SYNTHETIC COMMUNICATIONS
·
2022
·
IF 1.937
Jinchen Yang,Ling Chen,Yibo Dong,Jinli Zhang,Yangjie Wu
ABATRACTA direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.
研究领域:
有机化学
·
绿色化学
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Shuren Shao,Xingyuan Lu,Lun Zhang,Jihai Zhang,Aimin Zhang
An ionic conductive elastomer (ICE) is a novel type of ion conductive material that has emerged in recent years. Conventional ionic conductive materials such as hydrogels and solvent gels tend to exhibit poor weathering behavior due to the presence of water or solutions. Ions in ICE are migrated directly into the polymer network without solvents. In this work, a novel ICE based on polyurea (HUBTPU ILx) with a hard segment of hindered urea bonds (HUBs) is prepared. It has a three-dimensional network structure with outstanding mechanical properties. Furthermore, HUBs are introduced in the molecular structure so that the material possesses a certain reprocessing performance. This series of ICEs offer the combination of ideal properties, including the fantastic mechanical properties with the fracture strength of 4.3 MPa, the stretchability up to 1800% and high conductivity, up to 6.61 × 10–3 S/m. The applications of ICEs were demonstrated by creating a sensor that detects the movement of joints and breathing. Furthermore, it was also demonstrated that the reprocessing process had almost no effect on the sensing performance of the prepared sensors.
研究领域:
材料科学
·
传感器技术
✓ 已验证
DOI
高影响因子
Autophagy
·
2018
·
IF 11.1
Lun Zhao,Li Deng,Qing Zhang,Xue Jing,Meng Ma,Bin Yi,Jing Wen,Chaozhi Ma,Jinxing Tu,Tingdong Fu,Jinxiong Shen
Sulfonylurea (SU) herbicides inhibit branched-chain amino acid (BCAA) biosynthesis by targeting acetolactate synthase. Plants have evolved target-site resistance and metabolic tolerance to SU herbicides; the GCN2 (general control non-repressible 2) pathway is also involved in SU tolerance. Here, we report a novel SU tolerance mechanism, autophagy, which we call ‘homeostatic tolerance,’ is involved in amino acid signaling in Arabidopsis. The activation and reversion of autophagy and GCN2 by the SU herbicide tribenuron-methyl (TM) and exogenous BCAA, respectively, confirmed that TM-induced BCAA starvation is responsible for the activation of autophagy and GCN2. Genetic and biochemical analyses revealed a lower proportion of free BCAA and more sensitive phenotypes in atg5, atg7, and gcn2 single mutants than in wild-type seedlings after TM treatment; the lowest proportion of free BCAA and the most sensitive phenotypes were found in atg5 gcn2 and atg7 gcn2 double mutants. Immunoblotting and microscopy revealed that TM-induced activation of autophagy and GCN2 signaling do not depend on the presence of each other, and these 2 pathways may serve as mutually compensatory mechanisms against TM. TM inhibited the TOR (target of rapamycin), and activated autophagy in an estradiol-induced TOR RNAi line, suggesting that TM-induced BCAA starvation activates autophagy, probably via TOR inactivation. Autophagy and GCN2 were also activated, and independently contributed to TM tolerance in plants conferring metabolic tolerance. Together, these data suggest that autophagy is a proteolytic process for amino acid recycling and contributes to GCN2-independent SU tolerance, probably by its ability to replenish fresh BCAA.
研究领域:
植物生物学
·
分子生物学
·
植物病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Wenhui Yan,Shijun Li,Jieyao Wang,Xingyu Ma,Mingxuan Zhang,Lei Li
The recovery of gold from electronic waste by absorption is a sustainable process owing to its easy operation, low cost, and negligible energy consumption. Thiourea groups demonstrate a strong affinity toward Au(III); therefore, microporous polythioureas (PTUs) are believed to be emerging absorbents and advantageous over other porous materials. Motivated by the successful preparation of porous organic polymers (POPs) via domino polymerization in our recent report, the one-pot strategy is introduced to the synthesis of microporous PTUs. During the polymerization process, thiourea knots are formed between the reaction of amino and diisothiocyanate monomers and integrated into networks by the simultaneous self-cross-linkage of alkynyl, acetyl, or double-bond groups on the amine monomers. Eventually, the family of POPs exhibits a maximum surface area of 561 m2 g–1. The thiourea groups and microporous structures endow the products with high Au(III) adsorption capacities (maximum: 1159 mg g–1) and remarkable adsorption selectivity. Even in actual electronic waste, where the concentration of Au(III) (0.18 mg L–1) is much lower than that of other interference ions (approximately 200 mg L–1), 100% removal efficiency is accomplished. This achievement not only verifies the versatility of the domino polymerization methodology for the construction of POPs but also sheds light on the potential application of high-performance gold adsorbents in real scenarios.
