JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·Vol. 71
·期 8
·3622-3630
·
IF 2.4
Miao Yufeng,Sun Yanfei,Hou Yanbo,Qiao Yu,Gao Yuan,Luo Jun
Oxalyl dihydrazide (ODH) is a polymorphic organic compound,
and
distinct ODH polymorphs possess disparate physicochemical properties,
including melting point, solubility, and dissolution kinetics. Under
atmospheric pressure, the dynamic method was applied to obtain solid–liquid
phase equilibrium information on α-ODH within the temperature
range of 293.15–353.15 K. Twelve pure solvents were selected
for the tests, namely, water, ethanol, acetic acid, dimethyl sulfoxide
(DMSO), N -methyl-2-pyrrolidone (NMP), N- ethyl-2-pyrrolidone (NEP), N,N- dimethylacetamide
(DMAC), N,N- diethylformamide (DEF), N,N- dimethylformamide (DMF), 1,3-dimethyl-2-imidazolidinone (DMI), hexamethylphosphoramide
(HMPA), and formamide. Experimental results indicated that the solubility
of α-ODH monotonically increased with the increase in temperature
in all tested solvents. Three thermodynamic models (van’t Hoff
equation, Yaws model, and the modified Apelblat equation) were employed
to correlate the measured solubility data. In addition, the dissolution
thermodynamic properties (Gibbs free energy, entropy, and enthalpy)
of α-ODH in the tested solvents were calculated based on the
experimental solubility data and the van’t Hoff equation. Moreover,
Hirshfeld surface analysis was implemented to characterize dominant
intermolecular contacts inside the α-ODH crystal lattice. The
acquired solubility data offers reliable fundamental support for industrial
crystallization optimization of α-ODH.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Congteng Li,Yifan Liu,Xue Tian,Xin Dong,Qichao Ma,Kunyang Liu,Jinliang Zhu,Yuehe Gu,Yudong Li,Chengyu Wang,Haiyue Yang
Room temperature phosphorescent (RTP) hydrogels have garnered extensive attraction owing to their distinctive optical properties, low toxicity and cost-effectiveness. However, achieving efficient and long-lived afterglow emission in hydrogel systems remains a formidable challenge due to the severe quenching of triplet excitons by water molecules. Herein, taking inspiration from stimuli-responsive luminescent behavior of jellyfish, we propose a solvent exchange strategy to construct a cellulose-based RTP gel with polyethylene glycol (PEG)-induced phosphorescent behavior. Specifically, a cellulose/polyvinyl alcohol (PVA) double-network hydrogel system was constructed to confine carbon dots (CDs) within a rigid matrix, which preliminarily enabled phosphorescence emission. Driven by phase separation induced by PEG, the resulting gel with ultra-strong hydrogen-bonded networks exhibits green RTP emission with an extended lifetime of 255.55 ms and a tensile strength of 3.79 MPa, representing 370-fold and 17-fold enhancements, respectively, compared to the gel prepared using water as the solvent. Furthermore, the phosphorescent properties of the gel can be tuned by adjusting the molecular weight of PEG. Taking advantage of these properties, the cellulose-based RTP gels were further fabricated into various luminescent materials, which exhibited promising potential for information encryption and advanced anti-counterfeiting applications. A cellulose-based room temperature phosphorescent gel with ultra-strong hydrogen-bonded networks is developed through PEG-induced phase separation. The RTP gel exhibits enhanced phosphorescence lifetime of 255.55 ms and a tensile strength of 3.79 MPa, making it a promising candidate for advanced anti-counterfeiting applications. Download: Download high-res image (245KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
Joule
·
2026
·
IF 37.1
Haipeng You,Jiahui Chen,Ruhong Li,Long Chen,Ke Wang,Yuxin Qiu,Jiaqing Jiang,Yiting Lin,Menglei Yao,Hongming Yang,Yuhang Li,Zhen Song,Xiulin Fan,Chunzhong Li
Commercial lithium-ion battery electrolytes rely heavily on expensive LiPF 6 , making electrolyte cost a growing concern for battery deployment. Here, machine learning was used to help select dimethylacetamide as the basic solvent for LiNO 3 to yield a low-concentration electrolyte (0.38 M). Remarkably, techno-economic analysis shows that this approach directly reduces the cost of the electrolyte by up to 37.1%. The electrolyte delivered a 4.65-V electrochemical window, an ionic conductivity of 3.34 × 10 −3 S cm −1 , and stable operation from −40°C to 50°C. Its Li 3 N/LiF-rich and inorganic-organic hybrid interphases enabled stable cycling of NMC811, graphite, and lithium-metal electrodes. A 1-Ah NMC811||graphite pouch cell retained 91.3% capacity after 500 cycles. As validated here, dilute electrolytes are expected to present an innovative solution for low-cost batteries.
