CHROMATOGRAPHIA
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2018
·Vol. 82
·期 3
·683-693
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IF 1.401
Shen Chen,Wu Tong,Zang Xiaohuan
In this work, a zeolitic imidazolate framework-based graphene oxide composite (ZIF-8@GO) was prepared and used as the adsorbent in hollow fiber stir bar sorptive extraction. The stir bar was constructed of a small section of hollow fiber filled with 5 mg ZIF-8@GO and a thin stainless wire of 1.5 cm long in its lumen, and used to extract the trace levels of phthalate esters from children’s food samples prior to gas chromatography–mass spectrometric detection. The ZIF-8@GO showed a high adsorption efficiency for the compounds containing aromatic rings. The main experimental parameters that can impact the extraction efficiency including extraction temperature, extraction time, stirring rate, sample salinity, and desorption conditions were investigated. Under the optimized conditions, the limits of detection (LODs) for the five phthalate esters (diethyl phthalate, dipropyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, and di(2-ethylhexyl) phthalate) were 0.15–0.6 µg L −1 for CiCi beverage and pear juice samples, and 0.75–2.2 µg kg −1 for jam samples. The limits of quantitation (LOQs) were 0.5–2.0 µg L −1 for CiCi beverage and pear juice samples, and 2.5–7.5 µg kg −1 for jam samples. Wide linear ranges of 0.5–500.0 µg L −1 and 2.5–2000 µg kg −1 were obtained for CiCi beverage, pear juice samples and jam samples, respectively, with good repeatability (RSD < 11%) and high method recoveries (72%–100%). The lifetime test results showed that the ZIF-8@GO-based hollow fiber stir bar can be reused for 120 extraction cycles without a significant loss of extraction efficiency, indicating its high durability and stability. The established method was applied successfully for the determination of the phthalate esters (PAEs) in children’s food samples. Graphical abstract
研究领域:
分析化学
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食品安全
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环境毒理学
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暴露科学
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食品化学
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污染物检测
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JOURNAL OF MEMBRANE SCIENCE
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2018
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IF 6.578
Junbin Liao,Jiajie Zhu,Shanshan Yang,Nengxiu Pan,Xinyan Yu,Chao Wang,Jun Li,Jiangnan Shen
Developing highly ion conductive and desirable electrodialysis (ED) performance anion exchange membranes (AEMs) is of great significance. In this work, we report a strategy for fabricating novel AEMs based on a series of fluoro-methyl poly(arylene ether ketone)s having long-side-chain imidazolium groups for ED. Having hydrophilic conductive flexible side-chain imidazolium groups and rigid hydrophobic backbone within AEM matrix, the optimized AEM (PAEK-60-im) shows low water uptake of 24.9% at 80 °C and desirable ion conductivity of 22.01 mS cm –1 at 30 °C. In NaCl removal application of ED, PAEK-60-im shows the NaCl removal ratio of 69.66% within 120 min, outperforming commercial AEM-Type II (68.98%). Accordingly, it has a higher current efficiency of 83.7% but lower energy consumption of 5.9 kWh kg –1 , compared with the commercial one (82.0%; 6.6 kWh kg –1 ). In particular, in selectrodialysis application, possibly owing to the synergistic effect of pore-size sieving effect resulting from macro-separation morphology and hydration energy difference of SO 4 2– ions (–1000 kJ mol –1 ) and Cl – ions (–317 kJ mol –1 ) in feeding solution, PAEK-60-im shows significantly superior monovalent anion perm-selectivity (Cl − /SO 4 2− ) of 7.70 at 30 min, relative to commercial anion-selective Neosepta ACS (5.27) and many other reported mono-valent anion selective AEMs having elegant surface modified layers. The superior ED performance of the homogeneous PAEK-60-im is suggestive of its potential separation application.
研究领域:
材料科学
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化学工程
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电化学
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膜技术
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TALANTA
·
2018
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IF 4.244
Yucan Che,Hongyu Pang,Huiyu Li,Lei Yang,Xinyao Fu,Shiqi Liu,Lan Ding,Juan Hou
Fluorescent carbon quantum dots are emerging as a new class of fluorescent probes due to their unique optical properties . Herein, we presented a simple, one-pot and effective preparation strategy for copper-functionalized carbon quantum dots (Cu-CDs). The Cu-CDs demonstrated excitation-independent emissions, high fluorescent quantum yield (~ 24.4%) and excellent fluorescent stability. The fluorescence of Cu-CDs could be quenched efficiently in the presence of histidine (His) due to the coordination occurring between surface Cu and imidazole side chains of His. Thus, the Cu-CDs could be used as an efficient fluorescent probe for His detection. Under optimal conditions, the fluorescent signals of Cu-CDs decreased linearly with the concentrations of His over a range of 0.1–15 µM. The detection limit was 30 nM. The proposed method provided obvious advantages of rapid response, convenience, simplicity, high selectivity and sensitivity. Moreover, good results also have been obtained for His detection in real biological fluid samples.
