MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 10
·1-11
·
IF 5.3
Gu Yingqiu,Fang Puhao,Chen Yu,Xie Tianhua,Yang Guohai,Qu Lulu
A miniature multi-channel surface-enhanced Raman scattering (SERS) sensor based on polydimethylsiloxane (PDMS) is constructed to achieve rapid delivery of polluted water and specific identification of multiple components. Hg 2+ , organic pollutants, and sodium nitrite are successfully identified by the multi-channel SERS sensor using Cy5, cyclodextrin, and urea in the corresponding detection area. This multi-channel sensor exhibits excellent sensitivity and specificity, with detection limits of 3.2 × 10 −10 M for Hg 2+ , 1.0 × 10 −8 M for aniline, 6.9 × 10 −9 M for diphenylamine, 9.1 × 10 −8 M for PCB-77, and 7.5 × 10 −9 M for pyrene, and 5.0 × 10 −7 M for sodium nitrite. Compared with traditional analysis techniques, this method exhibited excellent recovery for the water pollutants ranging from 82.1 to 115.8%. The PDMS-based microchannel allows for simultaneous and rapid identification of multiple environmental pollutants, offering a portable detection method for emergency testing of environmental pollutants and routine determination of water pollutants. Graphical Abstract
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Journal of Environmental Chemical Engineering
·
2026
·
IF 7.5
Meng Wu,Hongfeng Lu,Wenjun Lin,Jun Hu,Zhiliang Yu,Jianming Yu
Volatile organic compounds (VOCs) are important precursors of ozone and secondary organic particulate matter, with an extensive range of sources and complex composition. Dichloromethane (DCM) and n -hexane, as common and typical VOCs, are extensively applied as solvents, extractants and cleaning agents in the pharmaceutical and chemical industries. The persistence, teratogenicity and carcinogenicity seriously harm the ecological environment and human health. In this study, combining the advantages of microbial electrolytic cell (MEC), the detoxification mechanism between low concentration n -hexane and DCM was analyzed. The results demonstrated that the n -hexane favored the enrichment of key functional genera, including degrading and electroactive microorganisms, which could be attributed to the mild toxicity of n -hexane at low concentrations and sufficient carbon sources. In contrast, DCM significantly inhibited the degradation of n -hexane. Metagenomic annotation results suggested that DCM was converted to formaldehyde via hydrolyzing haloalkane dehalogenase (DhlA) or DCM dehalogenase (DcmA). Formaldehyde was partly oxidized to carbon dioxide (CO 2 ) and partly assimilated into the ribulose monophosphate pathway or the serine pathway. And then converted to acetyl-CoA to enter the TCA cycle, which provided energy and material cycles for microbial metabolism. These results provided a new method for the detoxification of mixed VOCs and offer a new insight into the treatment and disposal of pollutants in practical engineering applications.
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Advanced Materials Technologies
·
2026
·
IF 6
Qian Zhang,Yuzhuo Wang,Wanze Wu,Bin Zhang,Xiao Gong
As a promising solution to the global water scarcity crisis, solar interfacial evaporation has been applied to seawater desalination. However, the manufacturing of solar evaporators that simultaneously demonstrate high efficiency and high pollution tolerance remains a challenge. To address this issue, we prepared superhydrophobic cotton fabric with both photocatalytic degradation and photothermal conversion functions. This cotton fabric-assembled evaporator exhibits excellent photothermal conversion performance, achieving an evaporation rate of 1.74 kg·m −2 ·h −1 under 1 Sun illumination. The cotton fabric achieved a 96.4% degradation rate of rhodamine B dye within 1 h under visible light irradiation. Additionally, the cotton fabric exhibited an oil flux of 18420.58 L·m −2 ·h −1 for dichloromethane, with an oil-water separation efficiency exceeding 99%. This work provides an innovative solution for the treatment of complex oily wastewater, which contains salt and dyes.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yongbo Yu,Qian Fei,Kailing Zhou,Jingbing Liu,Ziwei Ma,Hao Wang,Hui Yan
