RESEARCH ON CHEMICAL INTERMEDIATES
·
2015
·Vol. 42
·期 3
·2211-2220
·
IF 1.221
Liu Shuilin,You Kuiyi,Jian Jian,Luo Qing,Liu Pingle,Ai Qiuhong,Luo He’an
A simple and effective approach for highly selective preparation of nitrocyclohexane from cyclohexane using tert-butyl nitrite as a nitrating agent under atmospheric pressure has been successfully developed in this work. The results indicate that the N -hydroxyphthalimide catalyst gave the best results with 27.3 % of cyclohexane conversion and 88.0 % of selectivity to nitrocyclohexane under optimal reaction conditions. The present reaction provides a novel strategy for the synthesis of nitroalkanes from the nitration of low-carbon alkanes because of the mild reaction condition, simple experimental procedure and high selectivity towards the desired product. This method may be very significant to establish such a synthesis method for aliphatic nitro-compounds from the low-carbon alkanes in organic fields.
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Natural Products and Bioprospecting
·
2017
·Vol. 7
·期 6
·461-469
·
IF 0
Mahal Ahmed,Wu Ping,Jiang Zi-Hua,Wei Xiaoyi
Abstract Tetrahydrocurcumin (THC) is a major metabolite of curcumin and plays an important role in curcumin-induced biological effects. THC is a promising preventive and chemotherapeutic agent for cancer. A series of new pyrazole derivatives of THC have been synthesized as potent anticancer agents. Direct condensation of THC with various substituted hydrazines leads to new pyrazole derivatives of THC ( 1 – 18 ). The prepared compounds have been evaluated via in vitro MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay for their cell proliferation-inhibitory activity against human lung adenocarcinoma (A549), human cervical carcinoma (HeLa) and human breast carcinoma (MCF-7) cells. Most derivatives show significantly higher anticancer activity against all three tested cancer cell lines than the parent compound THC. Several compounds ( 7 , 8 , 12 , 13 and 15 ) display promising anticancer activity against MCF-7 cell line with IC 50 values ranging from 5.8 to 9.3 µM. The most active compound ( 8 ) is substituted with 4-bromophenyl group at the pyrazole ring and inhibits the growth of all three tested cancer cell lines with an IC 50 values of (8.0 µM, A549), (9.8 µM, HeLa) and (5.8 µM, MCF-7). The obtained compounds can be a good starting point for the development of new lead molecules in the fight against cancer. Graphical Abstract
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PubMed
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2014
·Vol. 302
·期 1
·123-130
·
IF 1.415
Sun Zhi-Zhong,Wei Hong-Yuan,Wang Guan-Quan,Zhou Zhi-Jun,He Jia-Heng,Wang Jing,Luo Shun-Zhong
[ 131 I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and [ 131 I]-5-(4-aminophenyl)-10,15,20-triphenylporphyrin ( 131 I-TPPOH and 131 I-TPPNH 2 ) were prepared and their biodistribution properties were evaluated in normal Kunming (KM) mice and SMMC-7721 tumor-bearing BALB/c mice. The optimized labeling yields were 98 and 96 % for 131 I-TPPOH and 131 I-TPPNH 2 , respectively. They were stable in vitro saline and in vivo. Both compounds had a specific affinity to liver and lung, and mainly metabolized through liver. They showed a time-dependent accumulation and retainable characteristics in SMMC-7721 tumor. These results supported their potential value for targeted tumor therapy agents.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2015
·Vol. 33
·期 11
·1618-1624
·
IF 1.835
Hu Wei,Cao Jing,Huang Yi-ling,Liang Sai
The anionic polymerization of N -vinylcarbazole (NVC) by using optically active anionic initiators such as the lithium salts of ( S )-1-(9H-fluoren-2-yl)-4-isopropyl-4,5-dihydrooxazole (( S )-1-FIDH) and ( S )-2-(9H-fluoren-2-yl)-4- isopropyl-4,5-dihydrooxazole (( S )-2-FIDH) and complexes of (-)-Sparteine with n -butylithium (n-BuLi-(-)-Sp) or fluorenyl lithium (FILi-(-)-Sp) was achieved. The yield and specific rotation of poly( N -vinylcarbazole)s (poly(NVC)s) were considerably affected by the molar ratio of ( S )-FIDH to NVC. The highest yield and specific rotation were obtained with Li- ( S )-1-FIDH as an initiator, with a molar ratio of monomer and initiator [M]/[I] = 10/1. The effects of the chiral initiators, type of solvent and the polymerization temperature were investigated. The obtained optical activity of polymers was attributed to asymmetric induction of the chiral initiators.