研究领域:
材料科学
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分析化学
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生物化学
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PubMed
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JOURNAL OF MEMBRANE SCIENCE
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2025
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IF 9
Ning Liu,Jie Wang,Huiyu Yang,Fan Cheng,Shuguang Bi,Guoliang Liu,Ying Ou,Hai Liu,Chunli Gong
In order to improve the proton conductivity, CH 3 OH barrier performance and long-term durability of proton exchange membranes in direct methanol fuel cells (DMFCs), herein, a novel functional nanofiber substrate (IL-ZIF-8@PVDF) was prepared by in situ growing metal-organic framework (ZIF-8) on poly(vinylidene fluoride) (PVDF) nanofibers, followed by modification with ionic liquid (IL) containing sulfonic acid groups. PVDF nanofibers can provide flexible mechanical support for ZIF-8, thereby effectively solving the processing difficulties of ZIF-8 caused by its brittleness. Further IL modification of ZIF-8 can not only increase the compatibility between ZIF-8@PVDF and the filling polymer, but also utilize the continuous PVDF nanofiber network to establish long-distance continuous H + transport pathways within the membrane. The as-prepared sulfonated poly (ether ether ketone) impregnated IL-ZIF-8@PVDF composite membrane showed a very high proton conductivity of 161.92 mS cm −1 (80 °C). Meanwhile, the presence of nanofiber backbone and ZIF-8 inside the membrane effectively limited the swelling and methanol permeation. The peak power density (PPD) of the DMFC output equipped with the membrane is up to 114.86 mW cm −2 (2 M methanol, 80 °C), 1.28 times that of the commercial Nafion 211. The durability test suggested that the composite membrane assembled DMFC possessed excellent open circuit voltage stability (only 6.3 % attenuation after 320 h of continuous testing). This work provides a new design idea for PEMs for DMFCs.
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Advanced Materials Interfaces
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2026
·
IF 4.5
Chunmin Jia,Yimin Lei,Hong Xu,Xin Meng,Yuxiang Wei,Peixian Li,Xiaohua Ma,Yue Hao,Xiaohui Jia
Programmed death-1 (PD-1) is a key biomarker for monitoring therapeutic response and resistance in non-small cell lung cancer (NSCLC) immunotherapy. Achieving highly sensitive, real-time detection of PD-1 is crucial for early prediction of treatment resistance and disease recurrence. However, current methods such as ELISA suffer from limitations in sensitivity, speed, and cost. To address these challenges, we develop a label-free biosensor based on semiconducting single-walled carbon nanotube field-effect transistors (CNT-FETs). The sensing interface is designed by wrapping s-SWCNTs with poly[9-(1-octylnonyl)-9H-carbazole] (PCz), enabling immobilization of anti-PD-1 antibodies via cation-π interactions. XPS analysis confirms antibody immobilization via reversible binding energy shifts in C 1s and N 1s spectra upon salt treatment, consistent with cation-π interactions, further validated by NaCl and imidazole competition assays. Using this strategy, the sensor achieves a detection limit of 8.39 fg/mL for murine PD-1—three orders of magnitude lower than ELISA, along with good specificity and favorable regeneration capability. In human serum, it shows promising performance, with 12 out of 14 NSCLC patient samples (85.7%) exhibiting good linear correlation. With rapid response, low cost, and simple operation, this platform offers a reliable strategy for point-of-care PD-1 monitoring during NSCLC immunotherapy.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Xiao-Hui Wang,Yue-Han Qin,Xue Xiao,Yu Chen,Shu-Ni Li
Histidine-functionalized Cu 2 O effectively stabilizes Cu + species under cathodic conditions. • The histidine functionalization enhances the co-adsorption of *CO and *NO x intermediates. • The formation of an interfacial hydrogen-bond network on the catalyst surface accelerates proton transfer kinetics. • The histidine-functionalized Cu 2 O catalyst achieves a high urea Faradaic efficiency alongside a notably high yield rate. Electrocatalytic C-N coupling for urea synthesis from CO 2 and nitrate (NO 3 - ) offers a sustainable alternative to the energy-intensive industrial process. Copper (Cu)-based catalysts are uniquely capable of activating both CO 2 and NO 3 - ; however, the catalytically active Cu + species is prone to over-reduction to Cu 0 under cathodic conditions, leading to poor selectivity and instability. Herein, we report a histidine-functionalized Cu 2 O nanospheres (His-Cu 2 O NSs) that stabilize Cu + under operating conditions. The preserved Cu + electronic structure promotes synchronized adsorption of *CO and *NO x intermediates, while protonated amino groups construct a hydrogen-bonded interfacial water network that accelerates proton transfer. As a result, the optimized catalyst achieves a urea Faradaic efficiency of 42.3% and a yield rate of 41.9 mmol h −1 g −1 at −1.1 V potential, with exceptional stability over 100 h in both H-type and flow cells. In situ spectroscopy and density functional theory calculations reveal that histidine coordination not only enhances *CO adsorption but also lowers the energy barrier for C-N coupling, thereby accelerating C-N bond formation. Meanwhile, the in-situ EXAFS results indicate that Cu + species can effectively be retained after histidine modification. This work establishes a molecular-level design principle for regulating complex multi-reactant electrocatalysis and provides a versatile strategy for promoting efficient C-N coupling reactions. Download: Download high-res image (156KB) Download: Download full-size image Functionalizing Cu 2 O nanospheres establishes a generalizable stabilization-via-delocalization principle providing a blueprint for designing durable organic-inorganic interfaces for electrocatalytic urea synthesis.
