Journal of the Taiwan Institute of Chemical Engineers
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2021
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IF 5.876
Bo Zhang,Chuyuan Huang,Lijuan Liu,Hongming Zhang,Xianfeng Chen,Qi Zhao
As an important pharmaceutical intermediate product, niacin is widely used in the production process where dust explosions could occur if processed in powdered form. Aluminum hydroxide and aerosil are commonly used in the manufacturing process as pharmaceutical excipients. The effects of dust concentration and dispersed pressure on the lowest ignition temperature of niacin dust cloud were experimentally investigated. Results show that niacin dust has an optimal ignition concentration and the lowest ignition temperature basically remains unchanged and then increases with the dispersed pressure. Inerting experiments of niacin dust were conducted at different dust concentrations, dispersed pressures and the addition of inert dust. With inert dust of aluminum hydroxide, aerosil or mixed aluminum hydroxide-aerosil, the lowest ignition temperature increases with inert dust concentration, and the inhibition effectiveness increases in the order of aluminum hydroxide, aerosil and mixed aluminum hydroxide-aerosil. The synergistic inhibition effect of aluminum hydroxide and aerosil is efficient, and its inhibition mechanism is mainly manifested by thermal stability, diluting the oxygen, and as a third body which has passive influence on the combustion chemical kinetic reaction. This work provides reference for prevention and mitigation of accidental explosions during processing, storage and transportation in the industry of pharmaceuticals.
研究领域:
安全工程
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制药工程
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DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
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IF 20.2
Bo Feng,Tingman Zhao,Jiada Du,Jiyuan Hu,Yun Shi,Jingkai Zhao,Jianmeng Chen
Methane selective catalytic reduction (CH 4 -SCR) technology has shown promise for controlling NO x emissions from natural gas generator sets. This study presents a highly efficient Ce 30 In 15 /HBEA catalyst featuring dual active sites, Al-O – (InO + )-Si site for CH 4 activation and ceria oxygen vacancy (Ce 3+ -□) site for NO x activation. However, the CH 4 -SCR activity of this catalyst decreased in the presence of H 2 O, SO 2 , C 3 H 6 , and CO 2 . The inhibitory effects on CH 4 -SCR activity followed by the sequence: H 2 O > SO 2 > C 3 H 6 > CO 2 . In particular, H 2 O combined with Al-O – (InO + )-Si to form inactive In(OH) 3-z z+ species and occupied Ce 3+ -□, preventing Ce 4+ -NO 3 – /NO 2 – formation. In/Ce sulfate formation via the reaction between SO 2 and In/Ce active sites hindered CH 4 and NO x adsorption and activation. The formed carbon deposits covered the active sites on the catalyst surface due to incomplete C 3 H 6 oxidation . In comparison, the dual active sites were almost unaffected by CO 2 . Overall, this study provides a basis for the rational design of novel catalysts for CH 4 -SCR.
研究领域:
环境科学
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催化化学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2014
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IF 4.331
Jun Hou,Lingzhan Miao,Chao Wang,Peifang Wang,Yanhui Ao,Jin Qian,Shanshan Dai
The presence of ZnO NPs in waste streams can negatively affect the efficiency of biological nutrient removal from wastewater. However, details of the toxic effects of ZnO NPs on microbial activities of wastewater biofilms have not yet been reported. In this study, the temporal and spatial inhibitory effects of ZnO NPs on the O 2 respiration activities of aerobic wastewater biofilms were investigated using an O 2 microelectrode. The resulting time–course microelectrode measurements demonstrated that ZnO NPs inhibited O 2 respiration within 2 h. The spatial distributions of net specific O 2 respiration were determined in biofilms with and without treatment of 5 or 50 mg/L ZnO NPs. The results showed that 50 mg/L of nano-ZnO inhibited the microbial activities only in the outer layer (∼200 μm) of the biofilms, and bacteria present in the deeper parts of the biofilms became even more active. Scanning electron microscopy (SEM) analysis showed that the ZnO NPs were adsorbed onto the biofilm, but these NPs had no adverse effects on the cell membrane integrity of the biofilms. It was found that the inhibition of O 2 respiration induced by higher concentrations of ZnO NPs (50 mg/L) was mainly due to the release of zinc ions by dissolution of the ZnO NPs.
