CARDIOVASCULAR DRUGS AND THERAPY
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2025
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IF 3.1
Huang Jie,Hou Xingyuan,Zhou Ni,Su Nan,Wei Shanshan,Yang Yuanying,Sun Taoli,Li Guangdi,Li Wenqun,Zhang Bikui
Purpose Doxorubicin (Dox) is a classic anthracycline chemotherapy drug with cause cumulative and dose-dependent cardiotoxicity. This study aimed to investigate the potential role and molecular mechanism of phenylacetylglutamine (PAGln), a novel gut microbiota metabolite, in Dox-induced cardiotoxicity (DIC). Methods DIC models were established in vivo and in vitro, and a series of experiments were performed to verify the cardioprotective effect of PAGln. RNA sequencing (RNA-seq) was employed to explore the mechanism of PAGln in DIC. Subsequently, the differentially expressed genes (DEGs) were subjected to comprehensive analysis using diverse public databases, and RT-PCR was used to confirm the expression levels of the candidate genes. Finally, molecular docking techniques were used for validation. Results PAGln effectively prevented both in vivo and in vitro Dox-induced myocardial injury and cell apoptosis. RNA-seq results showed that 40 genes were up-regulated and 54 down-regulated in the Dox group compared to the Con group, displaying opposite changes in the Dox + PAGln group. Enrichment analysis highlighted several mechanisms by which PAGln alleviated Dox-induced cardiotoxicity, including the lipid metabolic process, calcium-mediated signaling, positive regulation of store-operated calcium channel activity, and hypertrophic cardiomyopathy. In vitro and in vivo experiments confirmed that PAGln treatment could reverse the changes in the expression levels of Klb, Ece2, Nmnat2, Casq1, Pak1, and Apob in Dox. Molecular docking results showed that these genes had good binding activity with PAGln. Conclusions PAGln shows potential in alleviating Dox-induced cardiotoxicity, with Ece2 identified as key regulatory molecules related to endothelial dysfunction.
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Nature Communications
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2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Yu Bingcheng,Shi Jiangjian,Li Yiming,Tan Shan,Cui Yuqi,Meng Fanqi,Wu Huijue,Luo Yanhong,Li Dongmei,Meng Qingbo
Carbon-based perovskite solar cells exhibit a promising application prospect due to its cost effective and attractive hydrophobic nature and chemical inertness, but are still limited to unsatisfied device efficiency. Herein, we design a triple-layer full-carbon electrode for n-i-p typed perovskite solar cells, which is comprised of a modified macroporous carbon layer, a highly conductive graphite layer and a thin dense carbon layer, and each layer undertakes different contribution to improving the cell performance. Based on this full-carbon electrode, inorganic CsPbI 3 perovskite solar cells exhibit >19% certified efficiency which is the highest result among carbon-based CsPbI 3 devices. On one hand, carbon quantum dots decorated on the macro-porous carbon layer can realize better energy alignment of full-carbon electrode/spiro-OMeTAD/CsPbI 3 interface, on the other hand, highly conductive graphite layer is advantageous to carrier transporting. Typically, the top dense carbon layer exhibits significant thermal radiation ability, which can reduce the operational temperature of devices by about 10 °C, both from theoretical simulation and experimental testing. Thereby, packaged full-carbon electrode based CsPbI 3 cells exhibit much better photothermal stability at ~70°C accompanied by white light emitting diode illumination, which exhibit no efficiency degradation after 2000 h continuous operational tracking.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 10
·1-18
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IF 2.8
Huo Dongyu,Wang Qing,Zhu Fuliang,Wang Can,Dai Yile,Dai Jianfeng
Silicon-based anode materials have attracted significant interest due to their high theoretical specific capacity. However, their practical application is severely hindered by the substantial volumetric expansion during cycling. To overcome this limitation, a novel silicon–carbon nanofiber/carbonized Poria powder composite was synthesized via electrospinning followed by a simple heat treatment process. The carbonized Poria powder features a hierarchical porous structure, combining macropores and mesopores. The macropores effectively trap and constrain the silicon–carbon nanofibers, thereby enhancing the structural stability, while the mesopores increase the specific surface area, facilitating improved electrolyte penetration. The composite benefits from the conductive framework of nitrogen-doped carbon fibers and carbonized Poria powder, which collectively enhance its electrochemical performance. At a current density of 0.1 A g −1 , the composite exhibits an initial discharge capacity of 1579.7 mAh g −1 and a charge capacity of 1455.5 mAh g −1 . After 1000 cycles, the discharge capacity is maintained at 1277.2 mAh g −1 , corresponding to a capacity retention rate of 80.8%. Additionally, at a scan rate of 0.5 mV s −1 , the composite demonstrates a high pseudocapacitive contribution of 91.56%, which improves the lithium-ion diffusion rate, reduces cycling-induced stress and side reactions, and mitigates capacity degradation over extended cycling.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Zhang Tao,Zhao Hui-Feng,Chen Zheng-Jie,Yang Qun,Gao Niu,Li Li,Luo Na,Zheng Jian,Bao Shi-Da,Peng Jing,Peng Xu,Liu Xin-Wang,Yu Hai-Bin
Electrocatalytic oxygen evolution reaction (OER) is key to several energy technologies but suffers from low activity. Leveraging the lattice oxygen activation mechanism (LOM) is a strategy for boosting its activity. However, this approach faces significant thermodynamic challenges, requiring high-valent oxidation of metal ions without compromising their stability. We reveal that high-entropy alloys (HEAs) can efficiently activate the LOM through synergistic multi-path electron transfer. Specifically, the oxidation of nickel is enhanced by this electron transfer, aided by the integration of weaker Co-O bonds, enabling effective LOM at the Ni-Co dual-site. These insights allow the design of a NiFeCoCrW 0.2 HEA that exhibits improved activity, achieving an overpotential of 220 mV at a current density of 10 mA cm −2 . It also demonstrates good stability, maintaining the potential with less than 5% variation over 90 days at 100 mA cm −2 current density. This study sheds light on the synergistic effects that confer high activity in HEAs and contribute to the advancement of high-performance OER electrocatalysts.