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COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2026
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IF 8.2
Xinru Yan,Xianqiang Pei,Yan Wang,Leyu Lin,Yaoming Zhang,Qihua Wang,Shanhong Wan
The development of high-performance polymer composites—combining strength, low friction, and wear resistance—remains an industrial challenge. In the present study, zeolite imidazolate framework ZIF-62 served as a multifunctional filler to fabricate ZIF-62/PEEK composites via fused deposition modeling (FDM). The effects of ZIF-62 on PEEK’s friction and wear were systematically investigated. By modulating the Im/BIm molar ratio in ZIF-62, we controlled the kinetics and composition of interfacial transfer film formation during sliding, thereby enhancing PEEK’s tribological performance. The optimal composition (ZIF-62/PEEK with Zn:Im:BIm = 1:1.5:0.5) reduced PEEK’s wear rate by 90 % to 1.45 × 10 ⁻⁶ mm 3 /Nm under 4 MPa × 0.25 m/s. The mechanisms behind this improvement were discussed based on multiscale characterization and molecular dynamics simulations. It was revealed that Zn species were released through the breakage of Zn–N bonds and reacted with degraded PEEK to form ZnO, while simultaneously inducing tribo-catalyzed graphitization. These products combined with iron oxides from the counterface to form a robust transfer film. This work establishes ligand engineering as a strategy for designing next-generation PEEK tribomaterials.
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Nature Communications
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2026
·
IF 18.1
Zhao Jingwen,Yang Wujie,Fan Yanpeng,Chang Zhi,Zhou Haoshen
Hard carbon negative electrodes, owing to their abundant precursors and low operating potential, are promising candidates for sodium-ion batteries. However, sluggish desolvation kinetics and unstable electrode–electrolyte interfaces hinder their practical deployment. Here we report a melt-coating strategy to encapsulate hard carbon particles with a metal–organic framework glass. The resulting glass coating contains sub-nanometer channels that lower the desolvation activation energy, accelerate sodium-ion transport, and induce a thin, anion-derived solid electrolyte interphase rich in NaF during cycling. The optimized interface promotes the formation of quasi-metallic sodium clusters within the closed pores of hard carbon, activating a high-capacity sodium storage mechanism. Consequently, the glass-coated hard carbon delivers a reversible capacity of 462.2 mAh g −1 , cycling stability of 89.1% capacity retention after 4000 cycles at 1 A g −1 and 95.3% capacity retention after 8000 cycles at 2 A g −1 , and high-rate capability. This work offers insights into interfacial design strategies for durable sodium-ion storage in hard carbon negative electrodes.