研究领域:
环境化学
·
材料科学
·
资源循环利用
·
吸附分离
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Biosensors-Basel
·
2025
·Vol. 15
·期 12
·821
·
IF 5.6
Jie Chen,Shutao Liu,Sunyi Chen,Jingwen Mai,Maiwula Abudukadi,Yao Chen,Jie Lu,Guanglei Li,Chenchen Ge
Mycoplasma hominis (MH) is a prevalent opportunistic pathogen that is strongly associated with a wide range of urogenital tract infections and severe adverse pregnancy outcomes in clinical settings. Current MH detection methods, including microbial culture and qPCR, are time-consuming and rely on complex equipment, making them unsuitable for scenarios requiring rapid or simplified testing. In this study, we developed a visual readout biosensing platform by synergistically integrating recombinase polymerase amplification (RPA), CRISPR/Cas12a-mediated target nucleic acid recognition, and lateral flow biosensors for the rapid, sensitive, and specific identification of MH. The assay specifically targets the MH-specific 16S rRNA gene, achieving a limit of detection as low as 2 copies/reaction of recombinant plasmid containing the target gene with a total assay time of 60 min. Critical reaction parameters, including Cas12a-crRNA molar ratio, volume of RPA amplicon input, and Cas12a cleavage time, were systematically optimized to maximize the biosensor’s response efficiency and detection reliability. The platform exhibited exceptional specificity, with no cross-reactivity observed against common co-occurring urogenital pathogens, and effectively minimized aerosol contamination risks via a rigorous decontamination workflow. Furthermore, this work represents the first documented implementation of a contamination-control protocol for an MH-specific CRISPR-LFA assay. Notably, testing results from 18 clinical samples demonstrated the high specificity of this assay, highlighting its promising potential for clinical application.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Zhou Xiao-Xia,Yin Yi-Ting,Zhang Xiao-Yi,Li Shu-Sheng,Jiang Xu-Bao,Zhu Xiao-Li,Kong Xiang-Zheng
Fluorescent polyurea-carbon dots (PU-CD) were successfully achieved through a co-pyrolysis technique, combining polyurea (PU) with carboxyl-containing carbon dots (PCD) at a temperature of 220 °C. The PU was fabricated via a simple precipitation polymerization process using toluene diisocyanate in a water/acetone binary solvent system. PCD was generated by thermal treatment of poly(ethylene glycol) (PEG) at the same elevated temperature. To elucidate the structural characteristics of PU-CD, as well as its precursor components PU and PCD, a comprehensive suite of analytical techniques was employed, including transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), dynamic light scattering (DLS) and X-ray photoelectron spectroscopy (XPS). These analyses confirmed the formation of amide bonds resulting from the reaction between the terminal amines of PU and the carboxyl groups of PCD. An in-depth comparison of the fluorescence properties of PU-CD revealed marked enhancements in fluorescence intensity when contrasted with PU, PEG, and the individual PCD. The research explored the impact of various factors such as concentration, pH in aqueous solutions, and solvent type on the fluorescence emission of these materials, providing valuable insights into their emission mechanisms. It was particularly noteworthy that both PCD and PU-CD exhibited a confined-domain crosslink-enhanced emission effect. Utilizing the aqueous dispersion of PU-CD as a fluorescent probe, the detection of doxycycline (DOX), a long-acting, broad-spectrum, semi-synthetic tetracycline antibiotic, was achieved with a detection limit of 2.9×10 −7 mol/L. This study introduces a simple, green, and cost-effective fluorescent probe for the detection of DOX, which has significant potential for application in the realms of analytical chemistry and food safety monitoring in the future.
