Scientific Reports
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2026
·
IF 3.9
Xu Linlin,Lin Xiaoyan,Li Ling,Cai Rouying,Zheng Ying,Huang Jianyong,Weng Shaohuang,Zheng Chen
The convenient and widespread implementation of doxycycline (DOXY) detection still requires the development of new methods to enable rapid detection across various environments. In this study, blue-emitting nitrogen-doped carbon dots (N-CDs) were successfully prepared using glutamine and anhydrous citric acid as primary materials. Correspondingly, a simple and sensitive fluorescence method for detecting DOXY was developed using N-CDs as probe. The fluorescence intensities of N-CDs were significantly quenched by variable concentrations of DOXY based on the internal filtration effect, which was verified through quantum efficiency correction experiment. Under the optimized testing conditions, the concentrations of DOXY showed a good linear relationship with fluorescence quenching efficiencies in the range of 0.1-35 μg/mL, with a detection limit (LOD) of 0.018 μg/mL, suggesting the good analytical performance. This method was successfully applied for the determination of DOXY in human plasma, dairy products and tap water samples, demonstrating satisfactory recoveries and reproducibility. The results highlight the promising potential of this approach for clinical monitoring of blood drug concentrations, detection of drug residues, and environmental sample analysis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 3.9
Yao Junyi,Zhu Zhongzheng,Zheng Qitan,Xin Yi,Liu Hezhou,Li Hua
Polycaprolactone (PCL)-shape memory polyurethane (SMPU) is widely used in various fields due to its excellent performance. However, PCL-SMPU often struggles to obtain high fracture elongation and shape memory recovery ability because of its large crystal size and relatively low hydrogen bonding energy. To overcome the difficulties and achieve better properties, our research proposed an optimization strategy that combines hydrogen bonding and crystallization control, which involves introducing a small amount of polyethylene adipate 1, 4-butanediol ester (PBA) and adjusting the ratio of soft-to-hard segments. The addition of PBA can form strong hydrogen bonding with isocyanate and form secondary hydrogen bonding with PCL, which can significantly improve the tensile strength and fracture elongation through multiple-level hydrogen bonding. Moreover, regular PBA chains can form microcrystals, thereby not only ensuring the crystallinity but also refining the large crystal size of PCL segments and optimizing the stress distribution. Apart from compounding PBA, the adjustment of the ratio of soft-to-hard segments plays a significant role in resulting in a better overall performance. This modification endows the material with excellent mechanical properties (tensile strength of 20.29 MPa, elongation at break of 1462.09%) and shape memory properties. (Both shape recovery rate and shape fixation rate are above 99%, and the shape recovery driving force is 4.11 MPa.) Besides, the synthesized SMPU can achieve reversible deformation of 16.85% under 0.2 MPa external force. Based on the excellent performance mentioned above, this material has great potential for application in the field of intelligent actuators. Graphical
The synthesized PBA/PCL-based shape memory polyurethane acquires great overall performance, making it potential in the field of intelligent actuator fields and so on.
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Scientific Reports
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2026
·
IF 3.9
Zou Yufeng,Xiao Shunli,Wang Jiayi,Chen Qiru,Shu Liangyin,Chen Yifan,Hu Dingli,Tan Yuhua,Yang Sixuan,Liu Lianghong,He Qingjiao,Liu LH.,He QJ.
