International Journal of Electrochemical Science
·
2023
·
IF 1.5
Feng Yang,Jiayu Wei,Shihui Qiu,Chengbao Liu,Li Cheng,Haichao Zhao
The corrosion inhibition effect of polylevodopa (poly-(L-DOPA)) on Q235 carbon steel in 1 M HCl was studied owing to its low cytotoxicity and special structure. Electrochemical measurements show that the corrosion inhibition efficiency increases with the increase of poly-(L-DOPA) concentration and the immersion time. When the concentration of poly-(L-DOPA) is 300 mg/L, the corrosion inhibition efficiency can reach 97%. Confocal laser scanning microscopy (CLSM) and field emission scanning electron microscope (FESEM) proved that poly-(L-DOPA) has a good corrosion inhibition effect on Q235 carbon steel immersed in 1 M HCl. Poly-(L-DOPA) adsorbs on the surface of Q235 carbon steel to form a protective film, and followed the Langmuir adsorption isotherm.
研究领域:
材料科学
·
电化学
·
表面工程
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Qikai Si,Yang Yu,Wenjie Xu,Zhenglong Yang,Hongwu Zhang,Ting Su,Christophe Len,Deyang Zhao
Five biomass-based materials: sesame straw (SS), corn cobs (CC), bamboo powder (BP), wheat straw (WS), and furfural residue (FR), were sulfonated using sulfuric acid, as well as some commercial sulfonated catalysts, like Amberlyst, Nafion were compared for the production of ethyl levulinate (EL) from furfuryl alcohol (FAL). Remarkably, under optimum conditions (50 mg of 8% SO3H-FR at 170 °C for 5 h), 100% FAL conversion and 90% EL yield were achieved, along with stable recyclability in continuous flow. Dynamic evolution of GC in the function of reaction time under different temperatures was performed, indicating that FAL conversion to ethoxymethylfuran (EMF) occurs under a lower temperature (150 °C) and short time (45 min). On the contrary, the intermediates 5, 6, and 7 required a higher temperature for EL formation with the concomitant release of diethyl ether (DEE). Comprehensive characterizations demonstrated significant changes in the chemical composition of sulfur- or nitrogen-containing functional groups after sulfonation. In particular, the −S–O types (especially −SO3H) play a more critical role in EL production than the sulfur content alone. The adsorption energies and charge density differences of FAL (Eads) on pristine FR and the sites of −SO3H, −SO4, pyrrolic N, pyridinic N, and their complexes were compared. The FAL adsorption energy followed the order: Eads (complex) > Eads (−SO4) > Eads (−SO3H) > Eads (pyrrolic N) > Eads (pyridinic N)>Eads (pristine), indicating a synergistic adsorption effect among these functional groups in FR. Additionally, the electron transfer capacity was significantly enhanced after −SO3H doping.
研究领域:
化学工程
·
生物质能源
·
催化化学
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产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Can Chen,Changpeng Zou,Lin Li,Haidong Yu,Jixin Zhu,Jinhua Liu,Wei Huang
Levodopa, commonly used anti-Parkinson drugs in the clinic, is the most significant prodrug of dopamine that plays important roles in the treatment of Parkinson's disease. Therefore, monitoring content of levodopa of anti-parkinson drugs in human serum is extremely necessary. Herein, a simple, fast and low-cost method for levodopa detection is proposed depending on the in situ formation of blue and green emission fluorescent copolymer (FCP). The proposed method is based on the conversion of fluorescence emission peak of FCP from blue (430 nm) to green emission (535 nm) in 2 h. In this sensing system, both blue and green emission exhibit a high selectivity and sensitivity for levodopa determination in the range from 0 to 50 μM with a detection limit of 0.2 μM and 0.36 μM, respectively. Among them green emission FCP shows excellent recovery even at human serum concentrations up to 30%. Additionally, the proposed method was successfully applied to assess the content of levodopa in three anti-Parkinson drugs (carbidopa and levodopa CR tablets, levodopa and benserazide hydrochloride tablets, and levodopa tablets). More importantly, the levodopa determination of three anti-Parkinson drugs in human serum also exhibit an excellent recovery. Therefore, our strategy provides a promising method for mechanism study and treatment of Parkinson's disease.
