TETRAHEDRON-ASYMMETRY
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2010
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IF 2.625
Zhen-Wei Zhang,Gui Lu,Miao-Miao Chen,Ning Lin,Yong-Bo Li,Tamio Hayashi,Albert S.C. Chan
The first asymmetric Mannich-type reaction of methyl isocyanoacetate with N -sulfonylimines catalyzed by cinchona alkaloid derivatives yielded 2-imidazolines with high diastereoselectivities and good enantioselectivities (up to >99:1 dr and 70% ee). This reaction provided a convenient route to access various substituted 2-imidazoline-4-carboxylates and related α,β-diamino acids in high enantiomeric purities.
研究领域:
有机化学
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药物化学
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不对称合成
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催化化学
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生物有机化学
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DOI
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JOURNAL OF MATERIALS SCIENCE
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2023
·Vol. 58
·期 17
·7456-7468
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IF 4.5
Zhang Ning,Wang Zongliang,Zeng Yuqi,Guo Yueming,Wang Liqiang,Liu Jianguo,Wang Yu,Zhang Peibiao
Preformed three-dimensional scaffolds with insufficient mechanical properties, poor surgical performance, and morphological mismatch to defects with irregular shape have shown drawbacks in animal evaluations and clinical applications. This motivates the development of novel injectable systems to ideally fill bone defects, allowing in situ solidification within the host tissues while retaining high initial mechanical strength and appropriate porosity. In this study, an in situ forming scaffold with time-dependent pore formation inspired by the metamorphosis of a butterfly was fabricated by incorporating gelatin microspheres (GMs) into a poly(lactic-co-glycolic acid) (PLGA)-based injectable implant. After optimizing solvent, molecular weight and solution concentration of PLGA matrix, the injectable mixture could be easily injected into both aqueous solution and random-shaped grooves while in situ solidified instantaneously. The injectability enabled an in situ morphological match within an irregular bone defect, providing high initial strength in the early period. The toughness of the injectable implant also allowed them to be easily bent into a ring without breaking. Time-dependent pore formation was accomplished by gradual degradation of GMs, generating appropriate space for tissue ingrowth in the scaffold. It is expected that the injectable in situ forming implant would aid the bone healing process by maintaining initial mechanical support and creating a spatiotemporally evolutionary microstructure during bone tissue regeneration.
研究领域:
生物材料学
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组织工程
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骨科学
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再生医学
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高分子科学
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药物递送系统
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DYES AND PIGMENTS
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2025
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IF 4.2
Tingye Gu,Qing Guo,Dongming Qi,Pu Gao,Weiguo Chen,Zhihua Cui,Sateesh Bandaru
N -hydroxysuccinimide esters (NHS esters) are widely recognized as amine-reactive compounds due to their mild reaction conditions and high efficiency. In this study, NHS ester group was introduced into the dye chromophores to design and synthesize carboxylic acid succinimidyl ester dyes ( CSED s) in red, yellow and blue colors. The CSED s were characterized using high-resolution mass spectrometry, proton nuclear magnetic resonance, and infrared spectroscopy. When the NHS ester group was introduced, UV–vis absorption spectroscopy only slightly affected the molar extinction coefficient and maximal absorption wavelength. Hydrolysis studies demonstrated that CSED s hydrolyzed slowly in acidic environments but quickly in weakly alkaline ones, with near-complete hydrolysis taking place at pH 8.5 after half an hour. It was discovered that CSED s could successfully dye silk fibroin at room temperature in weakly alkaline conditions, producing a high color depth and more than 95 % color fixing. The binding of CSED s to silk fibroin was confirmed through covalent bonds using DMF stripping method and dialysis method. Furthermore, the color fastness of dyed silk fibroin to washing and rubbing was rated above grade 4–5. Compared to commercial dyes, the milder dyeing conditions of CSED s can save energy and did not require a significant amount of salt to promote the dyeing process.
