Environmental Science & Technology Letters
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2025
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IF 8.8
Lingjun Zeng,Mengyan Huang,Chongli Shi,Chen Wang,Jin Zhang,Yi Peng,Yang Zheng,Susu Wang,Jiawei Hong,Yangzhizhe Gao,María Dolores Hernando,Amadeo R. Fernández-Alba,Damià Barceló,Hui Li
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP), a widely used chlorinated flame retardant, is ubiquitous in dust, water, and biota. Parental exposure of Caenorhabditis elegans to environmentally relevant TDCPP (0.1–10 μg/L) reduced mean lifespan by 14.9–20.9% in parental nematodes and 8.07–28.2% in offspring. Multiomics analyses (transcriptomics and lipidomics) uncovered a previously unrecognized lipid-centered mechanism by which TDCPP impaired organismal health. Specifically, TDCPP suppressed the expression of daf-16 and downstream fatty acid desaturase (fat-5/6), leading to depletion of unsaturated lipid species, including triglycerides, diacylglycerols, lysophospholipids, and glycosphingolipids. This disruption was corroborated by phenocopy experiments showing that genetic deletion of fat-5/6 or dietary supplementation with saturated fatty acids (positive control) mimicked TDCPP-induced aging phenotypes. Moreover, TDCPP downregulated aak-2 and cpt-1, impairing mitochondrial β-oxidation and energy metabolism. These findings identified a novel daf-16–fat-6–AMPK–CPT-1 signaling axis, providing mechanistic insight into how the environmental pollutant TDCPP disrupts lipid homeostasis to promote aging and transgenerational toxicity.
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ACS Nano
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2025
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IF 16
Yishu Han,Rui Zhang,Zhuolin Wu,Huan Liu,Jianbin Luo,Dameng Liu
Reducing friction at the solid–liquid interfaces is critical for improving the efficiency of fluid transport, underwater equipment, and microfluidic devices. While macroscopic strategies have achieved significant friction reduction, experimental investigation into the underlying microscopic mechanisms remains limited, especially from atomic and electronic perspectives. In this work, an order-of-magnitude enhancement in slip length at the MoS2–water interface is achieved via self-assembled monolayers (SAMs), accompanied by measurable changes in interfacial electronic properties. Spectroscopic analyses performed in both air and aqueous environments reveal that the electronic state of MoS2 is jointly modulated by SAMs and interfacial water. Exciton recombination behavior under optical excitation serves as an indirect probe of interfacial electron transfer. Combined surface potential measurements and density functional theory simulations indicate that changes in surface electronic states may influence charge density which, along with SAM-induced hydrophobicity, governs the observed slip behavior. Electrostatic gating experiments further decouples the contribution of substrate hydrophobicity, enabling a more precise interpretation of the interfacial electronic influence. These findings suggest that interfacial electrons contribute to slip behavior at solid–liquid interfaces and offer valuable insights into electronic effects in nanoscale friction.
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LANGMUIR
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2025
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IF 3.9
Leyao Bi,Boyan Fu,Jiahui Lin,Junsheng Wen,Jiaxing Fu,Wenyue Tian,Binglin Zou,Chunjie Wang,Yue Wang
Acetylacetone is a highly volatile, flammable, and toxic compound that emits an irritating odor and poses significant threats to human survival and safety. Consequently, rigorous monitoring of acetylacetone concentrations is essential. Herein, we successfully synthesized GO-modified Co-doped ZnO (8-ZOC, 8 wt % Co/Zn) nanoparticles (NPs) with different GO contents (0.01–0.03 g) using a secondary hydrothermal method for the first time, achieving excellent performance in detecting low concentrations of acetylacetone gas. Among all samples, the sensor with a GO content of 0.02 g exhibits the highest response (598.22) to 5 ppm of acetylacetone at 250 °C, with a value 9.28 times higher than the response of 8-ZOC (64.50). Meanwhile, GO/8-ZOC-2 exhibits a rapid response, requiring only 3 s, which is 50% faster than 8-ZOC, and also features a recovery time that is 74 s shorter. Additionally, it presents outstanding selectivity and reproducibility and excellent long-term stability. The enhanced gas sensing performance of GO/8-ZOC-2 results from the combined effect of multiple factors, including the abundant oxygen vacancies created by GO modification, the relatively high specific surface area, and the synergistic effect of the p–n heterostructure. The excellent sensing performance exhibited by GO/8-ZOC materials endows them with significant potential for practical applications in the field of acetylacetone gas sensors.