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Food and Bioprocess Technology
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2024
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IF 5.3
Zhang Xu,Wang Rui,Zhang Wencong,Chen Cunkun,Ma Chao,Ji Ning,Zhang Nanxin,Lei Jiqing,Tian Yiming,Zhang Panpan
The shelf life of Dictyophora rubrovolvata ( D. rubrovolvata ) has been strongly limited by autolysis, a natural process of self-degradation. Conventional heat treatment methods (hot water or hot air) are not suitable for D. rubrovolvata fruiting bodies because of their fragile and porous structure. Therefore, in this work, we attempted to use microwave treatment (MT/100 W, 75 W, 50 W) to delay autolysis and extend the shelf life of D. rubrovolvata fruiting bodies. The results showed that MT could delay the decrease in cellulose, chitosan, and β-1,3 glucan contents by inhibiting the corresponding enzyme activity and maintaining a high level of energy charge by delaying the decrease in ATP and ADP. Meanwhile, compared with the control group (CK), D. rubrovolvata fruiting bodies after MT had improvements in many qualities during storage (4 °C, 95% RH), including delayed deterioration of water migration, sensory evaluation, browning, shear force, ethanol, malondialdehyde (MDA), relative conductivity, and respiratory rate. Furthermore, D. rubrovolvata fruiting bodies after MT maintained contents of umami compounds compared to CK, which included free amino acids, 5′-nucleotides, and equivalent umami concentration (EUC). The electronic nose (E-nose) results showed that MT maintained a better flavor. Notably, the effect of low power (50 W) was better than that of high power (100 W, 75 W). Thus, microwaves could effectively regulate autolysis and energy metabolism of D. rubrovolvata fruiting bodies during the postharvest period. Therefore, microwaves can be applied as a pretreatment method, providing valuable insights regarding postharvest mushrooms.
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Nature Communications
·
2020
·Vol. 11
·期 1
·1-10
·
IF 12.121
Tian Kesong,Wang Junyan,Cao Ling,Yang Wei,Guo Wanchun,Liu Shuhu,Li Wei,Wang Fengyan,Li Xueai,Xu Zhaopeng,Wang Zhenbo,Wang Haiyan,Hou Yanglong
Integrating nitrogen species into sp 2 -hybridized carbon materials has proved an efficient means to improve their electrochemical performance. Nevertheless, an inevitable mixture of nitrogen species in carbon materials, due to the uncontrolled conversion among different nitrogen configurations involved in synthesizing nitrogen-doped carbon materials, largely retards the precise identification of electrochemically active nitrogen configurations for specific reactions. Here, we report the preparation of single pyrrolic N-doped carbon materials (SPNCMs) with a tunable nitrogen content from 0 to 4.22 at.% based on a strategy of low-temperature dehalogenation-induced and subsequent alkaline-activated pyrolysis of 3-halogenated phenol-3-aminophenol-formaldehyde (X-APF) co-condensed resins. Additionally, considering that the pseudocapacitance of SPNCMs is positively dependent on the pyrrolic nitrogen content, it could be inferred that pyrrolic nitrogen species are highly active pseudocapacitive sites for nitrogen-doped carbon materials. This work gives an ideal model for understanding the contribution of pyrrolic nitrogen species in N-doped carbon materials.