Finger millet ( Eleusine coracana L., EC) is a nutritionally dense and medicinally valuable cereal crop with a long history of use in traditional health practices. Contemporary pharmacological studies have demonstrated that extracts from EC and its individual chemical constituents exhibit a wide range of health benefits and therapeutic properties. For instance, they possess antioxidant activity, can reduce blood glucose levels, and enhance gastrointestinal health. However, the full spectrum of their chemical constituents remains to be fully elucidated. In this study, we established a state-of-the-art analytical workflow integrating Ultra-High-Performance Liquid Chromatography coupled with Quadrupole-Orbitrap Mass Spectrometry (UHPLC-Q-Exactive Orbitrap MS) with Feature-Based Molecular Networking (FBMN) and Parallel Reaction Monitoring (PRM) for comprehensive chemical profiling of EC. A total of 126 compounds were unambiguously identified, including 64 flavonoids, 24 phenylpropanoids, 21 organic acids, and 22 other metabolites. Notably, 44 of these represent novel reports in EC, significantly expanding its known chemical repertoire. Further verification via Western Blot (WB) showed that the ethanol extract of EC (1 ~ 100 µg/mL) could concentration-dependently inhibit the overexpression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-induced RAW264.7 macrophages, which initially confirms its in vitro anti-inflammatory activity. The analytical method established in this study enables rapid and efficient identification of the major chemical constituents of EC, laying a foundation for its quality control, exploration of bioactive components, and mechanism research.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 3
·242
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IF 2.8
Zhang Jianhua,Li Lu,Hao Rong,Lei Zhipeng,Ma Yun,Li Yuanyuan,Kang Ailiang
CaCu 3 Ti 4 O 12 (CCTO) has been widely studied for capacitor applications due to its excellent giant dielectric constant and frequency stability, but its development is limited by its low breakdown field strength ( E b ). To promote E b and primarily clarify the intrinsic mechanism, a synergistic strategy combining Sr substitution for Ca in CCTO ceramics with the polymer pyrolysis method was adopted. With the increase of Sr substitution, the average grain size of the ceramics gradually decreased and E b was remarkably enhanced. In particular, an E b of 106.0 kV/cm at a current density of 0.05 mA/cm 2 was achieved for Ca 0.4 Sr 0.6 Cu 3 Ti 4 O 12 ceramics, which is mainly attributed to the tremendous increase in grain boundary resistance induced by the increase of grain boundary density and formation of the insulating secondary phase SrO resulting from Sr substitution. We hope this study will provide a potential solution for the fabrication of CCTO-based dielectric ceramics with excellent E b .
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 12.6
Jingya Xiu,Lin Liu,Lingao Yin,Yihong Peng,Ziqi Li,Ziyun Lin,Yilin Song,Degong Yang,Jiulong Zhang,Chunrong Yang
Immunogenic cell death (ICD), instigated by reactive oxygen species (ROS), has emerged as an efficacious strategy for augmenting the immunogenicity of tumor cells. However, the effects of ICD are severely diminished by elevated levels of glutathione (GSH) within tumor cells to maintaining intracellular redox homeostasis. To address this, the novel carrier-free self-assembled nanoparticles are designed to aggravating redox dyshomeostasis by reducing GSH and increasing ROS levels. The nanoparticles (ZDS NPs) were established by the self-assembly of zinc ions (Zn 2+ ), doxorubicin (DOX) and Nrf2 siRNA. The ZDS NPs exhibited the ultra-high entrapment efficiency of DOX (99%) and siRNA (89%), and the releases of DOX and siRNA were both pH-dependent owing to the cleavage of coordinate and hydrogen bonds under acidic conditions. Following the endocytosis of ZDS NPs by tumor cells, redox homeostasis was significantly disrupted, DOX and Zn 2+ enhanced the production of ROS via activating cGAS/STING pathway, whereas siRNA reduced GSH levels by decreasing the expression of Nrf2 protein. This further promoted a stronger ICD effect with elevated secretion of ATP, HMGB1, CRT, thereby inducing the maturation of DCs and activating a more robust anti-tumor immunity. This study presents a novel approach for the synergistic enhancement of ICD in cancer immunotherapy.
