JOURNAL OF MOLECULAR STRUCTURE
·
2024
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IF 4
Yili Ding,Yanzhi Ma,Charles Ding,Jiehua Nie,Zhe Xu
Through cyclodextrin selection from phase solubility study, complexation method screening, and complexation condition optimization by using single and orthogonal strategy, the complexes of trimethoprim with methyl β -cyclodextrin, HP β -cyclodextrin and HP- γ -cyclodextrin with the best solubility increasing so far were prepared and confirmed by FTIR, DSC and proton NMR spectra. The in vitro pharmacokinetic study showed that trimethoprim was 80 %–90 % released in three complexes in 20 min., and in their dog's in vivo pharmacokinetic study, the C max was increased from 0.22 µg/mL to 0.85 µg/mL, 0.7 µg/mL and 0.72 µg/mL, the AUC 0∼40 was increased from 2.35 µg*h/mL to 3.94 µg*h/mL, 5.06 µg*h/mL and 6.73 µg*h/mL, the LC was shorten from 2.17 L/kg/h to 0.89 L/kg/h, 0.56 L/kg/h and 1.07 L/kg/h for the complexes with methyl β -cyclodextrin, HP β -cyclodextrin and HP- γ -cyclodextrin respectively. After combination with sulfamethoxazole cyclodextrin complex, the antibacterial activity of the complex of trimethoprim with methyl β -cyclodextrin was increased significantly compared with the pure drug alone, indicated that this complex can be used as new potent antibacterial agent.
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Advanced Science
·
2025
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IF 14.1
Xinchen Shen,Jiajia Zhang,Junhan Ou,Ziheng Bai,Tongyan Liu,Kaiyue Zhang,Kaixiang Zhu,James Q. Wang,Chaochen Wang,Qianting Zhang,Linrong Lu,Wenwen Huang
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, known for its early onset, strong metastatic tendencies, and poor prognosis. Conventional treatments, including chemotherapy and immunotherapy, often face challenges such as limited efficacy, adverse side effects, and high recurrence rates. To address these limitations, a family of tri-block chimeric proteins, cysteine-tagged silk-elastin-like proteins (cSELPs), is designed to form responsive in situ hydrogels for treating late-stage and metastatic TNBC. These cSELPs are de novo designed to integrate multiple functional protein motifs, including a photothermal agent binding motif, silk-inspired crosslinking motifs, and elastin-like thermo-responsive motifs. This unique sequence design enables the cSELP hydrogels to exhibit in situ gelation, photothermal responsive release of chemotherapeutic agent doxorubicin and immune checkpoint inhibitor anti-PD-L1, and antibacterial properties, leading to effective tumor microenvironment remodeling. By promoting immunogenic cell death and stimulating immune activation, this approach converts immunosuppressive “cold” tumors into immunologically active “hot” tumors. The cSELP hydrogel system demonstrates potent therapeutic efficacy against both primary and metastatic TNBC while maintaining excellent biocompatibility and long-term safety. This protein material platform offers an innovative strategy to reshape the tumor microenvironment and combine multimodal treatments into a single biocompatible system, highlighting its potential for clinical translation.
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RSC Advances
·
2025
·Vol. 15
·期 48
·40478-40490
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IF 4.6
Qisong Feng,Junjun Ma,Yankun Shen,Zheng Zhou,Shilian Wu,Juan Wang,Junpeng Li,Yu Yang
Flexible printed electronics represent a swift, efficient, and cost-effective technique for depositing metallic conductive materials onto flexible substrates, particularly with the pivotal advancement of functional conductive inks. Metal–organic decomposition conductive inks have garnered substantial interest owing to their straightforward synthesis, convenient storage, and low processing temperatures. However, during low-temperature heating, these inks frequently encounter issues such as fast pyrolysis and gas escape, leading to numerous defects in the microstructure of silver films. Moreover, low silver content results in a high volumetric shrinkage rate, negatively impacting electrical conductivity. To address these limitations, this study synthesized four distinct silver precursors and conducted an in-depth analysis of their chemical compositions, thermal behaviors, and microscopic morphologies. Conductive inks were developed with a high silver content using silver citrate as the silver source with gradient thermal volatilization and low-temperature reduction properties. The impact of solvents and complexing agents on the performance of ink formulations was then examined. Furthermore, the evolution of the inks' microstructure was investigated during thermal decomposition along with the influence of the microscopic morphology on electrical conductivity. Finally, the thermal decomposition mechanism was elucidated in detail. By introducing organic solvents with varying boiling points, the intensity of thermal decomposition was effectively reduced, thereby minimizing the appearance of surface defects such as bubble holes and sintering marks. This strategy significantly enhanced the density of the silver film, reduced its surface roughness, and improved its electrical conductivity.
