LANGMUIR
·
2025
·
IF 3.9
Jiaqi Xia,Shuangshuang Chen,Zhencai Guo,Cheng Chen,Jing Zhang,Zhiwei Zhang,Lixia Jia
By utilizing the etching reaction between a hydrophobic copper mesh (CuM) and an alkali solution to obtain a superhydrophilic copper mesh (AT CuM), and then only depending on the modification of linoleic acid (LA) at room temperature, a fluorine-free superhydrophobic copper-based material (CuM@Cu(OH)2@LA) was fabricated. Subsequently, a funnel-shaped fog collector was constructed by simple folding for fog collection, which collected 10 400 mg of water with a water-harvesting rate (WHR) of 13.9 mg min–1 cm–2 after 30 min. Meanwhile, the AT CuM was deposited with polydopamine to obtain a photothermal nonfluorinated superhydrophobic copper base material (CuM@Cu(OH)2/PDA@LA). CuM@Cu(OH)2/PDA@LA was folded in the shape of a boat, filled with degreasing cotton, and placed upside down for seawater desalination as the (CuM@Cu(OH)2/PDA@LA)/degreasing cotton photothermal interface evaporation device ([(CuM@Cu(OH)2/PDA@LA)/DC]-PTIED). Thanks to its photothermal effect and superhydrophobic property providing the possibility of desalination, the evaporation device was capable of photothermal heating and floating on the water, achieving an evaporation rate of up to 1.85 kg m–2 h–1 under seawater outdoor simulation test conditions. Condensed water, which was desalinated by [(CuM@Cu(OH)2/PDA@LA)/DC]-PTIED, met the World Health Organization (WHO) drinking water standards. In terms of durability analysis, both products maintained good wettability and performance after continuous 12 h mechanical abrasion, immersion in water, and UV irradiation. As a result, these two copper-based non-fluorine superhydrophobic materials had the advantages of superior performance, a simple preparation path, convenient operation, a mild reaction process, sustainable energy saving, and good application durability, providing a new perspective for the large-scale and low-cost production of freshwater resources in a low-carbon and sustainable way in underdeveloped areas.
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高影响因子
Fishes
·
2023
·Vol. 8
·期 3
·170
·
IF 2.3
Lei Zhang,Peng Shi,Lin Zhang,Yajun Wang,Jilin Xu,Xiaojun Yan,Kai Liao
Ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) are potent hormones mediating food intake according to the nutritional status in fish. However, limited information is available on these genes and their expression in response to nutrition in silver pomfret (Pampus argenteus). A comparison analysis revealed thatghrelinand GLP-1 were relatively conserved in marine fish. PYYa and PYYb shared a low identity and were clustered to different PYY branches.Ghrelin,pyya, andpyybmRNAs were highly expressed in the brain, whileglp-1was highly expressed in the gills and liver. TheghrelinmRNA expression was relatively high an hour post-feeding and decreased after 3 to 72 h of fasting. Theglp-1mRNA expression was increased after 6 to 24 h of fasting. ThepyyamRNA expression was increased after 72 h of fasting, while thepyybexpression remained stable during fasting. The diet with 14% lipid promoted the expressions ofglp-1,pyya, andpyyb, but inhibited theghrelinexpression. Theghrelinexpression in the intestine was increased after palmitic acid, oleic acid (OA), linoleic acid (LA), α-linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) incubation. OA decreased the expression ofglp-1and increased the expression ofpyya. The expression ofpyybwas downregulated by LA, DHA, and EPA. These results suggest the importance ofghrelin,glp-1, andpyyin coordinating food intake in response to fasting, dietary lipid concentration, and fatty acids in silver pomfret.Keywords:ghrelin;glp-1;pyy;fasting;lipid content;fatty acids;silver pomfretKey Contribution:This study provides insight into howghrelin,glp-1, andpyyrespond to fasting, dietary lipid concentration, and fatty acids in silver pomfret.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2023
·
IF 6
Yujie Chen,Ruhui Liu,Jingyan Li,Yanjie Wang,Chunfeng Guo,Xin Lü
1-Oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL) is the most abundant triacylglycerol (TAG) molecule in Chinese human milk. The selectivity of three lipases including Rhizomucor miehei lipase (RML), Thermomyces lanuginose lipase (TL), and Candida antarctica lipase (CALB) in OPL synthesis were evaluated. The effects of different reaction conditions on selectivity were first investigated. Unexpectedly, the three sn -1,3 regioselectivity lipases, also have selectivity for the structure of product TAGs. Compared with symmetric TAGs, lipases had poor selectivity toward asymmetric OPL. Furthermore, molecular simulations were used to deeply understand the molecular factors affecting lipase selectivity. The results showed that hydrophobic interactions, lipases lid domain flexibility, and the stability of hydrogen bonds between lipases and TAGs were the main molecular factors responsible for the selectivity of lipases.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2023