研究领域:
分析化学
·
材料科学
·
纳米技术
·
传感器
·
环境监测
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2022
·Vol. 44
·期 3
·2200693
·
IF 5.006
Zhen Li,Shuxiang Mei,Lu Luo,Siyuan Li,Xiaoyin Chen,Yuancheng Zhang,Wei Zhao,Xiaomeng Zhang,Ge Shi,Yanjie He,Zhe Cui,Peng Fu,Xinchang Pang,Minying Liu
Multiple and two-way reversible shape memory polymers (M/2W-SMPs) are highly promising for many fields due to large deformation, lightweight, strong recovery stress, and fast response rates. Herein, a semi-crystalline block poly(urethane-urea-amide) elastomers (PUUAs) are prepared by the copolymerization of isocyanate-terminated polyurethane (OPU) and amino-terminated oligomeric polyamide-1212 (OPA). PUUAs, composed of OPA as stationary phase and PTMEG as reversible phase, exhibit excellent rigidity, flexibility, and resilience, and cPUUA-C 7 -S 25 exhibits the best tensile property with strength of 10.3 MPa and elongation at break of 360.2%. Besides, all the PUUAs possess two crystallization/melting temperatures and a glass transition temperature, which endow PUUAs with multiple and reversible two-way shape memory effect (M/2W-SME). Physically crosslinked PUUA-C 0 -S 25 exhibits excellent dual and triple shape memory, and micro chemically crosslinked cPUUA-C 7 -S 25 further shows quadruple shape memory behavior. Additionally, both PUUA-C 0 -S 25 and cPUUA-C 7 -S 25 have 2W-SME. Intriguingly, cPUUA-C 7 -S 25 can achieve a higher temperature (up to 165 °C) SME, which makes it suitable for more complex and changeable applications. Based on the advantages of M/2W-SME, a temperature-responsive application scenario where PUUAs can transform spontaneously among different shapes is designed. These unique M/2W-SME and high-temperature SME will enable the applications of high-temperature sensors, actuators, and aerospace equipment.
研究领域:
材料科学
·
高分子化学
·
航空航天工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Lin Chen,Di Wang
A tunable cascade reaction of ureidomalonates and alkenyl azlactones was disclosed, which gave rise to the construction of N-aroyl α-amino acid ester and imide-functionalized hydantoins in moderate to good yields and with excellent diastereoselectivities. The reaction pathway was precisely manipulated by organocatalysis and phase-transfer/sunlight relay catalysis, respectively, to realize the divergent synthesis. The successful gram-scale preparation of representative products exhibited the application potential of this protocol. Mechanistic studies indicated that the exchange and phase transfer of ethoxy anion played a key role in altering the reaction pathway, and sunlight might accelerate the oxidation process at the late stage of the reaction triggered by phase-transfer catalysis.
研究领域:
有机化学
·
合成化学
·
催化
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jinlong Fan,Jie Zhang
Polymer blending has been an important method to create materials with specific properties that have synergistic effects. However, there are few reports on the mechanism of synergistic effects. It is well known that it is quite difficult to obtain ideal blends composed of nonpolar organosilicon polymers and polar polymers. In this paper, thermoplastic polyurea elastomer blends with a co-continuous microphase structure consisting of polysiloxane–polyurea (PDMS-PUA), polyether amine–polyurea (PEA-PUA), and compatibilizer PDMS-PUA-grafted PEA-PUA (PDMS-PUA-g-PEA-PUA) were prepared for the first time. For the first time, introduction of polysiloxane does not sacrifice mechanical properties of thermoplastic polyurea elastomers. For example, the tensile strength of the elastomer blend with 30 wt % PDMS-PUA content reached 25.7 MPa, which is higher than those of PEA-PUA and PDMS-PUA. The blends also show typical outstanding characters such as exceptional heat and water resistance. The mechanism of the synergistic effect on mechanical properties is revealed based on in-depth studies on mutual interphase interaction. In situ variable temperature infrared spectroscopic analysis (VTIR) shows that compatibilization facilitates the construction of a denser hydrogen bonding network at the blend interface, which is thought to play a key role in the co-continuous microphase structure. Microscopic morphological characterization shows that PDMS-PUA and PEA-PUA phases are deformed and oriented together during the stretching process, thus jointly resisting external forces. Moreover, the blends show an exceptional self-healing ability due to their strong and reversible hydrogen bonding network.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Fang Wu,Junfeng Li,Heng Quan,Jiang Han,Xiaoxuan Liu,Xiaokun Zhang,Jinglei Yang,Yong Xiang