A dual-ion (H + /Cl − ) electrochemical polarization strategy dynamically tunes EMW shielding in flexible CNTs@PANI composites. • Dual-ion intercalation restructures PANI to optimize its band gap, sheet resistance, and reflective EMW shielding. • Uneven ion accumulation enlarges dipole moment and dielectric constant, significantly boosting EMW absorption shielding efficiency. • Synergistic reflection-absorption modulation achieves an ultrahigh specific shielding effectiveness variation of 289.44 dB·mm −1 . • A flexible sandwich device offers tunable X-band EMW shielding (26.29–42.06 dB) and robust bending/cycling stability. Dynamic manipulation of electromagnetic waves (EMWs) represents an indispensable cornerstone for next-generation intelligent stealth and adaptive communication systems. Nevertheless, the practical implementation of state-of-the-art electromagnetic materials remains severely constrained by insufficient modulation capabilities arising from single regulatory mechanisms, along with compromised operational flexibility and reliability. Herein, we report a dual-ion-mediated electrochemical polarization strategy in a flexible carbon nanotube@polyaniline (CNTs@PANI)-based device, which enables precise dynamic regulation of EMWs via the synergistic modulation of electromagnetic reflection and absorption. In-situ structural characterizations coupled with theoretical simulations demonstrate that electric-field-triggered H + /Cl − dual-ion intercalation drives the structural rearrangement of PANI from a non-polarized quinoid state to a polarized benzenoid structure. This transformation increases the content of protonated imine groups from 33.01% to 60.97%, narrows the band gap from 2.62 eV to 0.99 eV, and lowers the sheet resistance by 82.4% (from 47.99 to 8.43 Ω·sq. −1 ), thereby tailoring the EMW reflection shielding effectiveness (SE R ) from 4.71 dB to 8.84 dB. Furthermore, the asymmetric electrostatic potential distribution induced by H + /Cl − dual-ion intercalation and accumulation in PANI backbone amplifies the dipole moment by 118% (from 4.02 to 8.77 Debye), generating a pronounced dielectric polarization effect accompanied by maximum enhancement ratios of 172% and 6300% for the real (ε’) and imaginary (ε”) parts of the permittivity, respectively, which boosts the absorption shielding effectiveness (SE A ) from 11.12 to 17.75 dB. Consequently, the synergistic modulation of reflection and absorption contributes to thickness-normalized specific shielding effectiveness variation amplitude (ΔSSE) of 289.44 dB·mm −1 for the CNTs@PANI within the X-band (8.2–12.4 GHz), surpassing previously reported systems. This work establishes a novel paradigm for designing high-performance adaptive EMW protection systems through dual-ion electrochemical engineering.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 28
·22149-22158
·
IF 6.7
Sun Ze-Rui,Xia Yu-Xin,Li Yi-Ran,Liu Li,Voglmeir Josef
The deacetylation of N -acetylglucosamine
(GlcNAc)
to glucosamine (GlcN) is a key step in enzymatic chitin valorization.
We identified a novel GlcNAc deacetylase (AbNGD) from Acinetobacter baumannii with high substrate specificity
and catalytic activity but poor thermal stability (half-life of 5.5
h at 37 ° C). Using the FireProt platform, we generated a combinatorial
mutant, AbNGD-M3 (T93P–C153T-A244M). Its optimal temperature
increased to 37 ° C, and its half-life reached 28.1 h (5.1-fold
improvement), while retaining 97% of wild-type catalytic efficiency
( k cat / K m =
3.4 mM –1 ·s –1 ). Site-directed
mutagenesis confirmed Asp54 and His160 as key catalytic residues.
Molecular dynamics simulations revealed that T93P reduces backbone
flexibility, C153T enhances β-sheet rigidity via hydrogen bonding,
and A244M improves hydrophobic packing by filling a core cavity. These
distal mutations collectively balance stability and activity. Substrate
channel analysis identified a likely transport pathway centered on
T1. This study expands the deacetylase repertoire and provides a framework
for engineering stable industrial enzymes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Songlin He,Changhua Li,Yongxin Hu,Chuan Fu,Yi Fan,Xiaoxia Huang,Rui Guo,Yi He
Multidimensional nanocomposites integrate smart protection and physical barriers to prolong the service life of water-based self-healing coatings. Herein, polyaniline (PANI) and phytic acid (PA) were efficiently loaded onto siloxene sheets via a facile one-pot strategy to fabricate a nanocomposite with barrier and dual-release properties, which was introduced into water-based epoxy coating. As a modifier, PA greatly improved the dispersion of fillers and further enhanced the barrier performance and self-healing ability of the composite coating. Electrochemical impedance tests were adopted to evaluate the anticorrosion behavior of the as-prepared coating on low-carbon steel in 3.5% NaCl solution. The SPA-reinforced EP coating delivers outstanding long-term corrosion resistance, whose low-frequency impedance modulus (|Z| 0.01 Hz ) is three orders of magnitude higher than that of pure EP after 60 days of saltwater immersion. The superior performance originates from favorable filler-matrix interfacial compatibility, passivation film barrier effect and metal complexation. Salt spray tests also verify its reliable self-healing protection after coating damage. It is certain that this will provide an effective approach for improving the long-term application of water-based epoxy coatings in marine environments. Download: Download high-res image (138KB) Download: Download full-size image
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Gaixuan Zhou,Nan Wu,Tao Mi,Xiaoji Liu,Zhijia Zhang,Songsong Zhang,Teng Ma,Guojun Wang,Qiang Wang,Lin Wang,Hao Wei