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ORGANIC PROCESS RESEARCH & DEVELOPMENT
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2025
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IF 3.5
Yong Song,Jinsong Li,Shikang Liu,Bo Jin,Rufang Peng
Although mechanochemical synthesis has gained widespread application, our understanding and enhancement of the control of the reaction need to be improved. In this work, we confirm that the mechanochemical reaction of the active pharmaceutical ingredient dantrolene is controlled by diffusion-controlled kinetics. On this basis, we demonstrate a novel approach to modulate mechanochemical reactivity through a diffusion enhancement strategy mediated by supramolecular interactions. The method employs a highly efficient spiral gas–solid two-phase flow technique, in which urea, an additive that can establish supramolecular interactions with 1-aminohydantoin hydrochloride, is introduced into the reaction system to substantially enhance diffusion, thus facilitating the efficient synthesis of dantrolene. Notably, in this diffusion enhancement process, the weakening of mechanical forces triggers the nucleation and growth of the active substrate to form structurally well-defined eutectic crystals that inhibit the reaction. This strategy reduces the mechanochemical reaction time of dantrolene and its analogs to less than 30 s. In addition, thiourea and acetamide, which are structurally similar to urea, promote the reaction, and their effects correlate with the number of supramolecular sites of action.
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ACS Applied Polymer Materials
·
2025
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IF 4.7
Shaojie Cao,Yufan Chen,Dejun Wen,Runchun Li,Mengdan Zhang,Ao Wang,Haiyan Li,Yan Xiao,Xueliang Xiao
Microscale surface design is pivotal for enhancing iontronic pressure sensors, yet achieving designed architectures through facile fabrication remains challenging. Here, we present an electrospun thermoplastic polyurethane (TPU) dielectric layer featuring dual-scale morphology─surface convexity coupled with tailored porosity. When integrated with solution-processed textile electrodes, this hierarchical fiber-composite structure facilitates superior iontronic sensing. The optimized sensor demonstrates exceptional performance: 0.829 kPa–1 maximum sensitivity across 0–120 kPa, 40 ms response/recovery time, 4 Pa detection limit, and high cycling stability (over 1000 cycles), attributed to synergistic electric double-layer (EDL) effects from patterned dielectric–electrode coupling. Practical applications in continuous physiological monitoring, wearable human–machine interfaces, and spatial pressure mapping validate its robustness. The solution-based fabrication approach underscores the device’s scalability. This work provides a composite design paradigm for high-performance flexible electronics through rational microscale surface design.
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ACS Nano
·
2025
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IF 16
Shujie Li,Houde Wu,Li Guo,Xiaoyi Wang,Gang Shu,Xinxing Li,Shao-Kai Sun
Achieving high resolution while minimizing contrast agent dosage remains a key goal, yet a major challenge in contrast-enhanced computed tomography (CT) imaging. Herein, we propose an artificial intelligence-assisted low-dose high atomic number contrast agent for ultrahigh-resolution CT imaging. As a proof of concept, high-quality PEGylated hafnium oxide nanoparticles (DA-HfO2 NPs) are synthesized, exhibiting superior X-ray attenuation, high hafnium content (36%), excellent water solubility, appropriate hydrodynamic size (13.5 nm), and prolonged circulation half-life (161.9 min). High-dose DA-HfO2 NPs enable extended ultrahigh-resolution vascular imaging with a spatial resolution of 0.15 mm and a time window of at least 60 min. More importantly, by integrating artificial intelligence, the low-dose contrast agent (at 25% of the standard dose) achieves imaging quality comparable to that of the high-dose agent in both contrast density and spatial resolution, while simultaneously enhancing biosafety. This strategy enables high-resolution imaging at reduced contrast agent doses and offers a promising approach for sensitive and safe CT angiography.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Aiqing Sun,Yongxiang Zhang,Jinfeng Zhang,Zhiqian Yang,Mengting Han,Mei Lyu,Yang Huang,Li’e Mo,Jun Zhu,Linhua Hu
The crystallization of perovskite films is highly sensitive to environmental conditions and fabrication processes, often leading to defect formation. Precise control over the ordered crystallization of perovskites is crucial for achieving high-performance perovskite solar cells. In this work, we propose a doping strategy using 6-chloropyridine-3-sulfonamide (6-CPS) to modulate perovskite crystallization. The multifunctional 6-CPS molecule, including the sulfonamide group (−SO2NH2), pyridine ring (C5H5N), and chlorine atom (Cl), enables strong multisite coordination with perovskite components. These unique interactions effectively regulate the perovskite crystallization process, yielding high-quality perovskite films with optimized morphology and reduced defect density. Furthermore, 6-CPS modification improves energy level alignment and enhances the optoelectronic performance of the devices. As a result, the optimized 6-CPS-modified devices achieved a champion power conversion efficiency (PCE) of 24.56%. Notably, the 6-CPS-treated devices exhibit significantly improved stability, retaining 85.44% of their initial PCE after 720 h of accelerated aging under 65 ± 5% relative humidity.
