Advanced Membranes
·
2026
·
IF 12.6
Wan-Ting Lin,Xuan-Ce Jin,Si-Yuan Zhang,Wan-Long Li,Zi-Lu Zhang,Xiao-Wei Luo,Zi-Jun Zhang,Zhi-Kang Xu,Ling-Shu Wan
Traditional thin-film composite (TFC) polymer membranes suffer performance deterioration in high-temperature liquid separation due to insufficient thermal stability. Herein, a facile and effective strategy was proposed to fabricate TFC nanofiltration membranes with enhanced thermal stability by using mono- n -dodecyl phosphate (MDP) as an oil-soluble surfactant to regulate the interfacial polymerization. MDP molecules markedly reduce the water/hexane interfacial tension and act as transport carriers to promote the diffusion of amine monomers, as validated by density functional theory (DFT) calculations. By adjusting the concentration of MDP in the organic phase, the polyamide thickness and compactness, surface properties, and the separation performance of the TFC membranes at high temperature can be effectively modulated. The optimal TFC membrane exhibits exceptional thermal stability, maintaining rejection to MgSO 4 > 98.5% and water permeance >35 L m −2 h −1 bar −1 during a continuous operation at 85 °C for 100 h. Temperature-dependent pore size analysis further confirms the enhanced structural integrity of the MDP-regulated TFC membranes under high temperature. This research establishes a novel paradigm for developing nanofiltration membranes with high thermal stability.
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CHROMATOGRAPHIA
·
2026
·
IF 1.6
Zhao Xingyun,Liu Xiaojian,Zhang Zhenwei,Jin Jiangyan,Yang Siyu,Zhao Chengxiao,Wu Rongfang,Zhang Liyun
Mesoporous silica particles were synthesized via investigating polymerization-induced colloidal aggregation (PICA) reaction process in our laboratory. Mesoporous microspheres with a particle size of about 2~7 μm and various surface morphology were first compared via varying the pH and molar ratio of formaldehyde/urea in the PICA process. The effects of salts and surfactant on the preparation were further investigated by fixing pH and molar ratio formaldehyde/urea (1:1.5), demonstrated that the particle size distribution became narrower when potassium sulphate and a nonionic surfactant were added together. The morphology, pore size distribution and the specific surface area of the synthesized mesoporous SiO 2 microspheres were observed and characterized by optical microscope, scanning electron microscope (SEM), dynamic light scattering (DLS), and specific surface area (BET) analysis. In the present study, synthesized materials modified octadecyltrichlorosilane (PICA-3@C18) were slurry-packed into a chromatographic empty column, resulting in successful separation of nonpolar compounds. Furthermore, the synthesized materials were functionalized with aminopropyl trimethoxysilane under optimized conditions and exhibited outstanding separation abilities. Aminopropyl trimethoxysilane was further bonded onto commercial SiO 2 , resulting in a stationary phase that exhibited better chromatographic performance than commercial amide columns, NH 2 columns, and other HILIC columns. This work provides insight into retention behavior in HILIC mode and offers a foundation for the development of other amine-based HILIC stationary phases.
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Small
·
2025
·
IF 12.1
Jichun Li,Yu Deng,Luyang Liu,Yidan Chen,Fengluan Jiang,Meihua Chen,Jianfeng Xia,Yonghui Deng
Flexible gas sensing devices have attracted a growing research interest in recent years due to their potential applications in various fields such as wearable electronics. Porous 2D metal oxide semiconductors (2D MOSs) with superior electrical and catalytic characteristics are deemed as promising materials for flexible gas sensors, especially for low-concentration gas detection; however, the synthesis of high-quality 2D MOSs remains challenging. In this study, 2D porous In 2 O 3 nanosheets with a high specific surface area (85.9 m 2 /g) and a thickness of 4.0 nm are synthesized via a scalable micro-explosion assisted caramelization reaction. The synthesis parameters affecting the formation of 2D porous metal oxide nanostructures are systematically studied, and a proposed growth mechanism is dominated by generating the sacrificial 2D carbon intermediate templates. Furthermore, flexible gas sensors are fabricated by depositing 2D porous In 2 O 3 nanosheets on polyimide substrates, which exhibit outstanding sensing performance with high sensitivity toward trace hydrogen sulfide (response value of 17.3 for 250 ppb) at 37 °C, excellent selectivity, and high stability. The sensor is further integrated into a wearable, flexible wireless sensing device, showing good reliability and great potential in detecting trace hydrogen sulfide in practical applications.
