JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2020
·Vol. 31
·期 8
·1-9
·
IF 2.489
Li Wan,Hu Xueying,Chen Jiawei,Wei Zhengnan,Song Chengwu,Huang Rongzeng
The intrinsic fragility of hydroxyapatite (HAP) restricts its wider applications for local delivery of antibiotics. The composites formed by integrating HAP with hydrogels can improve the properties of HAP. However, these reported composites not only require tedious preparation and employ organic solvent and toxic reagents, but also hardly have inherent antimicrobial property. In this study, N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine/nano-hydroxyapatite (Fmoc-L-Phe/nHAP) hybrid supramolecular hydrogels with antibacterial property and cytocompatibility was prepared by integrating nHAP as reinforcement with Fmoc-L-Phe supramolecular hydrogels. The results showed that nHAP bounds in the chamber of the gel network and adheres to the fiber of Fmoc-L-Phe due to intermolecular interaction, remarkably improving the mechanical strength of Fmoc-L-Phe supramolecular hydrogels. The results of inhibition zone experiment and MTT experiment showed that the Fmoc-L-Phe/nHAP hybrid supramolecular hydrogels possess antimicrobial property and cytocompatibility. In vitro release experiment of chlorogenic acid (CGA) from the hybrid supramolecular hydrogels was performed. The study of the release kinetics indicated that the release behavior of CGA from the hybrid supramolecular hydrogels is following Weibull model and release mechanism involved Fickian diffusion and erosion of the surface of hydrogel matrix. The release of CGA shows a good inhibition effect on S. aureus . The results show that the Fmoc-L-Phe/nHAP hybrid hydrogels with antibacterial property and cytocompatibility have promising applications as drug delivery carrier.
Due to the intrinsic fragility of hydroxyapatite (HAP), the properties of HAP could be improved by incorporation into hydrogels. However, these reported composites not only require tedious preparation and employ organic solvent and toxic reagents, but also hardly have inherent antimicrobial property. We prepared N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine/nano-hydroxyapatite (Fmoc-L-Phe/nHAP) hybrid supramolecular hydrogels by integrating nHAP as reinforcement with Fmoc-L-Phe supramolecular hydrogels. The results showed that nHAP bounds in the chamber of the gel network and adheres to the fiber of Fmoc-L-Phe due to intermolecular interaction, remarkably improving the mechanical strength of Fmoc-L-Phe supramolecular hydrogels. The results of inhibition zone experiment and MTT experiment showed that the Fmoc-L-Phe/nHAP hybrid supramolecular hydrogels possess antibacterial property and cytocompatibility. In vitro release experiment of chlorogenic acid (CGA) from the hybrid supramolecular hydrogels was performed. The study of the release kinetics indicated that the release behavior of CGA from the hybrid supramolecular hydrogels is following Weibull model and release mechanism involved Fickian diffusion and erosion of the surface of hydrogel matrix. The release of CGA shows a good inhibition effect on S. aureus . The results show that the Fmoc-L-Phe/nHAP hybrid hydrogels with antibacterial property and cytocompatibility have promising applications as drug delivery carrier.
研究领域:
材料科学
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生物医学工程
·
药学
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高影响因子
DYES AND PIGMENTS
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2021
·
IF 4.889
You Liu,Fang Liu,Jungan Wang,Hongyan Huang,Suhao Yan,Song Gao,Lin Wang,Wei Huang,Tianshi Qin
Wide-bandgap photovoltaics (WBPV) could not only provide electrical energy by photoelectronic conversion of the invisible part of the solar spectrum, but also usually had the unique advantage of high open circuit voltage ( V oc). In this work, we reported a novel HTM based on tetrakis (N-phenothiazine) Spirobifluorene (Spiro-PT), its HOMO energy level could be well matched with MAPbBr 3 perovskite HOMO energy level. This HTM could effectively suppress nonradiative recombination, which leads to an increase in the photovoltage of WBPV to more than 1.41 V. As a result, the n-i-p mesoscopic structured WBPV achieved a champion PCE of 7.36% as well as excellent operational stability exhibiting 91% of initial efficiency after 500 h continuous illumination without encapsulation. Based on the high V oc of the MAPbBr 3 /Spiro-PT device, the photovoltaic electrochromic device showed a response speed (the average coloring time was 40 s and the bleaching time was 272 s) and high average visible light transmittance contrast (about 37% in 450–780 nm), the corresponding electrochromic device with maximum dynamic contrast up to 46% at 600 nm between bleached and colored states. This WBPV-powered electrochromic system could provide a pathway towards stand-alone smart window technique for future energy-saving buildings.
