ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Ang Li,Song Xue,Yu Xu,Sihui Ding,Di Wen,Qi Zhang
A critical challenge in using deep eutectic solvents (DESs) in capillary electrophoresis (CE) is to develop separation systems in which a DES can really work as a single entity. To achieve this, the authors recently demonstrated a novel strategy that takes advantage of the aqueous dispersibility of hydrophobic DESs (or more accurately hydrophobic eutectic solvents (HESs)). However, the previous work was limited only to the separation of achiral analytes, e.g., analogues, homologues, and isomers. The present study was designed as a follow-up study in order to explore the feasibility of employing HES-type pseudo-stationary phases (PSPs) in CE for chiral separations . By using carboxymethyl-β-cyclodextrin (CM-β-CD) as a model chiral selector, we provide the first evidence that there is a potential synergistic effect between HESs and traditional chiral selectors. Specifically, the combined use of HES (−)-menthol:octanoic acid and CM-β-CD allowed excellent enantioseparations of several basic drugs which were not able to be resolved in the single CM-β-CD system. The enantioresolutions were significantly improved while the migration times of the enantiomers were also shortened due to the hydrophobic mechanism of the HES-type PSP. Critical factors influencing the novel chiral CE system were systematically investigated. Since HESs are considered as “designer” solvents with highly tunable properties, this study demonstrates the potential of employing HESs (or HDES)-type PSPs in CE for chiral separations .
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Analytical Methods
·
2022
·Vol. 15
·期 5
·648-654
·
IF 3.532
Luyao Zhao,Min Wang,Jiadong Wang,Jing Wu,Zhuoting Zhang,Xu Jing,Xiaowen Wang
A detection method of carbofuran (CBF) in water samples was reported using deep eutectic solvent (DES)-based dispersive liquid–liquid microextraction (DLLME) combined with digital image colorimetry (DIC), which was environmentally friendly, solvent-saving, rapid, and convenient. Under alkaline conditions, the green and multifunctional extractant DESs dissociated into linalool and heptanoic acid, and CBF was hydrolyzed to 2,3-dihydro-2,2-dimethyl-7-benzofuranol and further coupled with fast blue BB salt to form an azo derivative. Heptanoic acid led to the dispersion of linalool to extract the orange-red azo derivative; DIC was used for quantitative analysis using a smartphone with its associated ease of data-acquisition. This experiment optimized the types, molar ratios, and volumes of DESs and the amounts of sodium carbonate and sodium chloride. Under optimal conditions, the limits of detection (LOD) and quantitation (LOQ) were 0.024–0.032 mg L−1 and 0.081–0.108 mg L−1, respectively. The extraction recoveries in real samples (tap, pond, and river water) were 92.4–101.0% with a relative standard deviation below 4.6%. This method has successfully analyzed CBF in different water samples and shows prospects for the monitoring and control of CBF residues in other environmental samples.
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Food & Function
·
2022
·Vol. 14
·期 2
·796-809
·
IF 6.317
Ni-Na Xie,Cheng-Ying Wu,Qiong Ge,Jing Zhou,Fang Long,Qian Mao,Song-Lin Li,Hong Shen
Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects. However, the relation between their structures and antitumor functions remains unknown. Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed. Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure–function relationships. It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution. GP-n and GP-c showed anti-melanoma effects, whereas GP-a promoted its growth slightly. GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of Allobaculum and Bifidobacterium. However, the restoration effect of GP-a was weak, or even worse. In addition, these two bacteria were negatively correlated with the tumor weight and related with the altered SCFAs. In conclusion, GP-n is essential for the anti-melanoma effects of GP, and the potential mechanisms might be related with its specific regulation of Allobaculum and Bifidobacterium abundance, and tumor-associated SCFAs levels. The outcomes highlighted here enable a deeper insight into the structure–function relationship of GP and propose new opinions on its antitumor effect.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Ruiyu Fu,Tingze Ren,Yanhui Zhang,Xiaoli Guo,Xin Di
This paper describes a sensitive, simple and green analytical method for pretreatment of sulfonylurea and pyrethroid herbicides in water samples by supramolecular solvent-based liquid phase microextraction (SUPRAS-LPME). The SUPRAS was rapidly formed by nonanoic acid and tetrahydrofuran (THF)/water solution. The attractive features of SUPRAS-LPME include the simplicity, high enrichment factor, low cost and less consumption of organic solvents. The main influencing factors including type and volume of fatty acids, volume of THF , ionic strength, vortex time and volume of formic acid were optimized in detail, and then the significant variables were optimized by Box-Behnken design (BBD). Under the optimized condition, the proposed method shows high precision (RSDs < 13.7 %), low limits of detection (0.5–10 μg L -1 ) and limits of quantitation (10–45 μg L -1 ), acceptable recovery (71.3 %-95.9 %). The proposed method was successfully applied for analysis of sulfonylurea and pyrethroid herbicides in water samples, making it an alternative analytical strategy for determination of trace analytes at the microgram per liter range with desirable sensitivity.