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Sustainable Chemistry and Pharmacy
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2024
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IF 5.5
Xing Zhou,Ping-Yue Wang,Chen-Xi He,En-Jang Liu,Xiao-Hui Yao,Dong-Yang Zhang,Tao Chen
Recently, continuous-fluid catalysis technology has been widely used in biocatalysis. However, the poor stability of the reactor-supported enzyme and expensive manufacturing cost of the reactor restrict its use. Herein, a wood-based bioreactor, β-glucosidase@ zeolitic imidazolate framework-8@delignified wood (β-Glu@ZIF-8@DW), with attractive features was developed. The naturally oriented channels of the xylem-based reactor enable high throughput. The interference of the fluids through the porous inner walls in the directional channels of the xylem-based reactor considerably increased the probability of contact between the substrate and enzyme. Resveratrol with multifaceted biological activities exists in many plants, including Mulberry (Morus spp., Moraceae) and Camellia sinensis and Polygonum cuspidatum (P. cuspidatum) . However, it mainly presents in its glycosylated form (polydatin) rather than as free resveratrol in plant. To improve the acquisition of resveratrol, continuous convert polydatin into resveratrol by a bioreactor is a good strategy. The conversion rate of polydatin using the as-prepared reactor reached 98.98% in 2 h. The uniform distribution of β-Glu@ZIF-8 in the channel increased the stability of the bioreactor with an 80.28% conversion rate after seven cycles. The reactor provided an excellent strategy for continuous catalysis, which can be used for industrial production with low synthesis costs and high mass transfer efficiency. Therefore, it has great potential for commercial applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Dongdong Xu,Zongli Li,Zhennan Deng,Xin Nie,Yihuai Pan,Gu Cheng
Degradation profiles are critical for the optimal application of electrospun polymer nanofibers in tissue regeneration, wound healing, and drug delivery systems. In this study, natural and synthetic polymers and their composites were subjected to in vivo transplantation and in vitro treatment with lipases, macrophages, and acetic acid to evaluate their degradation patterns. The effects of environmental stimulation, surface wettability, and polymer components on the degradation profiles of the electrospinning poly(ε-caprolactone)/silk fibroin (PCL/SF) nanofibers were first evaluated. In vivo degradation study demonstrated that bulk degradation, characterized by the transition from microfibers to nanofibers, and surface erosion, characterized by fusion between the microfibers or direct erosion from both ends of the microfibers, occurred in the electrospun membranes; however, bulk degradation dominated their overall degradation. Furthermore, the degradation rates of the electrospun PCL/SF membranes varied according to the composition, morphology, and surface wettability of the composite membranes. After the incorporation of silk fibroin (SF), the degradation rate of the SF/PCL composite membranes was faster, accompanied by larger values of weight loss and molecular weight ( Mw ) loss when compared with that of the pure poly(ε-caprolactone) (PCL) membrane, indicating a close relationship between degradation rate and hydrophilicity of the electrospinning membranes. The in vitro experimental results demonstrated that enzymes and oxidation partially resulted in the surface erosion of the PCL/SF microfibers. Consequently, bulk degradation and surface erosion coordinated with each other to enhance the hydrophilicity of the electrospinning membranes and accelerate the in vivo degradation.
