ACS Sustainable Chemistry & Engineering
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2025
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IF 7.3
Kuan-Chang Chang,Xinqing Duan,Yu Jiang,Lei Lu,Dar-Jen Hsieh,Lei Li
Pectin, a widely available biomaterial, has become a promising candidate for bioelectronics. However, residual free carboxyl groups from the extraction process (commonly acid solubilization) cause poor optoelectronic stability, low transparency, and high electrical leakage, rendering pectin unsuitable for bioelectronics. This study employs a biomaterial-friendly supercritical carbon dioxide self-cross-linking (SCS) method to achieve the self-cross-linking of pectin molecules without a cross-linking agent or catalyst at low temperatures, resulting in enhanced pectin properties. SCS treatment induces esterification of free carboxyl groups with the pectin main chain, forming cross-linked ether bonds via intermolecular dehydration, leading to a denser structure replacing the original loose porous structure. The treated pectin film demonstrates superior optoelectronic performance, with a 4-fold reduction in leakage current and enhanced yellow-green light transmittance. An ultra-strong pectin material is obtained, whose Young’s modulus increased to 1.31 GPa, a 21.9% improvement over the untreated material, outperforming other pectin sources. The low-temperature supercritical method enhances pectin’s optoelectronic properties, making it more suitable for bioelectronics, while achieving unprecedented material strength through self-cross-linking. This advancement minimizes functional layer deformation, reduces power consumption, and extends the bioelectronics lifespan.
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LANGMUIR
·
2025
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IF 3.9
Yuchuan Qian,Tianhong Xu,Haiyuan Yao,Guangchun Song,Yuxing Li,Wuchang Wang,Xinran Yu,Zheng Xu
Flow blockage caused by hydrate deposition in deep-water–oil and gas pipelines seriously affects the safety of energy transmission. The structural stability of hydrates has a direct influence on the assessment of the development of hydrate deposition in pipelines, and the situation under hydrate-inhibitor-containing conditions may be more complicated. The effect of inhibitors on the structural stability of hydrate deposition under the action of flow scouring has not yet been clarified. The present study was based on the process of hydrate formation transformation under kinetic inhibitor-containing pectin conditions. The “concentration effect” of the pectin system causes the hydrate particle morphology to change from acicular to punctate. For the first time, the evolution model of microscopic fracture in the hydrate bed under the action of flow scouring in the high-mass transfer region was clarified. It was determined by microscopic dynamic data that there was reformation and filling of hydrate particles between the flow scouring fracture as well as growth and extension behavior, and a chain initiation-induced nucleation effect of hydrate particles was proposed. It was further found that pectin weakened the cohesion of hydrate particles, but when the pectin concentration was 0.25 wt %, there was an abnormal increase in cohesion. Enhanced mass transfer due to structural destabilization of the hydrate layer may be responsible for the continued formation and transformation of pectin system hydrates at low shear rates. This study shows for the first time the correlation between inhibitor concentration and hydrate conversion from the perspective of structural stability of hydrate beds and provides a theoretical basis for the engineering application of green inhibitors.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Lele Chen,Shaofei Zhang,Tingyu Liang,Xu Ding,Ling Ding,Jipeng Shi,Ji Zhang,Jianping Wu
The therapeutic potential of essential oils in feed and medicine is limited by their volatility, degradation, and poor bioavailability. To overcome these challenges, a novel colon-targeted microsphere was engineered for the controlled delivery of tea tree essential oil (TEO), as illustrated in Scheme 1 . A critical component of this system is a pH-responsive coating composed of pectin and starch, which acts as a colon-specific polymeric barrier. This coating demonstrated precise pH-responsive release, with minimal leakage in simulated gastric fluid (SGF) (only 10.87 % release over 4 h) and sustained, colon-specific release in simulated intestinal fluid (SIF) (79.77 % over 14 h). The core of the system, designated TEOCMT, was fabricated through the modification of montmorillonite (MMT) with cetyltrimethylammonium bromide (CTAB), resulting in organo-montmorillonite (CMT). Tea tree essential oil was then encapsulated within the interlayer spaces of CMT, forming an effective sustained-release system (TEOCMT). Compared to raw MMT (5.63 %), the TEO loading capacity of CMT increased 8.3-fold, reaching 46.79 %. Furthermore, the antibacterial activity of PS/TEOCMT microspheres was triggered in alkaline media, where they dissolved and released the TEOCMT core. This resulted in enhanced efficacy, particularly against S. aureus (MIC = 1.25 mg mL −1 ), which was superior to that of pure TEO (MIC = 2.5 mg mL −1 ). The PS/TEOCMT microspheres also exhibited excellent biocompatibility. This work presents a robust and effective strategy for unlocking the full potential of essential oils in colon-specific applications.
