International Journal of Environmental Research and Public Health
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2019
·Vol. 16
·期 2
·209
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IF 2.468
Huihui Chen,Xiaohong Gu,Qingfei Zeng,Zhigang Mao
As one of the most frequently detected pharmaceutical compounds in aquatic environments, carbamazepine (CBZ) has recently been shown to cause acute and chronic toxicity in a variety of non-target aquatic organisms. However, little is known about the ecotoxicological effects it has on the molting and reproduction of crustaceans. The aim of the present work was to evaluate the acute and chronic toxic responses to CBZ in the crustaceanDaphnia similis. After acute exposure (4 days), CBZ did not cause lethal toxicity at the tested concentrations. However, CBZ did inhibit the molting and release of chitobiase at concentrations higher than 6.25 μg/L, with 96 h EC50(median effective concentration) values of 864.38 and 306.17 μg/L, respectively. The results of chronic exposure showed that the mean number of molts, size of the first brood, mean number of offspring per brood, mean number of broods per female, and total offspring per female decreased significantly with increasing CBZ concentrations. Significant effects of CBZ on the molting or fecundity inD. similiswere observed even at concentrations as low as 0.03 μg/L. In conclusion, CBZ can cause inhibition of molting, delayed reproduction, and reduced fecundity inD. similis. CBZ toxicity toD. similisdepends on the timing and duration of the exposure. Moreover, our results indicated that CBZ would act as an endocrine disrupter inD. similis, as with vertebrates (e.g., fish).Keywords:carbamazepine;molting;Daphnia similis;chitobiase;chronic toxicity;reproduction
研究领域:
环境毒理学
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水生生态学
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医药污染
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2022
·
IF 10.753
Xiangmei Xiang,Juanjuan Zhou,Shaochen Lin,Nan Zhang,Gulizhabaier Abulipizi,Guikui Chen,Zhanjun Li
Microplastics (MPs) can adsorb and influence the toxicity of traditional pollutants significantly. Although the complex toxicity of MPs and molecular pollutants were frequently reported, rare work has been done on the influence of MPs on the phototoxicity of photosensitive pollutants under light illumination condition. Herein, polystyrene microplastics (PS) (~1 μm in diameter, 5.0 mg/L) was used as a model MP to investigate its influence on the phototoxicity of a soluble blue dye, methylene blue (MB) using Daphnia magna as a model organism. The results indicate that PS could adsorb MB effectively and quickly, thus led to concentrated MB on PS/water interface. D. magna ingested MB-adsorbed PS very quickly within tens of minutes. Although MB or PS alone led to negligible lethal phototoxicity to D. magna , PS significantly enhanced the lethal phototoxicity of MB (0.25 mg/L) to D. magna after light illumination (10 h) with the survival rate decreased by 63.3 % compared with the control in the dark. Further, the phototoxicity of MB was found positively consistent with PS concentration from 0.50 mg/L to 7.50 mg/L. The singlet oxygen fluorescence assay indicates that the presence of PS did not increase the total amount of singlet oxygen in the aquatic environment but increased the local concentration in the gut area via non-selective ingestion of D. magna . High level singlet oxygen generated in the gut might possibly be the main reason that led to the massive death of D. magna . Surface adsorption of photosensitive pollutants may transform inert MPs into persistent solid sources of singlet oxygen production and become a new potential lethal threat to aquatic small organisms and ecological equilibrium. This kind of MPs and light dual drive phototoxicity of photosensitive pollutants needs to paid more attention in understanding the uncertain ecological risk of MPs.
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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2011
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IF 1.378
Wenhua Song,Jing Guo,Feng Ding,Weixuan Hu,Zhen Li,Minling Gao
The acute toxicities of the six naphthoquinone compounds on Daphnia magna ( D. magna ) at 48 h were classified as harmful, toxic, and very toxic. The results indicated that log P played an important part in the toxicity of compounds to organism. And 1-carbonyl or the other hydrophobic substituents of the naphthoquinone compounds are likely to mediate the binding of the compound to the target via hydrogen bonding and hydrophobic interactions. Our results provided a foundation for further investigation using 3D-QSAR and HQSAR to evaluate the aquatic ecological risk and the mechanism of toxicity of naphthoquinones.
