INDUSTRIAL CROPS AND PRODUCTS
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2026
·
IF 6.4
Xue-Mei Yang,Xi-Ke Xu,Zhao-Ting Li,Xian-Peng Zu,Xin Chen,Hong-Yuan Dong,Wei-Dong Zhang,Bei Jiang,Yun-Heng Shen
First isolation of the polysaccharide from S. cannabina root. • It alleviates ethanol-induced cytotoxicity and oxidative stress in HepG2 cells. • SCPC-2 ameliorates ethanol metabolism by regulating ADH, ALDH, and CYP2E1 enzymes. • It activates the Keap1-Nrf2/HO-1 pathway to reduce oxidative stress and lipid peroxidation. • Provides a strategy for valorization of S. cannabina roots as functional ingredients. This study investigated the structural characteristics, conformational features, and hepatoprotective activity of a polysaccharide (SCPC-2) isolated from the roots of Sesbania cannabina , an underutilized industrial crop widely distributed in saline-alkaline regions. SCPC-2 exhibited an average molecular weight of 7.97 kDa and was composed mainly of mannose, galactose, rhamnose, glucose, arabinose, glucuronic acid, and galacturonic acid. Methylation analysis revealed that SCPC-2 contained diverse glycosidic linkages, including t-Man(p), t-Gal(p), t-Glc(p), and various branched residues, indicating a structurally complex architecture. NMR spectroscopy revealed characteristic oxygenated sugar-ring signals and representative H/C correlations, supporting the general carbohydrate structural features of SCPC-2. In vitro cell model assays demonstrated that SCPC-2 significantly improved the viability of ethanol-injured HepG2 cells. It reduced the levels of transaminases (ALT and AST) and the lipid peroxidation product MDA, while elevating the levels of antioxidants (SOD and GSH) and ethanol metabolism-related enzymes (ADH and ALDH). Mechanistic studies indicated that SCPC-2 alleviated ethanol-induced HepG2 cell damage by coordinately regulating ethanol metabolism and enhancing antioxidant defense via activation of the Keap1-Nrf2/HO-1 signaling pathway. These findings suggest that SCPC-2 may be a promising hepatoprotective agent, highlighting the potential for high-value utilization of S. cannabina roots.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 3.5
Fan Zhang,Weiji Dai,Rong Shu,Minna Ji,Weiguo Chen,Cuijiao Zhao,Yudong Zhang,Can Cui,Saifang Huang
Tri-metallic CoCuMoO x oxides were prepared as efficient glucose sensor. • The high-valence Mo 6+ can act as an electron acceptor for glucose oxidation. • A new pathway for Co 2+ and Cu 2+ to oxidize glucose was activated by Mo 6+ . The accurate and efficient non-enzymatic detection of glucose remains a significant challenge. This study reports a novel tri-metallic CoCuMoO x oxide synthesized via the co-deposition of Co 2+ and Cu 2+ on electrochemical oxidation derived MoO x as sensitive glucose sensor. The incorporated Co 2+ and Cu 2+ bring real active sites Co 2+/3+ , Co 3+/4+ , and Cu 2+/3+ redox couples for electrochemical oxidation of glucose. More importantly, the inactive Mo 6+ can activate the Co 2+ and Cu 2+ sites for glucose oxidation by acting as an electron acceptor. Due to the new pathway activated by Mo 6+ , the optimized CoCuMoO x @CC electrode exhibits superior glucose sensing performance, including a high sensitivity of 5958.7 μA·mmol −1 ·cm −2 in the linear range of 10 μmol to 1 mmol, a rapid response time of 3 s, a low detection limit of 2.2 μmol, and superior anti-interference performance. Meanwhile, the electrochemical measurements show good long-term stability of CoCuMoO x @CC electrode, with 92.5% of the original current remained at the 28th day. This work not only develops a promising non-enzymatic glucose sensing material but also advances the material design principles for glucose sensors based on high-valence transition metal ions. The incorporated Co 2+ and Cu 2+ bring real active sites Co 2+/3+ , Co 3+/4+ , and Cu 2+/3+ for electrochemical oxidation of glucose. More importantly, the inactive Mo 6+ can activate the Co 2+ and Cu 2+ sites for glucose oxidation by acting as an electron acceptor. Download: Download high-res image (141KB) Download: Download full-size image
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Food Bioscience
·
2026
·
IF 6.2
Gaigai Zhang,Jiuyang Liu,Zhiheng Yuan,Yushuang Chen,Lixia Zhang,Shangde Sun,Jianwei Lian,Shanshan Guo