研究领域:
环境科学
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微生物学
·
水处理
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Xiaoyan Li,Yuan Zhuang,Yejian Qian,Xinyan Wang,Rui Zhai
Methanol is widely recognized as a carbon-neutral fuel. This work used synchrotron vacuum ultraviolet photoionization mass spectrometry (SVUV-PIMS) to study the oxidation process of water/methanol/n-heptane mixes in a jet-stirred reactor (JSR) at a pressure of 1 atm, equivalence ratios (ϕ) of 1 and a temperature range of 500–1100 K. The results of the experiment indicate that the inhibition of n-heptane's oxidation at low temperatures (500–740K) is the primary manifestation of the action of methanol/water mixtures on n-heptane oxidation. The strong interactions among the components of water/methanol/n-heptane mixtures at low temperatures are primarily between methanol and n-heptane. The higher the methanol content, the greater the strength of inhibition of n-heptane oxidation. This inhibitory effect primarily results from the competition of methanol with ˙OH radicals. It is noteworthy that the chemical kinetic interactions between methanol-water mixtures and n-heptane not only manifest changes in the ˙OH radical pools but are also associated with the intermolecular chemical kinetic interactions between peroxyalkyl radicals (ROO˙) and CH 3 OH.
研究领域:
化学工程
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燃烧科学
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反应动力学
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产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
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2024
·
IF 1.9
Xiaoyu Yin,Yufan Zhao,Peng Guo,Peng Wu,Chao Chen,Aiming Zhang,Jiali Liao,Yuanyou Yang,Ning Liu,Tu Lan
The presence of carbonates or humic substances (HS) will significantly affect the species and chemical behavior of U(VI) in solution, but lacking systematic exploration of the coupling effect of carbonates and HS under near real environmental conditions at present. Herein, the sorption behavior of U(VI) on illite was systematically studied in the co-existence of carbonates and HS including both humic acid (HA) and fulvic acid (FA) by batch technique. The distribution coefficients ( K d ) increased as function of time and temperature but decreased with increasing concentrations of initial U(VI), Ca 2+ , and Mg 2+ , as well as ion strength . At pH 2.0–10.5, the K d values first increased rapidly and then decreased visibly, with its maximum value appearing at pH 5.0, owning to the changes in the interaction between illite and the dominant species of U(VI) from electrostatic attraction to electrostatic repulsion. The sorption was a heterogeneous, spontaneous, and endothermic chemical process, which could be well described by pseudo-second-order kinetic and Flory-Huggins isotherm models. When carbonates and HA/FA coexisted, the K d values always increased first and then decreased as a function of pH, with the only difference for HA and FA being the key pH (pH key ) at which the promoting and inhibiting effects on the sorption of U(VI) onto illite undergo a transition. The carbonates and HS have a synergistic inhibitory effect on the U(VI) sorption onto illite at pH 7.8. FTIR and XPS spectra demonstrated that the hydroxyl groups on the illite surface and in the HS were involved in U(VI) sorption on illite in the presence of carbonates. These results provide valuable data for a deeper understanding of U(VI) migration in geological media.
研究领域:
环境科学
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地球化学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
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2024
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IF 6.7
Cheng Qu,Yuchuang Geng,Zhongxiang Ding,Yuzhu Li,Hao Jiang,Mengke Su,Honglin Liu
A feedback inhibition effect of high autoinducer levels on metabolite secretion in Chromobacterium subtsugae (C. subtsugae) was evidenced by in situ spatiotemporal surface-enhanced Raman spectroscopy (SERS) profiling. The hierarchical hydrophobic plasmonic array in agar medium is structured by oil/water/oil (OL/W/OH) triphasic interfacial self-assembly. The hydrophobic layer acts as a “door curtain” to selectively permit adsorption of a quorum sensing (QS)-regulated fat-soluble metabolite, i.e., violacein (Vio), and significantly blocks nonspecific adsorption of water-soluble proteins, etc. The SERS profiling clearly evidences that the diffusion of N-hexanoyl-l-homoserine lactone (C6-HSL) in agar medium quickly triggers the initial synthesis of Vio in C. subtsugae CV026 but surprisingly inhibits the intrinsic synthesis of Vio in C. subtsugae ATCC31532. The latter negative response might be related to the VioS repressor of ATCC31532, which negatively controls violacein production without influencing the expression of the CviI/R QS system. Moreover, two sender–receiver systems are constructed by separately coculturing CV026 or ATCC31532 with Hafnia alvei H4 that secretes large amounts of C6-HSL. Expectedly, the cocultivation similarly triggers the initial synthesis of Vio in CV026 but seems to have a quite weak negative effect on the intrinsic synthesis in ATCC31532. In fact, the negative regulation in ATCC31532 might be affected by a diffusion-dependent concentration effect. The H4 growth and its secretion of C6-HSL are a slow and continuous process, thereby avoiding the gathering of local high concentrations. Overall, our study put forward an in situ SERS strategy as an alternative to traditional bioluminescent tools for highly sensitively analyzing the spatiotemporal communication and cooperation in live microbial colonies.
