MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2012
·Vol. 213
·期 20
·2192-2200
·
IF 2.361
Xiao-Hui Dai,Chun-Yan Hong,Cai-Yuan Pan
A novel double-hydrophilic block copolymer P(MEO 2 MA- co -OEGMA)- b -PAMA has been successfully synthesized by two-step RAFT polymerization. Then, the amino groups of PAMA blocks in the copolymers react with 1-pyrenecarboxaldehyde via a “Schiff-base” reaction, and the resulting copolymers are self-assembled to form spherical micelles in aqueous solution. Because the “Schiff-base” linkage is pH sensitive, the release rate of pyrene depends upon the pH of solution. Complete release is achieved at pH 1, and the control release is much faster at pH 5.5 than that at pH 7.4. With progress of pyrene release, the micelles are disassembled gradually and disappeared completely at last. This double-hydrophilic copolymer is a promising candidate of drug carrier for the aldehyde- containing hydrophobic drugs.
研究领域:
高分子化学
·
药剂学
·
纳米医学
·
生物材料
·
药物递送系统
✓ 已验证
DOI
高影响因子
MONATSHEFTE FUR CHEMIE
·
2014
·Vol. 146
·期 3
·441-447
·
IF 1.347
Li Longfei,Chen Lin,Liu Weifeng,Yang Yongzhen,Liu Xuguang,Chen Yongkang
5-Fluorouracil surface-imprinted thermosensitive magnetic microspheres were prepared by using Fe 3 O 4 -encapsulating carbon microspheres as cores, N -isopropylacrylamide as thermosentitive monomer, ammonium persulfate as initiator, N , N ′-methylenebisacrylamide as crosslinker, and 5-fluorouracil as template molecule. The formation of these hybrid microspheres was verified by field emission scanning electron microscopy, transmission electron microscopy, Fourier transformation infrared spectroscopy, thermogravimetry, and dynamic light scattering. The results of the latter measurements show that the as-synthesized microspheres have a hydrodynamic diameter of 326 nm with the lower critical solution temperature of around 43 °C. The obtained microspheres are magnetic and show good potential for controlled loading and release of 5-fluorouracil. Graphical abstract
研究领域:
药剂学
·
纳米医学
·
肿瘤治疗
·
高分子材料科学
·
靶向给药系统
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2010
·Vol. 55
·期 23
·7102-7108
·
IF 3.325
Huanshun Yin,Qiang Ma,Yunlei Zhou,Shiyun Ai,Lusheng Zhu
The graphene–chitosan composite film modified glassy carbon electrode (GCE) was fabricated and used to determine 4-aminophenol (4-AP). In 0.1 M pH 6.3 phosphate buffer solution , the redox peak currents of 4-AP increased significantly and the peak-to-peak separation decreased greatly at graphene–chitosan composite film modified GCE compared with bare GCE and chitosan modified GCE, indicating that graphene possessed electrocatalytic activity towards 4-AP. The experimental conditions were optimized and the kinetic parameters were investigated. The oxidation mechanism was discussed. Under the optimal experimental conditions, the oxidation peak current was proportional to 4-AP concentration in the range from 0.2 to 550 μM with the correlation coefficient of 0.9930. The detection limit was 0.057 μM (S/N = 3). Using the proposed method, 4-AP was successfully determined in water samples and paracetamol tablets with standard addition method, suggesting that this method can be applied to determine 4-AP in environments and pharmaceuticals.
研究领域:
电分析化学
·
药物代谢
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环境监测
·
生物传感器
·
分子诊断
·
转化医学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2016
·Vol. 217
·期 9
·1047-1056
·
IF 2.495
Liang Qiu,Chao-Ran Xu,Feng Zhong,Chun-Yan Hong,Cai-Yuan Pan
Pure cross-linked spherical micelles, nanowires, and vesicles are successfully fabricated from poly(2-hydroxypropyl methacrylate- b - p -(methacryloxyethoxy)benzaldehyde)s (PHPMA– b –PMAEBAs) through reversible addition-fragmentation chain transfer dispersion polymerization of MAEBA in methanol using PHPMA as a macro-CTA and subsequent cross-linking. The cross-linking reaction is conducted by stirring a mixture of 1,4-butanediamine and the resultant nano-objects in methanol at room temperature. For all polymerizations with feed molar ratios of MAEBA/PHPMA ranging from 75/1 to 240/1, the monomer MAEBA conversions are almost complete, and block copolymers with controlled molecular weight are obtained. The transmission electron microscopy, dynamic light scattering, and gel permeation chromatography results reveal that the following three factors significantly influence the morphology of the nano-objects: the feed molar ratio of MAEBA/PHPMA, the copolymer concentration, and the degree of polymerization of PHPMA. The cross-linked nano-objects are very stable in good solvents, the spheres and nanowires slightly decrease in size after cross-linking, whereas the vesicles slightly increase in size. The cross-linked nano-objects are stable in neutral solutions, but they dissociate in weekly acidic solutions. The loading of 1-pyrenemethylamine (PMA) into the vesicles and the unloading of PMA from the vesicles are studied.