Peanut oil is widely favored for its pleasant flavor and nutritional value. However, conventional processing techniques often lead to the loss of micronutrients in peanut oil and yield a product with a monotonous flavor profile. This study examined the impact of various combined biological pretreatments of peanut germination and enzymatic hydrolysis on peanut oil, with an emphasis on the improvement of its physicochemical properties, nutritional quality, and flavor profile. It was demonstrated that the nutrient composition and flavor profile of peanut oil could be remarkably enhanced by moderate germination combined with enzymatic hydrolysis. The total phenolic content in peanut oil was increased by approximately 5-fold (from 27.53 to 153.54 mg/kg), and the resveratrol content was enhanced from 0.25 mg/kg to 0.57 mg/kg. Furthermore, the combined treatment resulted in approximately a 10-fold increase in total volatile content (from 3343.87 to 54,761.83 μg/kg) compared with the untreated. Pyrazines, furans, and aldehydes were the predominant volatile compounds contributing to the desirable flavor of the treated peanut oil. Notably, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and phenylacetaldehyde were identified as key contributors, primarily imparting caramel-like notes to the treated peanut oil. This study offers a viable strategy for producing premium peanut oil with optimized nutritional and sensory profiles.
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Innovative Food Science & Emerging Technologies
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2026
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IF 6.9
Minbo Li,Xianbing Xu,Min Fan,Junjie Yi,Ming Du
Clean-label clarification of polysaccharide-rich mushroom hydrolysates is critical for producing high-quality natural seasonings. In this study, we developed a green polysaccharide-targeted clarification strategy termed cryo-induced molecular flocculation (CIMF), which offers a remarkable advantage of being additive-free and highly efficient compared with conventional clarification methods such as natural sedimentation, ethanol-assisted flocculation, and chitosan-assisted flocculation for clarifying Termitomyces albuminosus hydrolysates (TAH). CIMF achieved a high clarification efficiency (60.41%) without the use of external flocculants by selectively aggregating and removing insoluble polysaccharides (41.25%) while efficiently retaining peptides (96.15%). Structural analyses and molecular dynamics simulations further revealed that low temperature facilitated monosaccharide aggregation by reducing the solvent-accessible surface area and enhancing sugar–sugar interactions leading to compact cluster formation. In summary, CIMF represents a clean-label and polysaccharide-oriented clarification strategy that provides a sustainable and green approach for the manufacture of high-quality functional food ingredients.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 3
·174
·
IF 5.4
Xu Li,Zhang Jinmi,Hu Maoyuan,Li Jianlong,Li Sheng,Xiong Xiaoli
As crucial biomarkers, the rapid and sensitive detection of dopamine (DA) and uric acid (UA) is essential for disease prevention and diagnosis. In this study, MoS 2 /MoO 2 heteronanorod modified N-doped porous carbon nanofiber (N-PCNFs@MoS 2 /MoO 2 ) sensing electrodes for the simultaneous detection of DA and UA were fabricated by electrostatic spinning coupled with vulcanization reaction. The carbonization treatment of the ZIF-8/PAN precursor endows material with hierarchical pores and a highly conductive network, which significantly increases the specific surface area and active sites and provides a fast electron transport channel for electrochemical reactions. Moreover, the synergistic effect of MoS 2 /MoO 2 optimizes the ion transport pathway and further enhances the electrocatalytic performance. Experimental results show that the electrode exhibites excellent performance for the simultaneous detection of DA and UA. The linear range for DA detection is 0.5–35 µM with a limit of detection (LOD) of 0.038 µM (S/ N = 3), while UA shows a two-segment linear response with linear ranges of 1–20 µM and 20–110 µM, respectively, and a LOD of 0.245 µM (S/ N = 3). This electrode is capable of realizing the simultaneous detection of DA and UA in human serum, showing a broad application prospect in the field of biosensing.