研究领域:
微生物学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
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IF 9.038
Zhi-Ling Li,Rui Cheng,Fan Chen,Xiao-Qiu Lin,Xiao-Jing Yao,Bin Liang,Cong Huang,Kai Sun,Ai-Jie Wang
Antibiotics commonly exist in municipal, livestock and industrial wastewaters . However, the response of key microbiota performance in wastewater treatment plants to antibiotic exposure lacks systematic research. In this study, the short-term acute stress of four commonly used antibiotics (sulfamethoxazole, chlortetracycline, ciprofloxacin, and amoxicillin) on microbial denitrification performance was systematically investigated. All tested antibiotics exhibited the inhibitory effects in varying degrees by repeated addition for six cycles. The nitrate removal efficiencies ( NrE ) decreased to 7.98–26.80%, accompanied by the significant decrease of the expressed nar G gene, by exposure to sulfamethoxazole, chlortetracycline or amoxicillin. Nitrite reduction was inhibited more severely than nitrate reduction , which was further verified by the low- or non-expressed nir S and nos Z genes. Furthermore, a higher antibiotic concentration made stronger inhibitory effect. Except for chlortetracycline, 2.09–6.80 times decrease of k value was commonly observed as concentration increased from 10 to 50 or 100 mg L −1 . Even in a short period (24 h), antibiotics largely decreased the abundance of the dominant denitrifying bacterial genera ( Thauera , Comamonas , etc.), while, some unclassified populations ( Labrenzia , Longilinea, etc.) were enriched. This study provides theoretical researches on the microbial denitrification behaviors influenced by exposure to different antibiotics.
研究领域:
环境微生物学
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废水处理
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生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2025
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IF 7.8
Yanting Dong,Qiang Wang,Jie Yang,Nanwen Zhu
Sulfadiazine (SDZ), a type of antibiotics with refractory and high-mobile characteristics, can accumulate and be detected out in aquatic ecosystems all over the world. SDZ can be destroyed by ozonation, but the degradation effect is easily and negatively affected by carbonate ions (CO 3 2- ) which be eliminated by introduction of Ca 2+ in ozonation systems. Experimental results manifested that the maximum removal rate of 100 % and 94.15 % corresponding to SDZ and chemical oxygen demand (COD) were achieved under the optimum Ca(OH) 2 addition without pH adjustment. In addition, the presence of Cl - and humic acid inhibited the SDZ degradation to some extent. It could be found that Ca 2+ and OH - jointly played great roles in increased oxidation of ozonation. For one thing, quenching effect of CO 3 2- on •OH was eliminated through combination of Ca 2+ and CO 3 2- and low molecular intermediate forming insoluble precipitates. For another, OH - caused alkaline condition which was instrumental in existence of •OH. Moreover, successive addition of Ca(OH) 2 was proposed and proved to be feasible to elevate the •OH generation and oxidizing ability in O 3 /Ca(OH) 2 system. Ultimately, the three potential degradation pathways of SDZ were speculated basing on density function theory (DFT) calculations and identification of several intermediate products. Overall, this study provided promising insights for promotion of antibiotics removal and ozonation efficiency by alleviating the inhibitory effect of carbonate ions in aqueous environment.
研究领域:
环境科学
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水处理技术
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污染物降解
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高级氧化过程
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药物残留消除
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Yarong Bai,Yaqin Hou,Yaoping Guo,Ning Xiang,Xiaojin Han,Haiqiang Wang,Zhongbiao Wu,Zhanggen Huang
Hollow structures have attracted great interest in many areas for their diverse applications. In this work, a new catalyst with an open and hollow structure (Co 3 O 4 @CoMn 2 O 4 ) is designed for selective catalytic reduction of nitrogen oxides by ammonia (NH 3 -SCR). The as-prepared hollow-structured catalyst provides a high surface area and has thin shells. Owing to its structural benefits, this catalyst exhibited enhanced nitrogen oxides (NO x ) removal activity and better resistance to water and sulfur dioxide than cobalt manganate nanoparticles . It also has proved that both the Eley-Rideal and Langmuir-Hinshelwood mechanisms are present in the NH 3 -SCR process in this catalyst. The improved nitrogen selectivity after the addition of water and sulfur dioxide occurs owing to the inhibition of nitrous oxide formation through the Eley-Rideal and Langmuir-Hinshelwood mechanisms. The deep insight into the structure–activity relationship and the influence of water and sulfur dioxide on nitrogen selectivity provide a new perspective for constructing high-performance de-NO x catalysts.
