ANALYST
·
2023
·
IF 4.2
Ti Qin,Pinhao Li,Jun Li,Qianqian Guo,Ying Chen,Yu-E Wang,Ling Tao,Jian Huang,Xiangchun Shen,Xingjie Wu
Extracellular vesicles (EVs), as a type of subcellular structure, have been extensively researched for their potential in developing advanced diagnostic technologies for various diseases. However, the biomolecular and biophysical heterogeneity of EVs has restricted their application in clinical settings. In this article, we developed a size-exclusion chromatography-based technique for simultaneous EV size subtyping and protein profiling. By eluting fluorescent aptamer-treated patient plasma through a size-exclusion column, the mixture can be classified into 50 nm aptamer-bound EVs, 100 nm aptamer-bound EVs and free-floating aptamers, which could further enable the multiplex EV membrane proteins profiling by analyzing the fluorescence intensities of EV-bound aptamers. Using this technique, we successfully identified EV size subtypes for differentiating gastrointestinal cancers prognosis states. Overall, we developed a rapid, user-friendly and low-cost EV size subtyping and protein profiling technique, which holds great potentials for identifying crucial EV size subtypes for disease diagnosis in clinic.
研究领域:
癌症生物学
·
分子诊断
·
生物技术
·
临床研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Crystals
·
2021
·Vol. 11
·期 3
·278
·
IF 2.589
Liangqun Yang,Hongli Suo,Lin Ma,Min Liu,Wanli Zhao,Jianhua Liu,Lei Wang,Zili Zhang,Qiuliang Wang
In this study, boron powder with different particle sizes was purified by both chemical and heat treatment methods. The reduction in the particle size can improve the chemical purification with no effort on the heat treatment. The superconducting properties of the powder drastically changed even with only a partial elimination of oxygen. On the one hand, less oxygen content resulted in highTcandJcvalues under the low magnetic field, and most importantly, a significant improvement in the superconducting connectivity (Afvalue). On the other hand, the degradation ofJcunder a high field and a change in the pinning mechanism were also found, along with decreasing oxygen. This result indicated that oxygen, probably MgO, might act as the pinning center and as an obstacle for the supercurrent in MgB2at the same time. This work paves the way for obtaining pure oxygen-free MgB2and understanding the real effect of oxygen in MgB2.Keywords:boron powder;purification;particle size;MgB2;superconducting connectivity
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 21
·期 38
·5749-5756
·
IF 3.382
Wen Zeng,Haojie Lai,Tianyin Chen,Yueheng Lu,Zhihong Liang,Tingting Shi,Ke Chen,Pengyi Liu,Fangyan Xie,Jian Chen,Jianbin Xu,Qiulan Chen,Weiguang Xie
VO2 particles with a reduced size enable the optimization of its metal–insulator transition (MIT) temperature and hysteresis width. The accurate modulation of particle size and the underlying mechanism of transition behavior remains a critical issue. In this study, the annealing process of a V2O5 precursor film was systematically controlled with the guidance of the V–O phase diagram. The film undergoes a synergistic solid-state dewetting and pyrolysis process in the first step to form dispersed VO2 particles, and then a crystallization process to achieve the preferred orientation, which allows fine control of the particle size and crystallinity by thickness control of the precursor film. Then, the MIT behavior of VO2 particles with controlled sizes from 220 nm to 1.64 μm was systematically investigated. With decreasing size, the MIT temperature decreases and then increases with enlarged hysteresis. A minimum MIT temperature of 41 °C without hysteresis was realized. Size dependent crystallinity, strain and defect analyses showed that compressive stress dominates the MIT behavior of larger sized particles, while surface tensile stress and surface defect effects become prominent in smaller sized particles. This work provides a feasible strategy to control the size effect of dispersed VO2 particle films and deepen our understanding on the MIT behavior in single domains.
研究领域:
材料科学
·
凝聚态物理
·
纳米科技
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Yan Ziyang,Wu Angxuan,Wang Xilin,Huang Rongxia,Yan Nianping,Jia Zhidong,Wang Liming
In this paper, ZnO was used as a sintering aid as well as reactant in the reactive flash sintering (RFS) of zinc-containing ceramic materials at room temperature (25 °C). The RFS of ZnO-based ceramics, both ZnAl 2 O 4 and Zn 2 TiO 4 , were achieved with the application of a high electric field. Contrary to previous reports, the RFS of ZnAl 2 O 4 was divided into two stages according to temperature changes, and the effect of the reaction exotherm on the RFS was presented for the first time in this paper. In addition, the RFS produced a larger grain size of ZnAl 2 O 4 than conventional sintering did.
