Gels
·
2023
·Vol. 9
·期 9
·703
·
IF 4.6
Kaibo Xu,Liqin Cao
Herein, a green, carbon dioxide-in-water high-internal-phase emulsion (C/W HIPEs) was developed and stabilized with polyvinyl alcohol (PVA) for the formation of chitosan oligosaccharide/poly(acrylamide-co-sodium 4-styrene sulfonate) [COS/P(AM-co-SSS)] monolithic porous hydrogel. The obtained monolith was characterized via FT-IR and SEM. The SEM patterns depicted that the monoliths were interconnected, the void sizes were 78.5 µm, and the interconnected pore throats were 28 μm approximately. Mechanical measurement results indicated that the maximum compress stress of the monolith could reach 334.4 kPa at 90% strain, and it exhibited good mechanical stability. After 200 cycles of compression, it could still recover its original shape without cracking. The obtained COS-based monolith was selected to remove tetracycline (TC) for evaluating the adsorptive features of the interpenetrating pore-containing monolith. The monolithic COS/P(AM-co-SSS) hydrogel behaved with strong antibiotic adsorption capacity (1600.4 mg/g for TC). The adsorption process agreed well with the pseudo-second-order kinetic and Langmuir isothermal models. In addition, the porous monolith had a strong electrostatic force on TC according to the thermodynamic study. This work provides a green route for the development of novel monolithic hydrogels and highlights its potential application in the treatment of antibiotic-containing wastewater.Keywords:high-internal-phase emulsion;CO2-in-water;chitosan oligosaccharides;monolith;porous;hydrogel
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MOLECULES
·
2022
·Vol. 27
·期 12
·3686
·
IF 4.927
Xinlong Wang,Huahui Zeng,Xin Zhu,Duanjie Xu,Qikang Tian,Can Wang,Lingzhou Zhao,Junwei Zhao,Mingsan Miao,Xiangxiang Wu
Triptolide (TP) is a potential drug candidate for the treatment of cancer, but its use was hampered by its systemic toxicity and poor water solubility. Hence, a TP-CSO prodrug was synthesized by conjugating TP to chitosan oligosaccharide (CSO), and characterized by1H NMR, FTIR, DSC and XRD analyses. The TP-CSO containing about 4 wt% of TP exhibited excellent water solubility (15 mg/mL) compared to TP (0.017 mg/mL). Compared with TP, the pharmacokinetics of the conjugate after oral administration showed a three-fold increase in the half-life in the blood circulation and a 3.2-fold increase in AUC(0–∞). The orally administered TP-CSO could more effectively inhibit tumor progression but with much lower systemic toxicity compared with TP, indicating significant potential for further clinical trials. In conclusion, CSO-based conjugate systems may be useful as a platform for the oral delivery of other sparingly soluble drugs.Keywords:triptolide;toxicity;water solubility;pharmacokinetics;pancreatic cancer
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Chun-Xia Zhang,Yu Wang,Xinhe Duan,Kai Chen,Hong-Wei Li,Yuqing Wu
The cytidine 5′-monophosphate (CMP)-protected gold nanoclusters (AuNCs@CMP) was developed to be a fluorescent nanosubstrate for direct ratiometric determination of alkaline phosphatase (ALP). The binding mode investigations revealed that the ligand CMP binds to the gold core via two oxygen atoms of ribose and cytosine and leaves the phosphate group freely outside, promoting AuNCs@CMP to be the direct nanosubstrate of ALP. AuNCs@CMP emits at 570 nm while the hydrolysis product of AuNCs@Cyt emits at 485 nm; the large emission gap between them provided a ratiometric approach for ALP determination. Moreover, a natural and biofunctional oligomer , chitosan oligosaccharide (COS), was introduced to the system, which significantly amplified the fluorescence signals of AuNCs@Cyt and improved the limit of detection (LOD) down to 0.00026 U·L −1 . Furthermore, the intrinsic mechanism of AuNCs@CMP hydrolysis by ALP and the COS amplification on AuNCs@Cyt were studied in-depth, which indicated the emission enhancement was attributed to the aggregation-induced emission enhancement (AIEE) property of the produced AuNCs@Cyt. Finally, the developed approach was successfully applied to determine ALP in human serum and the evaluation of ALP inhibitors. Therefore, the present study develops a novel nanosubstrate for ALP determination in a range of 0.0050–0.25 U·L −1 and provides a straightforward way to amplify the fluorescence signal by employing available polymer. The work will stimulate and encourage the structural promotion of metal nanoclusters, and extend their biological applications broadly.