研究领域:
高分子化学
·
纳米材料
·
药物递送
·
生物医学工程
·
胶体与界面科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2020
·
IF 3.905
Yanshuxian Liu,Yilei Fan,Zhongping Huang,Huijun Liu,Lili Wang,Zhenlu Shen,Ichi Watanabe
A novel method based on on-line pyrolytic methylation-gas chromatography/mass spectrometry was established and applied into rapid determination of γ-hydroxybutyric acid (GHB) in human hair. With the pyrolytic methylation by tetramethylammonium hydroxide (TMAH), GHB was converted into its corresponding methyl ester in the pyrolyzer at 500 °C. Thus, GHB in hair samples could be well determined by GC/MS on a capillary column in SIM mode. To obtain optimum methylation conditions, important factors were investigated and then applied to the following experiments. The results were obtained as following: 500 °C as reaction temperature, 2:1 as the proportion of TMAH to GHB. The achieved calibration curve exhibited good linearity with the correlation coefficient of 0.9997 at the concentraion range of 2−200 ng/mg, and relative standard deviation (n = 3) from 1.3 %–7.7 %. The limit of detection and the limit of quantification were down to 0.3 ng/mg and 1.0 ng/mg, respectively. The precision ranged from 2.0 %–7.9 % and the recovery ranged from 98.5 %–107.4 %. The results of on-line pyrolytic methylation-GC/MS were in agreement with those observed by the referenced off-line silylation-GC/MS method. The method was applied to a real case of a woman addicted to GHB, the drug concentration in hair segments of 0−5 cm and 5−10 cm from the root strand well correlated with the use of GHB in different periods of her life. The proposed method demonstrated significant potential in the application of rapid determination for GHB in human hair.
研究领域:
法医毒理学
·
药物代谢
·
分析化学
·
生物样本分析
·
临床化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 21
·期 40
·16028-16034
·
IF 5.101
Jun Shi,Zhengzheng Zhang,Gefei Li,Shaokui Cao
Alginate/CaCO3 hybrid beads with pH- and thermal-responsive drug release properties were prepared under compressed CO2 using aliphatic poly(urethane-amine)s (PU) as the thermal-responsive component. Polyacrylic acid (PAA) was used as a crystal growth additive to control the structure of the hybrid beads. The hybrid beads were characterized by using scanning electron microscopy, X-ray powder diffraction and thermogravimetric analysis. The interaction between PAA and aliphatic PU contributed to the formation of alginate beads with a compact CaCO3 shell. Indomethacin release behaviour was found to be pH- and thermal-responsive. The release profiles were sustained with CaCO3 microparticles, indicating that the compact CaCO3 shell could hinder the permeability of the encapsulated drug and reduce the drug release effectively. The results suggest that the hybrid alginate beads can be used as “smart” polysaccharide materials for sustained dual-responsive drug delivery.
研究领域:
生物材料
·
药物递送系统
·
高分子科学
·
纳米医学
·
药剂学
·
生物化学
·
组织工程
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 50
·108538-108552
·
IF 5.8
Wang Yongqiang,Bai Yibo,Han Che,Li Zaimei,Lun Xiaowen,Zhang Conglu
Graphite-like carbon nitride (g-C 3 N 4 ) is favored for its excellent physicochemical properties. However, the high complexation rate of photogenerated carriers greatly limits its practical applications. Based on this, a novel CQDs-doped carbon nitride nanosheets composite (CNS/CQDs) was prepared and applied to the visible light–induced activation of peroxymonosulfate (PMS) for meloxicam (Mel) and tetracycline (TC) degradation. The photocatalytic degradation of Mel and TC were remarkably promoted in the CNS/CQDs+PMS+vis system. Mel photodegradation of 99.90% was achieved over 30 min with 20 mg CNS/CQDs and 20 mg PMS at pH11. And TC photodegradation of 95.97% was achieved over 45 min with 20 mg CNS/CQDs and 20 mg PMS at nature pH6.5. The TOC mineralization rates of Mel and TC were 75.49% and 52.00%, respectively. The transient photocurrent response and electrochemical impedance measurements (EIS) results indicated that the doping of CQDs could improve the charge transfer efficiency of pure g-C 3 N 4 , and CNS/CQDs had a low charge transfer resistance. Capture experiments and EPR tests explored the effective actives in the CNS/CQDs+PMS+vis system. Possible degradation pathways of Mel were also analyzed. This study provides valid residual drugs degradation under the dual conditions of visible light catalytic oxidation and persulfate oxidation, which will be a novel perspective for advanced oxidation technology to effectively remove organic pollutants from water.