研究领域:
材料科学
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光伏技术
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纳米能源
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智能窗技术
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器件物理
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Caidi Chen,Hengxin Xie,Yuyao Jiang,Yawen Chen,Yiran Liang,Gulihumaer Ruzetuoheti,Shijun Liao,Xiuhua Li,Biaowen Wei
In this work, AEMs based on poly(arylene ether sulfone)s skeletons were tailored with three kinds of hydrophobic components: biphenol (BP) with conjugate double benzene rings , bisphenol A (BPA) containing isolated double benzene rings and fluorene-9-bisphenol (FBP) with Cardo ring skeleton of four benzene rings. A series of quaternized poly(arylene ether sulfone)s (QPAES) membranes were fabricated successfully including QPAES-BP, QPAES-BPA and QPAES-FBP. The obtained membranes were applied in diffusion dialysis (DD) process of simulated waste acid (1.0 mol L -1 HCl and 0.2 mol L -1 FeCl 2 ) to figure out the influence of hydrophobic structures on DD performance. The dialysis coefficients ( U H + ) were in the range from 12.13 × 10 -3 m h -1 to 13.28 × 10 -3 m h -1 , while the separation factors (S) were in the range from 67.33 to 126.37. The resultant membranes show much better performance compared with the commercial TWDDA1 membrane ( U H + = 8.5 × 10 -3 m h -1 , S = 18.5). Interestingly, the membrane structures and properties revealed that the rigid aromatic component induced low water swelling, strong mechanical property and microphase separation , the nature of the structure offers high U H + as well as high S. The results show that the fabricated membranes are potential candidates for the acid recovery in diffusion dialysis, especially the QPAES-BP membrane tuned with rigid linear conjugated hydrophobic component.
研究领域:
高分子科学
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膜技术
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分离科学
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材料工程
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化学工程
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DOI
高影响因子
POLYMER
·
2011
·Vol. 52
·期 23
·5312-5319
·
IF 3.829
Dongyang Chen,Shuanjin Wang,Min Xiao,Dongmei Han,Yuezhong Meng
High-molecular-weight bulky-block poly(fluorenyl ether thioether ketone)s were successfully synthesized by a two steps one-pot protocol using N,N′ -dimethy- S -carbamate masked dithiols for vanadium redox flow battery (VRB) application. The followed sulfonation procedure gave birth to novel sulfonated block poly(fluorenyl ether thioether ketone)s (SPFETKs) with controlled ionic exchange capacities (IEC). Membranes with proton conductivities higher than (IEC > 1.66 mequiv. g −1 ) or comparable to (IEC < 1.66 mequiv. g −1 ) that of Nafion117 membrane were achieved. The VO 2+ permeabilities of SPFETKs membranes were much lower than that of Nafion117 membrane. The thermal properties, mechanical properties, oxidative stability , water uptake, proton conductivity, VO 2+ permeability and cell performance were investigated in detail.
