JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yonghao Yang,Bin Wang,Gensheng Wu,Yuan Tian,Gutian Zhao,Zhonghua Ni,Jie Cheng
The inadequate radial performance of poly (L-lactic acid) (PLLA)-braided stents has hindered the development of the treatment of peripheral vascular diseases. As the basic unit of the stent, the restraint form between monofilaments is the key factor affecting the radial performance. In this study, different concentrations of solutions are prepared using six-arm poly (lactide-co-ε-caprolactone) (6SPLCL) and hexamethylene diisocyanate at a mass ratio of 5:1 to restrain every interlacing point of the stent (full restraint). The findings reveal that fully restraining the interlacing points of the stent substantially improves radial strength, increasing the chronic outward force (COF) value by 30%, but concurrently, the flexibility is reduced, which could cause damage to blood vessels and lead to secondary thrombosis when used in curved vessels. Accordingly, the innovative structure of the stent is designed by restraining part of the interlacing points (restraint on both ends). The results show that the radial stiffness is increased by 16%, and the COF value is increased by up to 12% under the premise of keeping the flexibility basically unchanged. This research advances the ongoing efforts to enhance the understanding of the structural design for biodegradable braided stents to obtain appropriate mechanical properties and ultimately promote clinical outcomes.
研究领域:
生物医学工程
·
材料科学
·
心血管疾病治疗
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 4
·547
·
IF 4.034
Meng Li,Jian-Wei Guo,Wei-Qiu Wen,Jem-Kun Chen
A typical amphiphilic star polymer adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)]4with a specific hydrophilic/redox-sensitive/hydrophobic structure was designed and synthesized through ring opening and esterification reactions. The self-assembled nanomicelles were used as doxorubicin (DOX) delivery vehicles with suitable critical micelle concentrations (5.0 mg/L). After the drug being loaded, drug-loaded micelles showed good drug-loading efficiency (10.39%), encapsulation efficiency (58.1%), and drug release (up to 60%) under simulated biological environment conditions. In addition, the backbone structure of the biodegradable polymer was easily hydrolyzed by the action of biological enzymes. As expected, cell-based studies showed that the designed polymer micelles possessed good biocompatibility (a survival rate of 85% for NH-3T3 cells). Moreover, the drug (DOX) still maintained good anti-cancer effects after being loaded, which caused 40% of MCF-7 cells to survive. These redox-sensitive micelles showed anti-tumor therapeutic potential.
研究领域:
药剂学
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 47
·24100-24106
·
IF 6.895
Xia Li,Fang Yang,Chunfang Gan,Ruo Yuan,Yun Xiang
The simultaneous imaging of the dynamic expression variations of regulatory RNAs in cells, which remains a major challenge, has important applications in precise disease diagnosis, treatment and prognosis. Here, we describe the establishment of a biodegradable ZnO nanoparticle (NP)-assisted asymmetric amplification approach for the simultaneous imaging of microRNA-21 (miRNA-21) and programmed cell death 4 (PDCD4) mRNA at distinct expression levels in live cells. The DNA signal probe complexes are immobilized on the ZnO NPs and readily delivered into the target cancer cells via the endocytosis pathway. The acidic microenvironment in cancer cells leads to the dissolution of the ZnO NPs to release Zn2+ ions and the intracellular miRNA-21 activates the Zn2+-dependent DNAzyme to cleave the substrate signal probes with the assistance of the Zn2+ cofactor to show green fluorescence for imaging miRNA-21. Meanwhile, the PDCD4 mRNA can displace the other quenched signal probes to generate red fluorescence. Importantly, the PDCD4 mRNA sequences can be recycled and reused by using the DNAzyme-cleaved sequences as the fuel strands through two strand displacement reactions to yield amplified red fluorescence for detecting low levels of PDCD4 mRNA. Moreover, our approach can be used to evaluate the varied expression levels of miRNA-21 and PDCD4 mRNA responsive to different drugs in cells, reflecting its usefulness for precise cancer diagnosis and prognosis upon anticancer drug treatment.