Achieving lightweight microwave absorbers with strong attenuation, broad bandwidth and small matching thickness remains challenging for electromagnetic protection. Hollow ceramic microspheres (HCMs) are attractive lightweight supports owing to their low density and hollow structure, but their limited intrinsic dielectric loss and negligible magnetic response restrict microwave attenuation. Although binary hollow microsphere/ferrite or hollow microsphere/conductive-polymer systems can improve electromagnetic response, simultaneously balancing attenuation and impedance matching remains difficult. Herein, hierarchical HCM@NZF@PANI ternary absorbers were constructed by sequentially anchoring Ni–Zn ferrite (NZF) particles and depositing polyaniline (PANI) onto aminated HCMs. In this architecture, HCMs act as lightweight frameworks and scattering centers, NZF introduces auxiliary magnetic response and magnetic/dielectric interfaces, and PANI serves as a dielectric regulation layer. Structural characterizations confirmed rough core–shell microspheres with abundant multiphase interfaces. Increasing PANI content enhanced complex permittivity, dielectric loss tangent and attenuation constant while maintaining favorable impedance matching. HNP-60 delivered the optimal absorption performance, with a minimum reflection loss of −47.55 dB at 16.24 GHz at 1.5 mm and an effective absorption bandwidth of 5.52 GHz covering 11.76–17.28 GHz at 1.7 mm. The enhanced performance arises from multiple scattering, PANI-derived conductive loss, dipole polarization, Maxwell–Wagner interfacial polarization and auxiliary magnetic response. Radar cross-section simulation further verified the echo suppression capability of the coating, demonstrating a feasible interfacial regulation strategy for lightweight, thin and broadband ceramic-based absorbers.
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Advanced Materials Technologies
·
2026
·
IF 6
Yangyi Huang,Le Jing,Haosong Zhong,Siyu Chen,Yexin Pan,Xupeng Lu,Mitch Guijun Li
Multimodal wearable sports sensors capable of simultaneously detecting both physical and biochemical signals represent a transformative approach to comprehensive physiological monitoring during exercise. However, most existing systems either focus solely on physical parameters or suffer from limited sensitivity and sensing range when targeting high-concentration biochemical markers. There remains a challenge for integrated platforms that can robustly monitor metabolic status in realistic sports scenarios. This work presents M-SportSense, an integrated wearable platform for real-time multimodal sweat analysis that combines lactate and pH sensing. The core innovation is a laser surface micromachined PVC diffusion layer that dramatically enhances lactate detection performance. By employing a 1064 nm laser to create a circular hole array on the honeycomb PVC surface, the detection range is expanded by 100 times while simultaneously increasing sensitivity by 127%. The M-SportSense integrates laser-induced graphene (LIG) electrodes functionalized with lactate oxidase for lactate sensing, polyaniline for pH sensing, and serpentine LIG for temperature monitoring. A three-layer microfluidic device with optimized inlet design ensures efficient sweat collection and rapid refreshing rates. On-body validation during 20-min indoor cycling demonstrates stable multimodal detection of sweat lactate and pH, validating the platform's potential for personalized exercise monitoring, fatigue assessment, and real-time training optimization.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Minghui Wang,Qiaolin Guo,Zhenyong Hu,Yue He,Lai Zhang,Cuifei Chen
An ultrasensitive biosensor has been developed for miR-375 detection. • HRP is embedded into COFs to form stable HRP@COFs co-precipitated nanospheres. • The HRP@COFs preserved enzymatic activity and enhanced catalytic efficiency. • The biosensor has been successfully validated using clinical samples. The dysregulated expression of microRNA (miRNA) in various cancers has attracted considerable attention owing to their crucial roles in tumor initiation and progression. Among them, miR-375 has been recognized as a prospective biomarker for early malignancy detection and therapeutic monitoring. In this study, a highly sensitive electrochemical biosensor has been developed based on horseradish peroxidase (HRP)-embedded covalent organic framework (HRP@COFs) co-precipitated nanospheres for the detection of miR-375. The HRP@COFs nanocomposite effectively preserves the enzymatic activity of HRP while providing the structural stability and high loading capacity of COFs, thereby enhancing catalytic efficiency and signal amplification. In the presence of target miR-375, the azide-modified H1 hairpin probes on the HRP@COFs surface are activated, leading to the formation of a rigid H1-H2 duplex structure