研究领域:
高分子化学
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能源材料
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电化学
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膜科学与技术
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功能高分子
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DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2023
·
IF 2.5
Chenchen Ma,Zihan Ma,Ziyuan He,Xianjian Wang,Longhao Zhao,Xuegang Chen
Novel hydrophilic polymers consisting of fluorene modified by alkoxyl chain were designed and synthesized via radical polymerization from acrylic acid (PAAF) or acrylamide (PAMF) in the presence of azobisisobutyronitrile. All of these polymers were good water-soluble. The photophysical behaviors of the polymers and the selectivity and sensitivity to detection metal ions were studied by UV-visible and fluorescence spectroscopy technique, and some color changes were visible to the naked eye appeared. The PAMF fluorescent probe showed good selectivity and sensitivity to detection Fe3+ (2.4 × 10−7 mol/L) and PAAF exhibited good selectivity and sensitivity to detection Fe2+ (1.5 × 10−6 mol/L) and Cu2+ (5 × 10−7 mol/L) in water.
研究领域:
高分子化学
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分析化学
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材料科学
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传感技术
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荧光光谱学
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Qingsong Liu,Yan Zhu,Wentao Li,Junci Wu,Yi Zhang,Shouchun Ma,Chuanli Qin
Modified graphitic carbon nitride (MCN) was synthesized via calcinating β-alanine introduced melamine supramolecular precursors and poly(3-methylthiophene-co-fluorene) (P(3MT-co-F)) with improved planarity was prepared by polymerization of 3-methylthiophene (3MT) and fluorene (F) monomers. P(3MT-co-F)/MCN heterojunction was constructed by electrostatic self-assembly and the optimal 3P(3MT 1 -co-F 1 )/MCN exhibits excellent H 2 production performance of 11108 μmol h −1 g −1 under visible light, 150 times higher than MCN. The enhancement is attributed to the following aspects: First, F monomer as a rigid unit can regulate the main-chain torsion of P(3MT-co-F), enhancing planarity and facilitating intramolecular charge transport within copolymer. Second, N⋯S interactions and π-π stacking interactions at heterojunction interface improve the charge transfer and separation. Third, the incorporation of P(3MT-co-F) with narrow band gap into MCN not only broadens visible light absorption range and enhances visible light response, but also forms a Z-scheme heterojunction with MCN, further enhancing the charge separation and retaining the electrons with strong reducibility.
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高影响因子
Scientific Reports
·
2026
·
IF 4.9
Zhang Kaige,Wang Jing,Chen Yanrong,He Lijun,Zhang Qianchun
Ferrofluids are innovative functional media combing magnetic nanoparticles with liquid fluidity. In this study, a hydrophobic deep eutectic solvent-ferrofluid was prepared by dispersing oleic acid-coated magnetic nanoparticles in hydrophobic deep eutectic solvent composing of DL-menthol and lauric acid, and applied for magnetic assisted liquid–liquid microextraction of trace polycyclic aromatic hydrocarbons (PAHs) from water and food samples. Following microextraction, phase separation was achieved rapidly using an external magnetic field, eliminating the need for time-consuming steps such as centrifugation or ice baths. The material’s structure was characterized by X-ray diffraction and infrared spectroscopy, while its magnetic properties were examined with a vibrating sample magnetometer. Extraction parameters were systematically screened and optimized using Plackett–Burman and Central Composite design experiments. Under optimized conditions, the limits of detection and quantification were 0.05–0.2 µg L − 1 and 0.1–0.5 µg L − 1 , respectively, with intra-day and inter-day relative standard deviations ( n = 5) below 1.6% and 1.7%. The extraction mechanism was further explored using density functional theory. Then, this method was successfully applied to determine of PAHs from environmental water and food samples, achieving spiked recoveries of 85.9–103.0%. Its greenness and practical applicability demonstrate its potential for food analysis and environmental monitoring.