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高影响因子
Nature Protocols
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2026
·
IF 16
Gong Zhenggang,Yang Guangxu,Wu Tong,Wang Mengyao,Yang Jiarui,Lei Zhendong,Shuai Li
Practical lignin valorization strategies have the potential to enhance the profitability of lignocellulosic biorefineries. Leveraging the phenolic structure of lignin, commercially available lignins (for example, kraft, soda or biorefinery lignin) have been extensively studied as renewable substitutes for phenol in the synthesis of lignin–phenol–formaldehyde resin adhesives. However, the large-scale production and adoption of lignin–phenol–formaldehyde resin adhesives remain limited owing to challenges related to appearance, performance and cost. To address these limitations, this protocol outlines a comprehensive process for producing lignin adhesives with light colors, high adhesion properties and superior water and weather resistance. The procedure encompasses: (1) isolation of lignin from various types of biomass pretreatment liquors; (2) screening of high-quality lignins from the isolated lignins; and (3) performance assessment of lignin adhesives prepared directly from high-quality lignins without the need for chemical modification or additional processing. Additionally, this protocol provides a rapid and quantitative method for determining the condensation degree of lignin using a small amount of the isolated lignin sample (~50 mg) within a relatively short experimental time (5 h 20 min). This enables efficient quality evaluation and screening of high-quality lignins derived from different extraction methods and biomass sources. The entire process, from biomass to lignin adhesive fabrication, requires a total of 8 h 10 min and is designed for users with prior experience in biomass fractionation, chromatographic analysis and wood-based panel production.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2026
·Vol. 28
·期 2
·29
·
IF 2.6
Xu Yujie,Ling Ping,Huang Nafei,Ma Xian
Photothermal therapy (PTT) demonstrates significant potential as a cancer treatment; however, the protective autophagy triggered by PTT limits its effectiveness. This study fabricated multifunctional nanoplatforms, BM/GNPs@ZIF8 (BGZ), by concurrently coating the autophagy inhibitor bafilomycin (BM) and the photothermal agent gold nanoparticles (GNPs) in the ZIF8 using the "one-pot method." Subsequently, a targeted alteration was performed using folic acid (FA) to develop FA-BM/GNPs@ZIF8 (FA-BGZ). The co-delivery of BM and GNPs aims to integrate autophagy regulation with PTT in a synergistic manner. The final NPs, FA-BGZ, integrate pH responsiveness, PTT, and tumor-target abilities. The stability is markedly enhanced after coating with ZIF8 (GNPs@ZIF8), with minimal effect on photothermal performance. The FA-BGZ exhibits a photothermal significant impact of approximately 32.74%. Concurrent coating of BM can inhibit autophagy and interfere with cancer cells' defensive mechanisms. Additional in vitro biological experiments further validate that FA-BGZ exhibits a significant cytotoxic effect on cervical cancer SiHa cells under near-infrared (NIR) exposure (IC 50 : 16.52 ± 3.48 μg/mL), decreasing mitochondrial membrane potential (MMP), and increasing reactive oxygen species (ROS), which subsequently leads to cell apoptosis. These findings suggest that FA-BGZ is a promising nanodrug delivery system (NDDS) that could enhance synergistic treatment approaches in cervical cancer cells.
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Science China-Technological Sciences
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2026
·Vol. 69
·期 3
·1320201
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IF 4.9
Yan Tao,Zhu Yehan,Wu Yuting,Zhang Xin,Pan Zhijuan
The development of multifunctional intelligent textiles has become an important innovation direction in the field of textile engineering, under the dual demands of intelligent health monitoring and environmental protection. Although single-functional textiles with antibacterial, photochromic, and strain-sensing properties have been developed, they are unable to meet the demand for multifunctional textiles. In this respect, this study developed a poly(lactic acid) and poly(3-hydroxybutyrate)/ thermoplastic polyurethane/carbon black nanoparticle composite nanofiber yarn (PPTCY) with a hollow-core-sheath structure using a simple conjugate electrospinning technology. PPTCY possessed excellent mechanical strength and could be effectively woven. More importantly, it not only enabled real-time visual monitoring of ultraviolet (UV) intensity in the environment but also possessed excellent antibacterial properties and strain-sensing performance. Its ΔE value was up to 58.24, and its antibacterial rates against Escherichia coli and Staphylococcus aureus were both 99.99%. This fabric had excellent strain-sensing performance, high linearity, and durability under both pressure and stretching deformations. This research provides favorable technical support for the application of intelligent textiles in the field of UV protection and traffic safety.