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POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2025
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IF 6.8
Kai-Ping Cong,Ting-Ting Li,Cai-E. Wu,Gong-Jian Fan,Dan-Dan Zhou,Xiao-Jing Li,An-Di Suo
This study investigates the effects of Plasma-activated water (PAW) treatment on cell wall polysaccharide metabolism in goji berries during storage. The results indicate that PAW treatment modulates plant hormone levels and reduces the activity of cell wall-degrading enzymes, thereby slowing water loss and the softening process of the fruits. In the PAW-treated group, indoleacetic acid (IAA) and abscisic acid (ABA) levels were significantly lower than those of the control group in the later storage stages, while Gibberellin A 3 (GA 3 ) levels remained higher, suggesting a positive impact on hormone homeostasis. Additionally, PAW treatment effectively inhibited the decline in the molecular weight of water-soluble pectin (WSP) and sodium carbonate-soluble pectin (SCSP), as well as the increase in Polygalacturonase (PG) and β-glucuronidase (β-Glu) activity. Overall, PAW treatment played a beneficial role in delaying cell wall degradation and softening, maintaining structural stability, and thereby enhancing the storage quality and shelf life of goji berries.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Guichen Liu,Rong Liu,Chengyu Fu,Xiang Hu,Ke Li,Luke Yan,Peng Yang,Jian Zhao
The increasing pace of modern life has led to the widespread popularity of fresh-cut fruits among consumers. However, their susceptibility to spoilage and short shelf life remains a significant challenge. Thus, there is an urgent need for simple, eco-friendly, low-cost, and energy-efficient preservation strategies. Herein, we report a novel method based on amyloid-like protein aggregation. Fresh-cut fruits are immersed in an aqueous solution containing lysozyme, L-cysteine, and pectin under ambient conditions, forming a ~ 12 nm thick, transparent, and colorless proteinaceous nanocoating embedded with pectin on the fruit surface. This nanocoating preserves the fruit's natural appearance and visual appeal while forming an ordered amyloid-like structure that strongly adheres to moist surfaces and offers excellent barrier properties. When applied to polyethylene (PE) film, the nanocoating reduces O 2 , CO 2 , and water vapor permeability of PE film by 48%, 62%, and 17%, respectively. In addition, the lysozyme-based coating provides effective protection against microbial contamination. Compared to untreated apples, coated samples exhibit a slower deterioration rate and an extended shelf life from 2 to 4 days at room temperature, as demonstrated by delayed weight loss, reduced firmness loss, and inhibited browning. Biochemical assays show minimal increases in malondialdehyde, polyphenol oxidase, and peroxidase levels during storage, indicating attenuation of oxidative and enzymatic degradation. Meanwhile, total soluble solids and vitamin C levels remain largely stable. In vitro cytotoxicity assays and mice feeding studies confirm the nanocoating's safety and edibility. This versatile, sustainable approach is broadly applicable to fresh-cut fruits and vegetables and offers a promising biomass-based solution to help reduce global food waste.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 4.9
Pei-Ling Liu,Jia-Lin Wang,Yi-Ying Dong,Hong Liu,Jin-Ju Lei,Bin Xu,Xin-Ru Liao,Di Han,Zi-Hao He,Si-Xue Cheng
Epidermal growth factor receptor (EGFR) targeted cancer therapy offers high selectivity and reduced toxicity. However, the therapeutic efficacy is compromised by the poor bioavailability of hydrophobic drugs such as gefitinib (GEF), and the acquired resistance. Curcumin (CUR) can sensitize tumor cells toward EGFR inhibitors and reverse drug resistance, but its application is also hindered by low solubility. To address these limitations, we developed a zein-based drug delivery system for the co-delivery of GEF and CUR. The dual-drug loaded zein-based nanoparticles (GEF/CUR@ZNP) decorated by pectin were prepared by self-assembly. GEF/CUR@ZNP exhibited a mean diameter less than 300 nm, featuring a narrow size distribution and an encapsulation efficiency higher than 80 %. The therapeutic efficacy was evaluated in vitro using PC-9 cells. Compared with free drugs, GEF/CUR@ZNP led to significantly enhanced cellular uptake, resulting in improved induction of cancer cell apoptosis and higher efficiency in downregulation of proteins promote cancer progression (e.g., Sp1, Bcl-2, VEGF, Snail, and CD44). To evaluate the efficacy of the drug delivery system in a context more relevant to clinical settings, we evaluated the EGFR inhibition efficacy by using the blood samples containing circulating tumor cells (CTCs) from non-small cell lung cancer (NSCLC) patients, and immunofluorescence labeling confirmed that GEF/CUR@ZNP achieved most effective suppression of EGFR expression. These findings demonstrate that zein-based co-delivery of GEF and CUR can overcome multiple barriers to targeted cancer therapy, and offer a clinically relevant strategy for enhancing antitumor efficacy and personalizing cancer treatment.