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JOURNAL OF CLUSTER SCIENCE
·
2019
·Vol. 31
·期 2
·513-522
·
IF 2.125
Liu Qiang,Liu Yuqi,Zhang Qingqing,Wang Xinying,Li Wei
A new Pr(III)-based metal organic framework with formula {[Pr 2 (C 8 H 3 O 6 N)(SO 4 ) 2 ]·5H 2 O} n was hydrothermally synthesized and characterized by techniques of single crystal X-ray diffraction, infrared spectra (IR), thermogravimetric analysis (TGA), elemental analysis, powder X-ray diffraction (PXRD), and luminescent measurements. X-ray crystal structure analyses reveal that complex 1 is binuclear structure and all Pr(III) atoms show a coordination number of nine with a tricapped trigonal prismatic coordination geometry. Throughout the molecular structure, this lanthanide metal–organic frameworks exhibits a 3D architecture built by the 1D double-stranded chains of Pr ions linked by the 5-nitroisophthalic acid ligand and 2D Pr–SO 4 2− grid. In addition, the fluorescence, nitrogen adsorption properties and carbon dioxide adsorption properties of complex 1 were also investigated. The results indicate that the complex is not only a luminescent and mesoporous material, but also a potential material for selective absorption of carbon dioxide.
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JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 52
·期 13
·8207-8218
·
IF 2.599
Zhang Bin,Zhu Han,Zou MeiLing,Liu XinRong,Yang Hui,Zhang Ming,Wu WeiWei,Yao JuMing,Du MingLiang
Small-sized and well-dispersed Pt–Au nanoparticles (Pt–AuNPs) grown on carbon nanofibers (Pt–AuNPs/CNFs) with excellent electroanalytical and electrocatalytic performance in the detection of H 2 O 2 and the catalytic hydrogen evolution reaction (HER) were designed and fabricated via electrospinning technology and an in situ thermal reduction process. Large numbers of Pt–AuNPs were homogenously distributed on the CNFs. A Pt–AuNP/CNF hybrid with low Pt content was utilized as a bifunctional electrocatalyst, exhibiting a higher response current of 116 μA without an enzyme in the detection of H 2 O 2 and a lower overpotential ( j = 10 mA cm −2 at −235 mV) and Tafel slope (84 mV decade −1 ) for HER than the PtNPs/CNFs and the AuNPs/CNFs. These results were ascribed to the specific nanostructure of the well-dispersed Pt–AuNPs, the favorable electron transport capability, the excellent durability of the CNFs, and the enhanced surface-specific area of the Pt–AuNPs/CNFs. This study offers a green and facile method for constructing a specific bimetallic nanostructure for application in catalytic fields.
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CELLULOSE
·
2021
·Vol. 28
·期 6
·3505-3513
·
IF 5.044
Zhao Yan-Wen,Tian Mao-Zhang,Huang Pei
Characterized by low cost, flame resistance and mild processing procedure, freeze-dried clay aerogel is an ideal alternative for thermal insulation in building sector. However, the negatively charged surface of clay platelet and high freezing rate require the addition of a high amount of polymer to ensure the integrity of aerogel during freezing stage, which inevitably increases the density as well as the thermal conductivity of aerogel. Herein, we reported a green and versatile strategy to fabricate crack-free yet thermal insulative aerogel by introducing cellulose nanofibrils (CNFs) into starch/clay system. Owing to the abundant hydroxyl groups, high aspect ratio and excellent mechanical strength of CNFs, the CNF/starch/clay aerogels prepared exhibit enhanced crack resistance and compressive strength, enabling the reduction of starch content from 4 to 2% while maintaining the integrity of aerogel in the process of freezing. As a result, the density and thermal conductivity of aerogel significantly decrease from 0.12 to 0.05 g/cm 3 and 48.3 to 41.5 mW/mK respectively. Further crosslinked by glutaraldehyde, the CNF/starch/clay aerogels display improved moisture resistance, shape recovery and thermal stability. Being versatile and cost-effective, the present approach is thought-provoking for the up-scale production of freeze-dried clay aerogel for thermal insulation. Graphical abstract
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Bioresources and Bioprocessing
·
2021
·Vol. 8
·期 1
·1-14
·
IF 4.578
Gong Zhenggang,Yang Guangxu,Song Junlong,Zheng Peitao,Liu Jing,Zhu Wenyuan,Huang Liulian,Chen Lihui,Luo Xiaolin,Shuai Li
Abstract Lignin deposits formed on the surface of pretreated lignocellulosic substrates during acidic pretreatments can non-productively adsorb costly enzymes and thereby influence the enzymatic hydrolysis efficiency of cellulose. In this article, peanut protein (PP), a biocompatible non-catalytic protein, was separated from defatted peanut flour (DPF) as a lignin blocking additive to overcome this adverse effect. With the addition of 2.5 g/L PP in enzymatic hydrolysis medium, the glucose yield of the bamboo substrate pretreated by phenylsulfonic acid (PSA) significantly increased from 38 to 94% at a low cellulase loading of 5 FPU/g glucan while achieving a similar glucose yield required a cellulase loading of 17.5 FPU/g glucan without PP addition. Similar promotion effects were also observed on the n-pentanol-pretreated bamboo and PSA-pretreated eucalyptus substrates. The promoting effect of PP on enzymatic hydrolysis was ascribed to blocking lignin deposits via hydrophobic and/or hydrogen-bonding interactions, which significantly reduced the non-productive adsorption of cellulase onto PSA lignin. Meanwhile, PP extraction also facilitated the utilization of residual DPF as the adhesive for producing plywood as compared to that without protein pre-extraction. This scheme provides a sustainable and viable way to improve the value of woody and agriculture biomass. Peanut protein, a biocompatible non-catalytic protein, can block lignin, improve enzymatic hydrolysis efficiency and thereby facilitate the economics of biorefinery. Graphical abstract
