Materials Today Bio
·
2024
·
IF 8.7
Hui Yang,Sirui Huang,Xinwei Zhu,Yasi Chen,Chunming Xu,Ruohan Li,Pan Bu,Yufan Jiang,Changwei Li,Jie Yang,Zhenyi Chen,Weijie Peng,Lin Liu
Critical-sized bone defects present a formidable challenge in tissue engineering, necessitating innovative approaches that integrate osteogenesis and angiogenesis for effective repair. Inspired by the hierarchical porous structure of natural bone, this study introduces a novel method for the scalable production of ultra-long, copper-doped hydroxyapatite (Cu-HAp) fibers, utilizing the rapid gelation properties of guar gum (GG) under controlled conditions. These fibers serve as foundational units to fabricate three-dimensional porous scaffolds with a biomimetic hierarchical architecture. The scaffolds exhibit a broad pore size distribution (1–500 μm) and abundant nanoporous features, mimicking the native bone extracellular matrix. Physicochemical characterization and in vitro assays demonstrated that the copper doping significantly enhanced osteogenic and angiogenic activities, with optimized concentrations (0.8 % and 1.2 % Cu) facilitating the upregulation of osteogenesis-related genes and proteins, as well as promoting endothelial cell proliferation. In vivo studies further confirmed the scaffolds' efficacy, with the 1.2Cu-HAp group showing a remarkable increase in bone regeneration (bone volume/total volume ratio: 35.7 ± 1.87 %) within the defect site. This research offers a promising strategy for the rapid fabrication of multifunctional scaffolds that not only support bone tissue repair but also actively accelerate the healing process through enhanced vascularization.
研究领域:
生物材料学
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组织工程学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yong Zhang,Xuan Liu,Yujia Liu,Jiaqi Feng,Kexing Jiang
Lamellar membranes made from 2D materials have garnered significant attention as advanced separation materials for wastewater treatment, particularly for wastewater containing uranium (U(VI)). Nevertheless, it is still a great challenge to obtain assembled lamellar membranes with both high flux and retention rate from 2D materials. In this work, a method of in-situ loading hydroxyapatite nanoparticles onto MXene nanosheets and vacuum filtration to form a novel Ti 3 C 2 T x MXene/hydroxyapatite (MXene/HAP, MXHP) membrane had been developed for separating U(VI) from wastewater. From the characterization results, the MXHP membrane displayed an increasing trend of interfacial pores and interlayer channels for comparison to the pure MXene membrane, which could notably improve water permeability of MXHP membrane. Based on membrane separation experiments, the MXHP-2 membrane achieved a flux of 515.5 L/(m 2 ·h·bar) and a U(VI) retention rate of 98.2 % in the treatment of U(VI)-containing wastewater. Additionally, the MXHP-2 membrane exhibited strong recyclability with a high U(VI) retention rate of 85.3 % after five cycles. The U(VI) separation mechanism of MXHP-2 was photocatalytic reduction assisted dissolution-deposition. The above results could provide valuable insights for developing new composite membranes with high throughput and high uranium retention rate.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Dan Chen,Ming Zhai,Jing Zhang,Liqi Miao,Kan Li,Zhong Wang,Xiaozhi Wang
Gold-based catalysts are renowned for their exceptional low-temperature oxidation activity and have found widespread application in the thermos catalytic oxidation of formaldehyde (HCHO). In this study, an in-situ hydrothermal synthesis method was employed to prepare Au 0.5 Ni x /ATP catalysts. By altering the doping amount of Ni during the synthesis process, the impact of Ni doping on the catalytic reactivity was investigated. Compared to pure gold-based catalysts, the dispersion and sintering resistance of the Au 0.5 Ni x /ATP catalysts were enhanced. The OH - ions present in the alkaline solution provided by TPAOH disrupted the morphology of ATP, leading to a flocculent appearance for the Au 0.5 /ATP catalyst. With varying doping levels of Ni, the rod-like structure of ATP gradually recovered due to the strong interaction between Ni 2+ and OH-. On the Au 0.5 Ni x /ATP catalysts, NiO, being a p-type semiconductor, was prone to electron loss, with the lost electrons being captured by Au 3+ to form Au 0 and stronger Au and Ni interactions. When Ni species were introduced onto the Au/ATP surface, the synergistic effect between Au and Ni resulted in higher catalytic activity, favoring the catalytic oxidation of HCHO. The catalytic efficiency peaked when the Ni doping level reached 20 wt%.