研究领域:
分子生物学
·
癌症研究
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Kaili Wang,Jicai Wu,Min Wang,Fa Zhang,Xiujuan Li,Min Xu,Duoyi Zhu,Jikun Han,Juqing Liu,Zhengdong Liu,Wei Huang
Optoelectronic synapses have gained increasing attentions as a fundamental building block in the development of neuromorphic visual systems. However, it remains a challenge to integrate multiple functions into a single optoelectronic synapse that can be widely applied in wearable artificial intelligence and implantable neuromorphic vision systems. In this study, a stretchable optoelectronic synapse based on biodegradable ionic gelatin heterojunction is successfully developed. This device exhibits self-powered synaptic plasticity behavior with broad spectral response and excellent elastic properties, yet it degrades rapidly upon disposal. After complete cleavage, the device can be fully repaired within 1 min, which is mainly attributed to the non-covalent interactions between different molecular chains. Moreover, the recovery and reprocessing of the ionic gelatins result in optoelectronic properties that are virtually indistinguishable from their original state, showcasing the resilience and durability of ionic gelatins. The combination of biodegradability, stretchability, self-healing, zero-power consumption, ease of large-scale preparation, and low cost makes the work a major step forward in the development of biodegradable and stretchable optoelectronic synapses.
研究领域:
材料科学
·
神经科学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Lei Tang,Zhaoyuan Guo,Quan Zhao,Xi Fan,Yuji Pu,Bin He,Jianlin Chen
Negative pressure wound therapy (NPWT) is effective in repairing serious skin injury. The dressing used in the NPWT is important for wound healing. In this paper, we develop biodegradable amphiphilic polyurethanes (PUs) and fabricate the PUs into sponges as wound dressings (Bi@e) with Janus pore architectures for NPWT. The Bi@e is adaptive to all the stages of the wound healing process. The Janus Bi@e sponge consists of two layers: the dense hydrophobic upper layer with small pores provides protection and support during negative pressure drainage, and the loose hydrophilic lower layer with large pores absorbs large amounts of wound exudate and maintains a moist environment. Additionally, antibacterial agent silver sulfadiazine (SSD) is loaded into the sponge against Escherichia coli and Staphylococcus aureus with a concentration of 0.50 wt%. The Janus sponge exhibits a super absorbent capacity of 19.53 times its own water weight and remarkable resistance to compression. In a rat skin defect model, the Janus Bi@e sponge not only prevents the conglutination between regenerative skin and dressing but also accelerates wound healing compared to commercially available NPWT dressing. The Janus Bi@e sponge is a promising dressing for the NPWT.
研究领域:
医学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2023
·
IF 3.6
Kaiqi Li,Xiliang Liu,Youkun Fan,Shaomin Feng,Dongliang Chen
Prevention of encrustation on the surface has always been the biggest challenge for urological implants. In the field of ureteral stent design, biodegradability has attracted much attention in recent years, because biodegradable ureteral stents not only avoid secondary intervention, but also prevent encrustation due to surface renewal by degradation process. Furthermore, researches have focus on some surface parameters to provide guidance for the development of stent materials, such as hydrophilicity or surface charge. In this work, we synthesized two types of poly(ester-carbonate)s, poly(L-lactide-co-5-amino-1,3-dioxan-2-one) (P(LA-co-AC)) containing amino, and poly (L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-MCC)) containing carboxyl. Blending P(LA-co-AC) and P(LA-co-MCC) with poly(L-lactide-co-Ɛ-caprolactone) (PLACL) respectively, two types of ureteral stent materials were prepared. Due to the influence of ions formed by the dissociation of amino and carboxyl, two types of materials show differences in surface charge analyses. We further developed a dynamic urinary extracorporeal circulation (DUEC) system to assess in vitro encrustation of materials with different surface charges. The results of this comparative study identified that the materials with strong negative surface charge were most favorable for use as ureteral stent, and provided a new approach to surmount the problems faced by urological surgery which complied with the future trend of biodegradable ureteral stent design.
研究领域:
泌尿外科
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Xue Zheng,Yijing Du,Zetao Dang,Ke Lan,Guantong Liu,Jingyan Ren,Xin Wang,Shoujun Zhu
Neural imaging plays a crucial role in understanding the structure and function of the living body. While near-infrared-II (NIR-II) imaging techniques have emerged as potential tools for non-invasive and high-resolution imaging of neural activity, there have been rare relevant reports on in vivo neural imaging. This study presents the development of biodegradable NIR-II rare-earth nanoprobes as a novel contrast agent for enhanced neural imaging. The biodegradable NIR-II rare-earth nanoprobes exhibit excellent long wavelength emission, high quantum yield, and tunable biodegradation time in vivo. This work demonstrates the effectiveness of these nanoprobes in enhancing the imaging depth and resolution in a mouse model of neural activity, thereby facilitating a better understanding of the structure and function of the nervous system. Furthermore, their biodegradability ensures minimal long-term toxicity and allows for repeatedly monitoring of damaged nerves during the recovery or deterioration process. The results highlight the potential of biodegradable NIR-II rare-earth nanoprobes for advancing neural imaging techniques and facilitating deeper insights into neuroscience research and clinical diagnostics.
