JOURNAL OF CHROMATOGRAPHY A
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2025
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IF 4
Minyi Yuan,Zheng Zhao,Ji Wu,Sumin Bian,Yuling Liao,Ying Zhou,Huikai Shao,Zhengjin Jiang,Qiqin Wang
To meet the increasing demand for the separation of complex samples, a novel monolithic stationary phase with hydrophobic and hydrophilic functionalities was developed by using 3-(1-(4-vinylbenzyl)-1H-imidazol-3-ium) propane-1-sulfonate (VBIPS) as monomer, pentaerythritol triacrylate (PETA) as crosslinker. The optimized mixed-mode poly(VBIPS- co -PETA) monolith exhibited good mechanical strength, high permeability (K = 0.23 × 10 -14 m 2 in 100% ACN, 0.23 × 10 -14 m 2 in 100% MeOH, and 0.11 × 10 -14 m 2 in 100% H 2 O), and multiple interaction modes, including hydrophilic, hydrophobic, hydrogen, and electrostatic interactions. The highest column efficiency of 83,330 plates/m was achieved for thiourea at a linear velocity of 0.23 mm/s. Systematic evaluations confirmed strong retention and separation of polar substances (e.g., benzoic acids, nucleoside bases, phenols), primarily due to the sulfobetaine-derived hydrophilicity as well as effective separation of nonpolar substances (e.g., aniline, aryl ketones, polyaromatic hydroxy compounds), facilitated by π-π stacking interactions between analytes and benzene rings within the stationary phase. Overall, this zwitterionic imidazolium sulfonate-functionalized monolith successfully combines hydrophobic and hydrophilic groups in a single continuous bed, enabling efficient separation of both polar and nonpolar analytes under low backpressure. This work enriches the library of mixed-mode stationary phases, and broadens the detection scope for complex sample analysis.
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Journal of Functional Foods
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2025
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IF 4
Ying Chen,Shuhui Hu,Yanjun Guo,Yan Wang,Lei Chen,Xin He,Yajie Yu,Andong Ji,Shengjie Pei,Kelei Li,Xiaofei Guo,Duo Li
Hyperuricemia, a metabolic disorder caused by excessive uric acid accumulation, is a major risk factor for gout and related kidney damage. Current pharmacological treatments often have side effects, emphasizing the need for safer alternatives. This study investigated the preventive and therapeutic potential of apple polyphenols (AP) in hyperuricemia management, as well as the underlying mechanisms. A cross-sectional analysis of 15,121 Chinese undergraduates revealed that apple consumption was inversely associated with hyperuricemia risk (OR = 0.86; 95 % CI: 0.73–0.99; P = 0.028). A hyperuricemia mouse model was established by potassium oxonate and adenine for 21 days, and AP treatment significantly reduced serum uric acid levels by inhibiting both the activity and expression of xanthine oxidase, and by downregulating renal uric acid transporters URAT1 and GLUT9. Histopathological analysis indicated that AP alleviated kidney and liver damage caused by hyperuricemia. These findings highlight the dual regulatory effect of AP on uric acid synthesis and excretion, providing new insights into its potential as a natural dietary intervention for hyperuricemia management.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Chengwen Zhang,Zihan Li,Chengbo Qian,Ziyang Ye,Feifan Yu,Yuyuan Yao
Developing porous iron-based catalysts with high metal loading for highly efficient removal of the organic pollutants has been a challenge in environmental catalysis. In this work, the preparation of porous iron–nitrogen-co-doped carbon catalyst (pNC-Fe) innovatively utilized zinc nitrate (Zn(NO 3 ) 2 ) as a pore-forming agent and adenine for metal anchoring. The resulting catalyst possessed a high Fe loading (18.49 wt%) and a high specific surface area (395.69 m 2 /g), which enhanced the adsorption and degradation of pNC-Fe. As a demonstration, the maximum adsorption capacity of pNC-Fe for CBZ (389.7 mg/g) surpassed nearly all recently reported CBZ adsorbents. Additionally, pNC-Fe possessed an excellent adsorption regeneration capability even after 5 cycles, enhancing its reusability. Surprisingly, pNC-Fe in PMS system removed almost 100 % of 50 μmol/L carbamazepine (CBZ) in 15 min and performed an excellent k obs (0.5895 min −1 ), outperforming the majority of metal-based catalysts. Interestingly, the adsorption of CBZ by pNC-Fe also remarkably facilitated the degradation of CBZ. Notably, different from the free radical mechanism of most reported work, the quenching experiments and EPR detection demonstrated that the main reactive oxygen species (ROS) of the pNC-Fe/PMS system was singlet oxygen ( 1 O 2 ), endowing pNC-Fe with potential environmental anti-interference capability (less affected by common anions and pH variations). This work provides a valuable insight for the design of porous iron-based catalysts for wastewater remediation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Yue Zhao,Dong-Lei Wang,Xin-Ya Zhou,Da-Peng Wang,Zhi-Yong Sun,Zheng-Hui Qiu,Jin-Wei Zhang,Cun-Guo Lin
