ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Naijie Wang,Xiangqun Chen,Qiu Sun,Ying Song,Tiezhu Xin
Single-ion conducting polymer electrolytes (SICPEs) are considered as one of the most promising candidates for achieving lithium metal batteries (LMBs). However, the application of traditional SICPEs is hindered by their low ionic conductivity and poor mechanical stability. Herein, a self-standing and flexible polyurethane-based single-ion conductor membrane was prepared via covalent tethering of the trifluoromethanesulfonamide anion to polyurethane, which was synthesized using a facile reaction of diisocyanates with poly(ethylene oxide) and 3,5-diaminobenzoic acid (or 3,5-dihydroxybenzoic acid). The polymer electrolyte exhibited excellent ionic conductivity, mechanical properties, lithium-ion transference number, thermal stability, and a broad electrochemical window because of the bulky anions and unique two-phase structures with lithium-ion nanochannels in the hard domains. Consequently, the plasticized electrolyte membrane showed exceptional stability and reliability in a Li||Li symmetric battery. The assembled LiFePO4||Li battery exhibited an outstanding capacity (∼180 mA h g–1), Coulombic efficiency (>96%), and capacity retention. This research provides a promising polymer electrolyte for high-performance LMBs.
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CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Jie Zhang,Yingying Li,Jingyu Hu,Yuanqiang Sun,Ran Yang,Zhaohui Li,Lingbo Qu
Phosgene is a very dangerous but important industrial intermediate and is a significant threat to public health. There is, therefore, an urgent need to develop a rapid, visual, and on-site detection method for phosgene. Sensitive and selective phosgene responsive carbon dots (CDs) were synthesized by employing 2-nitro-4-aminodiphenylamine as precursors. The amine group of the CDs can interact selectively with phosgene to effect acylation reactions, which cause color changes from yellow to amaranth and remarkable changes in fluorescence from bright yellow to orange-red due to modification of the CDs’ intramolecular charge transfer (ICT) process. The CDs exhibited fast response (<2 s) for detection of phosgene with an ultralow detection limit (0.63 nM). Furthermore, a portable CD/polystyrene droplet system was developed for rapid and on-site visualization of phosgene. Specifically, the droplet system not only can realize rapid on-spot visual inspection of gaseous phosgene in the liquid phase with the naked eye, but also could make long-term visualization in the solid phase via a polystyrene membrane after solvent volatilization. This study has expanded the scope for application of CDs in sensing field, and provides a new and effective strategy for fabrication excellent platform for real-time detection of phosgene leakage in industrial and public safety applications.
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SENSORS AND ACTUATORS B-CHEMICAL
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2022
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IF 9.221
Yingying Li,Jie Zhang,Zengqiang Liang,Ran Yang,Lingbo Qu,Zhaohui Li,Yuanqiang Sun
It is of great significance for real-time monitoring of phosgene to protect public safety. In this paper, a new rhodamine derivate with highly rapid, special and sensitive response towards phosgene was synthesized and used as a phosgene probe based on its spirolactam ring-opening property and nucleophilic reaction with phosgene. To realize in situ visualization of phosgene, a fluorescent detection pen with gas-liquid reaction model was proposed for the first time using the mixture of the probe and polystyrene as ink. The detection film could be formed in situ by simply writing on desired surface and respond toward phosgene gas within 30 s with an ultra-low detection limit (2 ppm) with the naked eye. Such a fluorescence pen detection mode supplied a new strategy for the fabrication of an excellent platform for real-time detection of phosgene and other gas analytes.
