Advanced Intelligent Systems
·
2021
·Vol. 3
·期 4
·2000090
·
IF 0
Shengnan Chen,Heng Zhang,Xiangfei Yang,Xiaoguang Shao,Taihao Li,Na Chen,Zhenyi Chen,Wei Xue,Jiahua Pan,Shupeng Liu
Early diagnosis of prostate cancer (PCa) is always a great challenge in clinical practice, especially in distinguishing benign prostatic hyperplasia (BPH) from early cancer, due to the high similarity in pathology from the prostate-specific antigen (PSA) test and radiological detection. The conventional diagnostic methods are often less efficient in specificity and accuracy, leading to quite a few unnecessary biopsies. This work establishes a noninvasive diagnostic method for PCa by investigating urine samples using Raman spectroscopy and convolutional neural network (CNN) algorithm. The results of urine Raman spectra show the intensities of characteristic peaks for lipids, nucleic acids, and some amino acids are distinguishable between PCa and BPH, suggesting an abnormal metabolism caused by PCa, which can be detected by Raman spectroscopy. These data are then used to train an intelligent diagnostic model with CNN algorithm. The cross-validation results show the mean diagnostic accuracy, sensitivity, and specificity for PCa are 74.95%, 77.32%, and 72.46%, respectively. This noninvasive diagnostic method is a promising method for the early diagnosis of PCa, and the idea of using urine Raman spectroscopy with deep learning techniques for diagnosing PCa provides a reference for the application of artificial intelligence in the field of clinical medicine research.
研究领域:
肿瘤学
·
泌尿科学
·
分子诊断学
·
转化医学
·
生物光子学
·
临床化学
·
人工智能医学
✓ 已验证
DOI
Journal of Environmental Chemical Engineering
·
2021
·Vol. 9
·期 4
·105785
·
IF 5.909
Jinjia Guo,Yongmei Wang,Zhao Luo,Feng Zhang,Dewang Yang
Carbon cycle in coastal water is a significant dynamic component of global carbon budget , however, the diverse sources, carbon sinks and their complex interactions remained poorly understood. In order to detect the dissolved inorganic carbon (DIC) and their interactions, gas-liquid Raman spectroscopy was built and applied to simultaneously detect the constituents of air, dissolved CO 2 , HCO 3 - and chlorophyll in coastal water. The linear fitting curve between peak intensity and concentration was built for the quantitative analysis of HCO 3 - and CO 2 , meanwhile, the fluorescence peaks of chlorophyll at 679 nm were detected for the qualitative analysis. For the multi-components analysis, typical Raman spectra of the constituents of air, dissolved CO 2 , HCO 3 - in seawater, and the fluorescence spectra of chlorophyll in seawater were detected. Results showed that the time dependent change of CO 2 and O 2 in the air exhibited a contrary tendency, while that of dissolved CO 2 and O 2 was curved like a cosine. The changing tendency of relative concentrations of dissolved CO 2 was about 2 h earlier than CO 2 in air, due to the life activity of microorganisms driving the gas exchange at the air-sea interface. Furthermore, the study makes a study on the relationship between DIC and chlorophyll based on the detection of HCO 3 - and chlorophyll in coastal water, indicating that this gas-liquid Raman spectroscopy could successfully provide real-time analysis of multicomponent DIC in the air-sea exchanging process.
研究领域:
海洋化学
·
环境光谱学
·
碳循环
·
分析化学
·
生物地球化学
✓ 已验证
DOI
高影响因子
MethodsX
·
2019
·
IF 0
Chengyuan Liu,Zhiwei Liu,Hongkun Niu,Cong Wang,Zhaowen Wang,Bingliang Gao,Jingjing Liu,Mark Taylor
We provide a method for preparation of binder-free cathode for rechargeable aluminum-ion batteries (AIBs). Ultrasonicated natural graphite (u-NG) flakes in N-methylpyrrolidone (NMP) is drop-casted to a carbon fiber cloth (CFC) to obtain binder-free u-GF@CFC cathode for AIBs. We also provide an in-situ Raman spectral technology and the corresponding in-situ Raman cell to determine the mechanism of intercalation/deintercalation reactions of the chloroaluminate ions at cathode of AIBs. The in-situ Raman spectra are recorded using a Raman spectrometer combined with a potentiostat/galvanostat model electrochemical workstation. • A simple preparation method of a binder-free u-GF@CFC cathode is suggested. • The u-GF@CFC cathode is obtained by drop-casting ultrasonicated graphite flakes on the surface and internal gaps of the carbon fiber cloth. • The method includes the in-situ Raman spectral technology and the corresponding in-situ Raman cell.