This work investigates the novel application of a metal-complex hydrogen-bonded framework HOF-21 as an intelligent, chloride-responsive material for superior corrosion protection. A cost-effective and streamlined synthesis of HOF-21 was developed using rapid stirring at ambient conditions, offering a practical alternative to conventional static interfacial method. When embedded in epoxy coatings on copper substrates, HOF-21 significantly enhances anti-corrosion performance, outperforming traditional materials like ZnAl-LDHs. The protection mechanism is tripartite: effective chloride ion capture, reinforcement of the coating’s mechanical properties, and active protection. Experimental analyses, including kinetic and isotherm model fitting, confirm the exceptional chloride adsorption capacity, best described by pseudo-second-order and Temkin models. Molecular dynamics (MD) simulations elucidate the atomic-level mechanism, revealing that a unique hydrogen-bonded cage structure facilitates chloride sequestration. Furthermore, MD simulations demonstrate strong epoxy-HOF-21 compatibility and the formation of an interlocked structure that enhances mechanical cohesion. The active protection is attributed to the ion-exchange of fluorosilicate anions with chlorides. This work establishes M-HOFs as a versatile platform for chloride capture and provides a universal strategy for designing active-intelligent anticorrosion coatings.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 4
·233
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IF 5.4
Gao Xiang,Hou Yujiao,Lin Fang,Wen Limei,Guo Yali,Kong Weijun,Hu Junping,Yang Jianhua
An electrochemical (EC) molecularly imprinted polymer (MIP) sensor for therapeutic drug monitoring of olanzapine (OLZ) has been developed. A “rime-like” gold-platinum nanostructured film (Au-Pt NF) was fabricated on a screen-printed carbon electrode (SPCE) via an one-step hydrogen bubble dynamic template (HBDT) method, followed by electropolymerization of a polyaniline-based MIP. The Au-Pt NF/SPCE served as an ideal three-dimensional conductive substrate with a large active area and enhanced electron-transfer capability, endowing the specific MIP sensor with high sensitivity. Using [Fe(CN) 6 ] 3−/4− as a redox probe, the sensor quantified OLZ by the decrease in differential pulse voltammetry current caused by target binding. It exhibited two linear ranges (0.005–0.4 µM and 0.4–10 µM) with a detection limit of 0.94 nM, and demonstrated high selectivity, reproducibility, and stability. The sensor achieved recoveries of 96.7–102.7% for OLZ in tablets, urine, and whole blood. This work provides a reliable, all-EC sensing platform with strong potential for rapid OLZ monitoring in clinical settings.
Section
Graphical
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Annals of Translational Medicine
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2022
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IF 3.616
Huili Huang,Ying Tong,Tong Fu,Danmei Lin,Hansheng Li,Li Xu,Senyue Zhang,Yanzhe Yin,Yiran Gao
Background To use network pharmacology and gut microbiota sequencing to investigate the probable mechanism of Bining decoction (BN) in the treatment of gouty nephropathy (GN). Methods Firstly, the mechanism of therapeutic effects of BN on GN were collected by integrating network pharmacology. Secondly, the treatment effects of BN against GN in 30 Institute of Cancer Research (ICR) mice were evaluated by performing biochemical tests [uric acid, blood urea nitrogen, and creatinine (UA, BUN, and Cr)] and evaluating the renal weight index. Finally, 16S rRNA sequencing was utilized for elucidating the therapeutical effect of BN in GN. Results The results of gut microbiota sequencing analysis showed the abundance of Faecalibaculum , Romboutsia , Bifidobacterium , Bacteroides , Odoribacter , Lachnospiraceae NK4A136 group, unclassified_f__ Lachnospiraceae , Roseburia , norank_f__ Lachnospiraceae , Lactobacillus , Dubosiella , norank_f__ Muribaculaceae , and Turicibacter in the BN group had a significant changed between-group comparisons. Using a network pharmacology-related database, 413 active components of BN were identified, as well as 1,085 GN-associated targets. The 118 targets of disease targets and component targets were mapped, of which the top 10 genes were selected. The Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that 157 pathways were enriched, which was partially consistent with the metabolic pathways of gut microbiota sequencing analysis. Conclusions Combining 16S rRNA gene sequencing and network pharmacology analysis, similar signaling pathways were followed: “Pathways in cancer” and “Adipocytokine signaling pathway”. The results reveal that BN increases the abundance of Turicibacter , regulates the expression of JAK2 in the JAK/STAT pathway, increases the beneficial bacteria Turicibacter associated with intestinal butyric acid, which could enhance the intestinal barrier, and exert anti-inflammatory effects.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Junshuo Cui,Lanlan Sun,Qian Sun,Ying Xiong
Hypothesis Homogeneous dispersion of graphene is the precondition for constructing high performance graphene based composites. However, most of the current dispersants reported in literature still suffer excess usage to reach a desired graphene concentration. Residual of dispersant in composite may seriously affect its properties. Hence, it is expected to obtain effective dispersant with high reactivity to diminish its adverse impacts on graphene composites. Experiments A highly reactive graphene dispersant (DSiA) was synthesized by grafting silanol groups (Si-OH) onto adenine. Molecular structure and the performance of the dispersant were systematically characterized. Composites were fabricated by direct writing of the graphene dispersion on various substrates, and their features were evaluated by resistance, solvent erosion and tensile testing. Findings Graphene concentration can reach up to 6 mg mL −1 in the presents of DSiA at the weight ratio of 1:1 (DSiA: graphene). DSiA also exhibited good performance for stabilizing multi-walled carbon nanotubes (MWCNTs). Moreover, the dispersant is highly reactive. The graphene based composites showed good mechanical strength and excellent solvent resistance. Overall, the new dispersant provides an ideal choice to uniformly disperse graphene and suitable for fabricating high performance nanocarbon based composites.