研究领域:
催化化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yanlin Chen,Qingyan Zhang,Xijun Fu,Shuaishuai Guo,Qingyi Zeng
Hydroxyapatite (HAP) has been recognized as an effective absorbent for uranium. Recognizing and revealing its fate in coordinating with uranyl ions (U(VI)) under various conditions are vital for its practical application. In this work, HAP nanoflowers were synthesized by a simple wet chemical method, and the immobilization properties of HAP on U(VI) and U(VI) phase transformation during immobilization process were investigated systematically using a host of experimental methods and advanced characterization techniques. The results show that HAP can effectively immobilize U(VI) at high concentrations (50–3000 mg/L), with a maximum U(VI) adsorption capacity (q) of 10,200 mg/g and a distribution ratio (K d ) higher than 1.16 × 10 5 mL/g. Under the presence of sufficient U(VI) and a pH around 1.5 ∼ 3.0, HAP can rapidly react with U(VI) to form Autunite (Ca(UO 2 ) 2 (PO 4 ) 2 ·3H 2 O) with a nanoflake morphology, which is demonstrated excellently long-term stability. A moderately low pH that enables form adequately free calcium ions and phosphate groups via hydrolysis of HAP is essential to the mineralization of U(VI). This work is expected to pave the way for the use of HAP to develop highly efficient immobilization agents for the remediation of uranium-contaminated scenes and presents a comprehensive insight into the mechanisms of long-term U(VI) stabilization.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 38
·6047-6056
·
IF 4.776
Xiyu Li,Qin Zou,Li Chen,Wei Li
Hydroxyapatite (HA) has been broadly used for the repair of human hard tissues due to its bioactivity and similarity to the mineral of bones and teeth. We prepared a fluorine (F), ytterbium (Yb) and holmium (Ho) ternary doped HA (HYH-F) material and investigated its dual functions of bone repair and multimodal tracking. The results showed that the HYH-F material could display clear X-ray micro-computed tomography (Micro-CT) images based on Yb ions, and Ho ions due to its superparamagnetic properties for magnetic resonance imaging (MRI), while the F ions could enhance the upconversion (UC) fluorescence of the Yb/Ho combination. The ternary doped HYH-F material shows good compatibility with cells and bone tissue. A joint usage of Micro-CT imaging and UC fluorescence imaging distinctly and synergistically demonstrated the distribution state and degradation of the HYH-F material during new bone reconstruction. The single matrix HA material with ternary doping will be beneficial for future biomedical investigation and applications, and it can not only be a bone repair biomaterial, but also provide lifelong multimodal tracking efficacy.
研究领域:
生物医学
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材料科学
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医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Processes
·
2021
·Vol. 9
·期 11
·1927
·
IF 2.847
Tao Ou,Hairong Peng,Minhua Su,Qingpu Shi,Jinfeng Tang,Nan Chen,Diyun Chen
The exploration and rational design of easily separable and highly efficient sorbents with satisfactory capability of extracting radioactive uranium (U)-containing compound(s) are of paramount significance. In this study, a novel magnetic hydroxyapatite (HAP) composite (HAP@ CoFe2O4), which was coupled with cobalt ferrite (CoFe2O4), was rationally designed for uranium(VI) removal through a facile hydrothermal process. The U(VI) ions were rapidly removed using HAP@ CoFe2O4within a short time (i.e., 10 min), and a maximum U(VI) removal efficiency of 93.7% was achieved. The maximum adsorption capacity (Qmax) of the HAP@CoFe2O4was 338 mg/g, which demonstrated the potential of as-prepared HAP@CoFe2O4in the purification of U(VI) ions from nuclear effluents. Autunite [Ca(UO2)2(PO4)2(H2O)6] was the main crystalline phase to retain uranium, wherein U(VI) was effectively extracted and immobilized in terms of a relatively stable mineral. Furthermore, the reacted HAP@CoFe2O4can be magnetically recycled. The results of this study reveal that the suggested process using HAP@CoFe2O4is a promising approach for the removal and immobilization of U(VI) released from nuclear effluents.Keywords:cobalt ferrite;adsorption;hydroxyapatite;mineralization;uranium(VI)