研究领域:
神经科学
·
医学影像学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2012
·
IF 3.456
Qian Guo,Ping Luo,Yu Luo,Fang Du,Wei Lu,Shiyuan Liu,Jin Huang,Jiahui Yu
Biodegradable micelles with sheddable poly(ethylene glycol) shells were fabricated based on poly(ethylene glycol)- block -poly(γ-benzyl l -glutamate) (mPEG-SS-PBLG) diblock copolymer and applied as the carrier of 7-ethyl-10-hydroxy-camptothecin (SN-38) in order to enhance its solubility and stability in aqueous media. The diblock polymer was designed to have the hydrophilic PEG moiety and hydrophobic PBLG moiety linked by biodegradable disulfide bond, so in reducing environment the PEG shells can be detached. The polymer was able to form the micelles of nano-scale in aqueous media, suggesting their passive targeting potential to tumor tissue. Water-insoluble antitumor drug, SN-38, was easily encapsulated into mPEG-SS-PBLG nanomicelles by lyophilization method. When setting theoretical drug loading content at 10 wt%, the drug encapsulation efficiency (EE) was assayed as 73.5%. Owing to the disulfide bond in mPEG-SS-PBLG, intense release of SN-38 occurred in the presence of dithiothreitol (DTT) at the concentration of simulating the intracellular condition, however, micelles showed gradual release of SN-38 in the absence of DTT. Also, the mPEG-SS-PBLG micelles effectively protected the active lactone ring of SN-38 from hydrolysis under physiological condition. Compared with free SN-38, SN-38-loaded nanomicelles showed essentially decreased cytotoxicity against L929 cell line in 24 h, bare mPEG-SS-PBLG nanomicelles showed almost non-toxicity.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
BIOCONJUGATE CHEMISTRY
·
2021
·
IF 4.774
Meiling He,Yi Hou,Ce Zhu,Miaomiao He,Yulin Jiang,Ganjun Feng,Limin Liu,Yubao Li,Chen Chen,Li Zhang
A three-dimensional (3D) printed biodegradable hydrogel scaffold with a strong self-expanding ability to conform to the contour of irregular bone defects and be closely adjacent to host tissues is reported herein. The scaffold has a triple cross-linked network structure consisting of photo-cross-linked polyacrylamide (PAAM) and polyurethane (PU) as the primary IPN network and chemical cross-linked gelatin (Gel) as the secondary network, which confers the scaffold with good mechanical properties. The addition of PU in the polymerization process of acrylamide (AAM) can improve the ultraviolet (UV) photocuring efficiency of the hydrogel and incorporate abundant hydrogen bonds between the PAAM copolymer chain and the PU chain. The results show that the hydrogel scaffold contains regular structures with smooth morphology, excellent dimensional stability, and uniform aperture. The degradation rate of the hydrogel scaffold is controllable through adjusting cross-linking agents and can be up to about 60% after degradation for 28 days. More importantly, the rapid self-inflating characteristic of the scaffold in water, that is, the volume of hydrogel scaffold can increase to about 8 times that of their own in an hour and can generate a slight compressive stress on the surrounding host tissue, thus stimulating the reconstruction and growth of new bone tissues. The in vitro experiment indicates that the scaffold is nontoxic and biocompatible. The in vivo experiment shows that the PU/PAAM/Gel chemically cross-linked scaffold displays the desirable osteogenic capability. This UV-curable 3D printed self-adaptive and degradable hydrogel scaffold holds great potential for nonload-bearing bone repair.