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PubMed
高影响因子
EMBO Molecular Medicine
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2026
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IF 7.9
Liu Lijie,Yan Mengrong,Liang Ruoxu,Wu Qingxin,Qu Changbin,Wu Huiqi,Liao Zhi,Chen Huiyu,Zou Jingjing,Sun Zeyun,Niu Dongyu,Wu Liyuan,Zhao Li,Dai Jialing,Shen Jialun,Zhang Long,Zhang Wei,Peng Wei
Respiratory syncytial virus (RSV) remains a major cause of severe respiratory disease, and stabilization of the prefusion (preF) conformation of the F glycoprotein is central for vaccine development. Here, we report a structure-guided engineering strategy that enhances preF stability by reducing the hydrophobic cavity within the trimeric F protein. Targeted modifications at metastability-associated sites generated RVF-88, a disulfide-free stabilized preF immunogen that preserves key neutralizing epitopes, including antigenic site Ø, while exhibiting improved structural integrity and long-term storage stability. Formulated as an unadjuvanted bivalent vaccine, RVF-88 elicited potent neutralizing antibody responses and durable immune protection lasting up to 5 months in mice. Vaccination also protected both mice and cotton rats against RSV challenge. Structural analyses confirmed the intended cavity-reduction design, revealing a reduced apical hydrophobic cavity volume and surface area while maintaining the prefusion architecture. Together, these findings establish hydrophobic cavity reduction as a rational strategy for stabilizing prefusion RSV F and provide a promising next-generation vaccine candidate with improved stability and immunogenicity for further clinical development.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Junping Miao,Zhonghua Bai,Hanshuai Feng,Yiding Lu,Xinyu Yu,Panpan Dong,Shuaitong Liang
The transmembrane aquaporin (AQP) protein with high permeability and selectivity have received substantial attention for preparing biomimetic membranes. However, the biological activity and loading mass of AQP in membranes are facing challenges. Here, AQP was expressed in E. coli cell membranes via genetic engineering, and then the cell membranes containing AQP were used to develop a biomimetic nanofiltration (NF) membrane, thereby maintaining the biological activity and increasing the loading mass of AQP. The membrane with high water permeance (66.5 L m -2 h -1 bar -1 ) exhibited a rejection sodium sulfate of 75.5% and high brilliant blue R rejection (99.8%), confirming the precise sieving ability of AQP. The membrane not only showed the typical sieving mechanism of the negatively charged NF membranes, but AQP possessed specialized water channels. This work provides some insights into the construction of high-performance biomimetic membranes using transmembrane proteins with high perm-selectivity and numerous choices in nature.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Shucheng Tian,He Tao,Zhifang He,Tingting Chang,Bin Li,Jianye Li,Xueqing Li,Lu Wang,Zibo Yang,Zhihua Qiao
Ti 3 C 2 T x is a two-dimensional sheet-like material with abundant and tunable surface functional groups, showing excellent gas adsorption and transport ability in CO 2 separation. However, it suffers from several intrinsic limitations, including susceptibility to oxidation, restacking, and humidity sensitivity, which prevent it from being used alone as a membrane material for complex application scenarios. In this work, meltable ZIF-62 was selected as the continuous phase and Ti 3 C 2 T x as the dispersed phase. Thermal treatment was used to promote the softening and flow of ZIF-62, enabling the embedding and immobilization of Ti 3 C 2 T x . Finally, self-supporting Ti 3 C 2 T x /a g ZIF-62 composite glass membranes were obtained, and their gas separation performance was evaluated. The results show that the introduction of Ti 3 C 2 T x effectively improves the CO 2 permeability of the composite membranes while maintaining high separation selectivity. Specifically, the best overall performance was achieved at a doping content of 1 wt%, where the CO 2 permeability increased from 1403 Barrer to 5124 Barrer, and the ideal CO 2 /N 2 and CO 2 /CH 4 selectivities reached 44.9 and 30.7, respectively. The CO 2 /N 2 separation performance of this membrane exceeds the latest upper bound, while its CO 2 /CH 4 separation performance also shows a competitive level. In addition, this membrane maintained relatively stable performance in humid-gas, pressure-variable, and 160 h continuous operation tests.
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ANALYTICAL CHEMISTRY
·
2026
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IF 7.3
Liang Zhu,Lejun Liao,Yan Huang,Zhou Nie,Chunyang Lei
The highly sensitive analysis of small-molecule targets holds profound significance across diverse fields, ranging from clinical diagnosis and environmental monitoring to food safety. Herein, we developed a label-free electrochemical CRISPR platform gated by allosteric transcription factors (aTFs) for the ultrasensitive detection of various small molecules. In this system, the specific binding of target analytes to their cognate aTFs induces the release of programmable DNA adaptors, which subsequently trigger Cas12a to trans-cleave DNA probes anchored to the electrode surface. Consequently, the truncated DNA probes serve as initiators to form electroactive G-quadruplex/hemin complexes in situ via terminal deoxynucleotidyl transferase (TdT)-mediated elongation, generating a robust electrochemical response signal. Using TetR as a model aTF, this integrated electrochemical CRISPR biosensor achieved tetracycline detection with picomolar sensitivity. Furthermore, the versatility of this platform was demonstrated by extending its application to p-hydroxybenzoic acid and copper ions through the simple substitution of the aTF modules. The practical utility of the assay was further demonstrated by the robust detection of tetracycline in complex matrices such as milk. Ultimately, this study not only provides a novel strategy for constructing universal, label-free electrochemical CRISPR platforms but also paves the way for the sensitive detection of low-abundance non-nucleic acid targets.
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危险品化学品经营许可证（带存储）