研究领域:
生态毒理学
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环境科学
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药物化学
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DOI
高影响因子
CHEMOSPHERE
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2013
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IF 3.137
Xiaoyan Zhang,Peiyong Guo,Jinxiu Huang,Xiufu Hou
Suspended particles are a natural component of aquatic ecosystems. This study provides a report on the survival, growth and reproduction of common-scale and nanoscale particles of Daphnia magna Straus exposed to five types of particles (i.e. KN (kaolinite), MN (montmorillonite), MNn (nanoscale MN), NP (natural particles), and NPn (nanoscale NP)). The results of the study show that the suspended particles elicited a dose-dependent toxicity in KN, MN and MNn, with the following toxicity pattern: MN > KN > MNn. On the contrary, NP and NPn did not show any harmful effects on the animals. Instead, NP and NPn, especially NPn, contributed to the survivorship of the animals. The animals were able to survive throughout the 21-day period of bioassays, and when the particle concentration reached 600 mg L −1 , they produced many neonates without any addition of food. This experimental results also indicated that the nanoscale particles were less toxic than the common-scale ones, both for MN and NP. Moreover, the results of the 21-day period of bioassays indicated that when the organisms were exposed to particles of different size scales, they showed different selection patterns for allocating resources. This may be due to the generation of different assimilation and digestion patterns.
研究领域:
生态毒理学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
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2014
·Vol. 33
·期 11
·2522-2528
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IF 2.826
Chao Wang,Zhongbo Wei,Mingbao Feng,Liansheng Wang,Zunyao Wang
Hydroxylated multiwalled carbon nanotubes (OH-MWCNTs), with large amounts of hydrophilic groups attached on the nanoparticle surface, have caused considerable concern because of their inevitable release into aquatic environments. They may interact with other contaminants such as heavy metals and even influence their toxicity, fate, and transport. In the present study, the stability of OH-MWCNTs suspended in aerated Nanjing tap water (moderately hard) was evaluated using the spectrophotometric method. The toxicity of OH-MWCNTs to Daphnia magna was determined, and nontoxic concentrations were used in acute toxicity, accumulation, and sorption tests. It was found that OH-MWCNTs increased the Ni toxicity in a concentration-dependent manner under different pH levels. Nickel adsorption onto the OH-MWCNTs and the uptake of OH-MWCNTs increased the exposure of D. magna to Ni, which was verified by sorption and accumulation tests conducted under different pH levels. The lower pH level contributed to a higher overall toxicity, which could be interpreted by the increasing amount of Ni adsorption onto OH-MWCNTs with the decreasing pH levels. Environ Toxicol Chem 2014;33:2522–2528 . © 2014 SETAC
研究领域:
环境毒理学
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纳米科学
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产品关联
DOI
PubMed
高影响因子
LIMNOLOGY
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2018
·Vol. 20
·期 2
·173-179
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IF 1.13
Du Jingjing,Qv Mingxiang,Li Ke,Yin Xiaoyun,Meng Fanxiao,Yang Jingchao,Ma Chuang
The impacts of three commonly used benzophenone-type UV filters including benzophenone (BP), 2-hydroxy-4-methoxy-benzophenone (BP3), and 2-hydroxy-4-methoxy-benzophenone-5-sulfonicacid (BP4) were assayed in vitro using a cladoceran Daphnia carinata . The 24-h LC50 on D. carinata calculated for BP, BP3, and BP4 was 8.37, 2.18, and 82.27 mg l −1 , respectively. BP3 and BP4 significantly impacted on the time of D. carinata first molting at a concentration of 0.1 µg l −1 . BP4 had an inhibitory effect on D. carinata molting and BP3 had an inhibitory effect on D. carinata pregnancy at a concentration of 1 µg l −1 . Furthermore, BP4 significantly inhibited the number of D. carinata first brood per female at a concentration of 10 µg l −1 . All of the endpoints from acute and chronic toxicity demonstrated that the hydroxy group in BP3 and BP4 significantly enhanced the toxic effect compared to BP. Therefore, the toxicity of BP-type UV filters is related to their molecular structure.