Section
Graphical
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Ru Jia,Sha Yan,Xuezhe Huang,Zongyan Cui,Xiaofeng Xue
Honey is primarily composed of sugars, with their profiles governing its quality. Twelve types of sugars in 784 honey samples, including 20 types of Chinese monofloral honeys, were accurately quantified by ultra-high performance liquid chromatography coupled with evaporative light scattering detection. Turanose (1.48 ± 0.63 g/100 g) was the most abundant oligosaccharide, followed by maltose (1.33 ± 0.43 g/100 g), and erlose (0.96 ± 0.80 g/100 g) was the predominant trisaccharide. Using unsupervised clustering, these honey samples were segmented into three clusters: high-oligosaccharide (e.g., jujube and fennel honey), high-glucose and low-oligosaccharide (e.g., rape, lychee and rubber honeys) and moderate-oligosaccharide clusters. The correlation analysis revealed strong correlations among turanose, maltulose, kojibiose and isomaltose, suggesting co-transformation among these sugars during honey ripening process and guiding future research directions. This study elucidated the sugar profile characteristics of Chinese honey, laying the foundation for enhancing its quality.
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Foods
·
2026
·Vol. 15
·期 3
·409
·
IF 5.1
Hongyuan Zhao,Zihan Zhang,Xiaoyu Chen,Chao Tang,Li Song,Zhaoxin Lu,Yingjian Lu
Fructose dietary intake is one of the most common risk factors for hyperuricemia, which is a critical threat to human health, and the lack of an effective biological intervention method is the main problem in preventing hyperuricemia caused by fructose intake.Lacticaseibacillus rhamnosusFmb14 (L. rhamnosusFmb14) has a fructose-metabolizing ability to produce extracellular polysaccharides (EPSs), and the yield of EPSs reached 0.50 and 0.42 g/L after 48 h of fermentation in liquid media of glucose-MRS and fructose-MRS. Six pure polysaccharide components were obtained after purification. A hyperuricemic mouse model was subsequently established by feeding a 60% high-fructose diet with potassium oxyazinate for 8 weeks, and the results revealed thatL. rhamnosusFmb14 and fructose-derived EPS (F-EPS) intervention significantly reduced the serum uric acid level of the model mice from 133.6 μmol/L to 106.7 to 111.0 μmol/L. The content of XOD in the liver decreased from 2188.1 ng/L in the model group to 1797.9 ng/L in the H-Fmb14 group and 1906.6 ng/L in the H-F-EPS group, alleviating fatty liver degeneration and improving intestinal barrier (increasing OCLN and ZO1 expression in colon). The abundances ofallobaculum,bacteroides,Lactobacilli prevotella, andclostridium, the new potential biomarkers of fructose-induced hyperuricemia, were found to be modulated after Fmb14 and F-EPS intervention. The effects of Fmb14 and F-EPS in reducing uric acid synthesis and protecting the intestinal tract are very promising as food intervention agents in the prevention of hyperuricemia caused by fructose dietary.