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Food Bioscience
·
2023
·
IF 5.2
Kaiyong Yao,Qile Xia,Yan Cao,Bindan Chen,Jie Cai,Chenxing Liu
Yellow wine lees (YWL) are the main byproduct in the yellow wine brewing and can be used as animal feed. The deficiencies in fiber digestibility and amino acid equilibrium of YWL limited its utility value in animal feeding. The nutritional profile of YWL could be moderated after fermentation treatment. We fermented YWL with Candida utilis KF01 and Bacillus subtilis KF02, whose genomes were sequenced. We set three groups in the animal test with 15 Holstein cows : control, YWL, and fermented yellow wine lees (FYWL) group. 206 and 5 amino acid metabolism-related KEGG pathways, as well as 5257 (639 GO and 4618 eggNOG annotations) and 1579 (372 GO and 1207 eggNOG annotations) amino acid metabolism-related gene annotations were found in C. utilis KF01 and B. subtilis KF02. The collected milk samples were analyzed for composition. The contents of mono-unsaturated fatty acid (MUFA, 36.90% relative content), poly-unsaturated fatty acid (PUFA, 5.63% relative content), and essential amino acid (EAA, 2.01%) in the FYWL group milk were significantly (P < 0.05) higher. The content of flavor substances in the FYWL group (146.33 ng/mL) was the highest, followed by the control (89.19 ng/mL) and the YWL group (41.36 ng/mL). The principal component analysis (PCA) result presented the intra-group variations in flavor substances and differences in single substance among all groups. Feeding FYWL had significant effects (P < 0.05) in the Holstein cows on the milk composition.
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TALANTA
·
2023
·
IF 6.1
Zhenjia Chen,Luyao Zhao,Zhuoting Zhang,Jing Wu,Lixin Zhang,Xu Jing,Xiaowen Wang
In this paper, an analysis method for chlorpyrifos (CPF) in cereal samples was proposed using dispersive liquid‒liquid microextraction combined with an enzyme-linked immunosorbent assay. In the dispersive liquid‒liquid microextraction, deep eutectic solvents and fatty acids were used as solvents to extract, purify, and concentrate CPF in cereals. In the enzyme-linked immunosorbent assay, gold nanoparticles were utilized to enrich and conjugate more antibodies and horseradish peroxidase , while magnetic beads were used as solid supports to amplify the signal and shorten the detection time of CPF. The linearity range was 0.002–1 μg kg −1 , and the limit of detection was 0.0006 μg kg −1 . The extraction recoveries were 86.7–99.9% with a relative standard deviation of less than 7.0%. The proposed method was successfully used to analyze CPF in cereal samples (rice, wheat, maize, and millet) and has prospects for the pretreatment and detection of CPF residues in other food samples.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Jinming Xu,Hao Yuan,Huangmei Zhou,Yu Zhao,Ying Wu,Jie Zhang,Sanjun Zhang
Baijiu occupies a vital position in Chinese food and China's market. Strict evaluation of Baijiu is highly demanded. In this study, we constructed a novel fluorescent sensor array based on the single glutathione-protected gold nanoclusters (AuNCs) probe for the detection of organic acids and Baijiu. The fluorescence of AuNCs was simply modulated by three metal ions (Cu 2+ , Mn 2+ , and Ag + ), and formed new complexes as sensing elements. These four sensing elements responded variously to nine organic acids, and further chemometric analysis results allowed for the classification and quantification of acids. Moreover, the sensor array successfully identified 21 Baijiu samples of different brands among 11 aroma types. It could also distinguish Baijiu of different qualities as well as pure Baijiu from its adulterations and showed high selectivity among multiple interfering drinks. The results demonstrated that the AuNCs-based sensor array has considerable potential for quality monitoring of Baijiu.
