INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Yuman Dong,Peng Liu
Efficient approach was established to improve the drug delivery performance of the pH-triggered prodrug nanoparticles by introducing a polycation block as a pH-sensitive gatekeeper. With the help of the poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) block as a pH-sensitive shell gatekeeper, the proposed core-shell-corona PEG 43 - b -PDPA 65 - b -PFPMA 36 -DOX nanoparticles possessed a higher drug release rate in the simulated acidic tumor intracellular micro-environment while a lower premature drug leakage in the simulated weak basic normal physiological medium, compared with the core-shell PEG 43 - b -PFPMA 36 -DOX nanoparticles. The proposed strategy is expected to design high-performance drug delivery systems (DDSs) for tumor treatment, with improved anticancer efficacy but minimized toxic side effects.
研究领域:
药物递送
·
生物材料
·
肿瘤治疗
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2015
·
IF 5.056
Jia Xu,Lili Zhang,Xueli Gao,Haiyan Bie,Yunpeng Fu,Congjie Gao
In this study, a facile and novel strategy for constructing tunable antimicrobial NF membrane surface was developed by a simple electrostatic assembly of polycation–copper(II) complex on the polyacrylonitrile substrate surface followed by cross-linking. Polycation–copper(II) complex with high stability and charge density, using polyethyleneimine (PEI) as a capping ligand, was formed by exquisitely manipulating the pH and Cu 2+ concentration for strong assembly on the surface. We confirmed that PEI–copper(II) complex assembly was a good way to significantly improve the Cu 2+ loading efficiency in terms of loading time and loading amount with AAS and EDS measurements. We also demonstrated that cross-linking had a significant influence not only on the strong assembly of PEI–Cu(II) complex to the substrate surface but also on the controllable Cu 2+ release, which was confirmed by SEM, EDS and AAS measurements after exposing the NF membrane to bath sonication and real seawater. The NF membrane exhibited significant antimicrobial activity with antibacterial efficiency of more than 95% and prevented effectively the formation of biofilms for up to 6-month test. For real seawater softening, the NF membrane achieved approximately 32.3 L/m 2 h flux and 43.5%, 68.3%, 98.1%, 19.1% and 18.7% rejection of salt, SO 4 2− , Mg 2+ , Na + and Cl − , respectively, with a high softening efficiency (low S value) compared to other commercial NF membranes. We hope that the present method can be developed as a competitive technology for the fabrication of robust and versatile antimicrobial membrane, leading to the high efficiency of seawater softening.
研究领域:
环境科学
·
材料科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jieyu Sui,Ruixuan Zhou,Kunyan Sui,Pengfei Qi,Wenxin Fan
The high-efficiency removal of harmful and persistent polycyclic aromatic hydrocarbon (PAH) pollutants from natural water is critical for safeguarding human health. A major challenge lies in the absence of effective technologies to accelerate the transfer of chemically inert and electroneutral PAHs from contaminated water to nano-adsorbents or nano-catalysts. Herein, we present a novel TiO 2 /polycation composite hydrogel membrane featuring dual gradients of positively charged groups and TiO 2 nano-catalysts for the deep and high-efficiency removal of PAH pollutants. The gradient polycation hydrogel matrix facilitates the spontaneous absorption of PAHs through cation-π interactions, while driving the directional migration of PAHs towards the high-density side via enthalpy-driven force induced by the positive charge gradient. Consequently, irradiating the high-density side of the dual-gradient composite hydrogel, enriched with PAHs and TiO 2 nano-catalysts, enables rapid and deep photocatalytic degradation of PAHs (e.g., naphthalene and phenanthrene). Furthermore, a mathematical model based on the Flory-Rehner theory is firstly developed to precisely control the distribution of PAHs within the composite hydrogels. Our findings provide a robust framework for the design of advanced composite catalysts with substantially enhanced removal efficiency for PAH pollutants.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2015
·
IF 6.409
Meiding Yang,Jian Chen,Huipeng Zhou,Wenying Li,Yan Wang,Juanmin Li,Cuiyun Zhang,Chuibei Zhou,Cong Yu
A benzoperylene probe excimer emission in an aqueous buffer solution is observed for the first time, and a novel ratiometric fluorescence method based on the probe excimer emission for the sensitive detection of heparin and heparinase is demonstrated. A negatively charged benzoperylene derivative, 6-(benzo[ghi]perylene-1,2-dicarboxylic imide-yl)hexanoic acid (BPDI), was employed. A polycation , poly(diallyldimethylammonium) chloride (poly-DDA), could induce aggregation of BPDI through noncovalent interactions. A decrease of BPDI monomer emission and a simultaneous increase of BPDI excimer emission were observed. Upon the addition of heparin, the strong binding between heparin and poly-DDA caused release of BPDI monomer molecules, and an excimer–monomer emission signal transition was detected. However, after the enzymatic hydrolysis of heparin by heparinase, heparin was hydrolyzed into small fragments, which weakened the competitive binding of heparin to poly-DDA. Poly-DDA induced aggregation of BPDI, and a monomer–excimer emission signal transition was detected. Our assay is simple, rapid, inexpensive, sensitive and selective, which could facilitate the heparin and heparinase related biochemical and biomedical research.
