NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 10
·4282-4290
·
IF 3.069
Pengfei Chen,Shun Yao,Xianggui Chen,Yukun Huang,Hang Song
Herein, Fe3O4 magnetic nanoparticles (CD-MNPs, CM-CD-MNPs and MA-CD-MNPs) surface-modified with β-cyclodextrin (β-CD) and its derivatives, carboxymethyl-β-CD (CM-β-CD) and maleated-β-CD (MA-β-CD), respectively, were successfully synthesized via a layer-by-layer method, and the resulting nanocarriers possessed good magnetic character and biocompatibility. Using carmofur as a model drug, the results of loading and release experiments indicate that these magnetic nanocarriers can serve as targeted drug delivery systems in the future, and the loading capacity and release behaviour are highly dependent on the surface properties of the nanocarriers. Based on the molecular docking technique, for the first time, the correlation between the lowest binding energy (ΔGbinding) of the inclusion complex and the loading and release performances of the corresponding magnetic nanocarriers was investigated to establish a method to fast select an effective β-CD-based surface coating for the construction of high-performance magnetic nanocarriers. The results revealed a ΔGbinding-dependent manner demonstrating that the magnetic nanocarriers surface modified with the cyclodextrin unit with a larger absolute value of ΔGbinding would possess better loading and release performances. This encouraging result suggested that the ΔGbinding obtained from molecular docking could provide a significant reference for the fast selection of an effective surface coating during the construction of high-performance β-CD-based magnetic nanocarriers. Although it is clear that the present study should be considered only as a preliminary study, the good results obtained herein demonstrate the feasibility of this new type of approach.
研究领域:
材料科学
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药学
·
生物医学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 34
·20789-20794
·
IF 3.108
Vikramjeet Singh,Tao Guo,Li Wu,Jianghui Xu,Botao Liu,Ruxandra Gref,Jiwen Zhang
Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized γ-CDs in MOFs were crosslinked by diphenyl carbonate by a facile single step chemical reaction. Scanning electron microscopy and X-ray diffraction analysis revealed the almost perfect cubic shapes of the particles with a disordered internal structure. Contrarily to the non-crosslinked materials which immediately dissolved in water, the CD-cubes were remarkably stable after extensive washing with water. The CD-cubes possessed a mesoporous structure with pore size in the range of 2–4 nm and showed much higher BET surface and 8 times higher adsorption capacity for doxorubicin as compared to conventional cyclodextrin-sponges.
研究领域:
药学
·
材料科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Zhen Zhang,Sige Li,Dan Qiao,Nan Hu,Ying Gu,Qiliang Deng,Shuo Wang
Black phosphorus (BP) nanosheet is easily oxidized by oxygen and water under ambient environment, thus, reliable BP passivation techniques for biomedical applications is urgently needed. A simple and applicable passivation strategy for biomedical applications was established by encapsulating BP nanosheet into zeolitic imidazole framework-8 (ZIF-8). The resulted BP nanosheet in ZIF-8 (BP@ZIF-8) shows not only satisfied chemical stability in both water and phosphate buffered saline (PBS), but also excellent biocompatibility. Notably, BP nanosheet endows the prepared BP@ZIF-8 with prominent photothermal conversion efficiency (31.90%). Besides passivation BP, ZIF-8 provides the BP@ZIF-8 with high drug loading amount (1353.3 mg g–1). Moreover, the loaded drug can be controlled release by pH stimuli. Both in vitro and in vivo researches verified the resulted BP@ZIF-8 an ideal candidate for tumor multimodal treatments.
研究领域:
生物医学材料
·
肿瘤治疗学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 11
·7250-7256
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IF 3.9
Ke Yang,Junfeng Liu,Laichun Luo,Meilin Li,Tanfang Xu,Junfeng Zan
Silver nanoparticles have attracted great attention owing to their distinct physicochemical properties, which inspire the development of their synthesis methodology and their potential biomedical applications. In this study, a novel cationic β-cyclodextrin (C-β-CD) containing a quaternary ammonium group and amino group was applied as a reducing agent as well as a stabilizing agent to prepare C-β-CD modified silver nanoparticles (CβCD-AgNPs). Besides, based on the inclusion complexation between drug molecules and C-β-CD, the application of CβCD-AgNPs in drug loading was explored by the inclusion interaction with thymol. The formation of AgNPs was confirmed by ultraviolet-visible spectroscopy (UV-vis) and X-ray diffraction spectroscopy (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed the prepared CβCD-AgNPs were well dispersed with particle sizes between 3–13 nm, and the zeta potential measurement result suggested that the C-β-CD played a role in preventing their aggregation in solution. 1H Nuclear magnetic resonance spectroscopy (1H-NMR) and Fourier transform infrared spectroscopy (FT-IR) revealed the encapsulation and reduction of AgNPs by C-β-CD. The drug-loading action of CβCD-AgNPs was demonstrated by UV-vis and headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME-GC-MS), and the results of TEM images showed the size increase of nanoparticles after drug loading.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
npj Materials Degradation
·
2023
·Vol. 7
·期 1
·1-10
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IF 5.1
Yang Jingzhi,Ran Yami,Huang Luyao,Ren Chenhao,Hao Xiangping,Ma Lingwei,Zhang Dawei
2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) (PEG), and zwitterionic polymers are currently considered the most extensively studied antifouling hydrogel coatings. However, systematic identification of these coatings to unleash their potential properties is tremendously under-represented. Here, we report a high-throughput optimizing strategy that combines highly miniaturized hydrogel synthesis and screening to fine design zwitterion-based hydrogel coatings. Compared with the traditional one-by-one synthesis and characterization methods, the proposed high-throughput strategy accelerated the discovery of candidate materials with a high-efficiency and cost-effective approach. To tailor multiple parameters of coatings, 1575 unique coating combinations with continuous gradients were prepared only required 600 μL reactant. The mechanical stability and drug-loading capacity of the coating spots were sequentially evaluated via immersion swelling, flow, tape-peeling, and dye-retaining tests. This strategy could efficiently reveal the composition/structure-function relationships of the hydrogel coatings and also other materials, which is promising for the rapid screening and design of desired implantable device surfaces.
