JOURNAL OF CHROMATOGRAPHY A
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2026
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IF 4
Zongkai Li,Xiaoqing Wang,Qianqian Wang,Zhi Li,Qiuhua Wu,Chun Wang
Endocrine-disrupting bisphenols as endocrine disrupting chemicals present significant risks to the human endocrine system. Developing accurate and highly sensitive methods for detecting trace levels of bisphenols in food is crucial to ensure food safety and prevent health risks. Herein, a hydroxyl-functionalized covalent organic framework (TD-COF) was synthesized using 4,4′,4′'-triaminotriphenylmethane and 3,3′-dihydroxy-[1,1′-biphenyl]-4,4′-dicarbaldehyde as monomer. TD-COF demonstrates superior adsorption ability for bisphenols compared with hydroxyl-free COF, which can be primarily attributed to the presence of hydrogen bonding and π-π interactions. By combining high performance liquid chromatography-mass spectrometry and solid phase extraction technology based on TD-COF, a method for analyzing four bisphenols in river water and chicken was established. Under optimal conditions, the method exhibits a low detection limit (river water: 0.03-0.15 ng mL -1 , chicken: 1.4-3.5 ng g -1 ), satisfactory spiked recovery (river water: 87.0-107%, chicken: 88.5-105 %) and good relative standard deviations (river water: 4.5-6.5%, chicken: 4.0-5.7%).
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2026
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IF 9.2
Yanbin Wang,Liling Wang
In Fenton-like reactions, enhancing the activation efficiency of peroxymonosulfate (PMS) is a critical factor for generating diverse reactive oxygen species, but improving PMS adsorption capacity and accelerating electron transfer remain major challenges to boost reaction kinetics. This study designed and synthesized a novel copper-palladium (Cu-Pd) bimetallic spinel oxide, where Pd doping into spinel-structured and layered copper oxides effectively generated a substantial number of oxygen vacancies and precisely regulated the electronic structure–two core factors that dominate PMS activation efficiency. A key finding of this work is that electron delocalization at highly active Cu-Pd sites, coupled with abundant oxygen vacancies, enables rapid PMS activation and significantly promotes the cycling efficiency of Pd 2+ /Pd 0 and Cu 2+ /Cu + at the catalyst interface. In the Cu 2 PdO 3 /PMS system, the degradation efficiency of bisphenol A (BPA) reached 100% within 5 min, with a corresponding rate constant of 0.501 s −1 , which was 11.65 and 22.77 times higher than those of pure Pd oxide and Cu oxide, respectively. The integration of experimental characterization with density functional theory (DFT) calculations reveals that oxygen vacancies and electron transfer are the primary catalytic mechanisms: the pronounced electron delocalization at Cu/Pd sites facilitates the adsorption of ∗HSO 5 /∗OH intermediates on the “metal-Vo bridge” structure. This study provides a representative case and for spinel oxides-based PMS activation, offers novel insights into the regulatory roles of oxygen vacancies and electron delocalization, and lays critical references for the development of advanced environmental remediation catalysts.
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JOURNAL OF MOLECULAR STRUCTURE
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2026
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IF 4.9
Chen Su,Haimei Yang,Hanqian Ye,Yanhong Zheng,Lujian Mo,Zetong Song,Jingyao Wei,Yuan Sun,Haimei Huang,Zhongsheng Yi
The G protein-coupled estrogen receptor (GPER), widely expressed across human tissues, modulates key physiological processes and associated signaling pathways. Bisphenol A (BPA), a global high-production-volume chemicals, finds extensive use in diverse industrial applications. In this study, we employed an integrated approach of multispectral analysis and molecular simulations to systematically investigate the interaction mechanisms between GPER and bisphenol compounds (BPs), with BPA as a representative. Molecular docking predicted stable binding of BPs within the active pocket of GPER. Solvent-accessible surface area (SASA) analysis revealed an increase in both hydrophobic and hydrophilic surfaces upon BPs binding, indicative of alterations in the protein's microenvironment. Fourier transform infrared (FT-IR) spectroscopy further confirmed that BPs binding induces rearrangement in the secondary structure of GPER. Molecular dynamics simulations revealed an overall structural contraction of GPER upon ligand binding, a conformational change independently corroborated by three-dimensional fluorescence spectroscopy. Energy transfer distance measurements yielded binding distances ranging 2.20 from and 2.80 nm. Notably, the more compact BPF showed the closest proximity, whereas the flexible-chain analog BPE exhibited the farthest, underscoring how substituent structure dictates binding localization. Thermodynamic analysis highlighted the significant roles of hydrogen bonding and hydrophobic interactions. Complementarily, Molecular Mechanics/Poisson-Boltzmann Surface Area (MM-PBSA) and interaction region indication (IRI) analyses pinpointed van der Waals forces as a major contributor to complex stability. Collectively, our integrated findings decipher the molecular-level interaction mechanism between BPs and GPER. This work provides a theoretical foundation for assessing the endocrine-disrupting potential of bisphenol compounds and aids in the rational design of safer alternatives.