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Materials Today Communications
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2023
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IF 3.8
Ran Feng,Jiazhi Meng,Hualei Yuan,Xu Zhang,Chunlang Gao,Chaogang Ban,Yizhong Guo,Kaiwen Wang
Cancers, Down’s syndrome, Alzheimer’s and other diseases of gene mutation always occur with anomalous changes of DNA nucleic acid base. Therefore, the development of highly sensitive and reproducible nucleic acid sensors that based upon surface enhanced Raman scattering (SERS) is of immense interest for clinical medical analysis and diagnosis. Herein, a rationally designed core-shell assembly of Au nanoparticle wrapped with Au doped Bi 5 O 7 Br nanotube with eliminated fluorescent background and notable chemical enhancement effect was exploited and served as a SERS sensor for detection of adenine. Especially, we found the fluorescent background was remarkably suppressed in Raman spectra by introducing Au element into Bi 5 O 7 Br. The sensor exhibited a maximum SERS enhancement factor of up to 5.45 × 10 7 and a detection limit as low as 10 −11 M after constructing Au nanoparticle/Au atom doped Bi 5 O 7 Br heterojunction . More importantly, good reproducibility and long term stability under work condition were achieved. To gain in-depth understanding into chemical mechanism (CM) of the Raman signal enhancement, density functional calculations (DFTs) were combined with atom-specific model derived via aberration corrected transmission electron microscope (AC-TEM) to demonstrate the enhanced charge transfer (CT) and substrate-adsorbate adsorption. The doping and coupling strategy holds the potential to fabricate high signal-to-noise ratio SERS sensors for other molecule detection.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2022
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IF 10.753
Huifang Wu,Yubing Chen,Mengqi Xu,Yuwei Ling,Shiying Ju,Yanfeng Tang,Changlun Tong
Tetracyclines residues, particularly oxytetracycline (OTC) and tetracycline (TC), have raised extensive concern because of their serious adverse effects on human health. Herein, a dual-response fluorescent probe based on nitrogen-doped carbon dots (N-CDs) and Eu 3+ hybrid (N-CDs–Eu 3+ ) was developed to selectively determine OTC and TC. The N-CDs act as ancillary ligands of Eu 3+ and recognition units of OTC/TC, while the Eu 3+ ions chelated with N-CDs can also specifically recognize OTC/TC. Upon inclusion of OTC/TC, an enhancement in Eu 3+ emission occurs due to the energy transfer from OTC/TC to Eu 3+ and the efficient elimination of quenching effect caused by H 2 O molecule, which is attributed to the incorporation of N-CDs; while the blue fluorescence emitted by the N-CDs decreases under the inner filter effect and static quenching effect caused by OTC/TC. Based on the double and reverse response signals, the ratiometric detection of OTC and TC in the range of 0.1–45 μΜ and 0.1–30 μΜ is achieved with a detection limit of 0.017 and 0.041 μM, respectively. In addition, the noticeable variation in fluorescence color of the probe is integrated with a smartphone-assisted analysis device for the rapid on-site quantitative assay of OTC, where the detection limit is 0.15 μΜ. The results show that this probe performs with excellent specificity and anti-interference for both OTC and TC, and satisfactory detection results are obtained in lake water, milk, and honey samples, thereby confirming that the probe exhibits promising application in food safety and environmental monitoring.
