CELLULOSE
·
2024
·
IF 4.9
Zhang Hao,Chen Junfeng,Wang Yanan,Zhang Ying,Dou Huicheng,Zhong Hao,Guo Minghui
Wood-based laminated composites with excellent strength and toughness have attracted much attention, but it is a challenge to process fast-growing natural poplar wood with poor mechanical properties into high-performance laminated composites without the use of adhesives. In this study, natural poplar wood was delignified and TEMPO-oxidized by a “top-down” strategy to obtain a wood scaffold with a cellulose content of up to 98%, which was then used as a substrate and impregnated with Ca 2+ and PVA to form a large number of hydrogen and ionic bonds within the wood. Finally, under the action of hot pressing, laminated composites with high tensile strength (237 MPa), flexural strength (246 MPa) and impact toughness (50.45 KJ/m 2 ) were obtained, which also displayed excellent thermal stability and water resistance. This work demonstrates that the utilization of renewable fast-growing poplar wood as a substrate and glue-free bonding method can produce low-cost, sustainable and high-performance wood-based laminated composites.
✓ 已验证
产品关联
DOI
高影响因子
Science China-Materials
·
2025
·
IF 7.4
Li Hang,Wang Zehao,Tu Hongyi,Chen Min,Wu Yi,Wu Limin
Transparent superhydrophobic coatings hold significant potential for applications in architectural glass and optoelectronic devices. However, obtaining good compatibility between highly transparent, low haze and excellent mechanical stability in a superhydrophobicity coating remains a significant challenge. Inspired by the natural protection mechanism of the hierarchical structure of leaf veins, we have designed and fabricated transparent superhydrophobic coatings with highly detailed hierarchical vein-like ridges via a template-assisted multi-mask photolithography and inverted mold process combined with a spraying technique. The coated glass exhibited not only outstanding superhydrophobicity, with contact angle ⩾ 160° and sliding angle ⩽ 1.5° but also a high optical transmittance of 88.4% and a low haze of 8.1%, as well as remarkable mechanical durability and weather resistance.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Fiber Materials
·
2024
·
IF 17.2
Wang Ting,Shi Xiaoyu,Wang Yue,Sun Hengda,Sun Yu,Wang Gang,Jiang Hong
The acute pain induced by clinical procedures, such as venipuncture, dental operations, and dermatological treatments, as well as postoperative pain, drives the advancement of anesthetic techniques aimed at alleviating discomfort. This situation underscores the ongoing significance of effective pain management strategies within the field of anesthesia. This paper presents an integrated iontophoresis (ITP)-driven fiber-based microneedle patch (IFMP) regulated by a smartphone for controllable, long-lasting lidocaine transdermal delivery. The IFMP integrates pure cotton fiber canvas-based dissolving microneedles (MNs) with ITP into a patch, with the MNs tips and gel layers significantly increasing the drug-loading capacity, achieving a one-step drug administration strategy of “dissolution, diffusion, and ITP.” Lidocaine is released via the microchannels of MNs by passive diffusion. Additionally, an electric current initiates active ITP for lidocaine delivery, creating synergy. User-requirement-based drug release by precisely modulating electrical signals in rat pain models is described herein. A smartphone application enables precise dosage control. It offers three different delivery modes: single-dose, pulse delivery, and sustained-release, ensuring rapid onset, and long-lasting pain relief. This versatility makes the system suitable for various pain conditions. The IFMP represents a promising system for patient-controlled local analgesia treatment, enabling active and long-term local self-controlled pain management in a safe and regulated manner. Graphical Abstract The iontophoresis-driven fiber-based microneedle patch combines fiber-based dissolving microneedles with iontophoresis, facilitating controlled lidocaine release through diffusion and electrical activation for enhanced effect. Precise modulation of electrical signals allows user-requirement-based drug release in rat pain models. A smart application supports precise dosing in single-dose, pulse, or sustained-release modes, ensuring efficient and prolonged pain management.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 5
·1-9
·
IF 23.2
Shen Yong,Li Guojie,Cheng Yajie,Li Yahong,Alhadhrami A.,Fallatah Ahmed M.,Alshammari Dalal A.,Zhou Bing,Feng Yuezhan,Liu Chuntai