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FOOD CHEMISTRY
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2023
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IF 8.8
Yukun Yang,Xiaoxing Zeng,Yu Tian,Xiaomin Wang,Xu Jing,Ligang Yu,Baoqing Bai,Jinhua Zhang,Shu Qin
A universal design of turn-on fluorescent aptasensor based on aptamer functionalized gold nanoparticles (AuNPs) and luminescent metal–organic frameworks (LMOFs) complex (AuNPs-Apt/NH 2 -MIL-125(Ti)) was realized for bisphenol A (BPA) detection. LMOF NH 2 -MIL-125(Ti) was prepared using facial hydrothermal method. BPA aptamer functionalized AuNPs were prepared and adsorbed on the surface of NH 2 -MIL-125(Ti) to obtain platform of the fluorescent aptasensor. The fabrication process, sensing performance and applicability of the proposed aptasensor were characterized and investigated carefully. Linear detection range of the constructed aptasensor was from 1 × 10 –9 mol L –1 to 1 × 10 –4 mol L –1 with good selectivity, repeatability, stability and reproducibility under optimal experimental conditions. Meanwhile, the fluorescent aptasensor was successfully utilized for BPA detection in real samples with the recoveries of 95.80%-103.12%. The proposed aptasensor based on AuNPs-Apt/NH 2 -MIL-125(Ti) holds significant potential for BPA detection in environmental and food samples, promoting the construction and application of LMOFs-based aptasensor.
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SENSORS AND ACTUATORS B-CHEMICAL
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2023
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IF 8.4
Jizhong Wu,Wenya Wei,Muhammad Zareef,Shuhua Li,Qin Ouyang,Quansheng Chen
Bisphenol A (BPA) is an endocrine disrupting chemical having estrogenic properties that can enter the body through leaking from food containers or the food chain. An upconversion nanoparticle-based aptasensor integrated with microfluidic chip was simply designed to achieve the determination of BPA in foodstuff. Core-shell structured upconversion nanoparticles with 6.41-fold luminescence enhancement were used as fluorescence donors and gold nanoparticles as fluorescence acceptors to construct fluorescence resonance energy transfer (FRET) system. The BPA aptamer serves as a link between the building of the FRET system and the BPA-specific recognition component. The fishbone-structured microfluidic chip only needs 0.5 μL sample solution and 4 min to determine the presence of BPA. The proposed method has good linearity for BPA in the range of 0.02–100 ng/mL with calibration curve of y = 0.0918 x + 0.6477 and limit of detection of 0.014 ng/mL. It is tremendously competitive to perform on-chip analysis that enables microsampling and rapid determination.
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ENVIRONMENTAL POLLUTION
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2023
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IF 8.9
Rongqing Chen,Yunjia Liu,Jinlan Weng,Hua Huang,Xiaoying Gao,Zhipeng Wang,Jian Liu
The alteration of agricultural wastes into novel adsorbents can stimulate their scalability in realistic application, showing great economic and environmental advantages. Here, we proposed a strategy to engineer rice husk (RH) with microporous melamine-formaldehyde networks (MFNs) resins and the utilization for dynamic removal of organic micropollutants rapidly and efficiently. was pre-treated to acquire attractive surface and unique hierarchical porosity, endowing with surface functionalization and essential filtering properties. MFNs can be uniformly generated in-situ on the fully exposed cellulose backbones of the pre-treated RH. MFNs granules functionalized RH (RH@MFNs) exhibited high removal efficiencies over 90% within 30 min for the adsorption of hazardous organic compounds ( e.g., phenolic and antibiotic micropollutants) in static tests. Experiment results and density functional theory (DFT) simulation revealed that the synergy of hydrogen bonding, π-πinteraction, and micropore preservation dominates the adsorption. Further dynamic adsorption experiments showed that the removal efficiency and equilibrium removal capacity towards bisphenol A by RH@MFNs packed bed up-flow column were 2.6 and 67 times higher than that of raw RH, respectively. The column adsorption fits well with the Thomas model and bed depth service time (BDST) kinetic model. The inherent macropores inside RH and the roughness caused by the spiky structures and mesopores outside RH, as well as the accumulated MFNs granules, can lead to local turbulence of water flow around RH@MFNs, enabling fast and efficient adsorption. This sustainable and cost-effective preparation of RH-based adsorbents sheds light on the rational design of biomass waste adsorbents for realistic wastewater.
