antiproliferative activity, in which compound 4c was the best with the IC 50 values of 13.71, 9.42, 15.06, and 14.77 μM, and these results suggested that the introduction of sulfonyl could increase the antiproliferative activity of 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b]indole. Compounds 4e – 4g bearing alkyl, phenyl, and arylated alkyl produced good antiproliferative activity and the IC 50 value of 4 g was lower than 30 μM. The target compounds were more potent against A549 compared to the other three cell lines. Molecular docking studies revealed the binding orientations of all the synthesized compounds in the active site of c-Met. Moreover, molecular dynamics simulations have been performed to evaluate the binding stabilities between the synthesized compounds and their receptors.
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高影响因子
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
·
2018
·Vol. 39
·期 5
·611-617
·
IF 0.522
Qi Sun,Jianmei Li,Tao Le,Lei Zhang
Herein, a facile and enzyme-free CP sensor was fabricated by in situ electrochemical reduction strategy on the surface of glassy carbon electrode (GCE). Reduced graphene oxide (RGO) was chose as supporting materials for the distribution of platinum nanoparticles (Pt NPs) to obtain improved catalytic properties. The applicability and suitability of the obtained RGO-Pt/GCE for 4-CP detection were also evaluated. The results indicated that the RGO-Pt NPs modified electrode displayed much better catalysis and higher sensitivity for 4-CP oxidation. Under optimum conditions, the oxidation peak current was proportional to 4-CP concentration in the range from 0.1 to 500 μM with a detection limit of 51 nM. Meanwhile, it is demonstrated that the prepared sensor is also characterized by excellent feasibility, satisfactory reproducibility, good stability and high specificity. The results suggested that RGO-Pt/GCE could be a facile, cost-effective, and rapid tool for the prospect on-line evaluation of 4-CP in drinking water samples.
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高影响因子
BIOORGANIC CHEMISTRY
·
2020
·
IF 4.831
Shiyang Zhou,Gangliang Huang
In this study, a series of novel 7 H -benzo [ c ] [1,3] dioxolo [4, 5- f ] chromen-7-one derivatives were obtained by structural modification of the lead compounds with Fissitungfine B. A total 15 compounds were designed, synthesized and evaluated as inhibitors of tumor. These target compounds have the novel chemical structures that named three six-membered rings including one lactone six-membered ring. In vitro assay, the results showed that the target compounds have a broad spectrum and strong of anti-tumor activity. Such as the target compound 4n to MCF-7 was IC 50 = 0.35 ± 0.01 μM, to A-549 was IC 50 = 0.37 ± 0.01 μM, to Hela was IC 50 = 0.56 ± 0.02 μM, to MDC-803 was IC 50 = 0.53 ± 0.02 μM and COLO-205 was IC 50 = 0.50 ± 0.02 μM in vitro . At the same time, in vivo anti-tumor activity assay results showed that the target compounds had a good inhibitory effect on tumor growth. Among them, the target compound 4n had the best anti-tumor activity, it could inhibit tumor growth well at a low dose. The target compound 4n could be used as a candidate drug for further research and development, in order to be used as early as application in the clinical treatment of tumors.
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JOURNAL OF POWER SOURCES
·
2020
·
IF 8.247
Linbin Tang,Jianhua Zhang,Zhi Li,Xiaohao Liu,Qunjie Xu,Haimei Liu,YongGang Wang,Yongyao Xia,Zifeng Ma
Symmetric sodium ion full batteries with high energy density are expected to become promising storage devices. Na 7 V 4 (P 2 O 7 ) 4 (PO 4 )/C can be assembled into a high energy density symmetric full battery due to 3.85 V operating voltage as a cathode and 0.94 V operating voltage as an anode. Here, the as-prepared Na 7 V 4 (P 2 O 7 ) 4 (PO 4 )/C-GA (graphene aerogel) displays excellent electrochemical behavior as both cathode and anode . As the cathode, it can deliver a reversible capacity of 91.4 mA h g −1 at 1C (1C = 92.8 mA h g −1 ) and even shows 74 mA h g −1 capacity at 100C. Meanwhile, an ultra-long cycling property is obtained (77.2% capacity retention after 5000 cycles at 20C). As the anode, it can output 92.4 mA h g −1 at 25 mA g −1 and has a 79.2% capacity retention after 300 cycles at 50 mA g −1 . Interestingly, the symmetric full battery assembled with NVPP/C-GA outputs an initial 81.9 mA h g −1 capacity, a high 2.84 V working voltage, and 232.6 Wh kg −1 energy density at 25 mA g −1 . Therefore, our work shows potential application prospects of the symmetric full battery with Na 7 V 4 (P 2 O 7 ) 4 (PO 4 )/C-GA in energy storage systems .