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Nature Communications
·
2026
·
IF 18.1
Li Feng,Wu Qikang,Zhou Yan,Lv Shanshan,Meng Jing,Zhang Yongning,Dou Sixin,Cheng Yanyang,Chen Chang,Sun Wenming,Chen Zheng
Hybrid sites (M 1+x ) that incorporate single atoms (M 1 ) with clusters (M x ) hold great potential for overcoming linear scaling relations in electrocatalysis, but spatial decoupling of M 1 from M x fundamentally hampers intercomponent synergy. Here, we report a composite electrocatalyst (Zn 1 Fe 1+x / f -NC) featuring Fe x clusters encapsulated within nano-fingerprint carbon layers and surrounded by densely dispersed Fe/Zn-N 4 atomic sites. Decoupling experiments revealed that Fe 1 /Zn 1 atomic sites mainly initiate catalytic activity, while Fe x clusters further boost intrinsic activity, whereas nano-fingerprint carbon facilitates the confinement and stabilization of M 1+x . The Zn 1 Fe 1+x / f -NC demonstrates competitive oxygen reduction reaction performance, achieving a half-wave potential of 0.93 V and stability over 50 h. Zinc-air batteries with Zn 1 Fe 1+x / f -NC air cathode exhibit a peak power density of 263.82 mW·cm −2 and robust stability exceeding 2200 h at 10 mA cm −2 . Density functional theory calculations reveal that the atomic Zn sites, Fe x clusters and nano-fingerprint carbon layers jointly enhance the catalytic activity and stability by modulating the electronic structure of Fe-N 4 sites and optimizing the adsorption energy of the key intermediate, especially OH*.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Haixing Feng,Jionghong Liang,Aiyi Chen,Xutong Zhou,Haojie Liu,Zhaoxi Zhao,Ming Wu,Jiangwen Liu,Guie Xie
Metallic implants in diabetic patients face a critical dual challenge: excessive reactive oxygen species (ROS) and advanced glycation end-products (AGEs) accumulation severely impair osteointegration, while suppressing ROS is beneficial for tissue repair but compromises antibacterial defense. Here, we report an innovative multifunctional coating composed of manganese oxide nanoparticles and polydopamine (PDA) on a nano-network metallic substrate (TAMP), which enables dynamic regulation of ROS and near-infrared-triggered antibacterial activation. Under near-infrared irradiation (NIR), the coating induces mild photothermal heating (PTT) and synergistic photodynamic therapy (PDT) effects, leading to moderate ROS generation and achieving over 95% bactericidal efficiency against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) without damaging host tissue. In the absence of light, controlled manganese ion release scavenges excess ROS, restores redox balance, and promotes human mesenchymal stem cell proliferation. The coating exhibits long-term antibacterial stability, maintaining more than 96% bactericidal activity after 7 days, and enhanced corrosion resistance with corrosion current reduced to 9.88% of that of the bare substrate. This dual-mode, light-controllable, and ROS-adaptive system provides an innovative solution to reconcile infection control and tissue regeneration in diabetic oxidative microenvironments, offering a promising strategy for next-generation metallic implants.