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Long Li,Jibran Iqbal,Ying Zhu,Fang Wang,Feiyu Zhang,Wanchao Chen,Ting Wu,Yiping Du
Alumina, as a support material, was loaded together with chitosan and hydroxyapatite to form chitosan/Al 2 O 3 -HA composite beads and was used for estradiol and chrysoidin removal from aqueous solution in the present work. The physicochemical properties of the beads were studied with Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectrometry (FTIR), thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) surface area analysis. FTIR spectra confirmed that the chitosan was loaded successfully on Al 2 O 3 -HA, and functional groups were immobilized onto the surface of the beads after the synthesis. The adsorption condition including pH, the amount of adsorbent, initial concentration and time were evaluated during the batch experiments. Isotherm data best matched the Langmuir model and the pseudo-second-order model best described the adsorption kinetics . The maximum adsorption capacity was found to be 39.78 mg/g and 23.26 mg/g for estradiol and chrysoidine, respectively. The adsorbed estradiol and chrysoidin were completely eluted from the composite beads with the eluent of 0.1 M H 2 SO 4 /MeOH and the regenerated material was used in several cycles without deterioration in its initial performances. This study suggests that the developed composite beads have high potential for the efficient removal estradiol and chrysoidin from aqueous solution.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Environmental Technology & Innovation
·
2024
·
IF 6.7
Yaxin Liu,Congbin Xu,Tianran Sun,Jiemin Cheng
The toxicity of nanoparticles has attracted much attention, but the toxicity of nanoparticle types to soil fauna remains unclear. In this study, the earthworm ( Eisenia fetida ) was selected as a representative soil fauna to evaluate the toxicity of nano-hydroxyapatite (n-HAP), -zeolite (n-zeolite), and -iron tetroxide (n-Fe 3 O 4 ) to soil fauna. The results showed that the skin ultrastructure, mortality, growth, antioxidant systems, and genetic material of the earthworms were affected to varying degrees by different nanoparticles. A filter paper test indicated that dermal exposure to nanoparticles primarily caused lesions in the cuticle, microvilli, and nucleus of the epithelial cells of earthworm skin. Soil incubation experiments showed that all types of nanoparticles could cause weight loss in earthworms, but only n-Fe 3 O 4 resulted in their death. The reactive oxygen species and glutathione contents in earthworms exposed to n-Fe 3 O 4 were much higher than those in earthworms exposed to n-HAP and n-zeolite. All nanoparticles stimulated the catalase and lactate dehydrogenase activity and damaged the DNA of earthworms. Integrated biomarker responses showed that the toxicity to earthworms increased in the following order: n-HAP < n-zeolite < n-Fe 3 O 4 . The characterization results indicated that the differences in surface hydroxyl groups and surface charge may be the cause of the differences in toxicity between n-HAP and n-zeolite with similar properties. The highest toxicity of n-Fe 3 O 4 could be due to the size, spherical morphology, positive surface charge and the presence of Fe(II).