研究领域:
电化学
·
能源材料
·
纳米材料
·
电池技术
·
原位表征
✓ 已验证
DOI
MICROWAVE AND OPTICAL TECHNOLOGY LETTERS
·
2023
·Vol. 65
·期 5
·1433-1438
·
IF 1.5
Qiu-Shi Liu,Ming-Jiang Ma,Chong Lv,Guo-Qing Yang,Yan-Lei Yang,Jia-Hao Wang,Zhi-Xing Gao,Hong-Yu He,Xiao-Hua Zhang,Yuan-Peng Li,Bao-Zhen Zhao
Spatially offset Raman spectroscopy (SORS) is an important branch derived from conventional Raman spectroscopy. It has the characteristics to realize the concealed component identification covered by opaque and translucent media nondestructively and rapidly. This technology gradually plays an important role in basic and applied research of numerous areas. This paper focuses on the SORS potential application in food quality and safety inspection, and a SORS detection system has been setup. The ingredients of various concealed food additives have been identified by SORS and the optimum offset distance for detection has been obtained. Meanwhile, the identification effectiveness of the system for low-concentration additives in real foods has also been evaluated.
研究领域:
分析化学
·
食品科学
·
光谱学
·
食品安全
·
质量控制
✓ 已验证
DOI
高影响因子
OPTICAL MATERIALS
·
2019
·
IF 2.687
Jiang Wu,Haowen Bai,Wenjie Qu,Guanying Cao,Yanjie Zhang,Jingjie Yu
CsPbBr 3 quantum-dot borosilicate microcrystals and Eu 3+ -doped CsPbBr 3 quantum-dot microcrystals with different concentrations of Eu 3+ are successfully prepared by high temperature melting. The particle morphology of the microcrystals is characterized by scanning electron microscopy (SEM). The fluorescence characteristics are analyzed by fluorescence spectroscopy and CIE chromaticity coordinates . In this research, CsPbBr 3 quantum dots are effectively coated with borosilicate microcrystals to improve the stability of CsPbBr 3 quantum dots while ensuring its strong green emission at 517 nm. The energy transfer from CsPbBr 3 quantum dots to Eu 3+ occurs after doping. When changing the concentration of Eu 3+ , the emission peaks of perovskite broaden and blue shift occurs (517 nm→474 nm). The CIE color coordinate moves from (0.0807, 0.7200) to (0.4537, 0.2724). Therefore, the continuous adjustment of solid perovskite materials from green light to blue light and then to red light region is realized.
研究领域:
材料科学
·
纳米光学
·
无机非金属材料
·
光电子学
·
发光材料
·
固态化学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2016
·
IF 2.653
Xue-Dong Xiao,Lin Shi,Li-Hui Guo,Jun-Wen Wang,Xiang Zhang
The supramolecular interaction between the water-soluble pillar[5]arene (WP[5]) as host and dopamine hydrochloride (DH) as guest was studied by spectrofluorometry . The fluorescence intensity of DH gradually decreased with increasing WP[5] concentration, and the possible interaction mechanism between WP[5] and DH was confirmed by 1 H NMR, 2D NOESY , and molecular modelling. Based on significant DH fluorescence, a highly sensitive and selective method for DH determination was developed for the first time. The fluorescence intensity was measured at 312 nm, with excitation at 285 nm. The effects of pH, temperature, and reaction time on the fluorescence spectra of the WP[5]-DH complex were investigated. A linear relationship between fluorescence intensity and DH concentration in the range of 0.07–6.2 μg mL − 1 was obtained. The corresponding linear regression equation is Δ F = 25.76 C + 13.56 (where C denotes the concentration in μg mL − 1 ), with the limit of detection equal to 0.03 μg mL − 1 and the correlation coefficient equal to 0.9996. This method can be used for the determination of dopamine in injection and urine samples. In addition, the WP[5]-DH complex has potential applications in fluorescent sensing and pharmacokinetics studies of DH.