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JOURNAL OF POROUS MATERIALS
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2025
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IF 3.2
Feng Yulin,Xu Fen,Sun Lixian,Shao Qiwei,Xu Rudan,Chen Yue,Yu Chuyu,Du Maozhan,Xie Yingguang
The interfacial chemical bonding strategy has been proposed by utilizing the expanded graphite (EG) as substrate to overcome the inherent low conductivity of covalent organic frameworks (COFs) in supercapacitor in this work. A redox-active COF material grows in situ on the EG surface through a solvent-free synthesis method, successfully constructing a novel layered porous EG@COF composite. Analysis results of BET, XPS and resistivity of materials demonstrate that the EG@COF not only preserves the intrinsic high specific surface area of COFs, but also effectively reduces interfacial contact resistance via amidation reaction, significantly enhancing charge transfer efficiency. Electrochemical studies reveal that the optimized EG@COF-3 electrode has a high specific capacitance of 501 F g − 1 at 1 A g − 1 , with 92.3% capacity retention after 10,000 cycles, demonstrating a good cycling stability. Furthermore, the assembled EG@COF//AC asymmetric supercapacitor achieves an energy density of 16.4 Wh kg − 1 at a power density of 806.0 W kg − 1 . This work provides an effective solution to improve the conductivity of COF materials.
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BREAST CANCER RESEARCH
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2025
·Vol. 27
·期 1
·1-19
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IF 5.6
Kong Linghui,Hu Song,Zhao Ying,Huang Yan,Xiang Xiaobing,Yu Yang,Mao Xiaochun,Xie Kangjie,Zhu Xiaoyan,Xu Pingbo
Background The mechanisms underpinning neoadjuvant chemotherapy-induced vascular endothelial injury in breast cancer remain elusive. Our study aims to demonstrate that Neutrophil Extracellular Traps (NETs) play a pivotal role in neoadjuvant chemotherapy-induced vascular endothelial injury in breast cancer, elucidating that chemotherapy-induced upregulation of Solute Carrier 11a1 (Slc11a1) modulates Reactive Oxygen Species (ROS) generation, which may be critical for NETs formation.Methods We investigated the impact of neoadjuvant chemotherapy for breast cancer on NETs formation and vascular endothelial injury by analyzing NETs dsDNA and serum markers in patients, cells, and chemotherapy mouse models. RNA sequencing of neutrophils from chemotherapy mouse models was performed to identify the potential NETs formation-associated gene Slc11a1, which was further validated through cellular and animal experiments by assessing Slc11a1 expression, intracellular ferrous ion content, and ROS levels. Knockdown of Slc11a1 in human neutrophils and mouse models were also performed to further confirm the phenotypic results.Results Our study revealed that plasma NETs formation and endothelial injury markers were significantly elevated in breast cancer patients undergoing docetaxel & carboplatin (TCb) neoadjuvant chemotherapy, compared to controls. In these patients, NETs formation was associated with the augmentation of endothelial injury markers. Chemotherapy mouse models demonstrated that TCb treatment markedly elevated NETs formation and endothelial injury, which can be mitigated by CI-amidine, a protein-arginine deiminase inhibitor. In human neutrophils, we demonstrated that the TCb chemotherapeutic agents (combination of docetaxel and carboplatin) induced the formation of NETs, which subsequently facilitated damage to human umbilical vein endothelial cells in vitro. RNA sequencing of mouse neutrophils identified Slc11a1 as a key NETs formation-related gene, which was upregulated by TCb chemotherapy in neutrophils, leading to increased intracellular ferrous ion content and ROS generation. Knockdown of Slc11a1 in human neutrophils and mouse models demonstrated its reversal effect on TCb-induced ferrous ion upregulation, ROS generation, and NETs formation.Conclusion sOur research underscores the capacity of TCb neoadjuvant chemotherapy in breast cancer to augment NETs formation in neutrophils through Slc11a1-mediated ROS generation, which is linked to vascular endothelial injury. Our study elucidates the potential mechanisms underlying perioperative vascular endothelial injury in breast cancer patients undergoing neoadjuvant chemotherapy, offering novel insights into perioperative therapeutic management strategies for these patients.