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JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Yanrui Wang,Hailin Chang,Shu Jiang,Jialong Chen,Jinlong Wang,Heng Liang,Guibai Li,Xiaobin Tang
The interfacial polymerization (IP) plays a fundamental role in the fabrication of polyamide (PA) nanofiltration (NF) membranes with high ion selectivity and water permeability, which has enormous value for the increasing permeate quality and production in desalination. Herein, this study adopted a weak-polar organic solvent of ethyl formate (EF) to effectively regulate the IP process between piperazine (PIP) and trimesoyl chloride (TMC). The engineered PA separate layer conferred a uniform and ultrafine pore size (∼0.195 nm), exhibited a precise solute separation, and maintained a desirable permeability (18.4 ± 0.9 L m −2 h −1 bar −1 ). Molecular dynamics (MD) simulation indicated that EF involvement would significantly reduce the interfacial tension to motivate a fast and abundant diffusion of amine monomers from the aqueous phase into organic phase during the IP reaction, contributing to engineering a PA film with higher crosslinking degree. The optimized PA NF membranes conferred a more efficient rejection for divalent anions and cations (e.g., 99.5% for Na 2 SO 4 and 98.8% for MgCl 2 ). Remarkably, the membrane endowed a fairly high mono/divalent ion selectivity at sub-angstrom size, such as 145 for Cl − /SO 4 2− and 61 for Na + /Mg 2+ . The outstanding NF performance successfully broke the "trade-off" bound of perm-selectivity and was superior to the most "state-of-the-art" NF membranes. Overall, the co-solvent based IP strategy was beneficial to developing high-performance NF membranes without any significant changes to the existing fabrication process, and its facile and cost-effective merits were full of significance to the membrane manufacture.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Huihui Yang,Xiaosen Bai,Baolong Feng,Qinghua Wang,Li Meng,Fengzhong Wang,Yutang Wang
Advanced glycation end products (AGEs) are associated with the occurrence of human chronic diseases, and exist commonly in thermally processed foods, such as infant formula. Existing research mainly focuses on the discrete simulation system, which is time-consuming and challenging, but accumulates of a large amount of valuable data. This study aimed to propose a specific Molecular Transformer-based model trained on the data curated from literature to predict the chemical reaction of AGEs, and apply it to infant formula to observe which new reactions could generate AGEs. The model achieved top-3 accuracy of 76.0% on the total dataset. Based on the model prediction results, five reactions were selected for experimental verification, and four of them were consistent with the model prediction results. This prospective study might potentially revolutionize the discovery of AGEs reactions and provide theoretical guidelines for designing a safer infant formula.
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Arabian Journal of Chemistry
·
2022
·
IF 6.212
Xin Liu,Hao Cai,Minjie Niu,Hui Yu,Mengqing Wang,Hui Zhu,Gang Cao,Ke Pei,Yu Duan,Jiantao Song
Fructus Corni (FC), as a promising Chinese medicinal herb, has aroused considerable interest. Generally, FC needs to be processed according to the limited standard policy in China before clinical application, while the investigations on the specific processing methods (such as wine steaming or high-pressure wine steaming) are unclear. A comprehensive metabolomics strategy based on integrated non-targeted metabolomics and targeted glycomics in this paper was implemented to investigate the influences of the different processing technologies such as steaming, wine steaming, high-pressure steaming, high-pressure wine steaming, wine immersion, and wine stir-frying on FC, respectively. UHPLC-Q-TOF-MS/MS was employed for identifying and distinguishing the secondary metabolites. A total of 85 components were identified in all groups. The results of PCA score plots showed that the crude and processed samples had a complete separation, and wine steamed and high-pressure wine steamed samples could be a category, indicating that the two processed products had a similar quality. Multiple chromatography including HPLC (C 18 )-PDA, HPLC (NH 2 )-ELSD, and HPGPC-ELSD was used for determining the molecular weight distributions, the monosaccharide compositions of polysaccharides, and the contents of free monosaccharides and oligosaccharides. The results indicated that the content and composition of saccharides were different in crude and different processed FC. The polysaccharides were composed of fucose, arabinose, galactose, glucose, galacturonic acid, mannose and rhamnose, and the free monosaccharides were composed of fucose, arabinose, galactose, glucose, mannose, rhamnose and fructose in all FC samples. The PCA score plots of the glycomics indicated that the crude and high-pressure wine steamed FC could be a category, showing that the two groups had similar chemical compositions. Ultimately, the simulation processing experiments indicated that the transformation of morroniside, polysaccharides, oligosaccharides, fructose, and glucose to 5-HMF through the reactions of dehydration and deglycosylation was the potential mechanism of enhancing the effects by processing. Conclusionly, the saccharides should be investigated as thoroughly as the secondary metabolites, and the high-pressure wine steamed FC could be an alternative to wine steamed FC.