✓ 已验证
产品关联
DOI
高影响因子
Virulence
·
2026
·
IF 6.8
Xueer Dou,Na Wang,Shuangshuang Yao,Xinrui Chen,Shasha Li,Jingying Xie,Xiangrong Li,Yanmei Yang,Yanqiao Wen,Adi Idris,Huixia Li,Ruofei Feng
Encephalomyocarditis virus (EMCV) infection causes viral encephalitis; however, the mechanisms underlying blood-brain barrier (BBB) disruption remain poorly understood. Here, we demonstrate that EMCV actively replicates in mouse brain tissue, induces robust neuroinflammation characterized by elevated proinflammatory cytokines and chemokines, and markedly increases BBB permeability as evidenced by Evans blue and sodium fluorescein extravasation. Importantly, tight junction (TJ) proteins ZO-1 and Occludin are selectively degraded at the post-transcriptional level, whereas Claudin-5 expression remains stable. Consistently, in vitro BBB models confirmed EMCV traversal, reduced transendothelial electrical resistance, and TJ disruption. Mechanistically, EMCV induces biphasic PI3K/AKT modulation and specifically downregulates AKT3. Notably, AKT3 knockdown exacerbates both autophagy and apoptosis, thereby accelerating ZO-1 and Occludin degradation while promoting viral replication. Furthermore, pharmacological inhibition of autophagy (chloroquine) or apoptosis (Z-VAD-FMK) effectively rescues TJ proteins and reduces viral load. Interestingly, the Caspase-8 inhibitor Z-IETD-FMK provides the most robust protection, implicating the extrinsic apoptotic pathway as the dominant route. Collectively, EMCV sequentially activates non-redundant AKT3-dependent autophagic and apoptotic pathways to degrade TJ proteins, ultimately enabling viral traversal across the compromised BBB and offering therapeutic targets for viral encephalitis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Caiping Ding,Yuhan Zhang,Zikang Chen,Wen Li,Shuangshuang Wu,Zixi Qin,Youju Huang
Alzheimer’s disease (AD) involves multiple interconnected pathologies, including amyloid-β (Aβ) aggregation, Cu2+ accumulation, oxidative stress, and mitochondrial dysfunction. Single-target therapies show limited efficacy, and most probes lack combined multipathology modulation and real-time imaging─often requiring extensive surface modifications for modest effects. Here, we report a simple five-in-one neuroprotective-guardian near-infrared luminescent carbon dots (NGN-CDs) synthesized via a glutathione-assisted solvothermal method in formamide. NGN-CDs enable simultaneous intervention in AD pathology and real-time monitoring without complex functionalization. Their strong negative surface charge suppresses Aβ aggregation and disaggregates preformed fibrils, reducing plaque deposition. The carboxyl-rich structure allows high-affinity Cu2+ chelation, blocking Cu2+-induced Aβ aggregation and reactive oxygen species (ROS) generation by inhibiting peroxidase-like activity. NGN-CDs also show dose-dependent broad-spectrum antioxidant activity, effectively scavenging ROS and alleviating oxidative stress. They selectively target mitochondria and preserve membrane potential under H2O2 or Aβ-Cu2+ challenge, protecting neuronal organelles. Their intrinsic near-infrared fluorescence at 685 nm enables stable, real-time visualization of AD-related processes. Standing out for its multifunctional synergy, this nanoprobe integrates five key functions─Aβ antiaggregation, Cu2+ detoxification, antioxidant activity, mitochondrial protection, and NIR imaging─into a single platform. This work presents an innovative strategy for synergistic AD intervention and a rational design framework for nanotheranostics in neurodegenerative diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Xuemei He,Lieyuan Zhang,Heng Zhang,Lang Qiu,Dunmin Lin