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BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Peter A. Halim,Hanan H. Georgey,Mina Y. George,Ahmed M. El Kerdawy,Mona F. Said
Responding to the great demand of developing potent NSAIDs with an enhanced safety profile and reasonable selectivity, in the present study novel 4-fluorobenzamide derivatives were synthesized and screened for their anti-inflammatory and analgesic activities using carrageenan-induced rat paw edema method and acetic acid-induced abdominal writhing in mice, respectively. All the new target compounds except the carbamothioylhydrazine series ( 5a-d ), and the 4-fluorophenyl thiadiazolo derivative 6b showed promising anti-inflammatory activity ranged between 53.43 and 92.36% inhibition of edema (at 3 h) compared to the reference standard indomethacin (65.64%). All the newly synthesized compounds showed potent analgesic activity ranged between 71 and 100 % writhing protection compared to indomethacin (74.06%). Moreover, the most active compounds; the ester hybrids 2a,b , the thioureido quinazolinones 4b,c , and the thiadiazole congener 6a , showed promising gastric tolerability with ulcer index ranged between 0 and 6.60 compared to indomethacin (12.13). The thioureido quinazolinone derivatives 4b , c showed the most potent anti-inflammatory and analgesic activities with a remarkable gastric tolerability compared to the other derivatives. The 4-chlorophenyl derivative 4b is considered the most promising analogue showing 92.36% inhibition of edema, 100% writhing protection in analgesia testing, and a COX-2 selectivity index of 5.75 which was better than that of indomethacin and celecoxib standards (selectivity index = 0.27 and 4.55; respectively). Moreover, it showed an ulcer index equals zero with gastric acidity and mucin levels comparable to that of the control group indicating its minor effect on gastric cell physiology and its high tolerability. Molecular docking studies predicted the binding pattern of the newly synthesized compounds in COX-1 and COX-2 enzymes confirming the ability of the most active candidates to satisfy the structural features required for binding and rationalized their selectivity based on their docking binding patterns and scores. Furthermore, the newly synthesized 4-fluorobenzamide derivatives possess promising predicted pharmacokinetic properties indicated by calculating their key physicochemical parameters and absorption percentages.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2015
·
IF 4.169
Kexin Hou,Fengli Chen,Yuangang Zu,Lei Yang
An efficient method for the extraction of vitexin , vitexin-4″- O -glucoside, and vitexin-2″- O -rhamnoside from Phyllostachys edulis leaves comprises heat treatment using an ionic liquid–lithium salt mixture (using 1-butyl-3-methylimidazolium bromide as the solvent and lithium chloride as the additive), followed by ultrasound-assisted extraction. To obtain higher extraction yields, the effects of the relevant experimental parameters (including heat treatment temperature and time, relative amounts of 1-butyl-3-methylimidazolium bromide and lithium chloride, power and time of the ultrasound irradiation, and the liquid–solid ratio) are evaluated and response surface methodology is used to optimize the significant factors. The morphologies of the treated and untreated P. edulis leaves are studied by scanning electron microscopy. The improved extraction method proposed provides high extraction yield, good repeatability and precision, and has wide potential applications in the analysis of plant samples.
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高影响因子
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
·
2022
·Vol. 77
·期 9
·643-649
·
IF 1.115
Gao-Feng Wang,Hai-Ying Yang,De-Qun Peng,Shu-Wen Sun
Two coordination polymers, [Zn 2 (bipmo) 2 (1,4-nda) 2 ]
n
( 1 ), {[Cd(bipmo)(1,4-nda)]·(H 2 O)}
n
( 2 ), (bipmo = bis(4-(1 H -imidazol-1-yl)phenyl)methanone, H 2 (1,4-nda) = naphthalene-1,4-dicarboxylic acid), were synthesized under solvothermal conditions. The complexes have been characterized by elemental analyses, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 possesses 3D 2-fold interpenetrating nets with the Schläfli symbol {6 5 ·8}. Complex 2 consists a 3D net with the Schläfli symbol {4 4 ·6 10 ·8}. The luminescent properties of complexes 1 and 2 have been investigated.
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2025
·
IF 10.5
Qinqin Chen,Xing Jin,Qifan Zheng,Min He,Liqiao Han,Jun Yan,Min Zhan,Pengwei Zhang,Peifeng Ke,Jianbing Wang,Xianzhang Huang,Qiaoxuan Zhang
High-affinity anti-double-stranded DNA (anti-dsDNA) antibodies serve as essential biomarkers for systemic lupus erythematosus (SLE), exhibiting particularly strong correlations with active disease manifestations and renal pathology. However, conventional detection methods require urea treatment to quantify these antibodies, necessitated by the heterogeneity of endogenous antibodies, which complicates assay procedures and compromises accuracy. In this study, a novel ratiometric electrochemical (EC) biosensor for the direct detection of high-affinity anti-dsDNA antibodies in serum without additional sample processing has been developed. This biosensor conducted by a novel T(6–4)T dimer dsDNA capture probe and integrated with a self-assembled 4-mercaptophenylboronic acid@gold nanoparticles@6-ferrocenyl-1-hexanethiol (4-MPBA@AuNPs@6-(Fc)HT) composite signal tag. Leveraging the highly specific of the T(6–4)T dimer dsDNA capture probe and multi-amplification capability of 4-MPBA@AuNPs@6-(Fc)HT, the platform exhibited non-specific interferences, higher sensitivity (limit of detection:1.60 IU/mL), and efficient preparation. Clinical serum analysis showed good correlation with indirect immunofluorescence (IIF) (r = 0.629, p < 0.001), superior diagnostic performance (AUC = 0.893 vs. IIF AUC = 0.900) in differentiating SLE patient from healthy control (CON). Notably, EC results correlated more strongly with renal impairment (r = 0.426, p < 0.01) than IIF (r = 0.321, p > 0.05), highlighting its superior clinical utility for monitoring disease. This strategy provides a robust and straightforward approach for serum high-affinity anti-dsDNA antibodies detection, offering significant potential for SLE diagnosis and progression monitoring.
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