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Advanced Healthcare Materials
·
2026
·
IF 11
Yixuan Gao,Haonan Wu,Jian Yang,Junyu Meng,Junhua Zhang,Han Zhang,Jian Yang
Acute lung injury (ALI) features vascular endothelial damage, impaired barrier function, and excessive ROS accumulation, which depletes endogenous peroxidases and disrupts redox homeostasis. Transcriptomic comparison between control and ALI model groups verified marked dysregulation of genes linked to oxidative stress, inflammation, and endothelial barrier dysfunction. To date, exogenous enzyme supplementation represents a necessary strategy for treating ALI, yet very few options are available to halt excessive ROS accumulation within the critical therapeutic time window. Here, we developed a nanozyme system (SCP@CD) capable of solving this problem by encapsulating autofluorescent Mn/S-co-doped carbon dots (CDs) into polymer micelles self-assembled via a Schiff base formed by sialic acid-modified chitosan oligosaccharide and protocatechualdehyde. As a targeting ligand, sialic acid enables active targeting of E-selectin on inflamed endothelium, realizing enhanced fluorescence for noninvasive in vivo tracking. Chitosan oligosaccharide linked to sialic acid reduces systemic toxicity, while the Schiff base formed by chitosan oligosaccharide and protocatechualdehyde mediates pH-responsive release via cleavage in acidic inflammatory microenvironments. SCP@CD functions as an exogenous enzyme supplementation via the multi-nanozyme activities of CDs and achieves synergistic anti-inflammatory and endothelial barrier-repairing effects by regulating inflammatory mediators and junctional proteins. This platform offers a novel precision nanomedicine strategy for ALI.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Hongmei Yu,Yuanrong Zheng,Changyu Zhou,Lianliang Liu,Libin Wang,Jinxuan Cao,Yangyin Sun,Jun He,Daodong Pan,Zhendong Cai,Qiang Xia
The potential of ultrasonication-driven molecular self-assembly of whey protein isolate (WPI) with chitosan (CS)/chitooligosaccharide (COS) to stabilize Pickering emulsions was examined, based on CS/COS ligands-induced partial unfolding in remodeling the Pickering particles features. Multi-spectral analysis suggested obvious changes in conformational structures of WPI due to interaction with CS/COS, with significantly higher unfolding degrees of WPI induced by COS. Non-covalent interactions were identified as the major forces for WPI-CS/COS conjugates . Ultrasonication enhanced electrostatic interaction between CS's -NH 3 groups and WPI's -COO − groups which improved emulsification activity and storability of WPI-COS stabilized Pickering emulsion. This was attributed to increased surface hydrophobicity and decreased particle size compared to WPI-CS associated with differential unfolding degrees induced by different saccharide ligands. CLSM and SEM consistently observed smaller emulsion droplets in WPI-COS complexes than WPI-CS/COS particles tightly adsorbed at the oil-water interface. The electrostatic self-assembly of WPI with CS/COS greatly enhanced the encapsulation efficiency of quercetin than those stabilized by WPI alone and ultrasound further improved encapsulation efficiency. This corresponded well with the quantitative affinity parameters between quercetin and WPI-CS/COS complexes. This investigation revealed the great potential of glycan ligands-induced conformational transitions of extrinsic physical disruption in tuning Pickering particle features.