Developing a multifunctional protection material compatible with infrared (IR) stealth and electromagnetic interference (EMI) shielding is urgently required but challenging to ensure special human safety and maintain the smooth operation of electronic equipment. Herein, it is designed and fabricated a double-layered ANF/MXene film containing a thermally insulated aramid nanofiber (ANF) aerogel and low emissivity MXene coating with integrated long-term thermal camouflage at elevated temperatures and highly efficient EMI shielding capability. In this system, the lower aerogel film can act as a barrier to insulate heat transfer through its novel skin–core structure under ultralow directional thermal conduction, while the upper Ti 3 C 2 T x MXene coating can provide a very low emissivity surface and highly conductive network. Owing to its unique double-layer structure, the ANF/MXene film demonstrates a significant EMI shielding effectiveness of 43.6 dB and a remarkably low emissivity of 0.24, delivering excellent IR stealth performance across various ambient temperatures. This research lays the foundation for the creation of versatile protective materials that have great potential for use in both military and civilian contexts.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2024
·
IF 2.9
Cheng Jun-Hu,Zhang Xinxue,Ma Ji,Sun Da-Wen
Tropomyosin (TM), the major allergen in shellfish, is a common protein cause of allergenic diseases, hence a sensitive, efficient method for TM detection is urgently needed to protect allergy sufferers in food products. In this work, a novel fluorescent aptasensor for TM-sensitive detection based on DNA-templated silver nanoclusters (AgNCs) and catalytic hairpin assembly (CHA) was designed. With the rapid separation and enrichment of magnetic beads, the detection of TM was converted to the detection of cDNA (complementary DNA). Then the cDNA was utilized as the initiator to successfully trigger the CHA amplification technique, which ultimately formed double-stranded to induce high fluorescence signals by AgNCs. Specifically, the cDNA could trigger repeated cycles, which enabled signal amplification and enhanced aptasensor performance with an excellent linear relationship in a wide linear range from 0.1 to 50 μg/mL (R 2 = 0.9967) and a desirable low detection limit of 0.0179 μg/mL. It is worth noting that the method was successfully validated with high specificity and stability for detecting processed shrimp products, implying great potential in the field of allergen assay.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-12
·
IF 5.3
Huang Yang,Wu Shangming,Yang Siyi,He Miao,Ma Wenhao,Fa Huanbao,Wang Yongzhong,Hou Changjun,Yang Mei
Dopamine (DA) is a key neurotransmitter whose concentration affects various neurological disorders. Unlike previous methods that synthesize non-fluorescent polydopamine (NFL-PDA) under alkaline conditions, this study introduces a novel “turn-off” sensing method for DA using NFL-PDA synthesized through a unique reaction pathway. In our approach, CuO 2 nanodots, created via a simple reduction method, catalyze the formation of hydroxyl radicals (•OH) in acidic conditions, triggering the oxidative polymerization of DA into NFL-PDA. The reaction between DA and CuO 2 nanodots in acidic solution was examined to understand the process. UiO-66-NH 2 was then used to test NFL-PDA’s fluorescence quenching ability and to further investigate the DA determination mechanism. Results showed that fluorescence quenching was due to enhanced non-radiative energy transfer and Förster resonance energy transfer (FRET) between NFL-PDA and UiO-66-NH 2 . This led to the development of a simple “turn-off” fluorometric DA determination method with a linear range of 0.1–200 μmol/L and a limit of detection (LOD) of 0.0575 μmol/L. Although this method does not outperform existing NFL-PDA synthesis methods under alkaline conditions, it provides a new synthesis approach and application for sensing DA, contributing to the basic theory of chemical sensing. Additionally, DA determination in human serum samples was successfully achieved, with results consistent with high-performance liquid chromatography (HPLC). Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Xiong Jinqi,Mao Shanjun,Luo Qian,Ning Honghui,Lu Bing,Liu Yanling,Wang Yong