研究领域:
材料科学
·
陶瓷工程
✓ 已验证
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Haoran Xu,Guang Fu,Duclenh Phan,Liuxin Xiang,Thiquynhxuan Le,Libo Zhang
Ultrasound enhanced evaporating crystallization has been proposed to solve the problems of low crystallization yield and uneven particle size in the evaporating crystallization process of ammonium sulfate solution at atmospheric pressure. The effects of key operating parameters, including the ultrasound power, stirring speed, pH value, and ultrasound time, on the yield of ammonium sulfate product and the duration of solid–liquid transformation time are studied. The results show that the ultrasound crystallization can increase the ammonium sulfate yield by 52.9 %, reduce the solid–liquid transformation time of ammonium sulfate by 10 %, and obtain ammonium sulfate products with higher crystallinity and more uniform particle size. Ultrasound promotes the crystallization of ammonium sulfate by enhancing the transfer of heat in the solution and reducing the supersolubility of the ammonium sulfate solution from 937.5 g/L to 833.33 g/L. This study provides experimental justification for the use of ultrasound in atmospheric evaporative crystallization.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2017
·
IF 9.466
Changwang Zhang,Yong Xia,Zhiming Zhang,Zhen Huang,Linyuan Lian,Xiangshui Miao,Daoli Zhang,Matthew C. Beard,Jianbing Zhang
A new strategy for narrowing the size distribution of colloidal quantum dots (QDs) was developed by combining cation exchange and quantized Ostwald ripening. Medium-sized reactant CdS(e) QDs were subjected to cation exchange to form the target PbS(e) QDs, and then small reactant CdS(e) QDs were added which were converted to small PbS(e) dots via cation exchange. The small-sized ensemble of PbS(e) QDs dissolved completely rapidly and released a large amount of monomers, promoting the growth and size-focusing of the medium-sized ensemble of PbS(e) QDs. The addition of small reactant QDs can be repeated to continuously reduce the size distribution. The new method was applied to synthesize PbSe and PbS QDs with extremely narrow size distributions and as a bonus they have hybrid surface passivation. The size distribution of prepared PbSe and PbS QDs are as low as 3.6% and 4.3%, respectively, leading to hexagonal close packing in monolayer and highly ordered three-dimensional superlattice.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Haibin Sun,Xue Guo,Jiao Li,Guochang Li,Zanzhong Yang,Hao Ding,Weilu Yan,Shuai Qi,Peng Wang,Youjie Song
In order to clarify the effect of grain size on the electrical performance of BaZr 0.1 Ce 0.7 Y 0.1 Yb 0.1 O 3-δ (BZCYYb) solid electrolytes with addition of NiO, microcrystalline (~1.5 µm) and ultrafine-grained (~280 nm) BZCYYb electrolytes (with 1 wt% NiO) were fabricated by the conventional and two-step sintering method, respectively. The results show that compared with microcrystalline electrolytes, the ultrafine-grained electrolytes have similar grain-interior conductivities, but much lower grain-boundary conductivities, illustrating that the grain boundary is not conducive for ionic transport. As a result, the electrical conductivity of microcrystalline electrolytes (1.9 × 10 −2 S cm −1 at 600 °C in wet air) is higher than that of ultrafine-grained electrolytes (1.1 × 10 −2 S cm −1 at 600 °C in wet air). In addition, the OCV (open-circuit voltage) values of electrolyte-supported single cells show that the undesired electronic conduction exists in the electrolytes due to the BaY 2 NiO 5 impurity formed by the reaction of NiO and BZCYYb. The ultrafine-grained electrolytes show lower OCV values than that of microcrystalline ones, due to the prolonged electronic transport paths. Therefore, large-grained or grain boundary-free microstructure are necessary for improving the electrical performance of BZCYYb electrolytes.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2013
·Vol. 15
·期 9
·1-7
·
IF 2.175
Zong Kai,Lu SiHeng,Wang Hao,Sun YuXiu,Liu JingBing,Yan Hui
Cu 2 ZnSnSe 4 quantum dots (QDs) with controllable sizes have been synthesized via a hot-injection method. The diameters of the QDs range from 3.2 to 10.1 nm with the tunable band gap from 1.27 to 1.54 eV by adjusting the reaction temperatures from 180 to 240 °C. Structural and Raman scattering data confirm that Cu 2 ZnSnSe 4 is obtained without other secondary phases. The band gaps of the QDs with diameters less than 4.6 nm show an obvious blue shift to higher energy due to quantum confinement effect. It indicates that the Cu 2 ZnSnSe 4 QDs can be a potential candidate for quantum-dot-sensitized solar cells in the future.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Sciences
·
2019
·
IF 3.556
Hongyan Sun,Ruyuan Jiao,Hui Xu,Guangyu An,Dongsheng Wang
In order to evaluate the influence of particle size and particle concentration on the coagulation process, two kinds of particle suspensions, nanoparticles and microparticles , were employed to investigate the effect of particle size on coagulation mechanisms with varying coagulation parameters. Results showed that it is easier for nanoparticles to cause self-aggregation because of Brownian motion, while interception and sedimentation are the mainly physical processes affecting particle transport for microparticles, so they are more stable and disperse more easily. The particle size distribution and particle concentration had distinct influence on the coagulation mechanisms. Under neutral conditions, as the amount of coagulant increased, the coagulation mechanism for nanoparticles changed from charge neutralization to sweep flocculation and the nanoparticles became destabilized, re-stabilized and again destabilized. For microparticles, although the coagulation mechanism was the same as that of nanoparticles, the increased rate of aluminum hydroxide precipitation exceeded the adsorption of incipiently formed soluble alum species, resulting in the disappearance of the re-stabilization zone. Under acidic conditions, Brownian motion dominates for nanoparticles at low particle concentrations, while sweep flocculation is predominant at high particle concentrations. As for microparticles, charge neutralization and sweep flocculation are the mechanisms for low and high particle concentrations respectively. Under alkaline condition, although the mechanisms for both nano- and microparticles are the same, the morphology of flocs and the kinetics of floc formation are different. At low particle concentrations, nanoparticles have larger growth rate and final size of flocs, while at high particle concentrations, nanoparticles have higher fractal dimension and recovery factors.