研究领域:
分析化学
·
生物化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2024
·Vol. 14
·期 12
·925
·
IF 3.8
Guanyu Qie,Miao Zhai,Kake Zhu,Xuedong Zhu
The development of hierarchically structured zeolites to mitigate diffusion limitations and improve catalytic performance constitutes a focus of current research. In this study, we present the synthesis of hierarchical disk-shapedMTWzeolite (ZSM-12-P) with shortened channel length using polycation [-C5H9N+C10H10N+C5H9-C3H6-]n[Br−]2n(PDIP) as an organic structure-directing agent (OSDA). The ZSM-12-P zeolite forms disk-shaped structures with thicknesses ranging from 140 to 160 nm and exhibits rotational intergrowth. These structures are composed of interconnected nanocrystalline domains that form mesopores accessible from the outer surface, while the microporous channels extend along the thickness direction. In addition, the polycationic OSDA possesses strong interaction with framework andMTWstructure-directing ability, enabling the successful synthesis of the Al-rich ZSM-12-P. Owing to its strong acidity and improved diffusion property, the Pt/HZSM-12-P catalyst demonstrates enhanced catalyticn-dodecane hydroisomerization activity and isomer yield.
研究领域:
催化化学
·
材料科学
·
石油化工
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 40
·24995-25003
·
IF 3.361
Hao Guo,Longli Ma,Chaojing Yan,Xiaohua Ma
The polycation gel polymer electrolyte (PGPE) is a promising electrolyte material for supercapacitors due to its high ionic conductivity and great flexibility. Herein, we report a novel flexible PGPE film, which is prepared by thermal copolymerization. The superiority of PGPE is attributed to the existence of charged groups in the polymer skeleton. Consequently, the crystallinity of the polymer is effectively reduced, and the migration of the lithium ion is evidently promoted. Moreover, the liquid retention capacity of the film is improved, which enhances its ionic conductivity as well. The reported PGPE exhibits a high ionic conductivity of 57.6 mS cm−1 at 25 °C and a potential window of 0–1.2 V. The symmetrical PGPE supercapacitor (AC/AC) shows 95.21% mass-specific capacitance retention after 5000 cycles at 2 A g−1 with a maximum energy density of 12.8 W h kg−1 and a maximum power density of 5.475 kW kg−1. This study confirms the exciting potential of PGPE for high performance supercapacitors.