·
IF 4.7
Xi-Ya Liu,Hui-Mei Sun,Yi-Hong Luo,Mao-Ye Li,Hai-Bing Liu,Su Liu
In insects, glutathione S -transferases (GSTs) play a pivotal role in the detoxification of a wide range of pesticides. The cigarette beetle, Lasioderma serricorne , is an economically important pest insect of stored products. Recently, pyrethroid insecticides have been used to control this pest. However, little is known concerning the responses and functions of GSTs in L. serricorne under pyrethroid exposure. In this study, transcriptome sequencing was performed on L. serricorne , and a total of 14 GSTs were identified by retrieving the unigene dataset. Of these, 13 predicted GSTs fell into six cytosolic classes, namely, delta, epsilon, omega, sigma, theta, and zeta, and one was assigned to an “unclassified” group. The GST genes were differentially expressed in various larval tissues and at different developmental stages. Exposure to the pyrethroid insecticide lambda-cyhalothrin (LCT) caused oxidative stress in L. serricorne larvae and led to significantly elevated expression levels of six genes, among which LsGSTe1 was the most upregulated. Recombinant LsGSTE1 protein displayed LCT-metabolizing activity. Furthermore, LsGSTE1 protects cells against oxidative stress. Moreover, knockdown of LsGSTe1 by RNA interference dramatically increased the susceptibility of L. serricorne larvae to LCT treatment. The results from this study provide sequence resources and expression data for GST genes in L. serricorne . Our findings indicate that LsGSTE1 plays a dual role in LCT detoxification by metabolizing the pesticide and by preventing LCT-induced oxidative stress. Thus, the LsGSTe1 gene could be used as a potential target for sustainable management of the cigarette beetle.
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MOLECULAR PHARMACEUTICS
·
2022
·
IF 5.364
Mingyang Zhang,Chunlin Guo,Yifan Miao,Zhonggui He,Chutong Tian,Jin Sun
The oral absorption of paclitaxel (PTX) is restricted by poor solubility in the gastrointestinal tract (GIT), low permeability, and high first-pass metabolism. Lipid carriers, such as a self-microemulsifying drug delivery system (SMEDDS), have been deemed as promising vehicles for promoting oral delivery of PTX. Herein, a lipophilic disulfide-bridged linoleic prodrug (PTX-S-S-LA) was synthesized and efficiently incorporated into SMEDDS to facilitate the oral absorption of PTX. This study mainly aims to evaluate the usefulness of the disulfide-bridged linoleic prodrug incorporated with SMEDDS and provides a new strategy for efficient oral delivery of PTX. The prodrug SMEDDS showed a markedly higher drug loading efficiency (3-fold) compared to that of parent PTX. PTX-S-S-LA SMEDDS significantly increased the drug partition (about 1.9-fold) in the intestinal micellar aqueous phase compared to PTX in the in vitro lipolysis study. Additionally, the gastrointestinal (GI) biodistribution study demonstrated that SMEDDS could enhance the GI biological adhesion and go through the lymphatic system to transport. Moreover, it was found that the reduction-sensitive prodrug (PTX-S-S-LA) has good stability in the GIT, leading to an improved antitumor efficiency without significant GI toxicity. Overall, the PTX-linoleic prodrug (PTX-S-S-LA) in combination with SMEDDS provides a promising way to enable effective oral delivery of PTX.
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FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Yali Li,Yi Zhang,Yibin Zhou,Yufei Zhang,Mingming Zheng
A novel and effective approach based on the two-step ethanolysis-esterification strategy was proposed for the controllable and simultaneous preparation of 1-oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL), 1,3-dioleoyl-2-palmitoyl-glycerol (OPO) and 1,3-dilinoleoyl-2-palmitoyl-glycerol (LPL) with adjustable proportions. Enzymatic ethanolysis of fractionated palm stearin was carried out to yield 2-monopalmitoylglycerol (79.4 ± 0.6 %) with over 91.0 % purity at the optimal conditions. The immobilized Candida sp. lipase (CSL) on octyl-functionalized ordered mesoporous silica (OMS-C 8 ) was applied to re-esterify 2-monopalmitoylglycerol with oleic acid and linoleic acid for the simultaneous production of OPL, OPO, and LPL. The total content in the final products was 81.5 %, with 91.3 % of palmitic acid (PA) content at the sn -2 position. Besides, OPL/OPO/LPL was conveniently prepared with suitable proportions for worldwide infants by adjusting the ratio of acyl donors. This paper provides a novel and effective two-step ethanolysis-esterification strategy for the development of human milk fat substitutes (HMFS).