研究领域:
生物材料学
·
组织工程学
·
再生医学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Junjun Kong,Yi Li,Yungang Bai,Zonglin Li,Zengwen Cao,Yancun Yu,Changyu Han,Lisong Dong
A novel polyester poly(diethylene glycol succinate) (PDEGS) was synthesized and evaluated as a plasticizer for polylactide (PLA) in this study. Meanwhile, an effective sustainable filler, functionalized eggshell powder (FES) with a surface layer of calcium phenyphosphonate was also prepared. Then, PLA biocomposites were prepared from FES and PDEGS using a facile melt blending process. The addition of 15 wt% PDEGS as plasticizer showed good miscibility with PLA macromolecules and increased the chain mobility of PLA. The crystallization kinetics of PLA composites revealed that the highly effective nucleating FES significantly improved the crystallization ability of PLA at both of non-isothermal and isothermal conditions. In addition, the effective plasticizer and well-dispersed FES increased the elongation at break from 6% of pure PLA to over 200% for all of the plasticized PLA composites. These biodegradable PLA biocomposites, coupled with excellent crystallization ability and tunable mechanical properties, demonstrate their potential as alternatives to traditional commodity plastics.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
·
IF 8
Jia Shi,Qian Zhang,Yuanze Sun,Yumei Peng,Jie Wang,Xiang Wang
Microplastic has a significant impact on soil microbial communities, which play crucial roles in soil nitrogen (N) cycles. However, there is a limited understanding of their influences on genes associated with the entire N cycling pathways. Through a 120-day soil incubation using conventional (PE and PET) and biodegradable microplastics (PLA and PBAT), coupled with 16S rRNA and metagenomic sequencing, we investigated the responses of N-cycling genes to microplastics in two contrasting soils (i.e. black soil and loess soil). We found that biodegradable microplastics strongly altered microbial N functional profiles, and enhanced the abundance of numerous key genes involved in N fixation, organic N mineralization, N reduction, and denitrification. Furthermore, biodegradable microplastics significantly decreased net N mineralization (Nm) compared to control and conventional microplastic treatments, suggesting microbial N immobilization outweighed N mineralization. Analysis of the function-taxon bipartite network showed that the Nm was well predicted for the abundances and diversity of bacteria within specific modules, with Nm decreasing, the abundances of specific taxa in a given network modules increasing. These results indicated that biodegradable microplastics act as a carbon source to select specific taxa involved in enhancing N bioavailability (e.g., N fixation and organic N mineralization) to meet microbial N demand, which in turn filtered the bacterial community (decreased diversity but increased abundances) and gradually formed specific function-taxon modules. Comparing the two soils, microbes in the less fertile alkaline loess soil were more sensitive to biodegradable microplastics than those in the nutrient-rich acid black soil. Our study indicated that increasing usage of biodegradable plastics in the future may lead to accelerated soil microbial N limitation and transformation.
研究领域:
环境科学
·
微生物学
·
土壤学
✓ 已验证
DOI
PubMed
高影响因子
Polymer Chemistry
·
2013
·Vol. 4
·期 10
·3012-3019
·
IF 5.231
Haibo Wang,Fangming Xu,Yin Wang,Xiangsheng Liu,Qiao Jin,Jian Ji
The pH-triggered biodegradable micelles based on poly(β-amino ester)-graft-12-acryloyloxy dodecyl phosphorylcholine (PAE-graft-ADPC) were explored as an efficient acid-triggered anticancer drug delivery system. A pH-responsive biodegradable polymer was synthesized by using hydrophilic 12-acryloyloxy dodecyl phosphorylcholine (ADPC) and poly(β-amino ester) (PAE) via Michael addition reaction. Micelles with phosphorylcholine shells were prepared in aqueous solution and doxorubicin (DOX) was loaded into the core of the micelles with high efficiency (73%). Dynamic light scattering (DLS) and transmission electron microscopy (TEM) demonstrated that the size of the drug-loaded micelles was about 230 nm. DOX-loaded micelles were stable in the physiological environment, whereas they disassembled at pH 6.5 which is similar to the extracellular pH of most tumors. In vitro drug release showed that DOX release from micelles was faster at pH 6.5 than at 7.4. Intracellular uptake demonstrated that DOX was delivered into the cells effectively after the cells were incubated with DOX-loaded micelles at pH 6.5. Moreover, an in vitro cytotoxicity study indicated that the growth of HepG2 cells was inhibited remarkably when the cells were preincubated with DOX-loaded micelles at pH 6.5. The results indicated that the pH-triggered biodegradable micelles could serve as promising drug carriers for cancer therapy.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）