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Materials
·
2023
·Vol. 16
·期 22
·7242
·
IF 3.4
Jinhui Tang,Guangye Tu,Zongshuo Tao,Yu Yan
Alite dissolution plays a crucial role in cement hydration. However, quantitative investigations into alite powder dissolution are limited, especially regarding the influence of chemical admixtures. This study investigates the impact of particle size, temperature, saturation level, and mixing speed on alite powder dissolution rate, considering the real-time evolution of specific surface area during the alite powder dissolution process. Furthermore, the study delves into the influence of two organic toughening agents, chitosan oligosaccharide (COS) and anionic/non-ionic polyester-based polyurethane (PU), on the kinetics of alite powder dissolution. The results demonstrate a specific-surface-area change formula during alite powder dissolution:SS0=0.348e1−m/m0/0.085+0.651. Notably, the temperature and saturation level significantly affect dissolution rates, whereas the effect of particle size is more complicated. COS shows dosage-dependent effects on alite dissolution, acting through both its acidic nature and surface coverage. On the other hand, PU inhibits alite dissolution by blocking the active sites of alite through electrostatic adsorption, which is particularly evident at high temperatures.Keywords:alite;powder;dissolution;organic toughening materials
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APPLIED CLAY SCIENCE
·
2023
·
IF 5.6
Pierre Dramou,Yiyang Sun,Xu Ni,Fangqi Wang,Hua He
In this study, a three-dimensional nanocomposite with magnetic features made of magnetic iron oxide nanoparticles (Fe 3 O 4 ), graphene oxide (GO) and halloysite nanotube (Hal) was prepared and introduced for rutin separation from real sample based on magnetic solid phase extraction (MSPE) process. Hal was modified with chitosan (Hal-COS) and showed positive charge, which can combine with GO by electrostatic force self-assembly to fabricate Hal-GO. Based on this, in-situ growth of magnetic sphere on the surface of Hal-GO demonstrated high specific surface area, chemical and thermal stability, water solubility, and capacity of easy separation in aqueous solution. Several characterizations including FT-IR, HRTEM , TGA and XRD evidenced the successful synthesis of the nanocomposite. The results showed that the optimum adsorption pH was 6 and the optimum adsorption temperature was 25 °C. In addition, further experiments showed that the adsorption process conformed to the Langmuir adsorption model and pseudo-second-order kinetic model , which indicated that the maximum equilibrium adsorption capacity was 107.8 mg g −1 and the maximum equilibrium adsorption time was 120 min. With the optimized conditions, the methodological validation experiments showed that the linear range of MSPE based on Fe 3 O 4 @(Hal-GO) combined with HPLC was 10–100 μg mL −1 , the correlation coefficient of the fitting equation was 0.9991, the LOD and LOQ reached 0.87 μg mL −1 and 2.9 μg mL −1 respectively. It was confirmed that prepared Fe 3 O 4 @(Hal-GO) supported efficient enrichment of rutin when the results were compared to those of other studies.
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Journal of Energy Storage
·
2023
·
IF 9.4
Rui Wang
Zinc-bromine flow battery (ZBFB) is one of the most promising energy storage technologies due to their high energy density and low cost. However, their efficiency and lifespan are limited by ultra-low activity and stability of carbon-based electrode toward Br 2 /Br − redox reactions. Herein, chitosan-derived bi-layer graphite felt (CS-GF) with stable physical structure and abundant active sites is proposed and developed as cathodes for ZBFBs. In this uniquely developed electrode, the catalyst layer possesses oxygen and nitrogen co-doped surface enables high activity for redox reaction, whilst the wrapping structure enhances bonding force between catalyst layer and supporting layer to keep the stability against electrolyte flow. Moreover, the closely-bonding and partially-cracked catalyst layer ensures low electrical resistance between two layers and further emerges more inside active sites for bromine ions reactions. Consequently, the bi-layer electrode is demonstrated high electrochemical activity towards bromine ion redox reactions by cyclic voltammetry and electrochemical impedance spectra test. In battery charge-discharge measurements, a ZBFB employing CS-GF electrode yields a high current density of 120 mA cm −2 , with an ultra-high coulombic efficiency of 99 % and improved energy efficiency of 69 %. Furthermore, the proposed bi-layer electrode enables stable battery performance, which cycle for more than 100 cycles with minor 0.057 % energy efficiency decay per cycle. This work provides a promising strategy to develop high-activity and high-stability electrode that possesses great application potentials in ZBFBs and other energy storage systems .
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Li-wei Liu,Zheng-hao Ding,Ganggang Ren,Guang-di Wang,Xin Pan,Guo-hai Wei,Xiang Zhou,Zhi-bing Wu,Zhi-chao Jin,Yonggui Robin Chi,Song Yang
Directly constructing nanoparticles through the self–assembly of natural small molecules in aqueous media presents many opportunities for crop protection; however, this special strategy is hindered by the lack of simple and cost–effective preparation methods to date. Herein, we report a facile strategy for constructing multifunctional natural nanocapsules for treating plant diseases based on the special coassembly of natural small organic molecules and inorganic nanoparticles. In aqueous conditions, uniform curcumin nanocapsules (ZnO@Cur) are assembled through electrostatic interactions, coordination effects and hydration effects as mediated by trace of nanoscale zinc oxide. The nanocapsules obtained can be further modified to enhance stability by introducing a polydopamine coating (ZnO@Cur@PDA). The antibacterial activity of ZnO@Cur@PDA against plant-pathogenic bacteria was better than that of curcumin, ZnO NPs, ZnO@Cur and zinc thiazole in vitro. The nanocapsules effectively kill plant–pathogenic bacteria via tight binding to the bacterial surface, inducing reactive oxygen species accumulation and disrupting bacterial cell walls. ZnO@Cur@PDA display strong activities against rice bacterial blight with protective activity of 64.0 % and curative activity of 62.2%, which is much better than commercial drugs bismerthiazol (protective activity of 33.0 % and curative activity of 38.4%) and zinc thiazole(protective activity of 38.6 % and curative activity of 31.8%). ZnO@Cur@PDA display adequate washing resistance, and low rice plant toxicity; furthermore, they are degradable. Additionally, both the inner cavities and outer surfaces of nanocapsules bear abundant sites and spaces that can be further tuned for loading other pesticide molecules or flexible construct complex multifunctional nanoparticles. Our study should encourage further development in the coassembly of organic and inorganic materials via green processes for effective and tunable nanopesticides.