研究领域:
材料科学
·
能源存储与转换
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 18
·15175-15179
·
IF 3.289
Rui-Juan Shi,Yong Chen,Xiao-Fang Hou,Yu Liu
The molecular induced aggregation behaviors of a polycationic cyclodextrin, i.e. per-6-deoxy-6-(1-methylimidazol-3-ium-3-yl)-β-cyclodextrin (1), towards five anionic surfactants, i.e. sodium decyl sulfonate (SDES), sodium undecyl sulfonate (SUS), sodium dodecyl sulfate (SDS), sodium lauryl sulfate (SLS) and sodium dodecyl benzene sulfonate (SDBS), were comprehensively investigated in aqueous solution. The results showed that the introduction of 1 could efficiently decrease the critical aggregation concentrations (CAC) of the selected surfactants by a factor of 14–467, leading to the formation of nanoscale spherical particles with a diameter of 200–400 nm and nearly neutral or moderate positive zeta potential. Significantly, the resultant 1/SLS and 1/SDBS aggregates exhibited the ability of loading both anionic and neutral model substrates.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 5
·2100025
·
IF 4.979
Qinping Yang,Yanliang Dong,Xuanyu Wang,Zhihao Lin,Mingyu Yan,Weiwei Wang,Anjie Dong,Jianhua Zhang,Pingsheng Huang,Changrong Wang
pH-sensitive polyelectrolytes provide enormous opportunity for siRNA delivery. Especially, their tertiary amine structures can not only bind genes but also act as pH-sensitive hydrophobic structure to control genes release. However, the influence of molecular structures on siRNA delivery still remains elusive, especially for the asymmetric alkyl substituents of the tertiary amine groups. Herein, a library of N -methyl- N -alkyl aminoethyl methacrylate monomers (MsAM) with asymmetric alkyl substituents on the tertiary amine group is synthesized and used to prepare a series of tri-block polycationic copolymers poly(aminoethyl methacrylate)-block-poly ( N -methyl- N -alkyl aminoethyl methacrylate)-block-poly(ethylene glycol methacrylate) (PAMA-PMsMA-PEG). And the properties of these polycations and their self-assembled micelles are characterized, including molecular structure, proton buffering capacity, pH-sensitivity, size, and zeta potential. With the length increase of one alkyl substituent, the proton buffering capacity of both monomers and polycations is demonstrated to be narrowed down. The siRNA delivery efficiency and cytotoxicity of these micelles are also evaluated on HepG2 cells. In particular, poly(aminoethyl methacrylate)-block-poly( N -methyl- N -ethyl aminoethyl methacrylate)-block-poly(ethylene glycol methacrylate) (PAMA-PMEMA-PEG) elicited the best luciferase knockdown efficiency and low cytotoxicity. Besides, PAMA-PMEMA-PEG/siRRM2 also induced significant anti-tumor activity in vitro. These results indicated PAMA-PMEMA-PEG has potential for further use in the design of gene vehicles with the improved efficiency of siRNA delivery.
研究领域:
聚合物化学
·
分子生物学
·
基因治疗
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 16
·3379-3391
·
IF 4.726
Haixia Wang,Yakai Feng,Jing Yang,Jintang Guo,Wencheng Zhang
Targeting gene engineering should be considered as an effective method for promoting endothelialization of vascular grafts. Herein, we developed a targeting REDV peptide functionalized polycationic gene carrier for carrying the pEGFP-ZNF580 plasmid with the aim of enhancing the transfection and migration capability of human endothelial cells. This polycationic gene carrier with the REDV peptide (mPEG-P(LA-co-CL)-PEI-REDV) was prepared by the conjugation of the Cys-Arg-Glu-Asp-Val-Trp (CREDVW) peptide with the amphiphilic block copolymer methoxy poly(ethylene glycol) ether-poly(L-lactide-co-ε-caprolactone)-poly(ethyleneimine) (mPEG-P(LA-co-CL)-PEI). mPEG-P(LA-co-CL)-PEI nanoparticles (NP) and mPEG-P(LA-co-CL)-PEI-REDV nanoparticles (REDV-NP) were formed by the self-assembly of the corresponding polycationic polymers, and then their pEGFP-ZNF580 complexes were prepared via the electrostatic interaction with pEGFP-ZNF580 plasmids, respectively. Gel electrophoresis results show that the targeted REDV-NPs could compress pEGFP-ZNF580 plasmids into stable complexes and protect the plasmids against desoxyribonuclease degradation. MTT assay indicates that these targeted REDV-NP/pEGFP-ZNF580 complexes exhibit better cyto-compatibility than the non-targeted NP/pEGFP-ZNF580 complexes and the control PEI 1800 Da/pEGFP-ZNF580 complexes. In vitro transfection experiments and western blot analysis of EA.hy926 endothelial cells show that the pEGFP-ZNF580 plasmid expression and the relative protein level transfected by targeted REDV-NP/pEGFP-ZNF580 complexes are roughly consistent with that transfected by PEI 25 kDa/pEGFP-ZNF580 complexes. More importantly, the scratch wound assay results demonstrate that the migration capability of EA.hy926 cells has been improved significantly by the expression of the pEGFP-ZNF580 plasmid. Our results indicate that the polycationic polymer with functional REDV peptides can be a potential candidate as a pEGFP-ZNF580 plasmid delivery carrier and may be used in the endothelialization of vascular grafts.