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MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2022
·Vol. 223
·期 22
·2200216
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IF 2.996
Yangyang Xu,Haibin Zhu,Zhaofu Ding,Xianjun Zhao,Jiansong Yin,Bernadette Graff,Jiangang Gao,Jacques Lalevée
Here, a benzaldehyde substituted diacetylene vesicle formed through a self-assembly strategy in water is reported. Under UV irradiation, conjugated polydiacetylene (PDA) could be generated in the blue phase by 1,4-addition topopolymerization. Furthermore, this newly developed PDA vesicle displays distinctive colorimetric response to triple stimuli, including temperature, pH, and organic amines. Specifically, a clear blue-to-purple-to-red chromatic transition is observed for the PDA vesicle upon a gradient heating procedure from 25 to 75 °C. Although no obvious colorimetric changes happen when the PDA vesicle is exposed to acidic environments, it gradually turns into red color in alkaline aqueous solution or atmosphere with increasing pH values. More interestingly, this PDA vesicle can serve as an excellent sensor to distinguish some typical aliphatic/aromatic amines based on its different colorimetric and morphologic transformation behaviors. It is suggested that the incorporated benzaldehyde head group in PDA plays an essential role for the resulting responsiveness to the various environmental stimuli. As the preparation method is simple and straightforward, the novel PDA vesicle introduced here holds great potential as a promising sensor with the naked eye.
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NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 34
·16341-16351
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IF 3.925
Wanjun Jiang,Shiyu Wu,Guorong Fan,Zongde Wang,Shangxing Chen,Yangping Wen,Peng Wang
The extraordinary properties and unique structure of porous carbon have rapidly turned it into a new favorite in the development and application of high-performance electrocatalytic sensors. Nitrogen, phosphorus co-doped hollow porous carbon microspheres (PRM-HPAs) as an oxidase-like electrocatalytic sensor for baicalin were successfully developed by two-stage activation using both 3-aminophenol and formaldehyde as carbon sources, phosphoric acid as an activator and dopant, and N-dehydroabietoyl-L-alanine as a soft-template. Low-temperature activation in air is the key to obtaining the hollow structure, and increases the content of oxygen-containing groups. High-temperature activation with phosphoric acid in nitrogen significantly increases the micropore content of PRM-HPA, and realizes phosphorus doping. The introduction of a soft-template can effectively prevent the agglomeration of carbon particles, and form uniformly dispersed hollow carbon microspheres. The PRM-HPA with a specific surface area of 1388 m2 g−1, pore volume of 0.69 m3 g−1, and pore size of 17 Å displays excellent electrocatalytic ability, oxidase-like characteristics, and an excellent electrochemical response of about 118-fold enhancement for baicalin in linear ranges of 0.03–7.99 μM with a low limit of detection of 4.3 nM. This work will open a new pathway for the preparation of co-doped hollow porous carbon microspheres and the application of renewable rosin resource.
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JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
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2022
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IF 2.506
Linlin Wang,Qiang Hu,Yanmin Huang,Qipeng Xiong,Yong Chen,Chunfang Gan,Yuanfei Zhang,Guoqin Cui,Jianguo Cui
The controlled release formulations (CRFs) are considered an effective way to solve damage to the environment caused by traditional pesticide formulations. To change the defects of traditional neonicotinoid formulations that dissolve quickly in soil, three types of thiamethoxam (TM) CRFs microspheres with content of 20% TM were prepared using microcrystalline wax (MK) as the matrix, laurate acid tapioca starch ester (MSK) and stearyl dehydroabietic acid ester (MDK) as the regulators of ingredient release. The release behavior of CRFs microspheres in water and soil showed that the microspheres had superior stability and different TM sustained-release periods, and TM release of the microspheres in soil was faster than that in water. The release rate is TM/MDK > TM/MSK > TM/MK. In water, the release of thiamethoxam technical was finished after 38 hours. However, for TM/MK, the release rate was 94% after 240 hours, and the release time was extended by 6 times. Meanwhile, TM/MDK has a particular pH-responsive release. Research shows that using microcrystalline wax as the matrix, by adding MSK or MDK to adjust the release of ingredients, pesticide CRFs microspheres with different release periods can be prepared to achieve the purpose of controlling the release of pesticides.