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ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Kaibo Xu,Liqin Cao,Zhouyu Wang,Liu-ping Chen
Hemoperfusion (HP) is one of the most prominent therapies for treating uremia, hyperbilirubinemia, and acute drug toxicity. The comprehensive performance of currently used porous HP adsorbents needs to be improved due to the impediment to their synthesis strategy. Herein, green carbon dioxide-in-water high internal phase emulsions (C/W HIPEs) were utilized and emulsified with poly(vinyl alcohol) (PVA) for the formation of a heparin-mimetic chitosan oligosaccharides/poly(acrylamide-co-sodium 4-styrenesulfonate) [COS/P(AM-co-SSS)] monolith, which exhibited good mechanical properties, stable swelling performance, hydrophilic properties, anticoagulant effect, and low hemolysis. It showed a strong toxin adsorption capacity (415.2 mg/g for creatinine, 199.3 mg/g for urea, 279.5 mg/g for bilirubin, and 160 mg/g for tetracycline). The adsorption process of porous COS/P(AM-co-SSS) followed the pseudo-second-order kinetic and Langmuir isotherm models. Moreover, the porous materials had a strong electrostatic force on creatinine. The removal of creatinine by simulated in vitro blood perfusion was 80.2% within 30 min. This work provides a green preparation strategy for developing novel HP materials, highlighting their potential application value in blood and environmental purification.
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ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
·
2019
·Vol. 45
·期 1
·29-40
·
IF 1.518
Liu Xiaoli,Xie Wancui,Yang Xihong,Zhan Xiaobei,Xia Wenshui
The aim of this work was to develop a novel, nontoxic, bioactive antimicrobial material based on a natural polymer, chitosan oligosaccharides (COS), a natural pyrone compound, kojic acid (KA), and piperazine. The COS-based polymer (COS-O-MB) has been synthesized by selective partial alkylation reaction to graft kojic acid, KA, and piperazine onto the COS molecular chain. Then, physicochemical properties and bioactivity of the COS-O-MBs were evaluated and it was characterized by FT-IR, NMR spectroscopy, Mw, PID, antimicrobial activity, hemolysis assay, biocompatibility, animal toxicity, and antimicrobial action mode studies. The results revealed that the alkylation reaction took place at the C-6 position of COS, and the as-prepared COS-O-MB significantly enhanced the antimicrobial activity and biocompatibility and reduced the hemolytic activity in vitro in comparison with that of the free COS and KA. Meanwhile, the antimicrobial action mode studies proved that COS-O-MB can pass through the anionic microbial membrane, destroy the cytomembrane integrity, and potentially affect protein denaturation, demonstrating that exposure to COS-O-MB results in the death of microbial cells. But importantly, COS-O-MB is not toxic to human cells. Hence, low hemolytic activity to human red blood cells, and nontoxic nature to female mice of SLAC KM strain, made this novel polymer material a promising and effective compound for food and pharmaceutical industries.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Nanqi Zhao,Chaofan Guo,Ziyao Liu,Lin Chen,Yayun Hu,Minyi Han,Feng Huang,Zhuangli Kang,Xianchao Feng
This study investigated the effect of different hydrocolloids on the improvement of the printability and post-processing stability of minced chicken meat, each hydrocolloid was prepared with 1 % formulation and compared with the control. The effects of these hydrocolloids on the rheological properties of chicken mince and complex model printing capability were explored separately, while the cooking loss and microstructure changes of the samples before and after heating were analyzed. The results showed that the chicken mince gel containing carrageenan was more suitable for printing, increased the yield stress and apparent viscosity of the samples, and the printing process was easier to mold. In addition, carrageenan increased the hardness of the samples, and the microstructures were compact and changed little during the heating process, and the water was locked in the gel matrix, reducing shape changes during the heating process. The use of hydrocolloids improves the stability of post-processing of chicken 3D printing.
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危险品化学品经营许可证（带存储）