NEW JOURNAL OF CHEMISTRY
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2016
·Vol. 40
·期 10
·8225-8228
·
IF 3.277
Ming Zeng,Tao Wang,Dong-Mei Cui,Chen Zhang
An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated benzyl alcohol containing functionalities such as halogens. Monosubstituted to tetrasubstituted biguanidines also afforded the desired products.
研究领域:
有机化学
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催化反应
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DOI
高影响因子
Antibiotics-Basel
·
2022
·Vol. 11
·期 2
·162
·
IF 5.222
Xia Xiao,Quanmin Huan,Yanhu Huang,Yuan Liu,Ruichao Li,Xilan Xu,Zhiqiang Wang
Tigecycline (TIG) is one of the last effective options against multidrug resistance bacteria. Recently, the RND (resistance–nodulation–division) efflux pump gene cluster,tmexCD1-toprJ1, and the tetracycline-efflux pumptet(A) mutation were reported to mediate high level resistance to TIG in clinically important pathogens, weakening the efficacy of TIG. In this study, we report the potent synergistic effect of the antidiabetic drug metformin in combination with TIG againsttet(A) mutant andtmexCD1-toprJ1positiveK. pneumoniae. The fractional inhibitory concentration index (FICI) of TIG and metformin were less than 0.05 for all the tested isolates. The time–kill curve assay showed that the combination of TIG and metformin exhibited much better antimicrobial effect than TIG alone. The synergistic effect was also confirmed in vivo using a well-studiedGalleria mellonellalarvae model. Mechanistic studies demonstrated that metformin disrupted the important component of proton motive force, the electric potential (Δψ) and the function of efflux pump, thereby increasing the intracellular concentration of TIG. This finding revealed that metformin might be a possible adjuvant of TIG for combating with superbugs carrying thetet(A) mutant andtmexCD1-toprJ1genes.Keywords:tigcycline;metformin;tmexCD1-toprJ1;tet(A);synergy
研究领域:
微生物学
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药理学
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传染病学
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DOI
PubMed
高影响因子
Journal of Cancer
·
2022
·
IF 4.478
Kezhong Tang,Qing Chen,Yanmo Liu,Lantian Wang,Wenjie Lu
Hepatocellular carcinoma (HCC) is one of the most lethal cancers in the world. Sorafenib is the first small-molecule multi-kinase inhibitors approved by FDA for treatment of advanced HCC. Metformin has been demonstrated to have benefit for preventing cancer progression. In human recurrent HCCs, NF-E2-related factor 2 (Nrf2) was overexpressed and associated with poor survival. Nrf2 related signaling pathway plays central role to mediate cellular resistance to sorafenib through protecting HCC cells from ferroptosis. The effect of Combination treatment for HCC cells and the intrinsic mechanism have not been reported. In this study, metformin augmented the anti-tumor effect of sorafenib for HCC through ferroptosis induction by inhibiting Nrf2 related pathway. Based on the results of Nrf2 knockdown and p62 knockdown study, the combination of sorafenib and metformin suppressed proliferation of HCC cells through p62-Keap1-Nrf2/HO1 signaling way. Size of xenografts treated with the combination of sorafenib and metformin was smaller than other groups in vivo . Moreover, the combination treatment greatly induced ferroptosis in HCC cells through inhibiting Nrf2 expression. Based on our findings, the combination treatment suppressed proliferation of HCC cells through ferroptosis induction, by p62-Keap1-Nrf2/HO1 signaling way.