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TALANTA
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2023
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IF 6.1
Qingying Wang,Lianfang Chen,Xiaoyan Cui,Jie Zhang,Yaohui Wang,Xiupei Yang
Herein, a covalent organic framework (COF) was grown on a magnetic metal-organic framework (MOF) by a solvothermal method for the efficient extraction of bisphenols (BPs). The magnetic solid-phase extraction (MSPE) of four bisphenols (bisphenol A, bisphenol B , bisphenol AF and bisphenol C) was carried out without adjusting the pH and salt concentration. When 30 mg Fe 3 O 4 @NH 2 -MIL-88(Fe)@TpPa was used to adsorb for 25 min, 6 mL methanol was used to elute for 20 min, and the extract was detected by high-performance liquid chromatography (HPLC). The proposed method has a low detection limit of 0.011–0.036 ng mL −1 , a wide linear range of 0.05–100 ng mL −1 , and a correlation coefficient (R 2 ) of 0.9980–0.9998. The intra-day and inter-day precisions are 0.74–2.54% and 1.68–3.72%, respectively. Bisphenol A was determined by applying the proposed method to the determination of actual milk samples. The standard addition experiment showed that the relative recovery of the four bisphenols was 85.70–119.7%. Pseudosecond-order, first-order, Langmuir and Freundlich models were applied to explore the adsorption characteristics of Fe 3 O 4 @NH 2 -MIL-88(Fe)@TpPa. In general, the established Fe 3 O 4 @NH 2 -MIL-88(Fe)@TpPa-MSPE-HPLC-UV method exhibits attractive sensitivity, simple manipulation, and excellent reusability, and it has excellent prospects for the detection of trace BPs in complex milk matrices.
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CHEMICAL ENGINEERING SCIENCE
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2023
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IF 4.7
Qiuhui Xu,Wenxiang Zhang,Quan Chi,Yuhang Yang,Xi Tan,Jikai Liu,Huaming Xiao,Xian Wang
Endocrine disrupting chemicals (EDCs) are pervasive emerging pollutants found in environmental water, stemming from their widespread use in personal consumer products. This study presents a novel magnetic Porous organic cage (POC) material, Fe 3 O 4 -COOH@CC3R-OH, which has been proven to be highly effective in eco-friendly eliminating EDCs. Featuring a tetrahedral morphology with core–shell structure, the new magnetic adsorbent boasts a substantial Brunauer-Emmett-Teller surface area of 94.02 m 2 /g and a particle pore size of 1.14 nm. Rigorous optimization of adsorption conditions for eight specific EDCs was conducted, complemented by insightful molecular docking simulations shedding light on the adsorption mechanisms. Furthermore, the developed Fe 3 O 4 -COOH@CC3R-OH magnetic solid phase extraction-assisted high performance liquid chromatography-tandem mass spectrometry (MSPE-HPLC-MS/MS) method exhibits good sensitivity and precision in the quantitative detection of EDCs in environmental water samples. This integrated approach provides a robust platform for both efficient removal and accurate detection of EDCs, advancing water quality control and safeguarding human health.
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JOURNAL OF CHROMATOGRAPHY A
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2023
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IF 4.1
Yuting Zhang,Lin Hao,Jie Li,Weihua Liu,Zhi Wang,Qiuhua Wu,Chun Wang
Amine-functionalized porous organic polymers (EDA-POP-PC and EDA-POP-BT) were prepared by post-modification of POP-PC and POP-BT with ethylenediamine (EDA) for the first time. The POP-PC and POP-BT were obtained through Friedel-Crafts acylation reaction of potassium tetraphenylborate with p -phthaloyl chloride (PC) and 1,3,5-benzenetricarbonyl trichloride (BT), respectively. The EDA-POPs exhibited superior adsorption capacity for phenolic endocrine disrupting chemicals (EDCs). After magnetically functionalization, the obtained M-EDA-POP-PC was employed as a magnetic adsorbent for enrichment of phenolic EDCs from real samples prior to high performance liquid chromatography-ultraviolet detection. The current strategy showed low detection limits (S/ N = 3) of 0.02–0.07, 0.04–0.08 and 0.04–0.10 ng mL −1 for river water, white peach juice and lychee juice, respectively. The method recoveries were 81.7%–115% with relative standard deviations below 8.6%. The proposed strategy showed good practicality for sensitive determination of phenolic EDCs in real samples.