研究领域:
环境科学
·
毒理学
·
土壤生物学
✓ 已验证
产品关联
DOI
高影响因子
Nano Energy
·
2020
·
IF 16.602
Yuanyi Zhou,Haipeng Wang,Xuechen Liu,Simeng Qiao,Dengkui Shao,Jing Zhou,Ling Zhang,Wenzhong Wang
The cascading of methane valorization and methanol upgrade, both of which are important in C 1 chemistry, becomes a promising strategy to fabricate value-added chemicals from methane directly. Reconciling the contradiction between the C‒H bond activation of methane and the over-oxidation susceptibility of methanol is critical but challenging. Herein, we report the piezocatalytic methane conversion over hydroxyapatite (HAp) under ultrasonic vibration at ambient conditions, obtaining alcohols as liquid products without any sign of CO or CO 2 . Mechanistic studies reveal that the piezocatalytic effect of HAp drives H 2 O and methane activation and supplies hydroxyl radical (·OH) to attack the methane C‒H bond, while the ultrasonic-induced negative surface charge (SC) promotes methanol dehydration into methyl carbene as a fascinating C 1 building block to facilitate product upgrade into C 2 and C 3 alcohols. Attributing to the enriched SC which tunes the surface acid-base property, piezocatalysis presents a new approach for C‒C coupling.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2017
·
IF 2.764
Jinchuan Wu,Changshun Ruan,Yufei Ma,Yuanliang Wang,Yanfeng Luo
The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite (HA) scaffolds was investigated by sintering the mixture of rod-shaped HA (r-HA) and spherical HA (s-HA) with polyacrylamide used as the sacrificial template. It was found, for the first time, that addition of r-HA into s-HA could exponentially decrease the porosity of sintered HA scaffolds and enhance their compressive strength with the increase of r-HA content. The mechanism, according to the results from scanning electron microscopy and X-ray diffraction, lies in the restriction of s-HA to the grain formation and growth of r-HA during sintering and results in the fusion of r-HA with s-HA. These findings suggest that mixture of r-HA and s-HA might provide a new and facile way to improve the compressive strength of porous HA scaffolds.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Lingjun Kong,Yang Ruan,Qingying Zheng,Minhua Su,Zenghui Diao,Diyun Chen,Li’an Hou,Xiangyang Chang,Kaimin Shih
A considerable amount of uranium (U(VI))-containing industrial wastewater is generated from both uranium mining and processing, and nuclear electrical power generation. Discharge of U(VI) containing wastewater causes severe damage to the environment and leads to a loss of resources. Uranium sorption on hydroxyapatite (HAP) has been studied extensively to address the abovementioned issues. In the present study, BC-HAP was recovered through phosphate sorption from wastewater, which was first reused as a potential sorbent for extracting uranium from aqueous solutions comparing to commercially available nano-HAP. The sorption behavior of uranium and its transformation on the recovered BC-HAP were investigated by conducting batch experiments as well as Fourier-transform infrared, scanning electron microscopy, and x-ray diffraction analyses. BC-HAP had superior sorption ability for uranium extraction. Autunite precipitant at nano-scale is observed after uranium sorption. Partial desorption of uranium was observed in the presence of Na 2 CO 3 and NaHCO 3 . Surface complexation and phosphate dissolution precipitation contributed to the favorable uranium sorption. Thus, recovered BC-HAP can be widely used as a promising and cost-effective adsorbent to extract uranium from aqueous solution.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2018
·
IF 3.024
Wenda Jia,Guangyue Xu,Xiaohao Liu,Feng Zhou,Huixia Ma,Ying Zhang,Yao Fu
Inedible natural oils are desired resources for renewable fuel and chemical production. Herein, a nonprecious metal cobalt catalytic system was developed for selectively hydrogenating fatty acids and natural oil into fatty alcohols or long-chain alkanes. The cobalt-based catalysts were prepared by a wet-impregnation method with a series of supports including HZSM-5, CeO2, ZrO2, SiO2, Al2O3, TiO2, and hydroxyapatite (HAP) for hydrogenating stearic acid. Among these catalysts, Co/HAP exhibited the highest activity and 97.1% yield of 1-octadecanol was obtained at 190 °C and 4 MPa H2 in water. Additionally, the Co/HAP was capable of directly hydrogenating the natural oil, Jatropha oil, to fatty alcohols without any preprocessing, and 83.1 wt % yield of alcohols could be achieved at 190 °C and 4 MPa H2 in water. Co/HAP could also catalyze the complete conversion of stearic acid and Jatropha oil to long-chain alkanes when dodecane was used as solvent. X-ray power diffraction, transmission electron microscopy, H2 temperature-programmed reduction, and NH3 temperature-programmed desorption were carried out, and the high catalytic activity of Co/HAP could be due to its desired acidity, cobalt particle dispersion, and stronger metal–support interaction. The Fourier transform infrared results indicated that the high efficiency of Co/HAP could also be due to the absorption of fatty acid on the surface of catalyst which thus promoted the hydrogenation process over Co species. The possible reaction pathway was also proposed according to the conversion process tracking of stearic acid.
研究领域:
化学工程
·
可再生能源
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）