through competitive hybridization with H2 hairpins. The resulting H2-H1-HRP@COFs complexes are subsequently anchored onto the electrode surface via click chemistry. Upon the addition of H 2 O 2 , HRP catalyzes aniline polymerization and deposition, resulting in a significant electrochemical response. This biosensor achieves ultrasensitive detection of miR-375 with a detection limit as low as 230 aM. It has been successfully validated using clinical samples, demonstrating great potential for reliable breast cancer diagnosis. This work highlights the synergistic advantages of integrating HRP with COFs, providing a robust and efficient platform for microRNA detection and expanding the applications of COFs-based materials in biosensing and clinical diagnostics. Download: Download high-res image (151KB) Download: Download full-size image
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Qingping Xin,Gangrong Hong,Huajian Gao,Wei Huang,Jiaxin Wu,Kun Wan,Meiting Gao,Ningning Gao,Huiguo Wang,Yuzhong Zhang
The increasing emission of carbon dioxide (CO2), which is the main component of greenhouse gases, has led to a series of global environmental problems. Membrane separation technology, which is characterized by low energy consumption, minimal pollution, and simple operation, has been widely applied in CO2 gas separation. The development of high-performance gas separation membrane is imperative, and the development of materials and membrane preparation technology needs to be explored. In this study, covalent triazine framework (CTF-1) is synthesized by combining trifluoromethanesulfonic acid (CF3SO3H) and terephthalonitrile (DCB), and then a PTFE/CTF-1 composite membrane is fabricated by the spin coating method with CTF-1 as the selective layer and poly(tetrafluoroethylene) (PTFE) as the support layer. The nitrogen-rich framework in CTF-1 acts as a selective layer, which enables to interact with CO2 through dipole–quadrupole interaction to preferentially adsorb CO2, but also capitalizes on the strong stability and porous structure of the PTFE membrane. By regulating the spin coating speed, the selective layer thickness is regulated, and a series of CTF-1 with distinct gas separation performance are achieved. When the spin coating speed is 3000 rpm, the PTFE/CTF-1 composite membranes show the best gas separation performance with a CO2 permeance of 548 GPU (unit of membrane permeance, 1 GPU = 10–6 cm3(STP)/(cm2·s·cmHg)) and a CO2/N2 selectivity of 17. Meanwhile, an exploratory fabrication of PTFE/CTF-1/PANI composite membranes is proceeded, followed by regulating the polymerization time to acquire an optimal gas separation performance with a CO2 permeance of 301 GPU and a CO2/N2 selectivity of 36.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 7.3
Yang Liuxin,Cheng Yiyu,Qin Si,Jiang Jun,Zhong Shiyi,Bi Xinyue,Xu Jiali,Wang Kai,Qiu Shuang,Li Xiang
Cellular resilience to therapy often arises from adaptive
mechanisms
that safeguard iron–sulfur (Fe–S) proteins. Here, we
present a rational strategy to overcome such resilience by integrating
two synergistic vulnerabilities, copper toxicity and Fe–S cluster
homeostasis, into a single molecular scaffold. Inspired by a bacterial
sulfur mobilization (SUF) inhibitor, we hybridized its core structure
with a copper-transporting 8-hydroxyquinoline moiety to generate HDQ , HDQ-S , HDQ-Ph , and HDQ-Me . They coordinate copper via hydroxyquinoline and efficiently transport
copper into cancer cells, with HDQ-Me achieving an efficacy
comparable to that of the clinical copper ionophore elesclomol ( ES ). Strikingly, HDQ alone suppresses Fe–S
proteins across multiple functions, including respiration, iron homeostasis,
and DNA replication. HDQ -mediated copper loading triggers
cuproptosis hallmarks, DNA damage, and ATP collapse, generating a
synergistic lethality. This work establishes HDQs as
bifunctional tools that cotarget copper and Fe–S protein homeostasis,
validating a convergent therapeutic strategy against resilient cells.
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STAR Protocols
·
2026
·Vol. 7
·期 3
·104786
·
IF 1.4
Yuchen Huang,Lexuan Hou,Lin Zhu,Xi Yang,Gang Li
Summary Here, we present a dynamic combinatorial library-versus-proteome activity-based protein profiling (DCL-ABPP) workflow for high-throughput covalent ligand discovery. We describe steps for integrating a dynamic combinatorial library with proteome-wide mass spectrometry to generate and screen hundreds of ligands in situ , eliminating the need for pre-synthesis. We detail procedures for two complementary modes: competitive screening, which identifies enzyme inhibitors (e.g., serine hydrolases) through family-wide probe competition; and direct screening, which maps covalent ligand binding sites on cysteines. For complete details on the use and execution of this protocol, please refer to Huang et al. 1
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危险品化学品经营许可证（带存储）