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Applied Biological Chemistry
·
2026
·Vol. 69
·期 1
·8
·
IF 4.2
Jia Xuewei,Xue Huijie,Yang Xiao,Yan Qingdan,Gao Yuan,Qin Yanchong,Li Tianxiao,Hu Jun,Xu Chunping
This study examined the structural features and anti-aging mechanisms of a pectic polysaccharide (AAP) extracted from Actinidia arguta leaves. AAP was extracted via three-phase partitioning coupled with ammonium sulfate precipitation and subsequently purified on a DEAE-52 cellulose column. Structural characterization via FT-IR, GC‒MS, NMR, and SEC-MALLS-RI revealed that AAP is a rhamnogalacturonan I (RG-I)-type pectin, consisting of rhamnose, arabinose, galactose, and galacturonic acid with a molar ratio of 20.1:28.4:14.8:36.7, with a weight-average molecular weight (Mw) of 4.14 × 10 5 g/mol and a random coil conformation in aqueous solution; the Congo red assay confirmed that it does not possess a stable triple-helical structure. In Caenorhabditis elegans models, AAP significantly prolonged lifespan and improved exercise capacity, accompanied by reduced accumulation of lipofuscin and reactive oxygen species. Transcriptome profiling revealed 334 differentially expressed genes (DEGs) in response to AAP treatment, with bioinformatics analysis indicating enrichment in metabolic pathways (e.g., lipid metabolism, amino acid metabolism, one-carbon metabolism), extracellular matrix homeostasis, and innate immunity. The key regulated genes included upregulated fat-7 (lipid desaturase), alh-2 (aldehyde dehydrogenase), and collagen-encoding genes ( col-138 , lon-3 ) and immune-related dod-17 , as well as downregulated fmo-2 (involved in one-carbon metabolism). Protein‒protein interaction (PPI) network analysis revealed that collagen-encoding genes and other genes served as core regulatory nodes; qRT‒PCR validated the expression trends of key DEGs, such as fat-7, lon-3, and dod-17, which were consistent with the transcriptomic data. These findings demonstrate that AAP exerts antioxidant and anti-aging effects in C. elegans by coordinating multiple pathways, emphasizing its potential as a natural anti-aging ingredient for functional foods or pharmaceuticals.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Yuang Ma,Yihui Zhang,Huixia Ma,Yaolan Yang,Wenhua Zhou,Wentao Jin,Chao Chen,Jianghao Wang,Bolong Li,Huiping Ji,Feng Zhou,Kai Qiao,Zhenyu Zhang,Haoan Fan,Jie Fu
The high production cost and inherent instability of 5-hydroxymethylfurfural (HMF) present major bottlenecks for the scalable synthesis of 5-methoxymethylfurfural (MMF), a promising biobased fuel additive and platform chemical. To address this, we propose a novel and cost-effective one-pot strategy that incorporates quaternary ammonium salts as stabilizers within a dimethyl carbonate (DMC)−methanol solvent system catalyzed by Amberlyst-15. This approach effectively suppresses the degradation of the HMF intermediate during the tandem conversion of fructose, achieving an MMF yield of 77.2% under the optimized conditions. Mechanistic investigations by Fourier transform infrared and 1H nuclear magnetic resonance spectroscopy confirm that the quaternary ammonium stabilizers coordinate with the hydroxyl and aldehyde groups of HMF through electrostatic interactions, thereby shielding it from hydration and enhancing etherification selectivity. Thus, it achieves the necessary intermediate stabilization without the economic and separation penalties of conventional DMSO or ionic liquid systems, providing a practical foundation for developing an economically viable route to MMF production.
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Small Methods
·
2026
·
IF 8.7
Runhan Xiao,Zhengyi Cao,Yu Feng,Yangjian Xu,Chuang Tian,Jiawen Liu,Jie Cheng,Haomin Wang,Zhonghui Li,Yun Wu,Pai Li,Shujie Tang,Guanghui Yu
Research on graphene transfer technology is very important for the practical applications of graphene films. Among the graphene transfer schemes, the electrochemical bubbling process is an efficient and scalable method. However, since this method involves the rapid exfoliation of graphene, ensuring the quality of the bubbling-transfer graphene remains a challenge. Herein, glucose is introduced into the bubbling solution, and its intercalation effect between graphene and the metal substrate weakens the coupling between them, making graphene easier to exfoliate. Graphene grown on a variety of different substrates is transferred by the glucose-assisted electrochemical bubbling method. The single-layer and bilayer graphene transferred by glucose assistance show excellent electrical properties, further demonstrating the high quality of graphene. This work provides a universal method for the transfer of graphene, which is expected to become the basis for its future applications.