Polyurea/poly(urea–formaldehyde)/Al 2 O 3 hybrid microcapsules with a dense Al 2 O 3 nano-layer containing 4,4′-methylenebis cyclohexyl isocyanate (HMDI) have been successfully fabricated via combaning Atomic layer deposition (ALD) process and interfacial/in-situ polymerization process. This dense Al 2 O 3 nano-layer can be controllable deposited in the form of a single atom film through continuous self-limiting reactions of Al(CH 3 ) 3 and H 2 O on the surface of the PU/PUF microcapsules at a temperature range of 120–180 °C. The formed hybrid microcapsules showed a monodispersed diameter of ~60 µm with a controlled and nano-sized Al 2 O 3 shell. Moreover, the deposited Al 2 O 3 nano-shell significantly increased the thermal stability and mechanical property of hybrid microcapsules, which could maintain their integrity under harsh conditions. In addition, by embedding hybrid microcapsules into an epoxy matrix, an excellent anticorrosion performance in scratched coatings via self-healing functionality was obtained. Therefore, the formed hybrid microcapsules with enhanced thermal stability and mechanical property via ALD process could promote their practical application in self-healing composites.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
YueYue Zhang,Jinjuan Wang,Ang Yu,Yuanfei Wu,Xiaojia Huang
Efficient extraction is an essential and challenging step in the simultaneous monitoring of the commonly used phenylureas (PUs) and sulfonylureas (SUs) in complex matrices. For this purpose, a new magnetic adsorbent based on fly ash (MAFA) was prepared through simple one-pot strategy without the application of organic solvent. The pre-treated fly ash, FeCl 3 and FeCl 2 were dissolved in water, and then the mixture reacted to form MAFA by means of simple one-pot hydrothermal technology for 2.5 h. The structure, morphology, spectroscopic, charged and magnetic properties were inspected by various characterized techniques. Combining the magnetic solid phase extraction (MSPE) format, the obtained MAFA presented satisfactory co-extraction performance towards PUs and SUs. The relevant adsorption process and behavior were well fit for Freundlich adsorption model and pseudo-second-order kinetics. After the optimization of extraction parameters, sensitive, reliable and practicable method for the simultaneous monitoring of studied PUs and SUs in aqueous and soil samples was developed by the combination of MAFA/MSPE and HPLC. The established method displayed high sensitivity (limits of detection were 0.0027–0.011 μg/L and 0.041–0.20 μg/kg for water and soil samples, respectively), good spiked recoveries (81.7–113 % and 81.0–114 % for water and soil samples, respectively) and excellent precision (RSDs did not higher than 9.2 %). Furthermore, approach accuracy was confirmed by means of confirmatory experiments.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Zitong Deng,Xing Su,Jizhen Li,Xiaodong Li,Jin Xu,Dichang Xue,Chengwang Shi,Xulong Zhang,Wei Zhang,Hong Yu,Ruibin Wang,Meishuai Zou
Many newly developed polyurethane elastomers (PUEs) often rely on organic solvents for dissolving specific components such as chain extenders, in order to achieve improved mechanical toughness, self-healing capability, etc. However, solvents complicate the synthesis and raise multiple problems relating to post-processing, greatly limiting the application of self-healing PUEs. Herein, a novel bulk polymerization routine for synthesizing polyurea elastomers is designed by specific chain extender well-dissolved in the prepolymer, as well as moisture-assisted curing without using any solvent. The synergy of aromatic disulfide dynamic chemistry and urea bondage endowed the resultant elastomers with high toughness, ultrafast (∼1 s) and efficient (up to 98.6%) self-healing capability at various temperatures (∼-23°C), resistance to puncture, colorless and transparent nature approaching the standards of photovoltaic glass. The work offers a facile, adjustable and efficient routine for constructing high-performance polyurea elastomers, which have big promise not only in the field of material science, but also in the industrial production and application of polyurethanes.
研究领域:
材料科学
·
高分子化学
·
工业生产
·
应用化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）