As a crucial industrial process for the production of bulk and fine chemicals, semi-hydrogenation of alkynes faces the trade-off between activity and selectivity due to undesirable over-hydrogenation. By breaking the energy linear scaling relationships, we report an efficient additive-free WO 3 -based single-atom Pd catalytic system with a vertical size effect of hydrogen spillover. Hydrogen spillover induced hydrophilic polar layer (HPL) with limited thickness on WO 3 -based support exhibits unconventional size effect to Pd site, in which over-hydrogenation is greatly suppressed on Pd 1 site due to the polar repulsive interaction between HPL and nonpolar C=C bonds, whereas this is invalid for Pd nanoparticles with higher altitudes. By further enhancing the HPL through Mo doping, activated Pd 1 /MoWO 3 achieves recorded performance of 98.4% selectivity and 10200 h −1 activity for semi-hydrogenation of 2-methyl-3-butyn-2-ol, 26-fold increase in activity of Lindlar catalyst. This observed vertical size effect of hydrogen spillover offers broad potential in catalytic performance regulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 33
·45588-45601
·
IF 0
Wu Haixia,Han Xiao,Guo Xinrui,Wen Yiyun,Zheng Bin,Liu Biming
The performance of catalytic ability of MFe 2 O 4 /MoS 2 in the ozonation process was investigated in this work. The synthesized MnFe 2 O 4 /MoS 2 was optimize prepared and then characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photo-electron spectroscopy, and magnetic saturation strength. The results showed that when C phenol = 200 mg/L, initial pH = 9.0, Q = 0.10 L/min, and C MnFe2O4/MoS2 = 0.10 g/L, MnFe 2 O 4 /MoS 2 addition improved the degradation efficiency of phenol by 20.0%. The effects of pH, catalyst dosage, and inorganic ions on the phenol removal by the MnFe 2 O 4 /MoS 2 catalytic ozonation were investigated. Five cycle experiments proved that MnFe 2 O 4 /MoS 2 had good recyclability and stability. MnFe 2 O 4 /MoS 2 also showed good catalytic performance in the treatment of coal chemical wastewater pesticide wastewater. The MnFe 2 O 4 doped with MoS 2 could provide abundant surface active sites for ozone and promote the stable cycle of Mn 2+ /Mn 3+ and Fe 2+ /Fe 3+ , thus generating large amounts of •OH and improving the degradation of phenol by ozonation. The MnFe 2 O 4 /MoS 2 /ozonation treatment system provides a technical reference and theoretical basis for industrial wastewater treatment.
✓ 已验证
产品关联
DOI
PubMed
BMC CANCER
·
2024
·Vol. 24
·期 1
·1-17
·
IF 3.4
Zhao Wenyue,Liu Yang,Yang Ying,Wang Liming
Background Lung adenocarcinoma (LUAD) is a non-small cell carcinoma. Ribonuclease/angiogenin inhibitor 1 (RNH1) exerts multiple roles in virous cancers. E2F1 is a critical transcription factor involved in the LUAD development. Here, we analyze the expression of RNH1 in LUAD patients, investigate the biological function of RNH1 in LUAD, and demonstrate its potential mechanisms through E2F1 in LUAD. Methods In the present study, we presented the expression of RNH1 in LUAD based on the database and confirmed it by western blot detection of RNH1 in human LUAD tissues. Lentiviral infection was constructed to silence or overexpress RNH1 in NCI-H1395 and NCI-H1437 cells. We assess the role of RNH1 on proliferation in LUAD cells by MTT assay, colony formation assays, and cell cycle detection. Hoechst staining and flow cytometry were used to evaluate the effects of RNH1 on apoptosis of LUAD cells. The function of RNH1 in invasion and migration was investigated by Transwell assay. Dual luciferase assay, ChIP detection, and pull-down assay were conducted to explore the association of E2F1 in the maintenance of RNH1 expression and function. The regulation of E2F1 on the functions of RNH1 in LUAD cells was explored. Mouse experiments were performed to confirm the in-vivo role of RNH1 in LUAD. mRNA sequencing indicated that RNH1 overexpression altered the expression profile of LUAD cells. Results RNH1 expression in LUAD tissues of patients was presented in this work. Importantly, RNH1 knockdown improved the proliferation, migration and invasion abilities of cells and RNH1 overexpression produced the opposite effects. Dual luciferase assay proved that E2F1 bound to the RNH1 promoter (-1064 ∼ -1054, -1514 ∼ -1504) to reduce the transcriptional activity of RNH1. ChIP assay indicated that E2F1 DNA was enriched at the RNH1 promoter (-1148 ∼ -943, -1628 ∼ -1423). Pull-down assays also showed the association between E2F1 and RNH1 promoter (-1148 ∼ -943). E2F1 overexpression contributed to the malignant behavior of LUAD cells, while RNH1 overexpression reversed it. High-throughput sequencing showed that RNH1 overexpression induced multiple genes expression changes, thereby modulating LUAD-related processes. Conclusion Our study demonstrates that binding of E2F1 to the RNH1 promoter may lead to inhibition of RNH1 expression and thus promoting the development of LUAD.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Li Shuji,Su Ke,Liu Xing,Jiang Xiuming,Xiang Guoqiang,He Lijun