研究领域:
肿瘤学
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分子生物学
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药理学
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DOI
PubMed
高影响因子
CARBON
·
2023
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IF 10.9
Lidong Yu,Yi Wang,Kai Li,Xueting Li,Mingyue He,Ce Chen,Fangshun Li,Bing Liang,Li Li,Ning Gu,Zhiguo Liu,Bingsheng Li,Guixue Wang,Jianglin Fan
Colorectal cancer (CRC) is the most common malignancy-related cause of death worldwide. The prognosis of CRC patients is strongly correlated with elevated plasma copper. The quantitative detection of plasma copper is highly essential for the field of biomedicine, and our hypothesis was that plasma copper may be a therapeutic target for treating CRC. Here, we developed metformin-based carbon dots (MFCDs). MFCDs have strong photoluminescence at 460 nm, which is quenched by Cu 2+ . Cu 2+ concentration and the fluorescence emission intensity of MFCDs are significantly associated (linear range of 0.5–40 μM with a detection limit of 0.30 μM). Additionally, administration of MFCDs significantly inhibited the growth of CRC xenografts in mice caused by the existence of biguanide functional groups. MFCDs treatment led to the increase of reactive oxygen species and subsequent DNA damage and cell cycle arrest. This study showed that the biguanide functional groups of MFCDs chelate with Cu 2+ , resulting in the reduction of Cu/Zn-superoxide dismutase and glutathione, which eventually reduces antioxidant capacity and ultimately induces cell apoptosis. These results indicate that MFCDs provide a novel approach for anticancer therapy.
研究领域:
肿瘤学
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材料科学
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生物医学工程
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药学
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DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Chunrui Rong,Dongxia Yan,Jiabao Li,Jian Feng,Jiayu Xin,Qing Zhou,Yi Li,Junli Xu,Xingmei Lu
The increase in the usage of polyethylene terephthalate (PET) leads to the generation of a large amount of waste, which may cause carbon emissions and waste of petroleum resources. The methanolysis method has attracted global attention, but limited by high reaction temperature and excessive use of methanol. We report here an efficient catalyst, tetramethylguanidine/1,5-diazabicyclo[4.3.0]-5-non-ene (TMG/DBN), converting waste PET into regenerated dimethyl terephthalate (rDMT) under 100 °C with almost equivalent methanol, achieving 100 % PET conversion and 93.1 % yield of rDMT. A series of analytical methods and theoretical calculations were used to reveal the enhanced interaction between the catalyst and reactants, which facilitates the degradation of PET at low methanol dosages. In addition, a kinetic model was also developed with a relatively low activation energy of 84.9 kJ/mol. This work provides an effective strategy for the up-grading recycling of waste PET under mild reaction conditions.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
·
IF 6.1
Fan Gao,Lingyun Zhu,Fan Zhang,Meng Li,Hairong Lian,Sen Feng,Xinfeng Cheng,Xianling Xiang
Metformin (MET) and its metabolite guanylurea (GUA) are prevalent in aquatic environments, raising concerns about their potential risks to aquatic organisms. However, the toxicity of these compounds through different exposure routes has not been reported. This study evaluated the effects of MET and GUA on the growth of the green algae Tetradesmus obliquus and on life table parameters of the freshwater rotifer Brachionus calyciflorus through various exposure routes, including waterborne, foodborne, and combined waterborne + foodborne. Our results indicated that both MET and GUA, at concentrations of 1 mg/L and 100 mg/L, inhibited algae growth, with GUA causing greater stress than MET. Additionally, compared to waterborne exposure, foodborne and combined waterborne + foodborne exposures of MET and GUA at these concentrations significantly decreased the net reproductive rate (R 0 ), intrinsic rate of population increase (r m ), and life expectancy (e 0 ) of B. calyciflorus . Notably, the impact of exposure routes on the life table parameters of B. calyciflorus was generally greater than the impact of exposure concentrations. Therefore, previous studies focusing solely on waterborne exposure may have underestimated the toxicity of MET and GUA.