研究领域:
生物化学
·
医学诊断
·
药物分析
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DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2020
·
IF 3.209
Congcong Yu,Qingpeng Cao,Tingting Tu,Yu Cai,Lu Fang,Xuesong Ye,Bo Liang
As a vital therapeutic agent for Parkinson's disease, dosage control of levodopa has always been a major obstacle in ensuring efficacy and curbing side effects. Simple and fast electrochemical detection methods are the main force in this field. Here, we presented a differential dual-strip method based on the coulometry for high accuracy determination of levodopa. The difference between the two strip signals with or without the tyrosinase extracted the levodopa signal from the samples. The Prussian Blue modified carbon screen-printed electrode was used to convert and amplify the electrochemical signal upon the presence of levodopa. The system exhibited a linear behavior in the 0–10 μM concentration range and a detection limit of 0.25 μM. Furthermore, it was proved to be stable in effectively distinguishing levodopa from complex samples through anti-interference experiments and serum tests. We demonstrated the superiority of dual-strip differential coulometry for the determination of levodopa towards Parkinson’s disease clinical management.
研究领域:
分析化学
·
医学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Shang-Jin Yang,Zhi-Yuan Xu,Ling-Yun Zou,Jiong-Chi Yu,Jian Ji,Zhi-Kang Xu
The advanced oxidation process of the photo-Fenton reaction can produce hydroxyl radicals with extremely strong oxidizing properties for the efficient and green degradation of various chemical and microbial pollutants. Herein, we report an approach to fabricating heterogeneous Fenton catalysts of β-FeOOH nanorods on porous substrates triggered by mussel-inspired coatings of levodopa (3,4-dihydroxy-phenyl-l-alanine, l-DOPA) and polyethylenimine (PEI) for efficient photocatalytic dyes’ degradation and sterilization. The l-DOPA-based coatings not only promote the formation and immobilization of β-FeOOH nanorods on the porous substrates by strong coordination between catechol/carboxyl groups and Fe3+ but also improve the energy band structure of the Fenton catalysts through a valence band blue shift and band gap narrowing. The photo-Fenton catalysts prepared by the l-DOPA-based coatings exhibit high electron transport efficiency and improved utilization of sunlight. Only 2 h of mineralization is needed to fabricate these catalysts with excellent photocatalytic efficiency, in which the degradation efficiency of methylene blue can reach 99% within 30 min, whereas the sterilization efficiency of E. coli/S. aureus can reach 93%/94% within 20 min of the photo-Fenton reaction. Additionally, the prepared catalysts reveal a high photodegradation performance for various dyes including methylene blue, methyl blue, methyl orange, direct yellow, and rhodamine B. Furthermore, the catalysts retain high dye degradation efficiencies of above 90% after five photodegradation cycles, indicating cycling performance and good stability.
研究领域:
环境科学
·
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Lei Ding,Chundan Ye,Junchen Zhu,Cuirong Sun
Chiral impurity analysis presents significant challenges due to limitations of detection methods. Levodopa (L-Dopa) is the primary medication for Parkinson's disease treatment for over 50 years. However, the detection of its chiral impurity is difficult due to the similarity of polarity. This study presents a novel analytical method for the quantitative detection of trace amount of D-Dopa, as well as other three impurities. The method demonstrated excellent chromatographic resolution for D-Dopa and L-Dopa (resolution = 4.15) and achieved a derivatization efficiency of 97% using a chlorine-labeled chiral probe (D-BPCl) for chemical derivatization, followed by analysis with liquid chromatography-tandem mass spectrometry (LC-MS/MS) on a conventional C18 column. Meanwhile, D-BPCl showed strong chiral selectivity on D-Dopa, and the ratio of mass spectrometric response for labeled D-Dopa to that of L-enantiomers was 2.78-fold under the same condition. The developed method demonstrates high sensitivity with detection limits of 7.88 μ g L -1 for D-Dopa, and 9.85 μ g L -1 for L-Dopa, with good linearity for every analyte (R 2 > 0.99), recoveries ranging from 94.1% to 106.8%, and high repeatability with relative standard deviation (RSD) values predominantly below 5%. Then the method was applied to analyze fifteen batches of levodopa tablets from five manufacturers. D-Dopa was successfully detected with the corresponding content ranging from 0.15% to 0.44%, which suggests that D-Dopa are more likely generated during the production process. The study underscores the significant safety concerns regarding Dopa-containing medications.