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高影响因子
Separations
·
2026
·Vol. 13
·期 8
·232
·
IF 3.5
Chuyue Zhang,Le Duan,Xu Wang,Lanlan Qiu,Deli Xiao
Reversed-phase chromatography stationary phases (such as C18) are widely used in commercial high-performance liquid chromatography (HPLC). However, when dealing with complex mixtures, they often exhibit limited separation capabilities and peak tailing phenomena. To address this problem, two novel HPLC stationary phases based on polyamine macrocycles were developed. A trianglamine macrocyclic stationary phase (TRI-Sil) was first prepared using chlorinated silica gel as the support, which can effectively separate a variety of aromatic compounds, but with limited selectivity for positional isomers such as phenylenediamine. To further improve the separation selectivity, a polyamine-silica macrocyclic stationary phase (CPAM-Sil) was synthesized by introducing a branched-chain-containing monomer. Under optimized conditions, CPAM-Sil achieved baseline separation of phenylenediamine and phenylenediol positional isomers and improved the separation of terphenyl isomers, with favorable asymmetry factors and high column efficiency compared with the commercial C18 column. Molecular docking confirmed multiple interactions such as electrostatic interactions and hydrogen bonding between the polyamine macrocycle (CPAM) and analytes. The CPAM-Sil column also exhibited good reproducibility and stability, showing promising potential for industrial application in chromatographic separation.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Shuangshuang Hou,Hui Gao,Peixuan Xie,Shiwei Jin,Fengtian Wu,Bien Tan
Microporous hyper-cross-linked polymers appending variant electron-withdrawing functional groups have enormous potential for selective CO 2 adsorption and separation, whereas these functionalities by lowering the charge density of monomers will decrease their reaction activity, which in turn is unfriendly for the direct and highly efficient preparation of polymers with high CO 2 uptake capacity. Herein a new amide “insertion” strategy for knitting polymers with ideal electron-withdrawing functionalities was advanced, and in this manner, a series of carboxyl enriched novel polymers were synthesized via the one-pot Friedel-Crafts alkylation reaction by using fluorene derivatives as emerging building blocks. The created polymer 3 possessing BET surface area 1947 m 2 g −1 have a CO 2 uptake of up to 20.03 wt% at 273.15 K/1.00 bar. Besides, the carboxyl and amide groups in structure could bestow the polymers an enhanced CO 2 /N 2 selectivity of 33.17 at 273.15 K. In addition, the hierarchical porosity and CO 2 adsorption capability of manufactured polymers can be intriguingly tailored, and prolonging the carboxylated side chains of building blocks by inserting different quantities of amide group will be propitious for bettering the porosity and CO 2 capturing capacity of manufactured polymers. Supported by charge density distribution simulation and electrostatic potential calculation, the peculiar changes in polymer structures and CO 2 adsorption features were also explained.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Bing-Wei Chen,Hua-Jun Zhai,Yan-Cheng Hu,Yan-Hong Tan,Jia Li,Zhilian Wu,Lin Shao,Jing-Pei Cao
High-energy-density (HED) fuels are crucial for volume-limited hypersonic propulsion systems, yet their petroleum-dependent production poses energy security challenges, especially for nations like China with scarce oil reserves. While coal-derived naphthalenes and anthracenes have been investigated for HED fuel production, their extended π-conjugation restrict tunability of key fuel properties. Here, we propose a molecular engineering strategy using coal-based fluorene as a versatile platform for the tunable synthesis of tailored HED fuels. The ring-increasing condensation of fluorene with benzaldehyde over CaO, coupled with hydrogenation, yields a tetracyclic fuel with higher energy density than JP-10, rendering it a prime candidate for high thrust application. The long-alkyl substitution strategy involving catalytic butylation and hydrogenation generates a butyl-tricyclic fuel with a balanced profile of energy density and flowability, demonstrating potential for cold-climate operations. Additionally, AlCl 3 -catalyzed skeletal rearrangement of hydrogenated fluorene produces trimethyladamantane with exceptional thermal stability, which may mitigate thermal management issues in hypersonic flight. Life-cycle assessment reveals that three fluorene-derived multicyclic alkanes show clear carbon-emission advantages over petroleum-based fuel JP-10. This study provides a strategic material solution for hypersonic aerospace applications, addressing critical performance demands while strengthening supply resilience through feedstock diversification.