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DOI
PubMed
高影响因子
RESOURCES CONSERVATION AND RECYCLING
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2025
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IF 10.9
Yusen Wu,Pengcheng Wang,Keyi Lin,Jiaqi Hu,Yonggao Fu,Jie Zhu,Jujun Ruan
The development of sustainable methods for the recycling and disposal of spent lithium-ion batteries (LIBs) has become a research priority. A large amount of waste graphite containing metals, such as Ni, Co, and Cu, was produced in the recycling process of LIBs. It was classified as hazardous waste due to its high metal leaching concentration and requires safe disposal. In this study, the concentration leaching of Ni, Co, and Cu was inhibited to less than 2 mg/L in the toxicity characteristic leaching procedure through the preparation of concrete composite materials. It showed that 1% graphite incorporation can increase compressive strength by 7.75% and stiffness by 4.53% after 7 days of curing. Scenario and cost-effect analysis showed that under the optimistic scenario, the net income of 2400 yuan per ton can be achieved through the disposal subsidy and product income. This study provides a solution with both environmental and economic benefits for the safe disposal of waste graphite and promotes the collaborative development of LIBs recycling and green building materials.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Tao Tian,Yifei Mao,Sheng Gong,Liang Zou,Yizong Huang,Yanshan Cui,Jinchao Wei,Peng Li
Although copper is essential for various functions in the human body, excessive intake can damage the nervous and immune systems. In this study, a new fluorescent covalent organic framework probe (DP-TFPB COF) was first reported. Relying on the rational design, the synthesized DP-TFPB COF demonstrates a distinctive fluorescence enhancement effect upon different solvent induction, achieving a quantum yield of up to 20.5 %. Then, a covalent organic framework-based ratiometric fluorescent system was developed, incorporating blue-emitting carbon dots to leverage the fluorescence energy transfer effect. Blue-emitting carbon dots served as the reference signal, while the DP-TFPB COF acted as the response unit, enabling successful quantitative detection of Cu 2+ . The mechanism study demonstrated that fluorescence quenching occurs through an electron transfer process, wherein the covalent organic framework serves as the electron donor and Cu 2+ functions as the electron acceptor. The developed method demonstrated excellent linearity for Cu 2+ within the concentration range of 0.5 to 200 μM, accompanied by a detection limit of 0.38 μM. The robust recognition capabilities exhibited significant effectiveness in the Cu 2+ analysis within herbal plants. The results correspond closely with those obtained using inductively coupled plasma mass spectrometry, thereby emphasizing its potential applicability in real samples with complex matrix.
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PubMed
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POSTHARVEST BIOLOGY AND TECHNOLOGY
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2025
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IF 6.8
Xiangyu Sun,Yining Cao,Yanxia Wang,Siqi Wu,Trust Beta,Xinchi Shi,Suyan Wang,Daniela D. Herrera-Balandrano,Pedro Laborda
Soybean sprouts are a popular and nutrient-dense traditional food in several countries; thus, they are susceptible to numerous infectious diseases during germination. This study examined the impact of methyl jasmonate (MeJA) at concentrations of 100 and 300 μM on isoflavone levels, antioxidant activities, and disease index against Fusarium sulawense in soybean sprouts. The application of 300 μM MeJA resulted in a 26 % reduction in the disease index of F. sulawense -infected soybean sprouts after 7 d of germination. The isoflavone content in MeJA-treated soybean sprouts increased, particularly on day 5 (7.71–9.57 g kg −1 ). Ten isoflavones were quantified, with genistin (∼1.3 g kg −1 ) being the most abundant and acetyl daidzin (∼0.19 g kg −1 ) the least abundant. On day 5, superoxide dismutase (SOD) and catalase (CAT) exhibited peak levels of 117 and 193 kU kg −1 , respectively, in F. sulawense -infected soybean sprouts when treated with 100 μM MeJA. The total phenolic content (TPC) in MeJA-treated soybean sprouts increased by 2-fold from day 1 to day 7, except for F. sulawense treatment. MeJA boosted the expression of several isoflavone biosynthesis-related genes in germinated soybeans, including PAL , C4H , 4CL , CHS , IFS , and CHI . Collectively, this study suggests that the application of MeJA in F. sulawense -infected soybean sprouts may enhance isoflavone biosynthesis and antioxidant activities.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Yanzhen Lou,Xinxiang Chai,Minglin Ji,Yanfang Sun,Foziljon M. Turakulov,Khaydar E. Yunusov,Guohua Jiang
In this study, a dual-network, dynamically cross-linked composite hydrogel was developed for wound closure and healing. The combined action of dopamine iron coordination reaction and Schiff base linkage between dopamine-modified oxidized hyaluronic acid (OHA) and polyacrylamide (PAM) was employed to form a dual-network, dynamically cross-linked structure in hydrogel. Then viscid germander herb (Vgb) extracted from total saponins was incorporated into the composite hydrogel to fabricate hydrogel wound dressing. The resultant hydrogel wound dressing demonstrated good biocompatibility in accelerating cell proliferation and migration. In vivo results demonstrated that compared with commercial dressings, the resultant hydrogel wound dressing facilitated wound healing on an infected full-thickness skin defect model by upregulating the gene expression of growth factors such as CD-31 and downregulating that of inflammatory factor IL-6. The transcriptomic results revealed that the biological mechanism by which Vgb regulated NF-κB and the innate immune system signaling pathways in the wound closure and healing processes.