研究领域:
环境科学
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毒理学
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Xiaochen Wang,Dong Zhou,Jun Qin,Yuanyue Zhang,Jiale Li,Mengjie Wan,Yimin Zhu,Guang Yang
Conventional cancer treatments face significant limitations, prompting the exploration of immune combination therapies targeting immune checkpoints as a means to overcome these challenges. The PD-1/PD-L1 signaling pathway plays a crucial role in tumor proliferation and immune evasion. TPP1, a peptide inhibitor targeting PD-L1, effectively blocks this pathway and suppresses tumor growth. Metformin has been shown to inhibit cancer cell proliferation, migration, and invasion while inducing apoptosis and inhibiting the expression of PD-L1. To leverage the synergistic therapeutic effects of TPP-1 and metformin, we designed and constructed a peptide–small molecule drug delivery system using tumor cell membranes. First, nanoscale tumor cell membrane vesicles were prepared via hypotonic ultrafiltration and coupled with the TPP1 peptide through co-incubation to form TPP1–cell membrane complexes. Simultaneously, mesoporous silica nanomaterials were synthesized and loaded with metformin by using the sol–gel method. Finally, the two components were mixed and sonicated to create the final drug delivery system. Both in vitro and in vivo experimental results demonstrated that this tumor cell membrane-based drug delivery system significantly prolonged the half-life of TPP1, maintained its ability to activate T cells and promote IFN-γ secretion, and effectively inhibited tumor growth. Our constructed nanodelivery system could provide a promising therapeutic platform for co-delivery of peptides and small-molecule inhibitors in cancer therapy.
研究领域:
生物医学工程
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肿瘤学
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免疫学
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DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 11
·1846
·
IF 3.164
Yuanfeng Pan,Xiao Zhao,Xiaoning Li,Pingxiong Cai
Developing the ideal biomaterials for wound dressing still remains challenging nowadays due to the non-biodegradable features and the lack of antimicrobial activity of conventional synthetic polymer-based dressing materials. To tackle those problems, a novel and green-based antimicrobial hydrogel dressing was synthesized in this work via modifying sugarcane bagasse cellulose with guanidine-based polymer, followed by crosslinking antimicrobial-modified cellulose with unmodified one at various ratios. The resulting hydrogels were comprehensively characterized with swelling measurements, compression test, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results indicated that the dressing possessed the degree of swelling up to 2000% and the compress strength as high as 31.39 Kpa, at 8:2 ratio of pristine cellulose to modified cellulose. The antibacterial activities of the dressing againstE. coliwere assessed using both shaking flask and ring diffusion methods. The results demonstrated that the dressings were highly effective in deactivating bacterium without leaching effect. Moreover, these hydrogels are biocompatible with live cell viability responses of (NIH3T3) cells above 76% and are very promising as wound dressing.Keywords:cellulose;guanidine-based polymer;hydrogel dressing;antimicrobial activity
研究领域:
生物材料
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伤口愈合
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可持续材料
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抗菌技术
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2014
·
IF 3.916
Kai Liu,Yaoguang Xu,Xinxing Lin,Lihui Chen,Liulian Huang,Shilin Cao,Jian Li
In order to improve the strength property and antimicrobial activity of paper simultaneously, we prepared a novel multifunctional agent based on carboxymethyl cellulose (CMC) by a simple two-stage method. The first stage was the oxidation of CMC to obtain the dialdehyde CMC (DCMC), and the second stage was the graft of guanidine hydrochloride (GH) onto DCMC to obtain DCMC-GH polymer. The strength property and antimicrobial activity of DCMC-GH-coated copy paper have been studied by the tensile test and inhibition zone method, respectively. The results showed that the dry strength index could increase about 20% after the paper was coated with DCMC-GH. The coating of DCMC-GH on paper also resulted in excellent antimicrobial activities against Escherichia coli and Staphylococcus aureus , and the inhibition zone became larger as the GH content grafted on DCMC increased. The novel DCMC-GH polymer would be a multifunctional coating agent for food packaging paper.