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高影响因子
ELECTROCHIMICA ACTA
·
2026
·
IF 5.6
Meng Wang,Zhe He,Saijin Wang,Yanli Zhao,Naitian Zhang,Ximing Cui,Xiaoyan Yu,Shi Zhou,Huiting Mao,Jinlian Li,Yiying Zhang
Zebrafish (Danio rerio) is a widely adopted vertebrate model in toxicological research, yet current growth-toxicity assessments rely heavily on morphological endpoints that demand long observation periods and thus preclude rapid screening or early warning. The persistent organic pollutant fluorene perturbs purine metabolism in zebrafish embryos at environmentally relevant concentrations and subsequently impairs embryonic development. Herein, we present a novel electrochemical sensor based on an iridium oxide-modified glassy carbon electrode (IrO₂/GCE) that enables ultrasensitive monitoring of xanthine and guanine (X/G) fluctuations as metabolic biomarkers of fluorene cytotoxicity. Comprehensive characterization by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV) confirmed the surface morphology, elemental composition, and electrochemical performance of the modified electrode, affording high sensitivity and a wide linear range for the simultaneous detection of four purines. Using X/G as sentinel analytes, the IrO₂/GCE platform successfully tracked dynamic purine metabolic changes in fluorene-exposed embryos, corroborated by high-performance liquid chromatography (HPLC). Notably, the electrochemical assay already detected fluorene-induced suppression of purine levels at as early as 24 hpf, with excellent concordance to HPLC data. The IrO₂/GCE sensing system therefore provides a rapid, reliable, and embryo-scale tool for developmental toxicity assessment of fluorene and lays a solid technical foundation for the early-warning monitoring of persistent organic pollutants in the environment.
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高影响因子
Food Analytical Methods
·
2026
·Vol. 19
·期 1
·61
·
IF 3
Huang Lei,Zhang Qiaoling,Zhao Yiwei,Ye Xilei,Chen Huaixia,Dang Xueping
In this study, the Cu 7 Mn 2 bimetallic cluster was synthesized via a solvothermal method using copper (II) chloride dihydrate (CuCl 2 ·2H 2 O) and manganese (II) chloride tetrahydrate (MnCl 2 ·4H 2 O) as the metal centers, and 1,2-cyclohexanediamine-N,N′-bis-(3-carboxylsalicylide) as the ligand. Subsequently, the Cu 7 Mn 2 bimetallic cluster fiber coating was prepared using a physical coating method and applied for the solid phase microextraction (SPME) of 7 polycyclic aromatic hydrocarbons (PAHs). The coating was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, thermogravimetric analysis, and contact angle measurement. Based on adsorption isotherms and density functional theory (DFT) calculation, the adsorption mechanism was speculated to be hydrophobic interaction, π-π stacking, and N − H···π interaction. The coating exhibited higher extraction efficiency for 7 PAHs than the Cu cluster, Mn cluster, commercial PDMS, and PDMS/CAR fiber coatings. Under the optimized extraction conditions, an SPME-HPLC method was developed for the determination of 7 PAHs in corn oil, sesame oil, blended oil, and rapeseed oil. The linear ranges of the method were 1.0 − 1000 µg·kg –1 for naphthalene, 0.1 − 1000 µg·kg –1 for anthracene, phenanthrene, and pyrene, 3.0 − 1000 µg·kg –1 for fluorene, 0.3 − 1000 µg·kg –1 for fluoranthene, and 1.5 − 1000 µg·kg –1 for 1-methylnaphthalene ( R 2 > 0.99), respectively. The limits of detection (LODs, S/N = 3) and the limits of quantitation (LOQs, S/N = 10) were in the ranges of 0.030 − 1.0 µg·kg –1 and 0.10 − 3.0 µg·kg –1 , respectively. The precisions (RSDs) were less than 10.0% and the recoveries were in the range of 82.9 − 115.2%. These results demonstrate that the Cu 7 Mn 2 bimetallic cluster coating is an effective SPME adsorbent for separation and sensitive determination of PAHs in edible oils. Graphical
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