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ANALYTICA CHIMICA ACTA
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2023
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IF 6.2
Yang Liu,Xueping Dang,Huaixia Chen
A molecularly imprinted polymer (MIP) monolithic column was prepared in situ in a pipette tip using phenol and bisphenol A as dual templates, 4-vinyl pyridine and β -cyclodextrin as bifunctional monomers . It was used for the selective and simultaneous solid phase extraction of eight phenolics, including phenol, m-cresol, p-tert-butylphenol, bisphenol A, bisphenol B, bisphenol E, bisphenol Z, and bisphenol AP. The MIP monolithic column was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy , thermogravimetric analysis and nitrogen adsorption experiment. The results of selective adsorption experiments showed that the MIP monolithic column can selective recognize the phenolics and have excellent adsorption property. The imprinting factor for bisphenol A can be as high as 4.31, and the maximum adsorption capacity for bisphenol Z can reach 201.66 mg g −1 . Under the optimal extraction conditions, a selective and simultaneous extraction and determination method for eight phenolics was established based on the MIP monolithic column and high-performance liquid chromatography with ultraviolet detection. The linear ranges (LRs) of the eight phenolics were 0.5–200 μg L −1 , the limits of quantification (LOQs) and detection (LODs) were 0.5–2.0 μg L −1 and 0.15–0.67 μg L −1 . The method was applied to detect the migration quantity of the eight phenolics from polycarbonate cups and had satisfactory recovery. The method has the advantages of simple synthesis, short extraction time, as well as good repeatability and reproducibility, which provides a sensitive and reliable strategy for extracting and detecting phenolics from food contact material.
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MICROCHEMICAL JOURNAL
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2022
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IF 5.304
Yan Wu,Panpan Cao,Yanhao Jiang,Yanjuan Liu,Yuefei Zhang,Wei Chen,Zhengwu Bai,Sheng Tang
Nowadays, the efficient detection of environmental organic pollutants has been a research focus in the field of chromatographic analysis . In this work, aminopropylimidazole was designedly introduced to adjust the hydrophobicity of the long-chain alkyl group , and a novel chromatographic stationary phase for the separation and analysis of environmental organic pollutants was specially prepared. Specifically, the waste aminopropyl silica gel (5 μm) was first recycled as the raw material, which was calcined at high temperature and then acidified with hydrochloric acid solution to obtain the activated silica gel. Afterwards, a new type of aminopropylimidazole/dodecyl dual-functionalized silica stationary phase (Sil-API-DD) was synthesized via one-pot reaction of the activated silica gel with 3-chloropropyltrimethoxysilane, dodecyltrimethoxysilane and 1-(3-aminopropyl)imidazole. The separation performance of Sil-API-DD was evaluated using environmental organic pollutants as the model analytes, and the results showed that an effective separation of seven alkylphenols, five bisphenols , six phthalates , seven steroid hormones and six benzophenones in reversed-phase chromatography was achieved. Moreover, the developed Sil-API-DD was found to exhibit more flexible selectivity and superior separation efficiency compared with the commercial C18 column under the tested conditions, suggesting a good application prospect.
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MICROCHEMICAL JOURNAL
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2022
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IF 5.304
Wenjing Wang,Fei Zhai,Fupei Xu,Min Jia
Novel enzyme-free amplified dual-terminal labeled split aptamer (SPA) probes were developed to achieve one-step rapid and sensitive detection of bisphenol A (BPA). By rational split, the original aptamer was divided into two segments named SPA-a and SPA-b to achieve target-driven self-assembly and form BPA/SPA complex. To achieve enzyme-free signal amplification and improved sensitivity, SPA probes were dual-terminal labeled with 6-carboxyfluorescein (FAM) fluorophores and black hole quencher 2 (BHQ 2 ). Two dual-terminal labeled SPA probes were induced to assemble a ternary complex with BPA to produce fluorescence resonance energy transfer effect, generating the decreased fluorescence intensity. The detection limit of dual-terminal labeled SPA probes was 0.89 ng/mL, which was 24-fold lower than that of single-terminal modification. Meanwhile, these SPA probes showed a rapid response to BPA, which could be completed in 5 min for one-step detection without complex cleaning and separation progress. The recovery rates in real samples were 94.17% to 107.28%. In brief, the dual-terminal labeled SPA probes showed substantial potential for onsite detection of BPA.
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