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
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2024
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IF 8.1
Yu-Hang Zhang,Rong-Yao Gao,Few Zhu,Li-Min Fu,Jian-Ping Zhang
Microplastics and nanoplastics (MPs/NPs) are emerging contaminants ubiquitous in the environment. These particles can act as carriers of hydrophobic organic compounds (HOCs), such as chlorpyrifos (CPF), an organophosphorus insecticide. This study investigates the acute toxicity of CPF combined with model polystyrene nanoplastics (PS-NPs) using Daphnia magna as a model organism. The uptake and accumulation of luminescence-labelled 240 nm PS-NPs were visualized and quantified during co-exposure tests. Heart rates were measured using a video-based method, and IC 50 values for heart rate were calculated to assess the acute toxicity of CPF. The results demonstrate that PS-NPs alone have no acute toxicity, while CPF exhibits high toxicity, with an IC 50 of 50.8 μg/L. However, in the presence of 50 μg/L PS-NPs, the IC 50 increased to approximately 400 μg/L, indicating an antagonistic effect of PS-NPs on CPF toxicity. The adsorption of CPF onto PS-NPs can reduce the concentration of free CPF, leading to aggregation and sedimentation of CPF-PS-NP clusters, thereby decreasing the uptake of CPF by D. magna . This interaction between CPF and PS-NPs in D. magna exemplifies the toxicity-attenuating effects and potential load capacity of nanoplastics for HOCs.
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
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2018
·Vol. 15
·期 7
·1520
·
IF 2.145
Zhuqiu Sun,In-Sun Kang,Qianyuan Wu,Jinying Xi,Hongying Hu
Ultraviolet (UV) photodegradation is increasingly applied to control volatile organic compounds (VOCs) due to its degradation capabilities for recalcitrant compounds. However, sometimes the UV photodegradation products are also toxic and can affect human health. Here, 10 VOCs at 150~200 ppm in air were treated using a laboratory-scale UV reactor with 185/254 nm irradiation, and the biotoxicity of their off-gas was studied by investigating their off-gas absorption solutions. The CO2increase and VOC decrease were 39~128 ppm and 0~42 ppm, respectively, indicating that the VOCs and their products were mineralized in off-gas absorption solutions. The total organic carbon (TOC) of the absorption solutions are 4~20 mg∙L−1. Luminescent bacteria andDaphnia magnawere used to detect the acute toxicity, and anumuassay was used to determine the genotoxic potential. Trichloroethylene showed a highest toxicity to luminescent bacteria, while chlorobenzene had the lowest toxicity. Water-soluble UV photodegradation products for styrene are very toxic toDaphnia magna. In theumuassay, the genotoxicities of off-gas absorption solutions of trichloroethylene, methylbenzene, ethyl acetate, butyl alcohol, and styrene were 51.26, 77.80, 86.89, 97.20, and 273.62 mg (4-NQO)·L−1respectively. In addition, the analysis of the genotoxicity/TOC and intermediates products indicated that the off-gas absorption solutions of styrene, trichloroethylene, and butyl alcohol contain many highly toxic substances.Keywords:VOCs;UV photodegradation;biotoxicity;luminescent bacteria;Daphnia magna
研究领域:
环境科学
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毒理学
✓ 已验证
DOI
PubMed
高影响因子
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
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2014
·Vol. 93
·期 2
·204-208
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IF 1.216
Hu Xue-lei,Sun Zhi-wei,Wang Jing-jing,An Min,Duan Shun-shan
The aim of this paper was to examine the sublethal toxic effects of nonylphenol ethoxylate (NP 10 EO), its primary degradation product nonylphenol (NP), and their mixture on Moina macrocopa . Chronic toxicity tests were carried out by using sublethal chemical concentrations. Results showed that all treatments reduced the survivorship, body length, and reproduction of M. macrocopa with NP being 10 %–20 % more toxic to M. macrocopa than NP 10 EO. Results also indicated that the toxic effects of NP 10 EO and NP mixture on M. macrocopa were more severe than that of any single chemical alone. At the highest concentration in this experiment, 0.337 mg L −1 NP 10 EO plus 0.0154 mg L −1 NP treatment caused the survivorship of M. macrocopa to zero, neonates number of reproductions to zero, 45.5 % reduction in the body length, and 88 % reduction in the total neonates number.