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ACS Applied Polymer Materials
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2025
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IF 4.7
Ji-Dong Liu,Jun Wu,Xinhua Liu,Xiang-Yun Du
Functional helical ionogel fibers have demonstrated considerable promise for use in sensing and smart wearable devices owing to their unique spiral architecture. However, conventional helical ionogel fibers currently encounter several challenges, including complicated preparation processes, insufficient control over the helical morphology, and a suboptimal mechanical performance, which seriously constrains their practical deployment. Here, a series of core–shell helical ionogel fibers are conveniently fabricated by using a coaxial microfluidic spinning technique. The fiber shell consists of poly(vinyl alcohol) (PVA), which is rapidly solidified during the spinning process via solvent exchange. The ionogel core of the fiber is constructed through in situ polymerization of a polymerizable deep eutectic solvent, milk powder, and metal salt (Li+, Tb3+, or Eu3+). The as-prepared core–shell helical ionogel fibers present remarkable flexibility, mechanical strength (6.1 MPa), and elongation (2352%) attributed to the synergistic effect of the PVA shell with high strength and the ionogel core featuring multiple physical interactions (including hydrogen bonds and metal coordination). Notably, the Eu3+-containing ionogel fiber possesses distinct red fluorescence, ion conductivity, and solvent-responsive characteristics. More importantly, the strain-sensing behavior of the fiber enables its application in wearable sensors for monitoring human motion signals. This study explores a feasible solution for fabricating high-strength, stretchable, and functional helical ionogel fibers suitable for application in flexible wearable devices.
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ANALYTICAL CHEMISTRY
·
2025
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IF 6.7
Siyu Yu,Yunshan Zhang,Fang Yang,Xueshuai Wang,Xiao Liu,Zhou Wang,Jing Ye,Jian Chen,Xianzhong Feng,Diming Zhang
The accuracy of single-nucleotide polymorphism (SNP) detection in long sequences is fundamentally constrained by the minuscule thermodynamic differences arising from single-base mismatches, wherein the overall probe binding energy frequently masks single-base-discrimination signals. Here, we develop a plug-and-play competitive hairpin conversion module (CHCM) based on strand-competitive hybridization and toehold-mediated strand displacement. CHCM incorporates two structured hairpin probes (H1 and H2) that specifically recognize wild-type and mutant alleles, respectively. Through thermodynamic competition triggered by single-base variations, the system precisely modulates probe-target binding stability, directing the formation of differential DNA assemblies that convert single-nucleotide information into detectable sequence signals. Critically, CHCM discriminates heterozygous samples with 0.1% mutation abundance in long-sequence backgrounds using only conventional fluorescent probes without enzymatic assistance. Furthermore, CHCM exhibits exceptional technical compatibility: it seamlessly integrates with upstream PCR amplification or downstream catalytic hairpin assembly (CHA) signal amplification while sustaining robust performance. Successful SNP genotyping in soybean leaf genomic DNA validates its practical utility. This work delivers a high-resolution, cost-effective solution for SNP detection in complex matrices and establishes a scalable modular framework for dynamic nucleic acid probe design.