研究领域:
环境科学
·
催化材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
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2024
·
IF 2.7
Chaochao Gong,Sailing Chen,Yunbing Tang,Huiqian Chen,Jianghuan Xie,Yanning Lv,Zhefan Shen,Yang Zhu,Shaowei Wang,Ren-shan Ge,Junzhao Zhao
The objective of this study was to examine the effect of 11 organochlorine pesticides on human and rat 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) in human placental and rat ovarian microsome and on estradiol production in BeWo cells. The results showed that the IC 50 values for endosulfan, fenhexamid, chlordecone, and rhothane on human 17β-HSD1 were 21.37, 73.25, 92.80, and 117.69 μM. Kinetic analysis revealed that endosulfan acts as a competitive inhibitor, fenhexamid as a mixed/competitive inhibitor, chlordecone and rhothane as a mixed/uncompetitive inhibitor. In BeWo cells, all insecticides except endosulfan significantly decreased estradiol production at 100 μM. For rats, the IC 50 values for dimethomorph, fenhexamid, and chlordecone were 11.98, 36.92, and 109.14 μM. Dimethomorph acts as a mixed inhibitor, while fenhexamid acts as a mixed/competitive inhibitor. Docking analysis revealed that endosulfan and fenhexamid bind to the steroid-binding site of human 17β-HSD1. On the other hand, chlordecone and rhothane binds to a different site other than the steroid and NADPH-binding site. Dimethomorph binds to the steroid/NADPH binding site, and fenhexamid binds to the steroid binding site of rat 17β-HSD1. Bivariate correlation analysis showed a positive correlation between IC 50 values and LogP for human 17β-HSD1, while a slight negative correlation was observed between IC 50 values and the number of HBA. ADMET analysis provided insights into the toxicokinetics and toxicity of organochlorine pesticides. In conclusion, this study identified the inhibitory effects of 3–4 organochlorine pesticides and binding mechanisms on human and rat 17β-HSD1, as well as their impact on hormone production.
研究领域:
药理学
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毒理学
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内分泌学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Weigang Ma,Chuanmin Wang,Xinran Wang,Xinyi Zhou,Ya Lu,Xin Guo,Nguyen-Minh-An Tran,Junsheng Yang,Huabin Yang,Danyang Wang,Hua Tan,Haibo Zhang
The vat photopolymerization (VPP) technology offers exceptional flexibility in design and manufaction of high-performance piezoceramic structures. However, due to the high refractive index and strong UV absorption characteristics of Pb-based ceramics, ceramic slurries are required to have a low solid content in for efficient deep-curing. This limitation often results in sintering distortion, cracking, low density, and deteriorated piezoelectric properties. To address these challenges, a heat treatment process was initially employed to spheroidize the PZT powder, which effectively decreased light scattering and absorption. Subsequently, high-refractive-index and highly reactive photosensitive resins were introduced to enhance the penetration of UV light and reduce the critical exposure energy of the slurry. Additionally, a hindered amine light stabilizer is added to capture the peroxy radicals to overcome the oxygen inhibition effect and further increase the curing depth. As a result, a PZT slurry with a high solid content of 45 vol.%, was successfully formulated, facilitating the manufacturing of PZT ceramics with complex structures. The sintered samples achieved a high relative density of 96.5% and a d 33 value of 573 pC/N. These optimized strategies provide a solid foundation for the development of high-performance PZT devices with intricate geometries.
研究领域:
材料科学
·
陶瓷
·
增材制造
·
光聚合
·
压电材料
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Yu-Qi Li,Bai-Hang Zhao,Xiao-Tang Chen,Yu-Qing Zhang,Hai-Shan Yang
Nanoparticles and antibiotics are toxic to humans and ecosystems, and they inevitably coexist in the wastewater treatment plants . Hence, the co-existence effects and stress mechanism of copper (II) oxide nanoparticles (CuO NPs) and ciprofloxacin (CIP) on simultaneous nitrification, endogenous denitrification and phosphorus removal (SNEDPR) by aerobic granular sludge (AGS) were investigated here. The co-existence stress of 5 mg/L CuO NPs and 5 mg/L CIP resulted in the synergistic inhibitory effect on nutrient removal. Transformation inhibition mechanisms of carbon (C), nitrogen (N) and phosphorus (P) with CuO NPs and CIP addition were time-dependent. Furthermore, the long-term stress mainly inhibited PO 4 3- -P removal by inhibiting phosphorus release process, while short-term stress mainly inhibited phosphorus uptake process. The synergistic inhibitory effect of CuO NPs and CIP may be due to the changes of physicochemical characteristics under the co-existence of CuO NPs and CIP. This further altered the sludge characteristics, microbial community structure and functional metabolic pathways under the long-term stress. Resistance genes analysis exhibited that the co-existence stress of CuO NPs and CIP induced the amplification of qnrA (2.38 folds), qnrB (4.70 folds) and intI1 (3.41 folds) compared with the control group.
研究领域:
环境工程
·
微生物学
·
污水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）