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BIODEGRADATION
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2024
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IF 3.1
Sun Shanshan,Wei Ran,Hu Siyi,Yang Meiyu,Ni Jinzhi
Considerable efforts that isolate and characterize degrading bacteria for polycyclic aromatic hydrocarbons (PAHs) have focused on contaminated environments so far. Here we isolated three distinctive pyrene (PYR)-degrading bacteria from a paddy soil that was not contaminated with PAHs. These included a novel Bacillus sp. PyB-9 and efficient degraders, Shigella sp. PyB-6 and Agromyces sp. PyB-10. All three strains could utilize naphthalene, phenanthrene, anthracene, fluoranthene and PYR as sole carbon sources, and degraded PYR in a range of temperatures (27–37 °C) and pH (5–8). Strains PyB-6 and PyB-10 almost completely degraded 50 mg L −1 PYR within 15 days, and 75.5% and 98.9% of 100 mg L −1 PYR in 27 days, respectively. The kinetics of PYR biodegradation was well represented by the Gompertz model. Ten and twelve PYR metabolites were identified in PYR degradation process by strains PyB-6 and PyB-10, respectively. Chemical analyses demonstrated that the degradation mechanisms of PYR were the same for strains PyB-6 and PyB-10 with initial dioxygenation mainly on C-4,5 positions of PYR. The degradation of 4,5-phenanthrenedicarboxylic acid was branched to 4-phenanthrenecarboxylic acid pathway and 5-hydroxy-4-phenanthrenecarboxylic acid pathway, both of which played important roles in PYR degradation by strains PyB-6 and PyB-10. To our knowledge, Shigella sp. and Agromyces sp. were found for the first time to possess the capability for PAHs degradation. These findings contributed to upgrading the bank of microbial resource and knowledge on PAH biodegradation.
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Biomass Conversion and Biorefinery
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2024
·
IF 3.5
Zhao Yuhong,Gong Zhuhua,Zhang Qi,Lu Hongjia,Liao Qinhong,Tang Jianmin,Zhang Wenlin
Enoki mushroom residue-derived porous carbon (EMRPC) was prepared using a simple ZnCl 2 activation method. Scanning electron microscopy, Thermogravimetric analysis, N 2 adsorption–desorption tests, X-ray diffraction, Raman spectroscopy, and Fourier-transform infrared spectroscopy were used to analyse the morphology, structure, and chemical composition of EMRPC. The effects of solution pH, initial dye concentration, adsorption time, and temperature on the adsorption of methylene blue (MB) dye by EMRPC and the recycling performance of EMRPC were investigated. The results demonstrated that EMRPC presented remarkable porosity and abundant surface groups. Moreover, the adsorption capacity of EMRPC for MB reached 437.5 mg g − 1 . The solution pH, initial MB concentration, adsorption time, and temperature affected the adsorption performance of EMRPC. The MB adsorption data fitted the pseudo-second-order kinetics and Freundlich isotherm models. The removal rate of MB exceeded 99.86% after five adsorption cycles, indicating the good recyclability of EMRPC. The as-prepared EMRPC exhibited excellent structure and adsorption performance. Therefore, it can be used as a high-quality adsorbent for MB removal.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2024
·
IF 0
Liu Yucheng,Zhu Mengke,Ji Xinghu,Tan Zhiyou,He Zhike
The reverse osmosis (RO) technique has been extensively employed in the advanced treatment of industrial water and wastewater. However, this process results in the production of a significant quantity of reverse osmosis concentrate (ROC), which contains high levels of salinity and organic contaminants, thereby posing serious environmental problems. This study reported a two-stage precipitation process utilizing quicklime (CaO) and caustic soda (NaOH) in conjunction with air blowing (carbonation) for the removal of Ca 2+ and Mg 2+ from real brackish water ROC of factory. In stage I, the CaO precipitation-carbonation process was employed to eliminate the majority of Ca 2+ from the ROC, while leaving Mg 2+ virtually unaffected, yielding high-purity CaCO 3 precipitates. In stage II, the NaOH precipitation method was utilized to eliminate the remaining Ca 2+ and Mg 2+ from the ROC. It was demonstrated that under optimal conditions, the removal rates of Ca 2+ and Mg 2+ exceeded 97%. Finally, the characterization of precipitates demonstrated the generation of high-purity CaCO 3 precipitates in stage I, as well as the formation of CaCO 3 and Mg(OH) 2 precipitates in stage II. The results confirmed the feasibility of employing the two-stage precipitation with carbonation process to economically treat ROC and enable its reuse, offering valuable insights for the treatment of industrial wastewater.
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
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2025
·Vol. 114
·期 3
·1-6
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IF 2.2
Huang Zaoquan,Li Xiaoyuan,Hou Siying,Zhao Yanjie,Lu Haijian,Wang Jun,Deng Yirong
To enhance phenanthrene degradation in soil, the effects of four surfactants on the thermal activation of sodium persulfate (SPS) were investigated. Sodium dodecyl diphenyl ether disulfonate (C 12 -MADS) was found to stabilize SPS by reducing the generation of sulfate radicals from its thermal decomposition. Optimal conditions for the surfactant-assisted persulfate system were determined to be 5 g/L of C 12 -MADS at a temperature of 60°C, achieving an 89.80% removal efficiency of phenanthrene in soil. The presence of OH − increased the system pH and decreased the removal efficiency. These results demonstrate that C 12 -MADS significantly enhanced the oxidation of phenanthrene and improves SPS utilization efficiency, contributing to the development of an effective surfactant-assisted persulfate system for soil decontamination.
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