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Journal of Future Foods
·
2026
·
IF 10.6
Yang Lin,Cong Li,Ping Shao,Huiliang Li
The antioxidant (AO) efficiencies and the distributions of cyanidin-3-O-glucoside (C3G) and its acylated derivatives in intact corn oil-in-water emulsions were determined using pseudo phase kinetic models and molecular simulation. Research indicates that the antioxidant activity of C3G and its derivatives were positively correlated with the percentage of antioxidants at the interface. The antioxidant efficiency demonstrates a "cut-off" effect with increasing chain length. Among the derivatives, octanoylated anthocyanin derivatives (C3G-C8) was found to be the most suitable AO for protecting corn O/W emulsions. Increasing the surfactant fraction, raised the percentage of all compounds at the interface, but the antioxidant efficiency decreased owing to the dilution of AO at the interface region. For the AO (C3G-C8) with intermediate hydrophobicity, the dilution effect was the most significant. To maximize antioxidant effectiveness, C3G-C8 should be used with the lowest emulsifier volume fraction necessary to physically stabilize the emulsions. The enzymatic acylation of anthocyanin with fatty acids of varying chain lengths was performed, and the lipophilicity and antioxidant properties of the resulting derivatives were investigated in this study. The findings could offer new perspectives on their application and expand the use of anthocyanin derivatives in protecting Pickering emulsions.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2026
·
IF 9.2
Guida Jiang,Yingge Shu,Ling Zhao,Ying Teng,Tao Chen,Runlai Luo,Zhongyuan Li
A slow-release permanganate (PM) and persulfate (PS) composite gel (P-PGSR) was developed to overcome the blocking effect of amorphous MnO 2 generated from PM and the futility of PS without activator in-situ chemical oxidation (ISCO) of sulfonamides (SAs) in groundwater plumes. Results showed that the release longevity of PM and PS from P-PGSR was lengthened 3-fold more than from powder in a column experiment. Low P-PGSR dosage, permeability of the porous medium and ionic strength facilitated the release efficiencies of PM and PS, which was not fully consistent with the degradation efficiencies of SAs. Approximately 99.1% sulfathiazole (STZ) at pH 6, and 83.9% sulfadiazine (SDZ), 92.4% sulfachloropyridazine (SCP) and 92.4% sulfamethoxazole (SMX) at pH 5, were degraded within 24 min by 1.25 g P-PGSR at 2.0 mL min −1 flow rate using 0.01 M NaCl as background solution. Co-existing 0.5 M anions inhibited the degradation of SAs. The addition of 5 mg L −1 fulvic acid enhanced the degradation of SDZ and SCP, but reduced the degradation of STZ and SMX. Increasing ration of PS and PM from 0 to 5 accelerated the k obs of SDZ, STZ, SCP and SMX by 5.5, 1.3, 18.1 and 5.6 folds, respectively, proving that P-PGSR is a novel self-catalytic oxidant to improve the remediation efficiency of ISCO. Radical quenching experiments illustrated that ∙OH was the primarily reactive species for the degradation of STZ and SMX, while SO 4 ∙ − played an important role in the degradation of SDZ, STZ and SCP. The intermediate products of SDZ, STZ and SMX indicated that aniline moiety oxidation, hydroxylation, deamination, and smiles-type rearrangement to produce SO 2 extrusion were involved in the degradation pathways of SAs by treatment with P-PGSR.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Yang Chen,Xuchao Yang,Yuan Li,Guang Liu,Fen Ran
Zinc has good ductility and high theoretical specific capacity (820 milliampere-hours per gram or 5854 milliampere-hours per cubic centimeter), making it an ideal electrode material for green rechargeable batteries. In zinc-based systems, aqueous zinc metal batteries feature high safety, low material cost, and simple preparation process, and thus have significant application value and development prospects in the field of energy storage. However, aqueous zinc metal batteries are prone to zinc dendrite growth, hydrogen evolution reactions and corrosion, etc., which leads to a short cycle life of aqueous zinc metal batteries. By using electrolyte additives, as an innovative strategy in energy storage technology, can effectively regulate the electrochemical behavior at zinc anode interface and extend cycle life. This review briefly introduces the main challenges faced by zinc anodes and their impact on electrochemical performance; based on the types of electrolyte additives and their main regulatory mechanisms, the corresponding design strategies are summarized, and the application and development direction of electrolyte additive strategies for stabilizing zinc anodes are prospected. The summaries and thoughts in this review may inspire any creativity for designing rational electrolyte additives for zinc metal batteries.
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Journal of Environmental Sciences
·
2026
·
IF 6.3
Yanli Kong,Pengjun Zhang,Shunliang Hu,Yunlong Xie,Zhonglin Chen,Jiangya Ma