研究领域:
分析化学
·
超分子化学
·
药物代谢
·
生物分析
·
药代动力学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Dan Wu,Mengnan Hu,Yongyi Zhang,Jing Zhou,Zhaona Wang
Surface enhanced Raman spectroscopy (SERS) is a key nondestructive detecting technology with a broad application demands. However, relative low stability and homogeneity of the SERS substrate hinder its practical applications. Here, a simple and flexible approach is proposed to achieve the arrayed SERS substrates with the periodicity and local randomness by directly growing silver nanoflowers on the patterned wafer fabricated by the optical interference method. By utilizing the hotspot effect of nanogaps within/between the Ag nanoflowers, the SERS substrates demonstrate the low detecting limit of 5 × 10 −10 M and 5 × 10 −9 M in one-dimensional (1D) and two-dimensional (2D) pattern structures for Rhodamine 6G (R6G) probe molecule, respectively. The periodicity assures the fabricated substrate a promising reproducibility and stability. After the 1D array structure is left for 21 days, the intensity of Raman signal of R6G maintains at 80%. Moreover, the proposed method has the advantages of simple preparation, low cost, flexible tunability, and easy-fabrication large scale substrate. The results indicate that the long-range ordered silver nanoflower array structures are promising candidates for the high performance SERS substrate in chemical analysis, medicine and environment monitoring.
研究领域:
分析化学
·
纳米生物技术
·
材料科学
·
环境监测
·
医学检测
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR RECOGNITION
·
2016
·Vol. 30
·期 1
·e2566
·
IF 2.091
Hua-jin Zeng,Min Miao,Ran Yang,Ling-bo Qu
In this study, the fibrillation of hen egg-white lysozyme (HEWL) in the absence and presence of different concentrations of silybin was studied by thioflavin T spectroscopy, Congo red binding assays, 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence assay, circular dichroism, and transmission electron microscopy. The experimental results indicated that not only the fibrillation of HEWL at high temperature (65°C) and low pH (pH = 2.0) could be inhibited effectively by silybin but also the inhibition of HEWL by silybin followed a dose-dependent manner. Molecular docking studies indicated that 2 possible binding modes could be found in the interaction between silybin and HEWL via van der Waals forces and electrostatic forces as well as hydrogen bonding. One of these 2 conformations was directly entered into the cavity of HEWL (binding site I); the other was bound to the surface of HEWL (binding site II). In this way, silybin could not only increase the hydrophobicity of the cavity or the surface of HEWL but also influence the microenvironment of the binding site, which was able to stabilize the structure of HEWL and delay the process of HEWL fibrosis.
研究领域:
生物化学
·
分子生物学
·
蛋白质科学
·
药理学
·
结构生物学
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2015
·
IF 2.288
Zhiyong Mao,Jingjing Chen,Liang Sun,Qifei Lu,Dajian Wang
(Ba,Sr) 3 MgSi 2 O 8 :Eu 2+ , Mn 2+ phosphors with 430/505/660 nm tri-bands or 430/660 nm dual-bands emission were demonstrated in this work by controlling the appearence or not of green emitting intermediate phases, (Ba,Sr) 2 SiO 4 :Eu 2+ . Through varying the stoichiometric amount of SiO 2 in precursor, the coexistence of green emitting intermediate phase tended to be sensitive and diversified. Laser Microzone Raman spectrum was employed to look insight into the lattice stretch and the preferential occupation sites of Ba 2+ ions in Sr 3 MgSi 2 O 8 lattices. The local structure and the crystal field of Eu 2+ luminescent centers were found to be disturbed by distorted arrangement of cross-linked [MgO 6 ] octahedra and [SiO 4 ] tetrahedra. This mechanism approach provided some new insights to further understanding the adjustment strategy of green emitting intermediate phases in (Ba,Sr) 3 MgSi 2 O 8 :Eu 2+ , Mn 2+ phosphor potentially applied as red/blue dual-bands emitting or red/green/blue tri-bands emitting materials.