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PROGRESS IN ORGANIC COATINGS
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2022
·
IF 6.206
Huizhou Fan,song Duan,Ruoyu Hong,Ying Xu
In this study, the ferrocene modified polyaniline [P(FcA- co -ANI)] with tunable electrical conductivity was prepared by introducing ferrocene groups into the main chain of polyaniline (PANI) with a hydrochloric acid dopant . The 1 H NMR, SEM, XRD and FT-IR results proved the successful preparation of the copolymers P(FcA-co-ANI). The corrosion resistance of the coatings on Q215 steel was investigated by EIS . The results showed that the P(FcA-co-ANI)/EP coatings and PANI/EP coatings all improved the long-term corrosion resistance by more than 2 orders of magnitude with comparison of EP coatings. Both coatings showed excellent corrosion inhibition . Furthermore, the |Z| 0.01 Hz values of the P(FcA-co-ANI)/EP coating started to recover in a shorter period of time and returned to higher values compared to the PANI/EP coating, and did not drop as sharply as the PANI/EP coating in the later stages of immersion. Besides, the results of R c and R ct values also show that the P(FcA-co-ANI)/EP coatings provide faster and better corrosion inhibition. This is due to the greater conductivity P(FcA-co-ANI) being more sensitive to the electrons generated by metal corrosion and so generating the passivation layer faster. The impact and peel tests show excellent mechanical properties and adhesion of the coating. This work offers some theoretical help for understanding the anticorrosion mechanism of PANI.
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Advanced Science
·
2022
·Vol. 9
·期 15
·2105894
·
IF 17.521
Pengkai Wu,Haitian Zhang,Yin Yin,Meiling Sun,Shuai Mao,Huihui Chen,Yexuan Deng,Shuai Chen,Shuo Li,Beicheng Sun
Nano-based immunotherapy of therapeutic biomolecules is attractive but tremendously hampered by the poor delivery efficiency. This study reports a novel delivery system of fluorinated-coordinative-epigallocatechin gallate (EGCG), referring as FEGCG/Zn, through the integration of fluorination and zinc ions (Zn 2+ ) into EGCG. The robust therapeutics of FEGCG/Zn are measured in terms of the regulating effect on programmed cell death ligand 1 (PD-L1), the effective delivery of diverse biomolecules, and the hitchhiking ability using living cells. Taking small interfering RNA of PD-L1 (siPD-L1) and erythrocytes as an example, the fabricated biomimetic system achieves excellent siPD-L1 delivery and further improves siPD-L1 accumulation in tumors. Finally, the combination of FEGCG/Zn and siPD-L1 promotes antitumor immunotherapy through alleviation of T cells exhaustion by regulating PD-L1 expression in tumor cells. The results demonstrate that FEGCG/Zn substantially regulates PD-L1 expression and improves immune-biomolecule delivery by forming biomimetic nanoassemblies, offering a versatile platform for cancer immunotherapy.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yuan Zhong,Kai Qu,Wenhua Yan,Kun Zhang,Xian Qin,Yi Wang,Meng Yan,Shuai Wu,Li Zhu,Essam Abdo Mohammed Saad Obaid,Guixue Wang,Wei Wu
The development of atherosclerosis (AS) is closely related to inflammation. The common feature of inflammatory sites is upregulation of vascular cell adhesion molecule-1 (VCAM-1), which has a strong affinity with very late antigen-4 (VLA-4). Endothelial cell membranes overexpressing VLA-4 (OEM) were used to camouflage rapamycin nanoparticles (RAP NPs) with reactive oxygen species (ROS) responsiveness to construct biomimetic nanodrugs [email protected] NPs. These nanoparticles were capable of enhancing the active target drug delivery and ROS-responsive drug release under the pathological overexpression of VCAM-1 and accumulation of ROS stimulus. In vitro and in vivo investigations confirmed that [email protected] NPs could enhance the active target drug delivery to atherosclerotic plaques and increase drug accumulation in the focal site, thus improving the bioavailability of drugs, reducing side effects and inhibiting the occurrence and development of atherosclerosis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Chunjing Guo,Yanguo Su,Ziting Cheng,Qiang Chen,Huimin Guo,Ming Kong,Daquan Chen
Chemodynamic therapy (CDT) has been widely used in the treatment of many kinds of tumors, which can effectively induce tumor cell apoptosis by using produced reactive oxygen species (ROS). In this paper, ROS-sensitive multifunctional marine biomaterial natural polysaccharide nanoparticles were designed. Aggregation-induced emission (AIE) molecules tetraphenylethylene (TPE) labeled and caffeic acid (CA) modified fucoidan (FUC) amphiphilic carrier material (CA-FUC-TK-TPE, CFTT) was fabricated, in which the thioketal bond(TK) was used as the linkage arm between TPE and fucoidan chain, giving the CFTT material ROS sensitivity. In addition, amphiphilic carrier material (FUC-TK-VE, FTVE) composed of thioketal-linked vitamin E and fucoidan was synthesized. The mixed carrier material CFTT and FTVE self-assembled in water to form nanoparticles (CFTT – FTVE@PTX-Fe 3+ ) loaded with PTX and Fe 3+ . The CDT effect was combined with the chemotherapeutic drug PTX to achieve tumor inhibition. In vitro cell studies have proved that CT/PTX nanoparticles have excellent cell permeability and tumor cytotoxicity. In vivo antitumor experiments confirmed effective antitumor activity and reduced side effects.