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FOOD CHEMISTRY
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2026
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IF 9.8
Yin-Yin Lv,Xian-Hao Zhang,Jia-Ni Zhou,Ying-Rui Wang,Zhu-Jun Zhang,Jia-Nan Yan,Bin Lai,Ce Wang,Hai-Tao Wu
The effects and mechanisms of four polysaccharides (xanthan gum (XG), pectin (PE), curdlan (CUR), and chitosan (CS)) at 2 % ( w /w) concentrations on the gelation of Spanish mackerel surimi were investigated. The gel strength, hardness and chewiness of surimi added with XG and PE decreased by 33.6 %–84.9 %, while those of the CUR and CS groups increased by 6.2 % to 38.9 %. Additionally, the incorporation of PE reduced water holding capacity and increased cooking loss. According to the International Dysphagia Diet Standardization Initiative framework, gels supplemented with XG and PE met levels 5 and 6 standards, respectively. Through strong electrostatic repulsion and steric hindrance, XG and PE impeded the approach and cross-linking of myofibrillar proteins and competed for water binding, which collectively weakened hydrophobic interactions, inhibited the formation of a dense gel network, and resulted in a soft and porous weak gel structure. This research provides insights into the development of dysphagia-friendly foods.
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FOOD CHEMISTRY
·
2023
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IF 8.8
Lechuan Wang,Mengzhuo Liu,Panpan Guo,Huajiang Zhang,Longwei Jiang,Ning Xia,Li Zheng,Qian Cui,Shihui Hua
Although protein-polysaccharide complexes have shown tremendous potential in stabilizing high internal phase Pickering emulsions (HIPPEs), it is unclear whether coacervates have the same potential to be used as effective Pickering stabilizers. In this study, HIPPEs were prepared by ovalbumin (OVA)-pectin (PE) coacervates during the transition from coacervates to complexes. The results showed that enhanced OVA-PE interactions significantly affected the wettability and surface-tension reduction ability of the OVA-PE coacervates. At pH 2, the coacervate-stabilized HIPPEs exhibited smaller oil droplet sizes (21.3±2.3 μm), tighter droplet packing, and finer solid-like structures through the bridging of droplets and the generation of stronger gel-like network structures to prevent coalescence and lipid oxidation. The gastrointestinal digestion results proved that the OVA-PE coacervates promoted lipid hydrolysis and improved the bioaccessibility (from 19.7±0.7% to 36.5±2%) of curcumin-loaded HIPPEs. Our work provides new ideas for the development of biopolymer particles as effective Pickering stabilizers in the food industry.
