JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2024
·
IF 4.1
Jie Song,Hong Luo,Ting Pan,Han Jiang,Yiwei Wu,Xiaoxiao Yu
Risperidone, olanzapine and aripiprazole have good efficacy in schizophrenia. Monitoring the concentration of antipsychotics in patients is helpful to provide a precise medication administration. Although many detection techniques based on large instruments have been developed, they are expensive and cumbersome, which are not conducive to clinical promotion. In this paper, rose bengal (RB) was firstly used as a low-cost fluorescent probe for the detection of antipsychotic drugs. Under the condition of pH 3.9, there is a strong negative electrostatic potential region in RB, which attracts positively charged antipsychotic drugs. This property allows the halogen atoms and oxygen atoms of RB to act as hydrogen bond donors to molecularly bond with the H atoms of the antipsychotic drugs, forming a non-luminous complex. The fluorescence intensity showed a linear quench relationship with the increasing concentration of risperidone, olanzapine and aripiprazole with low detection limits of 103, 82.0 and 81.0 μg L −1 , respectively. This fluorescent method has good selectivity and can be successfully utilized in detecting antipsychotic medications in human urine and pharmaceutical tablets.
研究领域:
医学
·
药理学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Haihua Wang,Mengjie Li,Yingning Zheng,Tao Hu,Yaqin Chai,Ruo Yuan
Though preferable progresses have been achieved to improve the photoelectric performance of fullerene (C 60 NPs) by sensitized structure in photoelectrochemical (PEC) field, further application inevitably suffers from the inherent scarcities of heavy metal-involved quantum dots as sensitizers containing restricted sensitization effect, complex preparation and biological toxicity. In this work, a PEC biosensor based on [Ru(dcbpy) 2 dppz] 2+ /Rose Bengal dyes co-sensitized C 60 NPs was constructed for ultrasensitive DNA (a fragment sequence of p53 gene) detection. With the merits of low toxicity and accessible operation, [Ru(dcbpy) 2 dppz] 2+ /Rose Bengal dyes exhibited a further sensitization efficiency towards C 60 NPs. Through modifying wide band gap C 60 NPs with two narrower band gap dyes ([Ru(dcbpy) 2 dppz] 2+ and Rose Bengal) to form a cascade-type energy band structure , the photoelectric conversion of C 60 NPs was significantly improved and the visible light absorption was markedly promoted, leading to an exceptional photocurrent signal. Additionally, Nt.BstNB I enzyme-assisted target recycling amplification was employed to convert a limited quantity of target to numerous SiO 2 NPs-labeled DNA sequences (the signal quencher), resulting in a sharp decrement of photocurrent since a dramatic increment of steric hindrance on the modified electrode surface, which was performed to quantitatively estimate target. The proposed PEC biosensor for DNA detection possessed a wide linear range from 0.1 fM to 1 nM with a calculated detection limit of 37 aM. This work opened up an intriguing avenue for determination of various targets such as DNAs, microRNAs and proteins, and exhibited desirable application potential in the clinic researches, cancer therapies and other related subjects.