研究领域:
材料科学
·
无机化学
·
发光材料
·
固体物理
·
光电子学
✓ 已验证
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Zhanshi Ni,Haobo Bi,Chunlong Jiang,Hao Sun,Wenliang Zhou,Zhicong Qiu,Qizhao Lin
Faced with increasingly severe environmental and energy issues, the development and utilization of solid waste have become a trend. In this study, a thermogravimetric-Fourier infrared spectrometer-mass spectrometer (TG-FTIR-MS) was used to carry out the co-pyrolysis experiment of coal slime and cellulose. The samples with mass mixing ratios of 0:10, 1:9, 3:7, 5:5, 7:3, 9:1, and 10:0 were pyrolyzed in N 2 atmosphere. The percentages of mass loss during the pyrolysis of coal slime and cellulose were 15.69 and 94.28%, respectively. The addition of cellulose to the coal slime could significantly improve the pyrolysis performance of the sample. It was detected by FTIR that the pyrolysis of the blends mainly formed C=O-containing compounds. MS was used to monitor the ion current intensity of gaseous products of sample pyrolysis online. The average activation energy of the reaction between coal slime and cellulose calculated by the Kissinger-Akahira-Sunose method were 237.59 kJ/mol and 174.06 kJ/mol, respectively. The principal component 1 and principal component 2 dominated the co-pyrolysis process of coal slime and cellulose. The MAE, RMSE, and R 2 of the artificial neural network prediction model for predicting the pyrolysis process of the sample were 0.5249, 0.8244, and 0.9994, respectively. This research provided basic theory and data support for understanding the co-pyrolysis of coal slime and biomass.
研究领域:
能源化学
·
环境科学
·
热化学转化
·
可再生能源
·
固体废物利用
✓ 已验证
DOI
高影响因子
POLYMER
·
2019
·
IF 3.771
Zongqian Wang,Haiwei Yang,Zun Zhu
Tremendous attention has been paid to the structure and properties of silk fibroin/sodium alginate (SF/SA) composite films . However, there is no report devoted to study the formation of hydrogen bonds and their effects on the structures and properties. Herein, SF/SA blends with different mass ratios were obtained and the technic of Gaussian multi-peaks-fitting of Fourier transform infrared spectrum (FTIR) was used to analyze their hydrogen bonds. From the results, the existence of the intermolecular and intramolecular hydrogen bonds was manifested, and the relative strength of the intermolecular hydrogen bond enhanced with the increase of SA content. The contribution of the intermolecular hydrogen bonding was as follows: OH⋯O (ether) > OH … π > OH⋯N. Meanwhile, the increase of intermolecular hydrogen bonding led to the increase of apparent viscosity of the SF/SA blend solutions. Moreover, the relationship between the hydrogen bond and properties (e.g, crystallinity , thermal stability, mechanical properties, morphology and etc.) of SF/SA composite films with different mass ratios were analyzed in detail.
研究领域:
高分子材料
·
生物材料
·
纤维科学
·
光谱分析
·
材料物理
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
·Vol. 43
·期 16
·14176-14182
·
IF 2.986
Lin Wang,Benxue Liu,Luyi Zhu,Yongshuai Xie,Yadong Lv,Chonghe Xu,Xiaotong Jin,Xinqiang Wang,Guanghui Zhang,Dong Xu
Polyaceticzirconium (PEZ) sol, which is the precursor of zirconia (ZrO 2 ) continuous fibers, has been synthesized by means of the reaction between zirconium oxychloride octahydrate (ZrOCl 2 ·8H 2 O) and potassium acetate (CH 3 COOK) in methanol. The polymeric structures and the rheological behaviors of the sols with different molar ratios of ZrOCl 2 ·8H 2 O/CH 3 COOK are different and would affect the spinnability and stability significantly. Herein, the polymeric structures and rheological behaviors of the PEZ sols with the molar ratios of 1:1, 1:1.5, 1:1.8 and 1:2 were investigated by Fourier transform infrared (FT-IR), 1 H nuclear magnetic resonance spectrum ( 1 H-NMR), thermogravimetry and differential thermal analysis (TG/DTA) and rheological measurements. The results showed the carboxyl group acted as a chelating ligand instead of bidentate ligand, and the water molecule coordinated to Zr 4+ was deprotoned gradually with the decrease of the molecular ratios. The different polymeric structures lead to a different rheological behaviors of the sols. It is divided into three types, the Newton fluid with a low viscosity produced by the charged linear polymeric structures, the shear thinning fluid with a high viscosity produced by the three-dimensional polymeric structures and the shear thinning fluids with a proper viscosity produced by the linear twining polymeric structures. Through the experimental guidance, we successfully synthesized a sol with suitable viscosity and stability, and used it to fabricate high quality ZrO 2 fibers.
研究领域:
材料科学
·
无机化学
·
高分子化学
·
纤维工程
·
溶胶-凝胶技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）