The development of highly efficient coagulants with broad pH adaptability remains a critical challenge in water treatment. In this study, a new type of polyaluminum chloride-manganese chloride composite coagulant (PAMCs) was synthesized, and the effect of manganese on changing the types of hydrolysis products and enhancing coagulation performance was systematically studied. A series of PAMCs with varying Al/Mn molar ratios and basicity ( B = [OH - ]/[M 3+ ]) were prepared, and their interactions with humic acid (HA) were evaluated. Results demonstrated that PAMC 2 (Al/Mn = 2:1, B = 2) exhibited superior HA removal efficiency under weakly alkaline conditions (pH 8-9), while maintaining stability over a broader pH range (pH 4-11). Mechanistic studies revealed that manganese incorporation primarily modified the speciation of hydrolysis products and the coordination structure of traditional flocs, favoring colloidal Al/Mn species rich in reactive hydroxyl groups (-OH) with stronger adsorption-complexation capabilities. Spectroscopic analyses confirmed that PAMC 2 preferentially interacted with the -COOH and -OH functional groups of HA to form stable HA-metal complexes. Hydrolysis product characterization further indicated that Mn addition promoted the formation of colloidal aggregates, enhancing sweep flocculation and ligand exchange under alkaline conditions. Furthermore, the promising application potential of PAMCs was evaluated in treating industrial dye wastewater. However, it must be acknowledged that the residual manganese concentration in treated water exceeded the WHO drinking water standard (0.1 mg/L), which currently limited its applicability in potable water treatment. Nevertheless, this study provided a new cost-effective strategy for another important issue (efficient treatment of neutral/alkaline industrial wastewater) and underscores the role of Mn in tailoring hydrolysis reactivity and broadening pH adaptability.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Linzi Huang,Xiaoqian Sun,Kunxiang Deng,Yuan Chen,Dan Guo,Xinyi Li,Yixi Xie,Pengcheng Zhao,Junjie Fei
Tert-butylhydroquinone (TBHQ), a widely used antioxidant for extending food shelf life, requires strict content control to ensure food safety. Here, we constructed a core-shell CdMoO 4 @ZnS S-scheme heterojunction via in situ growth for highly sensitive detection of TBHQ. Compared with our previously reported heterojunction sensors, this system achieves synergistic enhancement through polyvinylpyrrolidone-mediated morphology regulation and optimal shell-thickness engineering, effectively mitigating limitations in charge separation and stability. The developed photoelectrochemical sensor exhibits a wide dual-range detection capability (0.015–20 μM and 20–190 μM) with an ultralow detection limit of 1.8 nM. The exceptional sensing performance was elucidated by density functional theory calculations and redox potential analysis. Furthermore, the sensor achieves excellent recovery rates (97.05% - 104.23%) in real-sample analyses and retains more than 91.33% of its initial response after 8 weeks of storage, highlighting its strong potential for practical food-safety monitoring applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.7
Yi Chen,Zhen Tan,Huile Jin,Yan Jiao,Jun Li,Shun Wang
The development of rechargeable zinc–air batteries (ZABs) is fundamentally constrained by the sluggish kinetics of the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), which govern the discharge and charge processes, respectively. Although high-entropy alloys (HEAs) offer tunable electronic structures and multi-metal synergy, precisely controlling the adsorption strength of oxygenated species to achieve superior bifunctional activity remains challenging when limited to conventional 3d transition metals. Herein, we report a melamine-assisted pyrolysis strategy to synthesize a series of rare-earth (RE = Ce, Gd, La) integrated FeCoNiMn high-entropy alloy nanoparticles encapsulated within N-doped carbon nanotubes. Among these, the FeCoNiMnCe@NCNTs catalyst demonstrates exceptional bifunctional performance with a half-wave potential of 0.853 V for ORR and an overpotential of 273 mV at 10 mA cm −2 for OER, yielding a small potential gap (ΔE = 0.65 V). Experimental and theoretical analyses reveal that Ce integration induces favorable electronic structure modulation and enhanced orbital hybridization, which collectively optimize the adsorption free energy of oxygen intermediates and lower the energy barrier of the potential-determining step for both reactions. When applied as an air cathode in ZAB, the catalyst enables a high power density of 188.7 mW cm −2 and remarkable long-term charge-discharge stability exceeding 325 h. This work highlights the potential of RE-tuned HEAs as robust and efficient bifunctional electrocatalysts for next-generation energy conversion systems.
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JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Mengyuan Song,Haoyang Yuan,Changhao Tian,Chunguang Chen,Tao Huang,Aishui Yu
Tetraethylene glycol dimethyl ether (TEGDME) decomposition on the Au electrode surface is studied using in situ attenuated total reflectance surface enhanced infrared absorption spectroscopy (ATR-SEIRAS). Due to the weak solvation of TEGDME, the superoxide intermediate (LiO 2 /O 2 − ) of the discharge process rapidly gains electrons on the electrode surface to generate Li 2 O 2 . Furthermore, alkyl radical, formed by LiO 2 /O 2 − extracting hydrogen from ether, undergoes oxidative decomposition reactions to form by-products. During the charge process, amorphous film-like Li 2 O 2 obtained from surface-phase mechanism oxidizes in the low potential range of 3–3.4 V, while the oxidation potential of large-sized crystal Li 2 O 2 particles obtained from solution-phase mechanism is above 3.4 V. Besides, TEGDME is intrinsically unstable and can decompose at 3.8 V even the solution is saturated with argon, indicating that the degradation of ether-based electrolyte is inevitable during the cycling process. This work confirms the feasibility of ATR-SEIRAS in probing the reaction mechanism and electrolyte stability of lithium oxygen batteries , and provides direct spectroscopic evidence for subsequent optimization of electrolyte components.
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