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2017
·
IF 4.208
Dan Li,Hongxing Chen,Ran Bi,Haibo Xie,Yu Zhou,Yongju Luo,Lingtian Xie
In recent years, many new chemicals have been synthesized from biomass with an aim for sustainable development by replacing the existing toxic chemicals with those having similar properties and applications. However, the effects of these new chemicals on aquatic organisms remain relatively unknown. In this study, the effects of bisphenol A (BPA) and lignin-derived bisphenol (LD-BP, a BPA analogue) on Daphnia magna were evaluated. The animals were exposed to BPA, LD-BP, and their binary mixture at concentrations (2–2000 μg L −1 ) for 21 days. The expression of various biochemical markers and the effects on growth, molting, and reproduction parameters were examined. The results showed that the weight of daphnids significantly increased after exposure to BPA, LD-BP, and the binary mixture relative to that of the control animals. The activity of superoxide dismutase was significantly inhibited by LD-BP and the binary mixture. At the highest exposure concentration of the binary mixture, the activities of acetylcholinesterase and α-glucosidase, fecundity, and the number of neonates per brood were significantly altered. Our results showed that the effects of BPA and LD-BP on D. magna were generally comparable, except for the effect on the weight at their environmentally relevant concentrations (e.g., <20 μg L −1 ). The effects on the reproduction of D. magna could be mainly due to the shift in energy redistribution under BPA and LD-BP exposures. Our results implied that exposures to both BPA and LD-BP could potentially cause deleterious effects at the population level in D. magna .
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY
·
2022
·Vol. 31
·期 5
·735-745
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IF 2.935
Wei Xinrong,Li Xiao,Liu Hongsong,Lei Haojun,Sun Weijun,Li Dan,Dong Wu,Chen Hongxing,Xie Lingtian
Cadmium (Cd) is a non-essential element and can be toxic to aquatic organisms at low concentrations. Despite its well-known toxicity to Daphnia magna , the effects of Cd on physiological parameters (heart rate and thoracic limb activity) and molting- and reproduction-related genes are relatively understudied. In this study, D. magna were exposed to 0 (control), 25, 50 and 75 μg L −1 of Cd for 7 d and 21 d to determine the toxicity of Cd. The results showed that the Cd body burden in D. magna was significantly increased with elevated Cd concentrations, up to 13.4 μg Cd/g dry weight (dw) after exposure to 75 μg L −1 for 21 d. After 21 d of exposure, the body length and body weight of D. magna were significantly decreased in all Cd treatments compared to the control. The heart rate and thoracic limb activity were reduced by 4.3–11.7 and 5.0–10.3%, respectively. The levels of malondialdehyde (MDA) were increased by ~24–37% and the activity of catalase (CAT) was inhibited by ~50% compared to the control. The reproductive parameters (i.e., size of the first brood, the total number of offspring per female and the number of offspring per brood) were remarkably reduced, causing adverse effects on the population dynamics. In addition, the transcripts of genes ( cyp314 , cyp18a1 , ecra , usp , hr3 , cut , cht and cht3 ) related to the molting of D. magna were altered, whereas the transcripts of genes ( vtg1 , vtg2 and vmo1 ) related to reproduction were down-regulated. This study helps better understand the effects of Cd at different biological levels.
研究领域:
生态毒理学
·
分子生物学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2019
·
IF 4.527
Wei Lin,Ruifen Jiang,Sizi Hu,Xiaoying Xiao,Jiayi Wu,Songbo Wei,Yaxin Xiong,Gangfeng Ouyang
Nanoplastics (NPs) spread widely with water and air current, and they can accumulate in aquatic organisms, even penetrating biofilms, which may cause persistent toxicity and potential hazards. This current study aimed to reveal the toxicological mechanism of different functionalized polystyrene (PS) NPs on Daphnia magna ( D. magna ) by investigating toxicity endpoints in individual level and biochemical level. In this study, acute toxicity, behavioral parameters and biomarker responses of D. magna was measured in the exposure of different functionalized PS NPs (plain PS, PS-p-NH 2 , PS-n-NH 2 and PS-COOH). The results indicated that when exposed to the plain PS, ROS induction would activate MAPKs, thereby causing lethality and adverse behavior effects on D. magna ; while the functionalized PS NPs were less toxic than the plain PS, especially for PS-p-NH 2 which was severely flocculated after exposure, thus showing no immobilization at the investigated concentrations. Also, the antioxidant system was mainly stimulated due to the direct interaction with the cell surface receptor, which was different from the plain PS. Consequently, this work suggests significant effects of functional groups on NPs for environmental toxicity studies, and provides a better understanding of the toxicological mechanism on the toxicity of PS NPs toward D. magna .
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）