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ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Yongli Shi,Zhaoxin Zhang,Linji Li,Ningning Cao,Liman Zhang,Cuihong Hou,Wei Zhang,Kai Zhang
Porous cyclodextrin polymers (P-CDP) are commonly used for the rapid removal of organic micropollutants from water due to their high specific surface area and mesoporous pores. However, due to the lack of hydrophilic chelating groups at the interface, P-CDP has poor removal performance for heavy metal ions and hydrophilic organic pollutants. In fact, the water resource is often accompanied by a mixture of various types of pollutants (such as organic micropollutants, heavy metal ions, and hydrophilic organic pollutants). Here, we synthesized a multifunctional porous β-cyclodextrin polymer (P-CDP/EDTA) with multiple types of adsorption sites (amino, carboxyl, hydroxyl, cyclodextrin hydrophobic cavities, etc.) by introducing flexible EDTA modifier and rigid benzene ring cross-linking agent. P-CDP/EDTA has high specific surface area (SBET = 76 m2·g–1) and mesoporous pores (1.8–5.0 nm). The adsorption behaviors showed that P-CDP/EDTA can rapidly and high-capacity remove various types of organic micropollutants, hydrophilic organic pollutants, and heavy metal ions from aqueous solutions. P-CDP/EDTA has strong anti-ion interference performance and can effectively remove various types of pollutants at environmentally relevant concentrations through flow-through adsorption experiments. Altogether, P-CDP/EDTA represents promising materials for potential use in the rapid and high-capacity removal of various types of pollutants in water, achieving sustainable water purification.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
He Xu,Yanhao Hu,Mian Wei,Jiahao Wang,Enpei Zhang,Dechao Gu,Chengyu Liu,Jiajun Huang,Youmei Ma,Wei Yan,Jiahai Zhou,Yonghao Ye,He Bo
Dihydroxy acid dehydratase (DHAD) is a promising herbicide target, but no commercial DHAD inhibitors exist yet. The natural product aspterric acid (AA) has been shown to act on DHAD, inspiring us to discover novel cycloheptanone-pyrrole compounds (6aa-6ay) featuring α-hydroxycarboxylate fragments as potential DHAD-targeting herbicides. In Arabidopsis thaliana seed germination assays, most compounds demonstrated 100% inhibition at 200 μg/mL, comparable to that of the positive control penoxsulam. In greenhouse herbicidal activity tests, compound 6ag demonstrated over 85% control effectiveness against Eclipta prostrata, Amaranthus retroflexus, and Setaria viridis at a dosage of 150 g ai/ha, while also showing safety for rice. The binding model of 6ag with DHAD is similar to that of AA with DHAD, and the Kd value of 6ag binding to DHAD is 20 μM, indicating that 6ag acts with DHAD. With both herbicidal efficacy and crop safety, 6ag represents a promising novel lead compound for DHAD inhibitors.
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ACS Applied Polymer Materials
·
2025
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IF 4.7
Menghe Li,Tengfei Guo,Yifei Wang,Chaoxi Wu
Polysaccharide gels consisting of nanofibers offer considerable promise for biomaterials; however, except for bacterial cellulose, nanofiber gels formed by solely natural polysaccharides are still rare. Here, we present a self-assembled polysaccharide nanofiber gel based on Curdlan, exhibiting high elasticity, toughness, and antineuroinflammatory effects. A gelling method, termed phase separation+annealing (PSA), facilitated the formation of Curdlan hydrogels with a dense network of self-assembling nanofibers (∼20 nm in diameter), structurally analogous to natural β-glucan fibrils in fungi. These hydrogels exhibited exceptional mechanical performance with a tensile strength of up to 2.1 MPa and a fracture strain of 361%. Structural and formation analyses via X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, and molecular dynamics simulations demonstrated that the PSA method enabled the hierarchical organization of Curdlan chains into highly ordered triple helices, forming interconnected nanofibers. Additionally, the Curdlan hydrogels with enhanced nanofiber networks (CD-E, where “CD” denotes Curdlan and “E” refers to the annealing-induced enhanced nanofiber structure) exerted antineuroinflammatory effects in a lipopolysaccharide-induced neuroinflammation model by attenuating nitric oxide production, downregulating pro-inflammatory cytokines, and inhibiting iNOS and COX2 expression, while promoting a neuroprotective microglial phenotype via increased CD206 and decreased CD86 expression. These findings shed light onto Curdlan gels and can expand their applications from food additives to biomaterials.
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