研究领域:
药物分析
·
药物质量控制
·
手性分离
·
药物代谢
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2020
·
IF 6.146
Qianqian Guo,Fan Yang,Xiaohui Liu,Mengqing Sun,Yong Guo,Yanqin Wang
Silicoaluminophosphate-34 (SAPO-34) molecular sieves have important applications in the petrochemical industry as a result of their shape selectivity and suitable acidity. In this work, nanoaggregate SAPO-34 with a large external surface area was obtained by dissolving pseudoboehmite and tetraethylorthosilicate in an aqueous solution of tetraethylammonium hydroxide and subsequently adding phosphoric acid . After hydrolysis in an alkaline solution, the aluminum and silicon precursors exist as Al(OH) 4 − and SiO 2 (OH) − , respectively; this is beneficial for rapid nucleation and the formation of nanoaggregates in the following crystallization process. Additionally, to study the effect of the external surface area and pore size on the catalytic performance of different SAPO-34 structures, the alcoholysis of furfuryl alcohol to ethyl levulinate (EL) was chosen as a model reaction. In a comparison with the traditional cube-like SAPO-34, nanoaggregate SAPO-34 generated a higher yield of 74.1% of EL, whereas that with cube-like SAPO-34 was only 19.9%. Moreover, the stability was remarkably enhanced for nanoaggregate SAPO-34. The greater external surface area and larger number of external surface acid sites are helpful in improving the catalytic performance and avoiding coke deposition.
研究领域:
石油化工
·
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
·
2015
·
IF 2.321
Li-Xia Xie,Hai-Long Wu,Yu Fang,Chao Kang,Shou-Xia Xiang,Li Zhu,Xiao-Li Yin,Hui-Wen Gu,Zhi Liu,Ru-Qin Yu
This paper presented a method for the simultaneous determination of two target analytes, tyrosine (Tyr) and levodopa (Lev), in human plasma matrices using enzyme-induced excitation-emission-kinetic third-order calibration method based on the alternating quadrilinear decomposition (AQLD) algorithm. The work skillfully exploited the oxidation reactions of Tyr and Lev using polyphenol oxidase as a catalyst. A four-way data array was constructed by the kinetic evolutions of excitation–emission matrix fluorescence for a group of samples, and followed by the four-way data decomposition. The proposed method could be applied in plasma sample analyses with satisfactory results. The actual concentration of Tyr in human plasma was identified as 8.80 ± 0.54 μg mL − 1 , but Lev was not found in the presented sample. Using high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) as reference method, the F -test and t -test suggested that there were no significant differences between these two methods. The satisfactory results indicated that this third-order calibration method has the potential to give accurate quantitative analyses, particularly in complex systems containing unknown spectral interferents and existing serious collinearity problems.
研究领域:
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
CORROSION SCIENCE
·
2024
·
IF 7.4
Z.N. Jiang,J.M. Duan,X.Q. Zeng,S.Y. Peng,Y.R. Li,W. Xiong,C.F. Dong,G.A. Zhang
Cellulose , as a kind of renewable natural polymer , has great potential as green corrosion inhibitor . However, the low inhibition effect is the obstacle to its practical application. Herein we developed a high efficiency green cellulose derivative corrosion inhibitor , levodopa-carboxymethyl cellulose (LDCMC), by modifying carboxymethyl cellulose (CMC) with levodopa (LD) through a simple amidation reaction. The inhibition effect of CMC for mild steel in HCl medium is dramatically improved with an increase in inhibition efficiency from 56.98% of CMC to 97.27% of LDCMC. The intrinsic nature of the dramatically improved inhibition effect is in-depth unraveled by first-principles calculations based on density functional theory (DFT). CMC and LDCMC can adsorb on the mild steel surface through -OH, -COOH and LD fragment by forming the covalent bonds with steel surface. Benefiting from the additional strong adsorption of the benzene ring in LD fragment, the introduction of LD can significantly enhance the adsorption capacity of LDCMC, which is the intrinsic nature of the dramatical improvement in the inhibition effect of LDCMC.