研究领域:
生物材料
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医学工程
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 33
·13997-14004
·
IF 3.288
Yangyi Sun,Yijing Mao,Ningyu Di,Xiaolong Chen,Dongming Qi,Baoqing Shentu
Herein, using an acid-hydrolyzed tetraethyl orthosilicate (TEOS)/bis(triethoxysilyl)ethane (BTEE) mixture as a precursor for the traditional surfactant-assembly synthesis of mesostructured silica spheres instead of directly purchased commercial precursors, molecularly ethane-bridged hollow mesoporous silica spheres (MEB-HMSs) with radial mesochannels and an enlarged pore size were successfully synthesized without any additional core templates. The composition, pore size, particle size, shell thickness, and rate could be controllably tailored by only changing the amount of reagents used in the reaction. The cytotoxicity assay confirmed that MEB-HMSs have good biocompatibility, together with good Dox-loading capacity.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Wenfeng Yan,Junmao Li,Wei Long,Yulin Feng,Mingzhen He,Weifeng Zhu,Meiying Liu,Hui Ouyang,Xiaoyong Zhang,Yen Wei
In this paper, a simple method that relied on direct chain transfer free radical polymerization was reported to synthesize MSNs based polymeric composites (named as MCM-41-SH-poly (PEGMA- co -VPA)) using poly (ethylene glycol) monomethyl ether (PEGMA) and 4-vinyl phenylboric acid (VPA) as monomers. The utilization of MCM-41-SH-poly (PEGMA- co -VPA) to load and delivery curcumin (CUR) was also evaluated in detail. The structure, properties, drug loading and release behaviors were evidenced by various characterization techniques. The results from biological studies have shown that CUR can be effectively loaded on MCM-41-SH-poly (PEGMA- co -VPA) with high drug loading rate through formation of borate bond between CUR and VPA. More importantly, resultant drug-loading complexes displayed excellent water dispersibility and CUR could be released from complexes with pH responsiveness. Taken together, we have developed a simple method for surface modification MCM-41 and resultant composites could display improved properties for intracellular controlled drug delivery applications.
研究领域:
材料科学
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纳米医学
·
药物递送系统
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DOI
高影响因子
POLYMER BULLETIN
·
2021
·Vol. 79
·期 4
·2173-2188
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IF 2.87
Hou Jiazi,Zhou Guibin,Hu Jinlun,Wang Yihuan,Gao Shuang
Microparticles had attracted a lot of attention for biomedical applications because of their injectable and biomimetic properties. We reported a method for preparing Polylactic acid (PLA)/Polyvinylpyrrolidone (PVP) core–shell microparticles by single capillary electrospraying and explored their potential applications for drug-loading. The shape of microparticles can be controlled by varying ratios of PLA and PVP during the electrospraying process. Different morphologies were achieved including spindle-like, erythrocyte-like and disk-like microparticles. Furthermore, the method of preparing core–shell microparticles was simple and repeatable. Compared with spherical microparticles, erythrocyte-like microparticles can flow through capillaries by morphing into a parachute-like shape. When the particle morphology converted to disk-like, the increase of water contact angle attributed to the PVP rapid dissolution and the residual PLA interconnection to form a continuous hydrophobic membrane. Besides, the microparticle membrane was extremely low-toxic to cells by MTT assay. Taken together, we prepared injected core–shell microparticles by single capillary electrospraying, which had potential application in drug-loading.