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CHEMISTRY AND TECHNOLOGY OF FUELS AND OILS
·
2025
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IF 0.7
Chen Keyou,Luo Zhifeng,Zhou Quan,Yan Chaozong,Fu Haoran,Wang Qihai,He Jie
Fracturing fluid is the “blood“ of reservoir reconstruction technology. Single-well myriad square fluid and thousand square sand have become the main methods of volume fracturing in uncon-ventional oil and gas horizontal wells. With the gradual exploitation of oil and gas fields to the deep, higher performance requirements have been put forward for fracturing fluid. In this paper, nano- TiO 2 was modified by vinyltrimethoxysilane, and a new type of nanocomposite polymer (PTAS) was synthesized by aqueous solution polymerization of modified nano-TiO 2 with acrylamide (AM), acrylic acid (AA) and 2-acrylamide-2-methylpropylsulfonic acid (AMPS). The synthesis conditions such as monomer ratio, polymerization temperature, polymerization time, and initiator dosage were optimized by using the viscosity of the base solution as an index. The structure and properties of PTAS were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and thermogravimetric analysis. The experimental results showed that the nano-TiO 2 was successfully modified by vinyltrimethoxysilane, and the modified nano- TiO 2 was successfully attached to the polymer molecular chain. The performance evaluation results of PTAS showed that compared with the polymer without nano-TiO 2 P(AM-AA-AMPS), the salt resistance, sand carrying, temperature resistance, shear resistance, and gel breaking properties of PTAS were improved, This is due to the additional modified nano-TiO 2 , which enhances the polymer network structure and improves its structural stability, so that the polymer can maintain good thickening behavior performance while reducing the molecular weight, reducing the residue content after gel breaking, and reducing its damage to the formation. PTAS has a good potential for application in hydraulic fracturing.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2014
·Vol. 117
·期 4
·2127-2132
·
IF 1.694
Tang Hongbo,Su Yuchang,Hu Te,Liu Shidong,Mu Shijia,Xiao Lihua
In this work, different compositions of lanthanum hexaboride (LaB 6 ) and tin-doped indium oxide (ITO) nanoparticles were doped into poly(vinylbutyral) (PVB) matrix to prepare PVB/LaB 6 –ITO nanocomposite (PLINC) films by a solution casting method. X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis (TGA) and ultraviolet–visible–near infrared spectroscopy (UV–vis–NIR) were employed to characterize the PLINCs. The TGA and UV–vis–NIR results reveal that the nanocomposite films possessed outstanding thermal stability. The temperature where 5 % weight loss of the PVB matrix was improved after the addition of LaB 6 and ITO particles and the property for blocking near infrared light was also enhanced as compared with the case of pure PVB film.
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IONICS
·
2020
·Vol. 26
·期 10
·4937-4948
·
IF 2.394
Tian Leiwu,Yuan Haifeng,Shao Qinjun,Zaidi Syed Danish Ali,Wang Chong,Chen Jian
Surface modification plays a vital role in improving the rate performance and cycling stability of layered Ni-rich LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NCM622) cathode materials for Li-ion batteries. In this study, Li 2 MgTi 3 O 8 (LMTO)-coated NCM622 was successfully synthesized by wet coating combined with sintering process. The results of morphological analysis showed a uniform LMTO layer coated on the surface of NCM622 materials. The dual ions of Ti 4+ and Mg 2+ on surface structure of NCM622 were identified by X-ray diffraction and X-ray photoelectron spectroscopy. The surface coating layer prevented the direct contact between the active cathode material and the electrolyte which significantly reduced the side reactions, and the doping of Ti 4+ and Mg 2+ improved the structural stability of the NCM622 materials. The electrochemical performance indicates that NCM622 cathode with a coating layer of 0.5 wt% LMTO exhibited excellent cycle stability and maintained a capacity retention up to 76% after 200 cycles at 25 °C at 1 C-rate, which was higher than the value of 52% for the NCM622.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2012
·Vol. 31
·期 3
·377-387
·
IF 0.919
Shi Xue-bo,Wu Chun-lei,Rong Min-zhi,Czigany Tibor,Ruan Wen-hong,Zhang Ming-qiu
To improve creep resistance of directional polytetrafluoroethylene (PTFE) films, epoxy grafted nano-SiO 2 is mixed with PTFE powder before sintering and calender rolling. The aligned macromolecular chains (especially those in amorphous region) of the composite films can be bundled up by the nanoparticles to share the applied stress together. In addition, incorporation of silica nanoparticles increases crystallinity of PTFE and favors microfibrillation of PTFE in the course of large deformation. As result, PTFE films exhibit lower creep strain and creep rate, and higher tensile strength and hardness. The work is believed to open an avenue for manufacturing high performance fluoropolymers by nano-inclusions.
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高影响因子
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