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Advanced Science
·
2026
·
IF 14.1
Yan Xu,Weitao Yang,Yanjing Yun,Hui Wang,Zhuoyao Wu,Youyi Yu,Bingbo Zhang
Non-invasive visualization of glucose metabolism in living organisms remains a major challenge, as existing techniques cannot specifically detect glucose molecules with deep-tissue penetration and without ionizing radiation. To overcome this, we developed an enzyme-activated magnetic resonance imaging strategy (eaMRI) using a biodegradable nanoprobe, CrGOx@Lip, that integrates endogenous Cr 3+ ions with glucose oxidase for glucose-responsive imaging. Our approach leverages GOx not only as a catalytic engine to specifically oxidize glucose but also as a structural template to guide the in-situ synthesis of a potent MRI reporter (paramagnetic chromium gluconate). This design enables direct, specific amplification of MRI signals in proportion to local glucose concentration, achieving an 8.28-fold relaxivity increase. We validated this method for sensitive glucose mapping in vivo, including delineating Warburg-effect-driven tumors and quantifying pathological glucose accumulation in metabolic dysfunction-associated fatty liver disease (ΔSNR% = 18.51 ± 3.72 vs. 1.14 ± 1.39 in controls; p <0.001), and further demonstrated its utility in monitoring therapeutic efficacy via glucose-responsive signal changes. By synergizing enzymatic precision with nanomaterial engineering, our CrGOx@Lip-mediated eaMRI platform provides a glucose-specific, radiation-free, and non-invasive strategy for sensitive metabolic diagnostics in precision medicine.
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BIOLOGICAL TRACE ELEMENT RESEARCH
·
2026
·
IF 4.3
Zhang Shenao,Liu Pangwei,Jiang Yuge,Wu Huan,Cao Shijian,Xuan Shujuan,Wu Hongfei,Zhou An
Wilson’s disease (WD) is characterized by pathological copper accumulation, which drives hepatocellular oxidative stress and subsequent liver injury. While the first-line chelator penicillamine (PCA) effectively eliminates copper, it is associated with significant side effects. Dendrobium officinale polysaccharides, the active components in Dendrobium officinale , exhibit significant antioxidant and hepatoprotective effects. However, their potential in ameliorating liver injury in WD and as an adjunctive therapy to PCA remains unclear. This study investigated the hepatoprotective effects and underlying mechanisms of fresh Dendrobium officinale polysaccharides (FDOP), both alone and combined with PCA, in a copper-overloaded rat model. The results showed that FDOP significantly mitigated hepatic histopathological damage and reduced serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (AKP). It also alleviated oxidative stress by decreasing hepatic malondialdehyde (MDA) and oxidized glutathione (GSSG) levels while enhancing superoxide dismutase (SOD) activity. Furthermore, FDOP promoted copper excretion and reduced copper deposition in the liver, brain, and kidneys. Mechanistically, FDOP activated the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway, evidenced by upregulated nuclear Nrf2 and HO-1 expression and downregulated Keap1 expression, thereby enhancing the cellular antioxidant defense system. Importantly, the combination of FDOP and PCA outperformed either monotherapy in alleviating liver injury, promoting copper excretion, and activating antioxidant pathways. In conclusion, FDOP not only exhibits excellent hepatoprotective effects but also holds potential as an adjunct to PCA therapy, offering a novel combined treatment strategy for WD.
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