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 12
·1-9
·
IF 6.232
Peng Bo,Fan Mimi,Xu Jiamei,Guo Yang,Ma Yongjun,Zhou Min,Bai Jialei,Wang Jingfeng,Fang Yanjun
Blue carbon dots (BCDs) and red gold nanoclusters modified by bovine serum albumin (BSA-Au NCs) were selected as luminescent nanomaterials, and the nanohybrid materials were successfully prepared and applied to the fluorescent measurement of copper ions. The prepared ratio fluorescent probe has two emission peaks near 452 and 654 nm under an excitation of 330 nm. The fluorescence intensity was gradually quenched because Au NCs was aggregated in the presence of Cu 2+ , resulting in a gradation of the fluorescent color from red to pink to purple to blue for visual detection. BCDs have almost the same fluorescence intensity due to their light stability and chemical inertness to Cu 2+ and serve as a background reference in the sensing system. Under the optimal condition, the detection limit (LOD) is 16 nM, the linear range is 0.05–1.85 μM, and the coefficient of determination R 2 is 0.9987 for copper determination. Compared with other single probes, the ratio fluorescent probe in the current study has good water solubility, low cytotoxicity, and is easy to synthesize. The nanoprobe provides a high-quality and sensitive visible light platform for monitoring copper ions.
Graphical abstract
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2019
·Vol. 321
·期 3
·1093-1107
·
IF 1.186
Ma Zhili,Wang Yanfei,Liu Mouwu,Luo YiGe,Xie Xiaoqing,Xiong Zeng
Poly(cyclotriphosphazene-co-4,4′-diaminodiphenyl ether) crosslinked microspheres with active amino groups on the surface were prepared by one-step precipitation polymerization method. The as-prepared material were characterized by means of FTIR, XPS, XRD, EDS and SEM. The effects of pH, time of contact, dosage, initial concentration and temperature on the adsorption of uranium(VI) by the crosslinked microspheres were studied, and the adsorption mechanism was elucidated. Under the optimized adsorption conditions, the adsorption removal efficiency reached 97.03%. The experimental results fit the Langmuir isotherm model and adsorption processes comply with the pseudo-second-order kinetic model. Thermodynamic data revealed that the adsorption behavior of uranium(VI) on the microspheres was spontaneous and exothermic.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 29
·28942-28953
·
IF 2.8
Liu Wei,Zhong Xuan,Cheng Lei,Wang Jing,Sun Yongqi,Deng Yi,Zhang Zuotai
Removal of intracellular water in microbial cells remains a key issue for sludge disposal, and here, a novel method of enzymatic treatment with two enzymes, lysozyme and protease, was employed. Total internal reflection fluorescence microscope (TIRF) was applied to image the bacteria in sludge and quantify the evolution of sludge bacteria for the first time. The ratio of dead/live bacterial cells was always higher in the presence of lysozyme than in the presence of protease, indicating that lysozyme has higher activity in inducing bacterial cell degradation and releasing intracellular water. The compositions of extracellular polymeric substances (EPS) were further measured, and the results show that the dewatering performance of sludge is correlated both to the release of cell contents and the variations in EPS composition during cell degradation. Moreover, kinetic analysis demonstrated that the enzyme-catalyzed reaction was substantially completed within 1 h, i.e., the reaction was quite rapid during the first 1 h, and thereafter, it gradually reduced to stability. The mechanism of enzymatic treatment of sludge explored in this study thus not only enhanced the understanding of sludge deep dewatering but also provided significant methodological clues for the disposal of sludge.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 16
·4645-4654
·
IF 4.478
Jiang Haixia,Liu Chunlong,Qu Qi,Wang Mengfan,Qi Wei,Peng Xin,He Zhimin
The surface-enhanced Raman scattering (SERS) technique has displayed a broad application prospect in disease diagnosis owing to its high sensitivity, fast responsiveness, and high specificity. In this study, we developed a SERS-based immunoassay for the detection of cryptococcal capsular polysaccharide (glucuronoxylomannan, GXM), which is an important biomarker of cryptococcosis. The coupled localized surface plasmon resonance effect between magnetic SERS substrates and SERS tags gave rise to an enhanced Raman signal upon the formation of sandwich complexes, which contributes to the sensitive and specific detection of GXM. As a result, the developed method provided a lower limit of detection (1.25 ng/mL) than conventional methods, such as latex agglutination, lateral flow assay, and enzyme-linked immunosorbent assay. Additionally, a recovery experiment was performed to detect GXM in human serum, which also validated the potential advantages of a SERS-based immunoassay in the clinical diagnosis of cryptococcosis. Graphical abstract
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