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Processes
·
2023
·Vol. 11
·期 1
·255
·
IF 3.5
Ke Chen,Jingyun Zhang,Xing Liu,Peiyuan Zhang,Wenlong Yue,Zhiqiang Cai
Aspergillussp. D-23 was obtained by ultraviolet-diethyl sulfate (UV-DES) compound mutagenesis fromAspergillussp. C18 that the α-galactosidase was purified from. According to sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and non-denaturing polyacrylamide gel electrophoresis (Native-PAGE), the purified enzyme demonstrated apparent homogeneity. The monomeric α-galactosidase’s native molecular weight was 125 kDa. The optimal temperature of α-galactosidase was 65 °C, and 75% of the initial enzyme activity could be maintained between 45 and 55 °C. Its optimal pH was 5.0 with good pH stability. After incubating for 2 h at pH 3.0–8.0, it could retain more than 80% of its original activity. Different concentrations of metal ions had different effects on the α-galactosidase activity. High concentrations of Cu2+could strongly inhibit enzyme activity and low concentrations of Fe2+could promote enzyme activity. Additionally, as shown by thin layer chromatography and high-performance liquid chromatography, the enzyme also had good hydrolysis ability, which could efficiently hydrolyze melibiose and raffinose by more than 95%. Therefore, these excellent characteristics could make α-galactosidase a good candidate for the food and feed industries.Keywords:α-galactosidase;enzymatic characterization;Aspergillussp.;enzymatic hydrolysis;higher molecular weight
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DESALINATION
·
2023
·
IF 9.9
Xinxin Wei,Kaiming Fan,Peng Cheng,Yanling Liu,Shengji Xia
Simultaneous enhancement in the removal of organic micropollutants (OMPs) and water permeance is highly desirable for nanofiltration (NF)-based drinking water treatment . This study employed two cyclodextrin derivatives with different functional groups, i.e., (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) and sulfobutylether-β-cyclodextrin (SBECD), as aqueous additives for polyamide (PA) membrane fabrication. Characterization results revealed that HP-β-CD tended to enrich piperazine (PIP) monomers through hydrogen bonding, resulting in a thin but dense PA layer. Conversely, SBECD moderated PIP diffusion through electrostatic forces and steric hindrance , participated more in the interfacial polymerization reaction and yielded an active layer with a coexistence of polyester and polyamide. Both the CD derivative modified membranes exhibited improved surface hydrophilicity , enhanced roughness, and reduced active layer thickness, leading to over 60 % water permeance improvement without the obvious variation of pore size. This enabled the optimal membranes, especially the HP-β-CD incorporated one, highly advantageous in overcoming the trade-off effect between water permeance and OMP rejection. Meanwhile, the strongly negatively charged SBECD modified membrane showed reduced rejections for divalent cations, making it more resistant to scaling. This study offers an efficient approach to tailoring membrane water/solute selectivity and solute/solute selectivity, which has great potential in NF membrane development for drinking water treatment.