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Membranes
·
2023
·Vol. 13
·期 1
·61
·
IF 4.2
Olga Yu. Selyutina,Anna V. Mastova,Nikolay E. Polyakov
Anthracycline antibiotics, e.g., doxorubicin, daunomycin, and other anthraquinones, are an important family of antitumor agents widely used in chemotherapy, which is currently the principal method for treating many malignancies. Thus, development of improved antitumor drugs with enhanced efficacy remains a high priority. Interaction of anthraquinone-based anticancer drugs with cell membranes attracts significant attention due to its importance in the eventual overcoming of multidrug resistance (MDR). The use of drugs able to accumulate in the cell membrane is one of the possible ways of overcoming MDR. In the present work, the aspects of interaction of anthraquinone 2-phenyl-4-(butylamino)naphtho[2,3-h]quinoline-7,12-dione) (Q1) with a model membrane were studied by means of NMR and molecular dynamics simulations. A fundamental shortcoming of anthracycline antibiotics is their high cardiotoxicity caused by reactive oxygen species (ROS). The important feature of Q1 is its ability to chelate transition metal ions responsible for ROS generation in vivo. In the present study, we have shown that Q1 and its chelating complexes penetrated into the lipid membrane and were located in the hydrophobic part of the bilayer near the bilayer surface. The chelate complex formation of Q1 with metal ions increased its penetration ability. In addition, it was found that the interaction of Q1 with lipid molecules could influence lipid mobility in the bilayer. The obtained results have an impact on the understanding of molecular mechanisms of Q1 biological activity.Keywords:anthraquinones;NMR;molecular dynamics;lipid membranes
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FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Qiyong Guo,Bo Zheng,Deyi Yang,Ling Chen
The nutritional functions of resistant starch (RS) are closely related to its gut fermentation processes. The aim of this study was to explore the relationship between in vitro digestion and fermentation characteristics of heat moisture treatment induced chestnut starch-lipid (oleic acid; linoleic acid ; maize oil) complexes from perspective of ordered structural changes during simulated digestion process. The results showed the formation of ordered structures differed significantly among three complexes with similar RS content (∼40%), while their ordered structures decreased significantly after digestion. In contrast to chestnut starch, starch-lipid complexes could successfully encourage the production of healthy gut bacteria, and the difference in total ordered structure was the key factor in the generation of total short-chain fatty acids especially propionate during fermentation. Interestingly, correlation analysis found the presence of V-type complex might facilitate the proliferation of acetate-produced microbiota especially Lactobacillus , Lactococcus , and Bifidobacterium to produce acetate. Our findings could provide basic data on the creation of starch-based functional ingredients for optimal gut health.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Jie Zhao,Shuaiqian Wang,Diandian Jiang,Chong Chen,Jie Tang,Igor Tomasevic,Weizheng Sun
The stability behaviors of oxidized SPI emulsions under in vitro gastric conditions and the effects of pepsin diffusion on the proteolysis of emulsions were investigated using a static gastric model and the fluorescence recovery after photobleaching method. Results showed that protein oxidation increased the particle size of droplets and decreased the viscoelasticity of the interfacial layer. Compared to the control group (82.81 m 2 /s), the pepsin diffusivity decreased to 68.52 m 2 /s (7LA + LOX group) due to the space hindrance of oil droplets. After gastric digestion, protein hydrolysates were re-absorbed on the oil–water interface and formed a thick layer, thereby decreasing the size of oil droplets and reducing the contents of free amino acids in gastric digesta. The protein oxidation may affect the adsorption of interfacial proteins and alter the distribution of droplets, decreasing pepsin diffusion and ultimately impairing the emulsion gastric digestion. And this should be considered in the design of emulsion as the controllable delivery system.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Bin Chen,Zining Zhou,Yuze Li,Kok Bing Tan,Youting Wang,Xiaoping Rao,Jiale Huang,Xiaodong Zhang,Qingbiao Li,Guowu Zhan