Nitrogen-doped carbon dots (N-CDs) were prepared by self-exothermic procedure using grasshopper powder as a single precursor. The prepared N-CDs not only have excellent fluorescence properties, but also can catalyze and enhance the ultra-weak chemiluminescence of NaHCO 3 -H 2 O 2 . The reaction conditions of NaHCO 3 -H 2 O 2 -N-CDs CL were optimized. Under the optimal experimental conditions, when AA was added to the NaHCO 3 -H 2 O 2 -N-CDs CL system, AA had a significant inhibitory effect on the CL intensity of NaHCO 3 -H 2 O 2 -N-CDs. There was a good linear relationship between the calculated lg(I0/I) and the concentration of AA (C), and the calibration curve equation was lg(I 0 /I) = 0.03667 C-0.00708 (µM). The established CL analysis method has a detection limit of 0.12 µM for AA and a linear range of 0–50 µM. The selectivity of CL method was evaluated, and the method was successfully applied to the determination of AA in vegetable and fruit samples. The spiked recoveries were between 88.9% and 118.9%, which indicated that the method was simple, rapid, and sensitive, and had great potential in the determination of AA in foods.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-15
·
IF 14.7
Zhu Wenjun,Wei Ting,Xu Yuchun,Jin Qiutong,Chao Yu,Lu Jiaqi,Xu Jun,Zhu Jiafei,Yan Xiaoying,Chen Muchao,Chen Qian,Liu Zhuang
Transdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge. Herein, a transdermal delivery platform based on biocompatible fluorocarbon modified chitosan (FCS) is developed to achieve highly efficient non-invasive delivery of biomacromolecules including antibodies and antigens. The formed nanocomplexes exhibits effective transdermal penetration ability via both intercellular and transappendageal routes. Non-invasive transdermal delivery of immune checkpoint blockade antibodies induces stronger immune responses for melanoma in female mice and reduces systemic toxicity compared to intravenous injection. Moreover, transdermal delivery of a SARS-CoV-2 vaccine in female mice results in comparable humoral immunity as well as improved cellular immunity and immune memory compared to that achieved with subcutaneous vaccine injection. Additionally, FCS-based protein delivery systems demonstrate transdermal ability for rabbit and porcine skins. Thus, FCS-based transdermal delivery systems may provide a compelling opportunity to overcome the skin barrier for efficient transdermal delivery of bio-therapeutics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Human Cell
·
2024
·
IF 3.4
Zhang Ke,Zhang Hailing,Wang Bing,Gao Shanshan,Sun Caiping,Jia Cong,Cui Jinquan
Abnormal functions of trophoblast cells are associated with the pathogenesis of preeclampsia (PE). Nuclear receptor subfamily 2 group F member 1 (NR2F1) acts as a transcriptionally regulator in many diseases, but its role in PE remains unknown. Hypoxia/reoxygenation (H/R)-stimulated HTR-8/SVneo cells were used to mimic PE injury in vitro. NR2F1 overexpression alleviated trophoblast apoptosis, as evidenced by the decreased number of TUNEL-positive cells and the downregulation of caspase 3 and caspase 9 expression in cells. NR2F1 overexpression increased the invasion and migration ability of HTR-8/SVneo cells, accompanied by increased protein levels of matrix metalloproteinase (MMP)-2 and MMP-9. mRNA-seq was applied to explore the underlying mechanism of NR2F1, identifying growth differentiation factor 15 (GDF15) as the possible downstream effector. Dual-luciferase reporter, ChIP-qPCR, and DNA pull-down assays confirmed that NR2F1 bound to the promoter of GDF15 and transcriptionally inhibited its expression. GDF15 overexpression increased apoptosis and decreased the ability of invasion and migration in HTR-8/SVneo cells expressing NR2F1. MAPK pathway was involved in the regulation of PE. Administration of p38 inhibitor, ERK inhibitor, and JNK inhibitor reversed the effect of simultaneous overexpression NR2F1 and GDF15 on trophoblast apoptosis, invasion, and migration. Our findings demonstrated that NR2F1 overexpression inhibited trophoblast apoptosis and promoted trophoblast invasion and migration. NR2F1 might negatively regulate GDF15 expression by binding to its promoter region, which further inhibited MAPK signaling pathway in PE. Our study highlights that NR2F1 might sever as a potential target in PE. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）