研究领域:
生物传感器
·
分析化学
·
分子生物学
✓ 已验证
DOI
高影响因子
NANO
·
2022
·
IF 1.438
Hong Zhao,Zhenghua Du,Diandian Liu,Yijian Lai,Tao Yang,Mingyan Wang,Yuesheng Ning,Fujun Yin,Binyuan Zhao
The design and construction of semiconductor–metal heterojunctions are being considered to be an effective way to overcome the limited visible-light absorption of semiconductors. Herein, a facile and scale approach is reported for the first time to synthesize Cu/ZnO heterojunctions by one-step galvanic replacement between Zn and cuprous solution reaction. Two kinds of morphologies Cu/ZnO heterojunctions could be obtained by changing cuprous salt anion such as Br − , Cl − and I − . A flower-like Cu/ZnO heterostructured is chosen as a representative to demonstrate the facility and enhanced photocatalytic performance toward Rhodamine B degradation under visible-light irradiation. Results showed flower-like Cu/ZnO heterojunctions have higher photocatalytic performance than the other two morphologies. The galvanic replacement growth mechanism of Cu/ZnO heterojunctions was also further investigated. It is found that Cu/ZnO heterojunctions formed from Zn and Cu 2 O at an acid solution and room condition. This work indicates that galvanic replacement reaction at room temperature is an excellent technique to grow Cu/ZnO heterojunctions and demonstrates that the hole and electron transfer between Cu and ZnO can efficiently enhance their photocatalytic performance. This general method can also be further explored to guide the design of metal/metal oxide heterostructured on other substrates, such as Zn, Ni and Cu foils.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2022
·Vol. 16
·期 9
·1387-1398
·
IF 4.803
Han Yuyao,Xia Lei,Zhuang Xupin,Liang Yuxia
UiO-66-NH 2 is an efficient material for removing pollutants from wastewater due to its high specific surface area, high porosity and water stability. However, recycling them from wastewater is difficult. In this study, the cellulose nanofibers mat deacetylated from cellulose acetate nanofibers were used to combine with UiO-66-NH 2 by the method of in-situ growth to remove the toxic dye, rose bengal. Compared to previous work, the prepared composite could not only provide ease of separation of UiO-66-NH 2 from the water after adsorption but also demonstrate better adsorption capacity (683 mg·g −1 ( T = 25 °C, pH = 3)) than that of the simple UiO-66-NH 2 (309.6 mg·g −1 ( T = 25 °C, pH = 3)). Through the analysis of adsorption kinetics and isotherms, the adsorption for rose bengal is mainly suitable for the pseudo-second-order kinetic model and Freundlich model. Furthermore, the relevant research revealed that the main adsorption mechanism of the composite was electrostatic interaction, hydrogen bonding and π — π interaction. Overall, the approach depicts an efficient model for integrating metal-organic frameworks on cellulose nanofibers to improve metal-organic framework recovery performance with potentially broad applications.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Peiyao Wang,Silan Bai,Chen Chen,Yongtao You,Junhui Xiao,Xinrong Guo,Lishi Wang
Rose Bengal (RB) is used as a sensitizer in ambient water due to its property of catalyzing the production of singlet oxygen ( 1 O 2 ). However, this property also brings phototoxicity and carcinogenicity. The NaYF 4 :3%Er@NaYF 4 core-shell upconversion nanoparticles (UCNPs) with higher upconversion efficiency was synthesized to detect RB in ambient water. Due to fluorescence resonance energy transfer (FRET) between RB and UCNPs, the upconversion fluorescence at 538 nm emitted by UCNPs was quenched by the RB, while the emission at 566 nm of RB raised. In the best conditions, the ratiometric emission intensity F 566 /F 538 was positively proportional to RB concentration and the linear range was 0.04–15.0 μg·mL −1 (R 2 = 0.996). The detection limit (S/N = 3) of RB was 2.46 ng·mL −1 . The recoveries ranged from 99.0% to 105.6% (relative standard deviation 0.97–3.24%, n = 3) in tap water and 100.3%–104.9% (relative standard deviation 0.66–1.94%, n = 3) in lake water. This proposed method exhibits lower detection limit and larger linear, which possesses practical application value to the detection of RB in water.
研究领域:
环境科学
·
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TETRAHEDRON
·
2017
·
IF 2.651
Ling-Ling Wu,Li Tang,Shui-Gen Zhou,Yi-Jie Peng,Xiao-Dong He,Zhi Guan,Yan-Hong He
We report an example of Rose Bengal-photosensitized oxidation of tertiary amines for the synthesis of bis-1,3-dicarbonyl compounds. This protocol employs Rose Bengal as a visible-light absorbing photocatalyst without the need of a transition metal, and air as a green oxidant . Various functional groups were well tolerated to afford products with yields of up to 80% under mild reaction conditions.
研究领域:
有机化学
·
绿色化学
✓ 已验证
产品关联
DOI
高影响因子
TETRAHEDRON
·
2017
·
IF 2.651
Ling-Ling Wu,Gao H. Yang,Zhi Guan,Yan-Hong He
The Rose Bengal sensitized intermolecular [2 + 2]-cycloaddition of 3-ylideneoxindoles for the synthesis of spirocyclic oxindoles was developed successfully under visible light irradiation conditions. The cycloaddition products were obtained in good yields (up to 93%) with excellent diastereoselectivity and regioselectivity by using a low loading of Rose Bengal (0.125 mol%) as a triplet sensitizer. This work demonstrates the potential benefits of Rose Bengal in visible light catalysis.