研究领域:
环境科学
·
化学工程
·
胶体与表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shibo Han,Guangying Huang,Han Han,Xilai Yan,Jie Xie,Hongshen He,Ajoy Kanti Mondal,Weijie Lin,Fang Huang
Currently, most polyols used in polyurethane foam (PUF) synthesis are derived from petrochemicals. However, lignin as the most abundant aromatic biopolymer rich in hydroxyl groups, is a suitable filler for synthesizing polyurethane foam. Therefore, in this study, Kraft lignin (KL) was utilized as a partial substitute for flexible polyethylene glycol 400 (PEG400). After adding 15 % KL, NaCl was introduced as a medium for synthesizing LFPUF and Polydimethylsiloxane (PDMS) was used as a foam stabilizer. Lignin-based flexible polyurethane foam (LFPUF) with high elasticity was synthesized. The aromatic ring structure of KL acted as a reinforcement for the foam, while the flexible PEG400 provided excellent flexibility to LFPUF. Na + interacts with oxygen atoms in the long chain of PEG to form a cyclic crown ether structure. This promotes proximity and ordering of the hydroxyl groups, thereby facilitating proton transfer and optimising the cell size of the foam. Ultimately, the foam synthesized with 3 % NaCl (LFPUF-3%NaCl) exhibited an average cell size and hole size of 484.1 and 183.6 μm, respectively, significantly smaller than those of the foam synthesized without NaCl (843.5 and 249.3 μm, respectively). The foam resilience and elastic recovery of LFPUF-3%NaCl were 39.56 and 99.03 %, respectively, which was higher than that of the foam synthesized without NaCl (20.36 % and 97.08 %, respectively). In addition, LFPUF-3%NaCl maintained a high elastic recovery of 97.61 % after 20 cycles of compression. The egg drop test demonstrated that the foam effectively provided protective cushioning for fragile items.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Q.B. Chen,B. Meng,M.Y. Zhao,H. Xie,L.F. Bian,X. Yang
In order to investigate the grain size effect on the electrical conductivity of the submicron samarium-heavily-doped ceria , the Ce 0.8 Sm 0.2 O 1.9 (SDC20) ceramics with grain sizes from 128 nm to 533 nm were prepared by sintering at 1000–1300 °C in the air atmosphere. The crystalline structure, micro-morphology, density and electrical conductivity of the SDC20 ceramics were measured and characterized by XRD , SEM, TEM, Archimedes method and electrochemical impedance spectrum, respectively. All the sintered samples show the single SDC phase, low porosity and clean grain boundary without any impurities. The grain sizes of SDC ceramics grow continuously with the rising sintering temperature , and the relative densities increase as the sintering temperature rises from 1000 °C to 1200 °C and then decrease with the temperature from 1200 °C to 1300 °C. The specific grain boundary conductivity of SDC keeps decreasing while the grain and apparent grain boundary conductivities increase during the whole grain size range of 128–533 nm.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2016
·Vol. 8
·期 2
·55
·
IF 2.944
Baijun Liu,Yajun Wang,Mingyao Zhang,Huixuan Zhang
Particle coagulation is a facile approach to produce large-scale polymer latex particles. This approach has been widely used in academic and industrial research owing to its higher polymerization rate and one-step polymerization process. Our work was motivated to control the extent (or time) of particle coagulation. Depending on reaction parameters, particle coagulation is also able to produce narrowly dispersed latex particles. In this study, a series of experiments were performed to investigate the role of the initiator system in determining particle coagulation and particle size distribution. Under the optimal initiation conditions, such as cationic initiator systems or higher reaction temperature, the time of particle coagulation would be advanced to particle nucleation period, leading to the narrowly dispersed polymer latex particles. By using a combination of the Smoluchowski equation and the electrostatic stability theory, the relationship between the particle size distribution and particle coagulation was established: the earlier the particle coagulation, the narrower the particle size distribution, while the larger the extent of particle coagulation, the larger the average particle size. Combined with the results of previous studies, a systematic method controlling the particle size distribution in the presence of particle coagulation was developed.Keywords:emulsion polymerization;particle size distribution;coagulation;initiator
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）