研究领域:
材料科学
·
化学工程
·
计算化学
✓ 已验证
DOI
高影响因子
Pharmaceutics
·
2022
·Vol. 14
·期 7
·1384
·
IF 6.525
Xuan Liu,Shen Yan,Mengyuan Li,Shengyu Zhang,Gang Guo,Quanyi Yin,Zhenbo Tong,Xiao Dong Chen,Winston Duo Wu
This work was aimed to develop levodopa (L-dopa) nasal powder to achieve controllable drug release and high nasal deposition efficiency. A series of uniform microparticles, composed of amorphous L-dopa and excipients of hydroxypropyl methyl cellulose (HPMC), polyvinylpyrrolidone (PVP), or hydroxypropyl-β-cyclodextrin (CD), were fabricated by a self-designed micro-fluidic spray dryer. The effects of excipient type and drug/excipient mass ratio on the particle size, morphology, density, and crystal property, as well as the in vitro performance of drug release, mucoadhesion, and nasal deposition, were investigated. Increased amounts of added excipient, regardless of its type, could accelerate the L-dopa release to different extent. The addition of CD showed the most obvious effect, i.e., ~83% of L-dopa released in 60 min for SD-L1CD2, compared to 37% for raw L-dopa. HPMC could more apparently improve the particle mucoadhesion than PVP and CD, with respective adhesive forces of ~269, 111, and 26 nN for SD-L1H2, -L1P2, and -L1CD2. Nevertheless, the deposition fractions in the olfactory region for such samples were almost the same (~14%), probably ascribable to their quite similar particle aerodynamic diameter (~30 μm). This work demonstrates a feasible methodology for the development of nasal powder.Keywords:levodopa-doped nasal powder;spray drying;controlled drug release;strong mucoadhesive force;high deposition efficiency
研究领域:
药学
·
药物递送系统
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Drug Delivery and Translational Research
·
2022
·Vol. 13
·期 1
·9-17
·
IF 5.671
Yuan Hao,Zhang Zhengyu,Hu Liandong
In this study, a new gastro-floating sustained-release capsule (GFC) with levodopa (LD) and benserazide hydrochloride (BH) was successfully developed. GFCs were prepared by filling the LD and BH granules into hard capsules and coated with cellulose acetate (CA) solution as a controlled-release layer. The effects of formulation factors on the release of GFCs were conducted. The AUC 0~24 (µg h/mL) of LD were 69.31 ± 3.61 (μg h/mL) and 28.87 ± 2.58 (μg h/mL) and the C max were 7.84 ± 0.34 (μg/mL) and 9.21 ± 1.04 (μg/mL) in the GFCs and commercial tablets respectively. The relative bioavailability of LD was 267.55 ± 34.54%. Compared with commercial tablets, the pharmacokinetic study indicated that the developed GFCs provided a better sustained-release effect and higher bioavailability than commercial tablets. Graphical abstract
研究领域:
药剂学
·
药物代谢动力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biotechnology & Genetic Engineering Reviews
·
2023
·
IF 3.2
Yuan Li,Jiamin Zhu,Peng Sang,Yan Bai,Jinrong Lu,Hong Sun,Shun Wang
This study aims to study the effffects of Tiaoshen Changzhi acupuncture on behavior and striatum ΔFosB in rats with Levodopa-induced Dyskinesias (LIDs). In this experimental study, Levodopa-induced Dyskinesia (LID) rat models were established by 6-OHDA double-target injection and randomly assigned to six groups, with ten rats in each group. The rats were subjected to difffferent interventions for 28 days, and their behavior was observed. Additionally, the content of ΔFosB, a marker of neuronal activation, in the rat striatum was detected by immunohistochemistry and qRT-PCR. In contrallateral rotation behavior experiment and AIM experiment, the score of the model group was significantly increased, compared with the model group, the score of the Western medicine group, the ordinary acupuncture group and the Tiaoshen Changzhi group was significantly decreased (P < 0.01), the score of the Western medicine group and the Tiaoshen Changzhi group was significantly lower than the ordinary acupuncture group (P < 0.01), there was no statistical significance between the Western medicine group and the Tiaoshen Changzhi group (P>0.05). In the left forelimb function test, the score of the model group was significantly decreased, and compared with the model group, the left forelimb function score of the Western medicine group, the ordinary acupuncture group and the Tiaoshen Changzhi group were significantly increased (P < 0.01). The left forelimb function score of the Western medicine group and the Tiaoshen Changzhi group was higher than the ordinary acupuncture group (P < 0.05, P < 0.01). There was no statistical significance between Western medicine group and Tiaoshen Changzhi group (P > 0.05). After treatment, the content of ΔFosB in the striatum of the Western medicine group, the ordinary acupuncture group and the Tiaoshen Changzhi acupuncture group all decreased, the Western medicine group was better than the ordinary acupuncture group (P < 0.01), and the Tiaoshen Changzhi acupuncture group was better than the ordinary acupuncture group (P < 0.05). Tiaoshen Changzhi acupuncture can improve the behavioral performance of LID rats, reduce abnormal involuntary movement and contralateral rotation behavior and enhance the motor function of the left forelimb of rats. One of its therapeutic mechanisms for LID may be to reduce the expression level of ΔFosB in the striatum of LID rats, thereby reducing the symptoms of LID rats.
研究领域:
神经科学
·
针灸
·
药理学
·
行为科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）