研究领域:
有机化学
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
FIBERS AND POLYMERS
·
2023
·Vol. 24
·期 1
·1-14
·
IF 2.5
Wang Chuanfeng,Chen Yingbo,Wang Meng,Guo Renhao
A dual-layer (DL) PVDF loose nanofiltration (NF) hollow fiber membrane (HFM) was designed via optimized phase inversion process using a continuous online-coating device. Subsequently, the loose DL PVDF HFM was cross-linked through a one-pot amine-based reaction to improve the solvent stability. Changes in chemical structure were characterized using Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscope (XPS). The solvent stability in DMF of the membranes with different cross-linking time was investigated through measuring swelling ratio of the membranes. In addition, thermogravimetric analysis (TGA) and mechanical property were also conducted to study physico-chemical changes of the cross-linked DL PVDF hollow fiber membranes. The results showed that this cross-linking process significantly improved the stability in polar solvent, accompanied by a decrease in thermal stability and mechanical properties. A cross-linking time of 8 h was found to produce DL PVDF HFMs with most balanced properties. The performance of cross-linked membranes was evaluated via filtering various solutes in ethanol solution and typical solvents containing Rose bengal (RB). The cross-linked DL HFMs showed rejection of RB more than 99% in solvent with methanol, ethanol, isopropanol, and acetone and permeance of 9.3, 7.6, 5.2, and 8.7 L/(m 2 ·h·bar), respectively. Besides, the prepared membranes also presented exceptional performance stability for treatment of RB/ethanol solution. Thus, they have great potential for real organic solvent nanofiltration applications.
研究领域:
材料科学
·
化学工程
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2020
·
IF 4.831
Yuan Yu,Wei-Fan Lu,Zeng-Jie Yang,Na Wang,Xiao-Qi Yu
A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 4H -pyrimido[2,1- b ] benzothiazole derivatives from alcohols is described for the first time. Fourteen 4H -pyrimido[2,1- b ] benzothiazole derivatives were prepared with yields of up to 98% under mild reaction conditions by a simple operation. The photoorgano catalyst rose Bengal (rB) was employed to oxyfunctionalise alcohols to aldehydes. Compared with aldehydes, alcohols with more stable properties and lower cost, thus we used photocatalysis to oxidize alcohols into aldehydes. Next, the enzyme was used to further catalyze the reaction of Biginelli to produce the target product of 4H -pyrimidine [2,1- b ] benzothiazole. Experimental results show that this method provides a more efficient and eco-friendly strategy for the synthesis of 4H -pyrimido[2,1- b ] benzothiazole derivatives.
研究领域:
有机化学
·
合成化学
·
绿色化学
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Lingling Li,Zihao Lv,Hao Jiang,Xiaoxian Zhao,Lan Wu,Xiuming Cao,Helan Xu,Qufu Wei,Qingqing Wang
A pH-responsive bacterial cellulose (BC)-based composite nanofiber membrane functionalized with rose bengal (RB)-encapsulated ZIF-8 (BC/RB@ZIF-8) was developed via in situ growth for the targeted therapy of bacterial stomatitis. The BC film enhanced the photodynamic effect, addressing the challenges of photosensitizer aggregation-induced quenching and its reuse. The BC/RB@ZIF-8 nanofiber membrane demonstrated sustained photodynamic activity, maintaining a stable singlet oxygen (1O2) quantum yield under continuous 130 min irradiation. The nanofiber membrane exhibited robust mechanical properties, including a tensile strength greater than 33 MPa, high water absorption capacity (916.61 ± 4.7%), and optimal moisture vapor transmission rate (40.56 ± 1.37 g/m2·h), meeting the key requirements for oral wound dressings. In acidic infection microenvironments, ZIF-8 degradation facilitated the synchronized release of Zn2+ and RB, leading to dual-mode antibacterial action: (1) the continuous release of Zn2+ from ZIF-8 disrupts bacterial cell membranes through electrostatic interactions; and (2) ROS generation via Type I (•OH) and Type II (1O2) pathways, resulting in irreversible damage to bacterial cell membranes and components. This synergistic mechanism led to a 99.99% eradication of S. aureus and MRSA under acidic conditions, outperforming conventional therapies. Cytocompatibility and hemocompatibility were confirmed in accordance with ISO 10993 standards. The BC/RB@ZIF-8 nanofiber membrane represents a significant advancement in pH-responsive antibacterial materials, offering a promising alternative to antibiotic-based treatments for biofilm-infected oral wounds.