Herein, biomass-derived activated carbon (bio-AC) was synthesized using rice husk as a biotemplate and natural carbon source. After immobilization of Ni, the supported Ni/bio-AC showed excellent catalytic activity in the pyrolysis of fatty acids to paraffin-based biodiesel in H 2 -free and solvent-free conditions, corresponding to the conversion of 99.6% and a total alkane yield of 95.1%, including 88.9% heptadecane. Based on comprehensive characterizations, the calculated turnover frequency of Ni/bio-AC was 3.9 times that of conventional Ni/AC. Significantly enhanced olefin selectivity was further obtained by N-doping of Ni/bio-AC, which was attributed to the inhibition of -COO* dissociation by the Ni-N sites. The possible catalytic reaction pathways from stearic acid to heptadecane via aliphatic alcohol as a reaction intermediate were investigated. Besides, efficient conversions of saturated and unsaturated plant oils were also achieved over Ni/bio-NAC catalysts in Py-GC/MS through pulsed catalytic pyrolysis manner, showing a promising prospect for sustainable biofuels and chemical production.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2023
·
IF 4.7
Dong Guo,Simin Chen,Weiguang Zhang,Jun Fan
Paclobutrazol is a plant growth inhibitor widely used in agricultural production. However, toxicology studies of paclobutrazol enantiomers towards aquatic organisms are limited. Herein, effects of paclobutrazol and its two enantiomers (2 R , 3 R ; 2 S , 3 S ) on glycolipid metabolism of zebrafish have been systemically explored at the concentration of 10 mg/L through biochemical analyses, LC-MS/MS, molecular dynamics simulation, and gene expression. In all treatments, the contents of glucose, citric acid and lactate significantly were increased while the glycogen and pyruvate contents were decreased, in which (2 R , 3 R )-paclobutrazol exhibited a greater effect than the (2 S , 3 S )-enantiomer ( P < 0.05). Then, activities of hexokinase and lactate dehydrogenase in (2 R , 3 R )-paclobutrazol treatment were 0.74- and 1.18-fold higher than (2 S , 3 S )-enantiomer treatment, respectively ( P < 0.001), and the results of molecular dynamics simulation revealed that the binding free energy of hexokinase 1 to (2 R , 3 R )-paclobutrazol was higher than that to the antipode. Moreover, lipids including triglycerides , total cholesterol , fatty acids, bile acids and glycerophospholipids in zebrafish were strikingly affected after paclobutrazol exposure. The (2 R , 3 R )-paclobutrazol-treated group showed the most obvious changes, indicating that it possessed much stronger disruption ability on the lipid metabolism of zebrafish. Furthermore, qRT-PCR analysis results revealed that (2 R , 3 R )-enantiomer significantly impacted expressions of glycolipid metabolism-related genes ( hk1 , g6pc , pck1 , pk , aco , cebpa , cyp51 , fasn and ppara ) in zebrafish than (2 S , 3 S )-enantiomer ( P < 0.05). Briefly, this study provides new evidences for the toxicity of paclobutrazol to aquatic organisms and the potential risk to human health at the chiral level.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Lijuan Zhu,Wanfeng Hu,Ayesha Murtaza,Aamir Iqbal,Mengjie Kong,Jiao Zhang,Jiaxing Li,Xiaoyun Xu,Siyi Pan
Fresh-cut Chinese water chestnut (CWC) was treated with high pressure CO 2 (HPCD) to inhibit the browning reactions, and the underlying mechanism was investigated in this study. Results showed that HPCD at 2 MPa pressure significantly inhibited lipoxygenase activity and enhanced superoxide dismutase activity, leading to decreased malondialdehyde and H 2 O 2 contents in surface tissue. Moreover, HPCD could reduce total phenols/flavonoids content of surface tissue. Compare with control, homoeriodictyol, hesperetin, and isorhamnetin contents of 2 MPa HPCD-treated samples on day 10 were reduced by 95.72%, 94.31%, and 94.02%, respectively. Furthermore, HPCD treatment enhanced antioxidant enzyme activities, and improved the O 2 – scavenging ability and reducing power of inner tissue. In conclusion, by regulating ROS and membrane lipid metabolism, HPCD treatment with appropriate pressure could retard the biosynthesis of flavonoids and enzymatic oxidation of phenolic compounds in surface tissue, and enhance antioxidant activity of inner tissue, thereby, delaying the quality deterioration of fresh-cut CWC.
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危险品化学品经营许可证（带存储）