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RSC Advances
·
2022
·Vol. 12
·期 38
·25060-25067
·
IF 4.036
Dan Chen,Chunqiong Wang,Dezhi Yang,Huimin Deng,Qiulan Li,Li Chen,Gaokun Zhao,Junli Shi,Ke Zhang,Yaling Yang
The rapid and onsite detection of glyphosate in tobacco products is still a great challenge. In this study, a novel smartphone-assisted sensing platform for the detection of glyphosate has been successfully proposed through the peroxidase-like activity of Fe3O4-based nanozyme. Heptanoic acid/Prussian blue (PB) decorated Fe3O4 nanoparticles (Fe3O4@C7/PB) could catalyze and oxidize 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS, colorless) into a steel blue colored product in the presence of hydrogen peroxide. Glyphosate could specifically inhibit the peroxidase-like activity of Fe3O4@C7/PB by occupying the active site, thereby the glyphosate detection could be accomplished within 10 min by monitoring the color change of ABTS. This study has developed a smartphone-based portable detection platform for online analysis of glyphosate with a detection limit of 0.1 μg mL−1. The absorbance response curve of glyphosate showed good linearity in the concentration range of 0.125–15 μg mL−1 at 415, 647, and 730 nm. Moreover, by employing a co-precipitation technology and inhibiting the peroxidase-like activity, the glyphosate analysis would be less affected by the tobacco sample matrix. The nanosensor possesses excellent selectivity and anti-interference ability, which has application value in actual samples for onsite screening.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Xu Jing,Haoyue Xue,Xiaoyan Sang,Xiaowen Wang,Liyan Jia
A simple, rapid, and efficient pretreatment method of mefentrifluconazole enantiomers in cereal samples was established by dispersive liquid–liquid microextraction coupled with ultra-high-performance liquid chromatography-diode array detector (UHPLC-DAD). In this study, a novel ternary magnetic deep eutectic solvent (MDES) [octyltrimethylammonium bromide][cobalt chloride][acetic acid] was synthesized as the extractant. Acetic acid was used as the dispersant to promote the in situ dispersion of binary MDES [octyltrimethylammonium bromide][cobalt chloride]. The microdroplets of binary MDES containing mefentrifluconazole were separated by an external magnet. Device-assisted dispersion and time-consuming centrifugation steps were eliminated to ensure simplicity and rapidity of the pretreatment. Good linearity ranging from 0.01 μg g −1 to 2 μg g −1 was obtained. The extraction recovery varied from 82.9 to 95.0%. The limit of detection was 0.003 μg g −1 . Finally, this established approach has been applied for the enantioselective detection of chiral mefentrifluconazole in corn, rice, wheat, millet, and sorghum samples.