研究领域:
生物医学工程
·
材料科学
·
药剂学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yang Li,Xiaoyan Liu,Zhongming Liu,Shoujuan Wang,Fangong Kong
The problems of low drug loading capacity and short release time in traditional drug delivery systems would lead to repeated administration and an increase in the burden of treatment. To solve this problem, nanocellulose composite aerogels were designed and prepared as the drug carrier with an adjustable structure, good biocompatibility, high drug loading capacity, and long release time. In this study, polyethylene glycol (PEG) and β-cyclodextrin (β-CD) were introduced into nanocellulose through blending and physicochemical crosslinking to regulate and improve the network structure, drug loading capacity, and sustained release performance of nanocellulose composite aerogels. The pore structure and physicochemical structure of aerogel were explored to reveal the structure and effect between the structure of aerogel and drug release through advanced technologies such as X-ray photoelectron spectroscopy (XPS), micro-CT, scanning electron microscopy (SEM), and specific surface area (BET). The drug loading and release curves of aerogels were simulated to reveal the relevant mechanism through mathematical models, providing a theoretical basis for clinical application.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
E-POLYMERS
·
2022
·Vol. 22
·期 1
·664-675
·
IF 3.074
Di Hao,Dong-Yue Wang,Bin Dong,Sun-Chang Xi,Guan Jiang
Suzuki cross-coupling reaction was employed to easily obtain a triazine-based porous organic polymer (2,4,6-tris(5-bromothiophene-2-yl)-1,3,5-triazine [TBrTh]–1,3,5-benzene-triyltriboronic acid pinacol ester [BTBPE]–covalent triazine framework [CTF]) containing thiophene units. The chemical structure of TBrTh–BTBPE–CTF was revealed by solid-state 13 C NMR, Fourier-transform infrared, and X-ray photoelectron spectroscopy. TBrTh–BTBPE–CTF with an amorphous structure exhibited excellent thermal stability and intrinsic porosity (373 m 2 ·g −1 of Brunauer–Emmett–Teller surface area). Consequently, temozolomide (TMZ) was used as an oral alkylating agent in melanoma treatment to explore the drug loading and releasing behavior of TBrTh–BTBPE–CTF as a result of the low cytotoxicity of thiophene-based polymers. The successful loading of TMZ within the polymeric structure was suggested by thermogravimetric analysis and N 2 sorption isotherms. The release experiments were performed in phosphate-buffered saline at pH values of 5.5 and 7.4, exhibiting good controlled-release properties. These results suggest that the current porous organic polymer is expected to be a drug carrier for the delivery and release of TMZ.
研究领域:
材料科学
·
药学
·
肿瘤学
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2014
·
IF 2.269
Ling Li,Ke Ke Sun,Lu Fan,Wei Hong,Zu Shun Xu,Li Liu
Magnetic core–shell spheres Fe 3 O 4 @MOFs and Fe 3 O 4 @MOFs/GO were prepared using layer by layer assembly method. Fe 3 O 4 @MOFs and Fe 3 O 4 @MOFs/GO were characterized by XRD , FTIR, SEM, TEM and VSM. The results showed that both magnetic spheres were with core–shell structure. The method was proved to be valuable for producing core–shell structure with porous nanocomposite materials as shell. Methylene blue was selected as drug model to study the drug loading of the synthesized spheres. It was found that the addition of graphene oxide (GO) enhanced the drug loading amount of magnetic sphere.
研究领域:
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Yurong Li,Yongkang Wei,Zilong Gao,Guozheng Zhang,Mingkun Zhu,Hui Yan,Yeshun Zhang
Hydrogels, particularly multifunctional hydrogels, are attractive wound dressing due to their abundant exudate absorption performance, oxygen permeability, comparable moisturizing ability, and performance of locally delivering therapeutic drugs. However, it is challenging to achieve hydrogels that enable mechanical properties comparable to human skin and can uniformly load hydrophobic drugs as multifunctional dressings for wound management. Herein, we report a simple and rapid fabrication of hydrogels by directly inducing sericin protein gelation using acetic acid. The resulting sericin hydrogels demonstrate high transparency, excellent physicochemical and biological properties, and promising wound dressing materials. Notably, this sericin hydrogel system could encapsulate hydrophobic drugs during gelation, thus overcoming the limitation of inadequate amount and non-uniform loading of therapeutic drugs in hydrogels. Further, we selectively encapsulated hydrophobic ciprofloxacin (CIP) into sericin hydrogel to obtain a multifunctional wound dressing with favorable antimicrobial activities. The obtained CIP-loaded sericin hydrogel exhibited antibacterial activity against both Gram-positive bacteria (S. aureus) and Gram-negative bacteria (P. aeruginosa) in vitro. The in vivo studies demonstrated that the CIP-loaded sericin hydrogel effectively eliminated bacteria in wounds and significantly accelerated wound healing. Taken together, this sericin hydrogel system is potentially a promising dressing material for wound management.
研究领域:
生物材料
·
生物医学工程
·
药学
·
组织工程
·
伤口护理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）