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BIOMACROMOLECULES
·
2023
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IF 6.2
Jiaying Li,Yuji Pu,Sai Li,Bin He,Jianlin Chen
The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn’s disease is extremely cloudy. Maintaining the level of remission lesions in colitis is the default treatment attitude at present. Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment. Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release. Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine. In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres. In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
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IF 5.8
Qiqi Sun,Jun Chen,Quan Zhao,Ziyun He,Lei Tang,Yuji Pu,Bin He
Ulcerative colitis (UC) as an important type of inflammatory bowel disease is a chronic disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the insufficiency of drug delivery and retention. Herein, we fabricated an intrarectal formulation of olsalazine (Olsa)-loaded hydrogel microspheres (LDKT/Olsa) with good bio-adhesiveness and reactive oxygen species (ROS)-scavenging ability to enhance drug retention and therapeutic effect. Low methoxy pectin-dopamine conjugate/konjac glucomannan composite hydrogel microspheres (LDKT) with a size ranging from 10 to 100 μm were prepared by using Zn 2+ and ROS-sensitive thioketal as crosslinkers. Upon intrarectal administration, the negatively charged and dopamine-functionalized hydrogel microspheres efficiently adhered to cationic surface of inflammatory mucosa, scavenging ROS and releasing Zn 2+ and Olsa for antibacterial and anti-inflammatory effects. In the dextran sodium sulfate (DSS)-induced mouse UC model, the microspheres significantly reduced the levels of colonic ROS and pro-inflammatory cytokines, improved gut mucosal barrier integrity, and remarkably relieved colitis . Overall, the LDKT microspheres are promising carriers to deliver drugs for UC treatment.
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Journal of Cleaner Production
·
2023
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IF 11.1
Fei Zhu,Zhenqi Wang,Jingchun Huang,Wei Hu,Di Xie,Yu Qiao
Activated carbon derived from the organic solid waste is a promising material for ammonia removal. The components in the feedstock would affect the performance of activated carbon, but the detailed effect mechanism remains unknown. To reveal the correlations between the components of the feedstock and different ammonia adsorption styles of activated carbon, this study used pomelo peel to prepare ZnCl 2 -loaded activated carbon for ammonia adsorption via hydrothermal carbonization and KOH activation, focusing on the effect of the chemical components (cellulose, xylan , pectin, and lignin) on the physicochemical properties and adsorption performance of activated carbon. For raw activated carbon in moist conditions, ammonia was mainly adsorbed in the form of Lewis/Brønsted acid-base (37.8 mg/g), followed by the ZnCl 2 coordination compound and organic amine forms (22.3 mg/g). Lignin-added activated carbon had the highest adsorption capacity , 91.2 mg/g in moist conditions, followed by cellulose-added and xylan-added activated carbon. The presence of lignin was beneficial for the formation of the phenolic group of activated carbon (increased by 111.3%), which promoted ammonia adsorption in the form of Lewis acid-base, especially in dry condition. Cellulose and xylan enhanced the formation of carboxylic (i.e., increased by 53.0% for cellulose) and lactonic groups (i.e., increased by 73.4% for cellulose) of activated carbon, leading to an increase of ammonia adsorption in the form of Brønsted acid-base and organic amines in moist conditions. The results illustrated the detailed effect of the chemical components in the feedstock on the ammonia adsorption styles, which could guide the selection of appropriate materials to prepare activated carbon for highly efficient ammonia adsorption under various situation.
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FOOD HYDROCOLLOIDS
·
2023
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IF 10.7
Lin Li,Jia-Nan Yan,Bin Lai,Ce Wang,Jin-Jian Sun,Hai-Tao Wu
Chia seed gum was extracted using high-speed shearing technology and further purified via ethanol precipitation. The composition, structural and rheological properties of crude chia seed gum (CCSG) and purified chia seed gum (PCSG) were evaluated and further compared with twelve commercial polysaccharides (agar, xanthan gum , κ-/ι-/λ-carrageenan, guar gum, carboxymethyl cellulose , locust bean gum, pectin, acacia gum, sodium alginate and konjac gum). The extraction yields of CCSG were significantly improved from 1.80% to 6.25% by high-speed shearing for 2.0 min. Compared to CCSG (36.63% and 3.985 × 10 5 g/mol), PCSG had a higher total neutral sugar content (51.85%), lower molecular weight (1.718 × 10 5 g/mol) and looser surface morphology. Furthermore, PCSG and CCSG had different monosaccharide composition. However, both CCSG and PCSG exhibited pseudoplastic fluid behavior, but PCSG had higher viscosity and modulus values than CCSG at the same concentrations. Compared to commercial polysaccharides, PCSG had rheological characteristics similar to those of xanthan gum, with high viscoelasticity and good stability against temperature change. The relaxation time T 2 curves showed that CCSG and PCSG had better water-holding capacity than most commercial polysaccharides. This study provided theoretical guidance for the potential utilization of chia seed gum as a thickening and stabilizing agent in the food industry.
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