Dynamic electrostatic shielding using amine/carboxyl-rich carbon quantum dots. • Negatively charged carboxyl groups homogenize Zn 2+ flux via long-range repulsion. • Amine groups anchor Zn 2+ , favoring dense (101)-oriented zinc deposition. • Ultra-long life (3700 h), high CE (99.9%), and 93.6% retention over 1500 cycles. Aqueous zinc-ion batteries (AZIBs) suffer from dendrite growth and parasitic side reactions due to uneven interfacial ion flux and high water activity. Herein, we propose a dynamic electrostatic shielding strategy by employing amine/carboxyl-rich carbon quantum dots (FNCQDs) as a mild, low-resistance multifunctional electrolyte additive. Through integrated experimental and theoretical analyses, we reveal that negatively charged carboxyl groups (−COO − ) generate a long-range electrostatic repulsion field that homogenizes the Zn 2+ flux, while amine groups (−NH 2 ) serve as specific anchoring sites via Zn − N coordination to capture Zn 2+ and catalyze desolvation. In this optimized microenvironment, zinc deposition spontaneously favors the (101) crystal plane, enabling dense, low-polarization growth. The spatial steering and chemical trapping synergy is further reinforced by bulk electrolyte restructuring: FNCQDs modulate the solvation sheath and hydrogen-bond network, effectively suppressing water activity and parasitic reactions. Consequently, with FNCQDs-containing electrolyte, the Zn||Zn symmetric cell achieves an ultra-long cycle life exceeding 3700 h, the Zn//Cu half-cell delivers a high average coulombic efficiency of 99.9%, and the zinc utilization efficiency exceeds 95.6%. Moreover, the Zn//VO 2 full cell exhibits outstanding rate capability and a capacity retention of 93.6% over 1500 cycles at 5 A g −1 . This work establishes a dynamic electrostatic shielding paradigm for reversible metal anodes, paving a new avenue toward practical aqueous zinc-based energy storage systems. FNCQDs create dynamic electrostatic shielding: carboxyl repulsion homogenizes Zn 2+ flux, Zn − N coordination guides (101) deposition, enabling 3700 h life, 99.9% CE. Download: Download high-res image (107KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Shen Yan,Eric Brendle,Mengyuan Li,Shengyu Zhang,Xiao Dong Chen,Winston Duo Wu
Spray drying and spray freeze drying induce distinct particle structure. • IGC is highly effective in resolving molecular-level surface characteristics. • IGC-ID reveals surface leucine enrichment and elevated dispersive energy. • IGC-FC quantifies hydrophilic site reduction and maps polar surface areas. • Surface energetics serve as a quantitative predictor for wetting and release. The unpredictable wettability of pharmaceutical microparticles, often stemming from complex phase transitions during processing, frequently eludes conventional unidimensional assessments of surface hydrophilicity. In this study, mannitol-leucine microparticles were fabricated via spray drying and spray freeze drying. Their structural properties—including morphology, particle size, and polymorphism—were systematically correlated with surface energetics (dispersive energy, acid–base characteristics, and hydrophilic site distribution) as delineated by inverse gas chromatography (IGC). Increasing leucine content induced pronounced surface wrinkling, sustained crystalline stability, and resulted in larger particle sizes in spray-dried samples. Conversely, spray-freeze-dried particles maintained a relatively uniform morphology but exhibited unstable δ-mannitol polymorphs with enhanced dispersibility. IGC analysis uncovered that leucine enrichment elevated dispersive surface energy, attenuated surface basicity, and diminished the hydrophilic surface area, with these effects being more pronounced in the spray-dried samples. Crucially, both the absolute hydrophilic surface area and the fractional distribution of hydrophilic domains were identified as key determinants modulating particle wettability and release behavior. This study highlights the capacity of IGC to resolve multiparametric surface energetics, thereby advancing the mechanistic understanding of pharmaceutical particle wettability through non-invasive, high-precision characterization. Download: Download high-res image (129KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Murong Du,Runsong Cheng,Huaiyi Chen,Jingya Cao,Siyuan Pan,Jinlei Yang,Kexin Xu,Wenjing Wang,Peicong Ge,Sichun Zhang,Xinrong Zhang