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JOURNAL OF CHROMATOGRAPHY A
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2023
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IF 4.1
Tong Chen,Shuya Wang,Xufang Zong,Bingxiang Li,Ye Shu,Xinyuan Di,Wanning Zhu,Guangsan Song,Jun Jiang
Periodic mesoporous organosilicas (PMO) hydrophilic microspheres were synthesized by co-condensation of sulfated polysaccharide from Lilum lancifolium Thunb. bridged silane (SLLTPBS) and polyhedral oligomeric silsesquioxane (POSS) as stationary phase (PMO(SLLTP-POSS)) for per aqueous liquid chromatography (PALC), which would overcome the disadvantages of using a large amount of acetonitrile on the hydrophilic interaction liquid chromatography (HILIC) columns. Average particle size of PMO (SLLTP-POSS) microspheres was 4.9 μm, which was suitable for stationary phase. The retention mechanism of the stationary phase in PALC was mainly hydrophobic interactions and also included some ion-exchange interactions and electrostatic interactions. The acid-base resistance was greatly improved compared to the C18 column. The PMO(SLLTP-POSS) column under PALC mode had increased the resolution when separating some hydrophilic compounds such as eight organic acids and eleven sweeteners compared with the C18 column and HILIC column. The new column was more efficient than the HILIC columns. Additionally, a PALC-triple quadrupole mass spectrometry approach for the simultaneous identification of the eleven sweeteners was developed. The averagere coveries of the eleven compounds were 70.20%–91.33% with the relative standard deviation (RSD) range of 1.74% to 4.27%. The results showed good precision and accuracy of the method.
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Frontiers in Pharmacology
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2023
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IF 5.6
Lvyuan Fan,Zhiyu Pan,Xu Liao,Yilin Zhong,Juan Guo,Rui Pang,Xinhai Chen,Guozhu Ye,Yubin Su
Background: Methicillin-resistant Staphylococcus aureus (MRSA) has now become a major nosocomial pathogen bacteria and resistant to many antibiotics. Therefore, Development of novel approaches to combat the disease is especially important. The present study aimed to provide a novel approach involving the use of nucleotide-mediated metabolic reprogramming to tackle intractable methicillin-resistant S. aureus (MRSA) infections. Objective: This study aims to explore the bacterial effects and mechanism of uracil and gentamicin in S. aureus. Methods: Antibiotic bactericidal assays was used to determine the synergistic bactericidal effect of uracil and gentamicin. How did uracil regulate bacterial metabolism including the tricarboxylic acid (TCA) cycle by GC-MS-based metabolomics. Next, genes and activity of key enzymes in the TCA cycle, PMF, and intracellular aminoglycosides were measured. Finally, bacterial respiration, reactive oxygen species (ROS), and ATP levels were also assayed in this study. Results: In the present study, we found that uracil could synergize with aminoglycosides to kill MRSA (USA300) by 400-fold. Reprogramming metabolomics displayed uracil reprogrammed bacterial metabolism, especially enhanced the TCA cycle to elevate NADH production and proton motive force, thereby promoting the uptake of antibiotics. Furthermore, uracil increased cellular respiration and ATP production, resulting the generation of ROS. Thus, the combined activity of uracil and antibiotics induced bacterial death. Inhibition of the TCA cycle or ROS production could attenuate bactericidal efficiency. Moreover, uracil exhibited bactericidal activity in cooperation with aminoglycosides against other pathogenic bacteria. In a mouse mode of MRSA infection, the combination of gentamicin and uracil increased the survival rate of infected mice. Conclusion: Our results suggest that uracil enhances the activity of bactericidal antibiotics to kill Gram-positive bacteria by modulating bacterial metabolism.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
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IF 5.895
Yuan Shi,Xiaokang An,Binbin Zhang,Xinglu Pan,Xiaohu Wu,Jun Xu,Wensheng Xiang,Fengshou Dong,Xiangjing Wang,Yongquan Zheng
Guvermectin is a biopesticide isolated from the secondary metabolites of Streptomyces sp. NEAU6, an endogenous actinomyces of a Chinese medicine named Paris polyphylla. However, the environmental degradation behavior and biotoxicity of guvermectin are still unclear, which may affect its rational application. Therefore, the degradation of guvermectin in water at different pH values (pH 4, pH 6, pH 7, and pH 9) and with or without light was investigated in the laboratory. The results showed that guvermectin could be degraded in pH 4 solution, and the presence of light irradiation enhanced the degradation process with a DT50 of 2.95 and 12 days for photolysis and hydrolysis, respectively. However, guvermectin was fairly stable in other conditions. Three products transformed from guvermectin degradation were identified by UPLC-QTOF/MS. Biotoxicity assessment was performed on Danio rerio and Daphnia magna Straus by ECOSAR prediction and in vivo biological tests. The test data showed that guvermectin and its transformation products exhibited low toxicities to D. rerio and D. magna Straus (LC50/EC50 > 100 mg a.i./L), and the transformation products had lower toxicity than their parent substance. The results provided a reference for elucidating the potential risk of guvermectin to nontarget organisms and promoting its rational use.
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