研究领域:
基因治疗
·
生物医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Minyan Wu,Zirui Wang,Shumeng Liu,Qing Zhang,Xiaoji Zhou,Shusu Shen
Membrane separation technology is widely used in the treatment of dye wastewater because of its low cost, high separation efficiency, simple operation and no secondary pollution. In this study, a series of blend cellulose acetate (CA) membranes with different compositions were prepared by blending a polycationic liquid synthesized in laboratory with CA. The membranes were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy analysis and the surface properties including the water contact angle, mechanical strength, pure water flux, pore size and zeta potentials were also tested. The hydrophilicity of the membrane was improved by blending more additive. Compared with pure CA membrane, the surface zeta potential value of the modified membrane increased. The maximum pure water flux of the modified membranes was 32.51 L/m 2 ·h. In the experiment of filtering two cationic dyes (acridine yellow hydrochloride and Rhodamine B) with different molecular weights, it is found that the blend modified membrane with optimal performance showed better antifouling performance and higher rejection rate, the flux recovery rates of acridine hydrochloride yellow and Rhodamine B were 93.94% and 87.47%, and the rejection rates were 87% and 76.1%, respectively.
研究领域:
环境科学
·
化学工程
·
膜技术
·
废水处理
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Junqing Shen,Ping Guan,Aiyun Jiang,Wentao Fan,Shengnan Li,Yingliang Liu,Shengang Xu,Shaokui Cao
The intergranular interface modification of organic–inorganic hybrid perovskites (OHP) is an important issue to regulate the flexibility, stability, and resistive switching (RS) performance of resistive random-access memories (RRAMs). A novel strategy of polymer additives for OHP intergranular interface modification is explored in this work with the polyanionic backbone to improve the distribution of cage-shaped cavity molecules at the perovskite grain boundaries. Specifically speaking, poly(1-adamantylammonium acrylate) (PADAm) is first synthesized through the acid–base reaction of polyacrylic acid with 1-adamantylamine to simultaneously realize the introduction of a cage-shaped cavity molecule and the polyanionic backbone. Herein, organic ammonium cations 1-adamantylammonium (ADNH3+) in PADAm are applied as the cage-shaped cavity molecules to tune the dielectric property by being anchored at the perovskite grain boundaries. Meanwhile, polyacrylic anions in PADAm play the role of the polyanionic backbone to produce the more uniform distribution of ADNH3+. Simultaneously, the flexibility and stability of OHP RRAM devices are also improved due to the introduction of the polyanionic backbone. Consequently, the 4% ADNH3I-modified planar device exhibits the stable nonvolatile RS behavior with an on/off ratio of ∼104, even with one-month exposure under an ambient environment. Importantly, the introduction of PADAm in the flexible fibrous crosspoint of functional fiber Al@MAPbI3:PADAm and bare Al fiber further increases the on/off ratio to 108 due to the effectively improved distribution of hollow cage-shaped ADNH3+ at the perovskite intergranular interfaces together with the application of the fibrous crosspoint device configuration. Especially, these excellent crosspoint RRAM devices can be integrated into the woven fibrous RRAM array in the thermal plastic packaging configuration. In addition, the excellent multilevel RS behavior can also be realized in the woven fibrous RRAM array, indicating potential high-density data storage. This work provides a novel strategy of polymer additives bearing the polyanionic backbone to improve the flexibility, stability, and RS performance of perovskite RRAM devices.
研究领域:
材料科学
·
电子工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Bin Liu,Weiwei Zhao,Yutan Shen,Yaxun Fan,Yilin Wang
A versatile method to remove a broad spectrum of dye pollutants from wastewater rapidly and efficiently is highly desirable. Here, we report that the complex coacervation of cationic trimeric imine-based surfactants (TISn) with negatively charged hydrolyzed polyacrylamide (HPAM) can be used for this purpose. The coacervation occurs in a wide concentration and composition range and requires the HPAM and TISn concentrations as low as 0.1 g/L and 0.1 mM, respectively. Dye effluents treated by trimeric surfactants and HPAM complete phase separation within 30 s under turbulent conditions, which generates an exceedingly small volume fraction (0.4%) of viscoelastic coacervate and a clear supernatant with a dye removal efficiency of up to 99.9% for anionic and neutral dyes in dosages of up to 120 mg/L. Crowded molecular arrangement and thick framework in coacervate are responsible for the rapid phase separation rate and low volume fraction. The trimeric imine surfactant/polymer coacervation provides a simple, effective, and sustainable approach for the rapid removal of dyes and other organic pollutants.
研究领域:
环境科学
·
化学工程
·
水处理技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）