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Bio-Design and Manufacturing
·
2023
·Vol. 6
·期 4
·464-477
·
IF 7.9
Qiao Qian,Zhang Xiang,Yan Zhenhao,Hou Chuanyu,Zhang Juanli,He Yong,Zhao Na,Yan Shujie,Gong Youping,Li Qian
Cryobioprinting has tremendous potential to solve problems to do with lack of shelf availability in traditional bioprinting by combining extrusion bioprinting and cryopreservation. In order to ensure the viability of cells in the frozen state and avoid the possible toxicity of dimethyl sulfoxide (DMSO), DMSO-free bioink design is critical for achieving successful cryobioprinting. A nontoxic gelatin methacryloyl-based bioink used in cryobioprinting is composed of cryoprotective agents (CPAs) and a buffer solution. The selection and ratio of CPAs in the bioink directly affect the survival of cells in the frozen state. However, the development of universal and efficient cryoprotective bioinks requires extensive experimentation. We first compared two commonly used CPA formulations via experiments in this study. Results show that the effect of using ethylene glycol as the permeable CPA was 6.07% better than that of glycerol. Two datasets were obtained and four machine-learning models were established to predict experimental outcomes. The predictive powers of multiple linear regression (MLR), decision tree (DT), random forest (RF), and artificial neural network (ANN) approaches were compared, suggesting an order of ANN>RF>DT>MLR. The final selected ANN model was then applied to another dataset. Results reveal that this machine-learning method can accurately predict the effects of cryoprotective bioinks composed of different CPAs. Outcomes also suggest that the formulations presented here have universality. Our findings are likely to greatly accelerate research and development on the use of bioinks for cryobioprinting. Graphic abstract
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DESALINATION
·
2022
·
IF 11.211
Peng Cheng,Yanling Liu,Xiaoping Wang,Kaiming Fan,Pan Li,Shengji Xia
Interlayered thin-film nanocomposite (TFN) membranes have been proven to achieve enhanced water permeance for desalination applications , while those lacking effective control over the construction of interlayers were prone to unsatisfactory permselectivity . In this study, a high-performance TFN membrane was constructed via interfacial polymerization on a Metal-Organic Frameworks (MOFs)-interlayered polyethersulfone substrate. Regulating the thickness of the MOFs (copper-tetrakis(4-carboxyphenyl) porphyrin , Cu-TCPP) interlayer could effectively tailor the structural parameters (effective filtration area, selective layer thickness, and pore size) and physicochemical properties of the membrane. A resistance-in-series model was applied to analyze the hydraulic resistance distribution and the specific value of the intrinsic solution permeability of each layer of the TFN membranes. Results showed that the interlayer with a proper deposition density of MOFs nanosheets could simultaneously increase the cross-linking degree by adsorbing the PIP monomers and reduce the thickness of the PA layer to enhance the intrinsic permeability . The optimal membrane with a thin PA film (20 nm) displayed an excellent water permeance of 32.7 L·m −2 ·h −1 ·bar −1 and an ultrahigh NaCl/Na 2 SO 4 selectivity of 271.7. Moreover, the membrane demonstrated remarkable stability during 120 h filtration. This work provides a promising strategy for fabricating TFN membranes with higher selectivity and enhanced comprehensive performance.
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Current Research in Food Science
·
2022
·
IF 6.269
Simeng Shao,Weiyin Xu,Zhaoyang Xie,Mengyuan Li,Jingli Zhao,Xinxin Yang,Peng Yu,Hongmei Yang
Despite the widely recognized importance of ginseng carbohydrates, their structural analysis is still challenging due to structural complexity. This study presents the first ion mobility-mass spectrometry (IM-MS) combined with 1-phenyl-3-methyl-5-pyrazolone (PMP) labeling and multivariate data analysis for profiling carbohydrates in the seven ginseng products. 11 carbohydrates were tentatively annotated, including 5 first found in ginseng, and three of them were solely detected in black ginseng (BG) samples, speculated as monosaccharides bearing various groups based on MS 2 analysis. Furthermore, 3D profiles of carbohydrates in IM-MS of the samples showed good discrimination between the varieties of ginseng which were classified into two groups utilizing carbohydrate contents by PLS-DA. The big difference between BG and the others may be ascribed to the repeated heating and steaming process for preparation of BG products. Our findings may provide insights into the differences in bioactivity of different ginseng varieties for future research and show a valuable methodology for discovering unknown carbohydrates.
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CHEMOSPHERE
·
2022
·
IF 8.943
Zhongbao Ma,Long-Fei Ren,Diwen Ying,Jinping Jia,Jiahui Shao
The separation of hardness ions such as calcium and magnesium from hard water can improve water quality, which is important but technically challenging. Nanofiltration (NF) has attracted much attention because of its efficiency, environmental friendliness and low cost. However, common NF membranes with a singly (either positively or negatively) charged layer have insufficient water softening capacity. In this work, two types of dual-layer Janus charged polyamide NF membranes composed of oppositely charged inner and outer layers were developed for the first time by sequential electrospray polymerization strategy for efficient water softening. The effect of the microstructure of the dually charged barrier layer on the separation performance of divalent salt ions was explored. Detailed mechanistic studies revealed that the microstructure of the outer layer of the barrier layer played a crucial role in the ion separation of the Janus membrane due to its control of the reverse transport of ions. Janus charged polyamide NF membrane with a loose outer layer exhibited better water softening performance (93.6% of hardness removed) compared to the singly charged NF membranes due to the simultaneous dual electrostatic effect and no ion reverse transport confinement. This Janus charged NF membrane also possessed good antifouling performance, mainly due to its negatively charged outer layers. The mechanistic insights gained in this study reveal the huge potential of microstructural design toward high-performance Janus charged NF membranes, and provide important guidance on the future development of high-efficiency water softening NF membranes.
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