Single-cell lipid mass cytometry holds immense potential for functional phenotyping but is hindered by low throughput. To address this, we developed a high-throughput platform integrating a flow-focusing ionization source with a high-resolution time-of-flight mass spectrometer. This system achieved a maximum throughput of 1064.5 cells/min, representing a 20-fold increase over existing methods such as CyESI-MS (∼38 cells/min) and ILCEI-MS (∼51 cells/min). It enabled the detection and identification of 141 lipids from single cells for precise metabolic phenotyping. When applied to a peripheral blood mononuclear cell assay, the platform successfully analyzed and subtyped complex immune cell populations. Notably, it achieved the rapid, label-free identification of rare dendritic cells with an abundance as low as 1.53% within 3 min. This platform enables efficient screening of rare immune cell subsets based solely on metabolic signatures, establishing a robust foundation for immunology and translational medicine.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Wanyi Zhao,Haoran Chen,Man Zhang,Zhongbing Huang,Changsheng Zhao
Vascular restenosis, a significant complication after stent implantation, originates from the migration of vascular smooth muscle cells to the intima and the excessive extracellular matrix deposition, resulting in intimal hyperplasia. Thus, enhancing endothelial cell adhesion and reducing smooth muscle cell adhesion capacity are crucial to address this issue. Heparin, a naturally derived glycosaminoglycan, exhibits excellent anticoagulant activity and endothelial cell promoting effects, yet its clinical utility is constrained by bleeding risks, supply instability, immunogenicity, and demanding storage conditions. In this study, sulfonated carboxymethyl chitosan (SCCS) is employed as a heparin-mimicking polymer, immobilized on a glass substrate via dopamine-mediated adhesion. Compared with carboxymethyl chitosan, the SCCS-coated substrate significantly promotes endothelial cell adhesion while effectively inhibiting smooth muscle cell attachment. Additionally, the whole blood cell analysis and complement activation results exhibit that the SCCS coating has excellent blood compatibility. These findings suggest that the SCCS coating has the potential to be applied on various vascular stents to prevent restenosis, offering a nobel strategy for improving vascular interventional therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Kaiwei Wang,Fumin Wang,Xubin Zhang,Yi Zhai,Mingshuai Sun,Yan Chen,Jiaxing Zhang,Yihao Wang,Hongyu Wang,Yang Qin,Hao Ruan,Xuyang Zou
The nanosheet MFI zeolite synthesized with a short b-axis length exhibits broad potential for industrial applications due to its ability to facilitate mass transfer through the large straight-through channel along the b-axis. The current focus of research lies in the regulation of the zeolite crystal anisotropic growth rate through the addition of specific additives to the precursor liquid. The range of available additives, however, is limited, and their effects as well as potential mechanisms are still poorly understood. The impact of incorporating ten mononitrogen compounds into the gel on crystal growth was investigated. The influence of the N-containing compounds (functional group, C/N ratio, electrostatic potential of N atoms, and compound concentration) and growth time on crystal size was analyzed. N,N-dimethylformamide (DMF) and N-methylformamide (NMF) were revealed as potential inducers of the nanosheet zeolite. Herein, the effect of DMF on the nonclassical growth of the nanosheet zeolite is unveiled within crystallization engineering. The effects of various synthetic parameters on the DMF-assisted synthesis of nanosheet zeolites were also investigated. It is revealed that DMF plays a role in accelerating crystal growth and in regulating anisotropic crystal growth. This strategy can be extended to the synthesis of different heteroatomic nanosheet zeolites (such as Al-MFI, Fe-MFI, and Ti-MFI), and it is suitable for different types of silicon and metal sources. This study presents a straightforward strategy for the systematic and precise design and synthesis of nanosheet MFI zeolites, which exhibits significant potential for industrial utilization.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Rong Li,ZhiHui Hao,Xiangwei Zhao,Huilin Zhou,Zhimin He,Qin Dong,Wei Hong,Xinglong Gou
Metal sulfides, such as SnS2, have been extensively studied as separator modifiers in lithium–sulfur batteries (LSBs) owing to their dual functionality in chemically anchoring lithium polysulfides (LiPSs) and catalytically facilitating redox reactions. Nevertheless, poor electrical conductivity and limited catalytic efficiency restrict their practical implementation for LiPS transformation kinetics. To address these issues, we prepared Mo-doped SnS2 (Mo–SnS2) nanosheets with sulfur vacancies through a rapid one-pot formamide-assisted method. The incorporation of Mo heteroatoms not only improves conductivity but also induces favorable sulfur vacancies, synergistically promoting both adsorption and electrocatalytic conversion of LiPSs. The Li–S cell with a Mo–SnS2 nanosheet-modified separator delivers a remarkable initial capacity of 1007.5 mAh g−1 at 1C, maintains 799.5 mAh g−1 after 600 cycles with a low fading ratio of 0.034% per cycle, and demonstrates a favorable rate performance of 591.9 mAh g−1 at 5C. This defect engineering strategy through heteroatom doping offers a promising approach to concurrently mitigate the polysulfide shuttle effect and enhance the reaction kinetics in sulfur-based energy storage systems.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yingqi Liang,Yupeng Liu,Jun Wu,Lingyun Li,Xue Wu,Zekun Yan,Mingyu Chen,Elena V. Ushakova,Caishi Huang,Songnan Qu
The development of stimuli-responsive fluorescent nanomaterials with molecular pores is crucial for real-time monitoring of the delivery of functional non-fluorescent small molecules. Herein, a new type of yellow emissive porous carbon dots (CDs) derived from 3,9-perylenedicarboxylic acid was synthesized, employing a radical-assisted method under ambient pressure and mild heating conditions, and it is the smallest porous nanoplatform based on CDs. The molecular pores in the CDs can absorb L-arginine via intermolecular hydrogen bonds to form CDs and L-arginine complex (Arg@CDs). The absorbed L-arginine molecules in the molecular pores break the interlayer π – π interactions in the core due to the steric hindrance, leading to a fluorescence color shift from yellow to cyan. When exposed to an acidic environment, the absorbed L-arginine can be released, resulting in a recovery of yellow fluorescence. In vitro, Arg@CDs can be endocytosed by cells and localized to lysosomes, in which the acidic environment causes L-arginine release from the Arg@CDs with a fluorescence color change from cyan to yellow. Thus, Arg@CDs can be used as novel fluorescence color-sensitive pH probe for intracellular dynamic fluorescent imaging. Furthermore, in the mouse scald wound model, intravenous injection of Arg@CDs can significantly accelerate wound healing by promoting macrophage proliferation and anti-inflammatory action.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）