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JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Ruijuan Duan,Meiling Qi
This work presents the investigation of two new pentiptycene (PP)-functionalized triblock copolymers (PEPE1, PEPE2) for gas chromatographic (GC) analyses with an aim to address the separation problems toward analytes of high resemblance in properties and a wide variety of components in complex samples. Up to date, these two materials are not reported in any fields. The PEPE1 and PEPE2 columns showed close column efficiency (above 4000 plates/m) but differed in polarity, morphology and separation performance. As testified by the challenging Grob test mixture, the PEPE1 column exhibited comprehensively higher separation capability than the PEPE2 column and the commercial reference columns. Also, the PEPE1 column achieved high-resolution performance for both apolar and polar isomers of high resemblance, such as xylenes, phenols and anilines. Moreover, it displayed high inertness towards carboxylic acids and excellent separation repeatability and reproducibility tested by the aniline isomers with the RSD values in the range of 0.01–0.04% for run-to-run, 0.09–0.13% for day-to-day and 1.2–2.0% for column-to-column, respectively. Its application to GC–MS analysis of the essential oil from tea flowers demonstrated its advantageous separation performance towards a wide range of components and proved its feasibility for practical analyses of complex samples.
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FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Xiao Jia,Pei Yu,Qi An,Jingnan Ren,Gang Fan,Zelan Wei,Xixiang Li,Siyi Pan
The effect of microwave treatment on the content of glucosinolates (GSL) in radish seeds and volatile odor compounds in the microwaved radish seed oils (MRSO) is still unclear. In this study, a total of 13 GSL were identified and quantified in five radish seed varieties by UPLC-IMS-QTOF-MS, among which glucoraphenin, glucoraphasatin, glucoerucin accounting for up to 90 %. Total GSL decreased by 47.39–67.88% after microwave processing. Moreover, 58 odor compounds were identified in MRSO, including 6 sulfides, 12 nitriles, 2 isothiocyanates, 10 alcohols, 12 aldehydes, 5 ketones, 6 acids, and 5 others. The major odor compounds were (methyldisulfanyl)methane, dimethyltrisulfane, (methylsulfinyl)methane, 3-(methylsulfanyl)-1-propanol, methyl thiocyanate, hexanenitrile, 5-(methylsulfanyl)pentanenitrile, and 4-isothiocyanato-1-butene with odor activity value (OAV) higher than 1. The principal components analysis (PCA) results can distinguish MRSO from five different radish seed varieties, three of which (H20-18, H20-19 and H20-28) were in one group and other two (H20-23 and H20-26) were in another group. In addition, aliphatic GSL showed positive correlations with sulfides, isothiocyanates, and nitriles, while negative correlations with alcohols. This work provides a new insight into the odor contribution of GSL degradation products.
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ChemCatChem
·
2023
·Vol. 15
·期 19
·e202300703
·
IF 4.5
Xinzheng Ma,Luyao Guo,Ziang Zhao,Yu Meng,Xiaoling Mou,Ronghe Lin,Yihui Li,Li Yan,Hejun Zhu,Yunjie Ding
Graphical Heptanol oxidation : Melamine modification of commercial activated carbon can greatly tune the performance of Pt−Bi catalysts in n -heptanol oxidation. C 3 N 4 -modified AC favors the formation of PtBi alloy in comparison to N-doped AC, and consequently boosts the activity and selectivity to heptanoic acid. Different bimetallic platinum and bismuth catalysts supported on melamine-modified activated carbon (AC) are designed by a co-impregnation method. Through controlling the activation temperatures of the melamine−AC mixture, a series of N-doped and C 3 N 4 -modified AC (N−AC and C 3 N 4 −AC) are prepared. Combined powder X-ray diffractions, X-ray photoelectron spectroscopic, and high-angle annual dark-field scanning transmission electron microscopic studies demonstrate that the introduction of C 3 N 4 favors the formation of PtBi alloy and leads to increased particle sizes in comparison to the pristine and N-doped AC-supported bimetallics. The catalytic performance of the developed catalysts is evaluated in the oxidation of n -heptanol oxidation in a batch mode using O 2 as the oxidant. PtBi/C 3 N 4 −AC exhibits significantly boosted activity as well as selectivity to heptanoic acid as compared with the other catalysts. A high yield of heptanoic acid of 69 % can be achieved under the optimized reaction conditions. Furthermore, our work points to the PtBi alloy as the most active sites for the alcohol oxidation. Catalyst deactivation occurs in the cycling tests, mainly due to the collapse of the alloy phase and likely the decrease in particle sizes.
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