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NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 12
·5806-5818
·
IF 3.925
Xiaoxue Lin,Jianjun Shi,Zaifeng Shi,Satomi Niwayama
Surface-initiated ring-opening metathesis polymerization (SI-ROMP), based on the design of hydrophobic and antifouling monomers, was employed for the synthesis of grafting-modified graphene oxide (GO). The activity of copolymerization was investigated with the use of fluorinated norbornenes (NBFn) and polyethylene glycol-substituted norbornenes (Nb-PEG) as monomers in the presence of Grubbs 2nd generation catalyst in the solution conditions. These copolymerization conditions were applied to the modification of GO by SI-ROMP, and the polynorbornene-functionalized GO (GO-pNBFn-pNb-PEG) was obtained from the active catalyst sites on the GO surface. The results indicated that fine copolymerization activity was achieved under the molar ratio of 175 : 25 : 2 (NBFn : Nb-PEG : catalyst), whereas the activity of ROMP was decreased obviously with the increase of the Nb-PEG ratio and the side-chain length of the PEG groups. The modified GO retained the intercalated layer structure, and the growth of the polymers led to the decreased layer spacing. The grafting ratio could reach 37% by controlling the monomer concentration of 0.1 g mL−1 : 0.016 g mL−1 (NBFn : Nb-PEG) and polymerization time (t1 = 45 min and t2 = 90 min) under the mild reaction conditions. The grafted polymer films improved the dispersibility of GO in organic solvents and the contact angle of GO-pNBF10-pNb-PEG550 could reach 128°. The protein resistance of the modified GO had better anti-adsorption ability towards large molecular weight proteins.
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Asian Journal of Pharmaceutical Sciences
·
2023
·
IF 10.2
Yong Huang,Yi Lin,Bowen Li,Fu Zhang,Chenyue Zhan,Xin Xie,Zhuo Yao,Chongzhi Wu,Yuan Ping,Jianliang Shen
Ferroptosis has emerged as a potent form of no-apoptotic cell death that offers a promising alternative to avoid the chemoresistance of apoptotic pathways and serves as a vulnerability of cancer. Herein, we have constructed a biomimetic self-assembly nano-prodrug system that enables the co-delivery of gefitinib (Gefi), ferrocene (Fc) and dihydroartemisinin (DHA) for the combined therapy of both ferroptosis and apoptosis. In the tumor microenvironment, this nano-prodrug is able to disassemble and trigger drug release under high levels of GSH. Interestingly, the released DHA can downregulate GPX4 level for the enhancement of intracellular ferroptosis from Fc, further executing tumor cell death with concomitant chemotherapy by Gefi. More importantly, this nano-prodrug provides highly homologous targeting ability by coating related cell membranes and exhibits outstanding inhibition of tumor growth and metastasis, as well as no noticeable side-effects during treatments. This simple small molecular self-assembled nano-prodrug provides a new reasonably designed modality for ferroptosis-combined chemotherapy.
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