研究领域:
生物材料学
·
医学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Quanliang Li,Xiaomeng Wang,Jing Ren,Ping Chen,Dayong Ren
Rapid and reliable quantification of meat freshness is crucial for consumer health and food safety. In this study, two simple and portable photosensitive colorimetric cards were fabricated for rapid on-site detection of meat freshness. The colorimetric cards were prepared by dispersing Rose Bengal (RB) into sodium acetate-acetic acid and sodium citrate-citric acid buffer systems containing 3,3′,5,5′-tetramethylbenzidine (TMB) and fixed on filter paper, respectively. The hue of the colorimetric cards was intimately correlated with the amount of volatile base nitrogen absorbed from meat, by which the quality of the meat can be visualized qualitatively. Correlation analysis of total volatile basic nitrogen (TVB-N), red: blue ratio (R/B), total color difference (ΔE), and response sensitivity (S%) demonstrated the accuracy of the proposed colorimetric cards. Principal component analysis (PCA) revealed that the first two principal components of the photosensitive colorimetric cards explained 95.4 %, 93.2 %, 92.9 %, and 87.8 % of the variance of sodium acetate-acetate colorimetric card, and 73 %, 87.9 %, 87.1 %, and 92 % of sodium citrate-citric card, respectively, which allowed for a clear differentiation of meat freshness including freshness, sub-freshness, and spoilage. The prepared photosensitive colorimetric cards can accurately reflect meat quality within 4 min. The proposed colorimetric cards are expected to be a prospective universal platform for on-site accurate quantification of meat freshness.
研究领域:
食品安全
·
分析化学
·
传感器
·
比色检测
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Meng Kou,Feng Qin,Yongda Wang,Lixin Peng,Zheng Hu,Hua Zhao,Zhiguo Zhang
Background Photodynamic therapy (PDT) is emerging as a promising cancer treatment. The PDT efficacy is primarily attributed to the generation of singlet oxygen ( 1 O 2 ), stemming from the integrated effects of the photosensitizer, oxygen, and light. The singlet oxygen quantum yield ( Φ Δ ) serves as a bridge that links these parameters to the overall efficacy of PDT. The near-infrared luminescence of 1 O 2 provides a direct way for determining Φ Δ , but suffers from a poor signal-to-noise ratio. While the chemical trap probe method is detection-friendly, but it has a strict requirement for the excitation wavelength. Therefore, the existing methods for Φ Δ measurement are insufficient. Results In this work, we developed an approach to determine Φ Δ of a broader range of photosensitizers using only the commonly used solvent dimethyl sulfoxide (DMSO), which can be oxidized by 1 O 2 to dimethyl sulfone. This method establishes the relationship between 1 O 2 production and changes in DMSO absorption spectra, eliminating the need for additional chemical probes. This method was validated by measuring the Φ Δ of rose bengal (RB) through systematic changes in absorption spectrum of DMSO under various RB concentrations and different excitation light power densities. Moreover, the Φ Δ of hematoporphyrin monomethyl ether (HMME), as determined by this method, is consistent with measurements obtained using the 1,3-diphenylisobenzofuran (DPBF) trapping probe. This consistency further validates the reliability of this method. Significance and novelty This work presents a direct, probe-free method to determine Φ Δ , reducing potential interference and expanding the range of useable excitation wavelengths. Its ability to measure Φ Δ using only DMSO enhances the accuracy of photosensitizer measurement, and broadens the applicability of the method to a wide range of samples, thereby advancing research on the properties of photosensitizers and further promoting the development of PDT.
研究领域:
生物医学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）