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DOI
PubMed
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Chenglin An,Ting Xie,Guangxu Li,Jiangtao Wu,Xiaochun Wu,Wentao Jiang
While non-contact magnetic fields have been widely employed as stimuli for modulating magnetic, electric, and catalytic properties , their direct influence on gas sensing processes remains unexplored. The renaissance of multiferroics , whose surface electric polarization can be magnetically controlled via intrinsic magnetoelectric coupling effect, offers the possibility to manipulate gas sensing properties through magnetic field. Here, we investigated the effect of the external magnetic field on gas sensing performance using the most representative multiferroic material. Our experimental results demonstrate that the Bi 0.92 Dy 0.08 FeO 3 sensors exhibit a non-linear magnetic field-controlled acetone sensing performance. When the Bi 0.92 Dy 0.08 FeO 3 sensor is exposed to a 140 mT magnetic field, its gas response towards 100 ppm acetone rises from 12.7 to 20.3, reaching a 60 % increase. The response time decreases from 53 to 41 s, corresponding to a 113 % increase in reaction rate constant. These improvements are attributed to the magnetoelectric coupling effect, which induces surface uncompensated polarization and enhances domain conductivity, thereby promoting surface oxygen chemisorption and charge carrier transport. Our findings not only advance the fundamental understanding of magnetically tunable gas sensors but also broaden the potential applications of multiferroic materials.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2025
·
IF 3.3
Li Junjie,Liu Kunyi,Kang Kaijie,Zhao Lina,Zhang Banglei,Li Lang,Huang Hai,Jiang Liwen
Fermented salt-free bamboo shoots, a traditional fermented vegetable product, are esteemed in southern China for their unique flavor and aroma. The distinctive taste of these shoots is attributed to the volatile organic compounds (VOCs) and organic acids produced during fermentation. This study explored how organic acids and VOCs change over a 60-day fermentation period. The findings revealed notable variations in pH, total sugars, and organic acids throughout the process. Utilizing GC-IMS (gas chromatography-mass spectrometry) analysis, 65 volatile organic compounds (VOCs) were detected, which comprised alcohols, aldehydes, esters, ketones, and aromatic compounds. The concentration and composition of VOCs changed significantly during the fermentation process. Esters and aldehydes were the predominant VOCs. The changes in organic acids levels were correlated with the production of specific VOCs, indicating complex interactions between organic acids and VOCs during the fermentation process. Employing correlation analysis and OPLS-DA (orthogonal partial least squares discriminant analysis), we identified 14 pivotal volatile organic compounds (VOCs) and organic acids that exert the most significant influence on the flavor profile of fermented salt-free bamboo shoots. This study provides invaluable insights for enhancing both the processing and economic potential of bamboo shoots.
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Small
·
2025
·
IF 12.1
Jing Yang,Ruishu Xu,Haiyan Li,Hongwen Tao,Houen Zou,Wenjun Zeng,Haowen Huang
Gold nanoclusters (AuNCs) exhibit unique physicochemical properties but their functional transitions under external stimuli remain underexplored. This study reveals that ultraviolet (UV) irradiation triggers structural evolution in AuNCs, causing fluorescence loss while activating dual enzyme-mimetic activities. UV-induced particle enlargement and surface restructuring endow AuNCs with peroxidase-like (POD-like) and laccase-like functionalities. The POD-like activity enables sensitive glucose detection in human serum, while the laccase-like capability facilitates simultaneous detection and degradation of phenolic pollutants in wastewater. These light-responsive transformations demonstrate AuNCs' dynamic adaptability, bridging their intrinsic fluorescence and catalytic properties. The findings elucidate photo-regulation mechanisms in nanomaterial functionality, proposing a novel strategy for designing multifunctional nanosystems applicable in biosensing and environmental remediation. This work advances the development of adaptive nanomaterials with programmable features for biomedical and ecological applications.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）