研究领域:
材料科学
·
微生物学
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DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Xiang Zhou,Mengyun Wu,Lu Fu,Meng Liao,Liumi Deng,Luoxin Wang,Hua Wang,Yugui Xiang,Shaohua Chen
Traditional cellulose wrapping paper existing many problems, such as poor barrier, easy water absorption, etc. Herein, cellulose, polylactic acid non-woven fabric and antibacterial short fiber as raw materials, via wet papermaking process, prepared a biodegradable and antibacterial composite paper (SP/CFPLA-6%). Compared with the traditional cellulose paper, the water vapor transmittance of SP/CFPLA-6% decreased by 84.2%, showing obvious hydrophobicity. The tensile strength of SP/CFPLA-6% can reach 95.8 MPa, which is more than 70 MPa higher than that of ordinary cellulose paper, displaying promising antibacterial activity against Escherichia coli and Staphylococcus aureus . Meanwhile, SP/CFPLA-6% shows excellent biodegradability in biodegradation experiments. SP/CFPLA-6% offsets the shortcomings of ordinary cellulose wrapping paper and can be used as a substitute for traditional non-degradable plastic packaging materials.
研究领域:
材料科学
·
生物学
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产品关联
DOI
高影响因子
MACROMOLECULES
·
2022
·
IF 6.057
Weixing Xiong,Xiyu Wang,Yuanyuan Liu,Caihui Luo,Xinhua Lu,Yuanli Cai
Polymerization-induced electrostatic self-assembly (PIESA) represents a powerful method for the scalable synthesis of polyion complex (PIC) nanoparticles with various morphologies. Previous PIESA was driven by Coulombic interactions. Yet, biomimetic multivalent interactions, e.g., ionic hydrogen bonds omnipresent in proteins and potentially enabling access to new materials, remain unexplored. Herein, we update PIESA using arginine-like full-spectrum guanidinium ionic hydrogen bonds. Kinetic studies unravel that, at guanidinium-starving n+/n– (0.84), guanidinium interactions evolve from opposite-charge (6–73% conversion) into like-charge ionic hydrogen bonds (84 to >99% conversion), leading to ultrasmall clusters (2–5 nm, at 6–84% conversion) and size-tunable “large compound micelles” (14–25 nm, at 90 to >99% conversion). Longer guanidinium-block length results in the transformation of charge-neutral worms to positive-charge micron-scale large-area monolayer lamellae to multilayer platelets to tubular networks to vesicular aggregates, suggesting that the like-charge ionic hydrogen bonds are strong enough to overwhelm Coulombic repulsive interactions, and thus to revolutionize our PIESA chemistry for the precision synthesis of next-generation nanostructured biomimetic functional materials.
研究领域:
材料科学
·
聚合物化学
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纳米技术
·
生物材料
✓ 已验证
DOI
高影响因子
Journal of Functional Biomaterials
·
2024
·Vol. 15
·期 12
·388
·
IF 5
Siwei Sun,Xinyi Hou,Ke Li,Chenqi Huang,Yu Rong,Jiao Bi,Xueping Li,Daocheng Wu
Metformin (Met) is one of the most commonly prescribed first-line drugs for diabetes treatment. However, it has several issues, including low bioavailability, therapeutic platform, and side effects at high doses. In order to improve the therapeutic efficiency of Met, this study proposes a strategy of using Met and curcumin (Cur) to prepare Cur-Zn(II)-Met infinite coordination polymer nanoparticles (CM ICP NPs), and combining this with intraperitoneal injections, for the treatment of diabetic mice. Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), nanoparticle analysis, cytotoxicity experiments, and mice experiments were used to investigate structure, properties, and application effects. The results showed that CM ICP NPs exhibit a high drug encapsulation rate (100%), good stability, and an absence of in vivo and in vitro toxicity. The blood glucose level of diabetic mice after treatment was reduced to 6.7 ± 0.65 mmol/L at the seventh week. In terms of therapeutic mechanism, it appears that Met and Cur can synergistically regulate blood glucose in mice from multiple paths. This study provides a promising method for the treatment of diabetes using Met and other drugs.
研究领域:
药理学
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生物医学工程
·
代谢疾病研究
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产品关联
DOI
PubMed
高影响因子
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