研究领域:
环境科学
·
光催化化学
·
水处理技术
·
纳米材料
·
高级氧化工艺
·
药物代谢
·
环境污染物降解
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Jing Li,Sanming Li,Zhonggui He
In the present work, molecular imprinting silica xerogel (MISX) with selective recognition function aiming to regulate drug therapy was synthesized using biomimetic method with poly(ethyleneimine)s (PEIs) as the polymer template and levorotatory ofloxacin (LOFL) as recognition template. Ultraviolet spectroscopy wavelength scanning was used to test the removal process of LOFL, and characteristics of selective loading ofloxacin (OFL) into MISX were investigated using Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Molecular recognition functionality of MISX was intensively studied, including OFL loading and release. The results suggested that MISX possessed ability to recognize and selectively adsorb LOFL into MISX in OFL aqueous solution. Amorphous phase of adsorbed molecules contributed to molecular recognition because amorphous state increased the stability of LOFL that were selectively adsorbed into MISX, which induced stronger hydrogen bonding formed between LOFL and MISX so as to improve LOFL recognition ability. In vitro release revealed that OFL-MISX tablet initially released LOFL and later gradually OFL into dissolution medium. Thus conversion of drug release with different pharmacological activity had special value in delivering systems.
研究领域:
药剂学
·
药物化学
·
纳米医学
·
生物材料
·
分子识别
·
药物递送系统
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Kaipei Luo,Shaoping Yin,Ruixia Zhang,Hua Yu,Guangji Wang,Juan Li
The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver. In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer. mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase . mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro . More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo , with a TIR of 75.9%. The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
·
分子靶向治疗
·
药物递送系统
·
转化医学
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2022
·
IF 3.656
Liang Qin,Yan Li,Deyun Ma,Fenglan Liang,Lidian Chen,Chenyang Xie,Jiayong Lin,Yani Pan,Guizhen Li,Fenrou Chen,Peiru Xu,Canlin Hong,Jiaxing Zhu
Two transition metal-based MOFs , {[Ni 2 (pip) 2 (bimb) 1.5 ]·2(H 2 O)} n ( 1 ), and {[Zn(pip)(bimb)]·DMF} n ( 2 ) (pip = 5-phenyl-isophthalate, bimb = 1,4-bis(imidazole-1-ylmethyl)benzene) have been successfully prepared. Complex 1 displays a three-dimensional structure with a 7-connected svk topology with a point symbol of (3 3 ∙4 14 ∙5 3 ∙6). Complex 2 performs a two-dimensional (4,4) sql net with channels of 7.0 × 5.5 Å 2 and 10.5 × 4.7 Å 2 along the b and c axis, respectively. The magnetic result of 1 shows an antiferromagnetic coupling between the two metal centers. Desolvated 2 adsorbs around 15.25 wt% 5-fluorouracil (5-FU). The 5-FU was slowly released without any burst release. The degradation of methyl orange caused by oxidizing sulfate radicals (SO 4− ) in a Fenton-like process has also been explored.
研究领域:
无机化学
·
材料科学
·
药物递送
·
环境催化
·
配位化学
✓ 已验证
DOI
高影响因子
Journal of Analytical Methods in Chemistry
·
2022
·Vol. 2022
·期 1
·2565494
·
IF 2.594
Qiulong Zhao,Chunxue Wang,Jiaxin Cheng,Hui Yan,Ling Wang,Dawei Qian,Jinao Duan
According to the sixth edition of China’s “New Coronavirus Diagnosis and Treatment Plan (NCDTP),” ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested to take with extreme caution and full reasons. Therefore, we aim to describe the pharmacokinetics of seven active phytochemicals and semiquantification of nine relevant metabolites in ReDuNing injection (RDN) after combining with cefuroxime sodium (CNa) for injection in rat plasma. Male Sprague–Dawley rats were randomly assigned to six groups, and they were intravenously administered, respectively, with different prescriptions of RDN (2 mL/kg) and CNa (225 mg/kg). At different time points (0.03, 0.08, 0.17, 0.24, 0.33, 0.50, 0.67, 1, and 6 h) after administration, the drug concentrations of iridoids glycosides, organic acids, and metabolites in rat plasma were determined using ultrahigh-pressure liquid chromatography coupled with linear ion rap-orbitrap tandem mass spectrometry (UHPLC–LTQ–Orbitrap–MS), and main pharmacokinetic parameters were estimated by noncompartment model. The results showed that there were differences in pharmacokinetic parameters, AUC (0-t) , T 1/2 , C max , CL of iridoids glycosides, and organic acids, after the intravenous administration of the different combinations of RDN and CNa. Moreover, different combinations of the injections also resulted in different curves of relative changes of each metabolite. The obtained results suggested that RDN and CNa existed pharmacokinetic drug–herb interactions in rats. The findings not only lay the foundation for evaluating the safety of RDN injection combined with CNa but also make contributions to clinically applying RDN injection combined with CNa, which works potentially against severe forms of COVID-19.
研究领域:
药理学
·
药物代谢
·
中药学
·
临床药学
·
分析化学
·
病毒学
·
转化医学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 112
·111217-111225
·
IF 3.289
Sijie Zhao,Huiru Yang,Cai Zuo,Lu Sun,Liwei Ma,Hua Wei
Star-shaped polymers are attractive as drug carriers due to the integration of relatively easy synthesis compared to the preparation of hyper-branched dendrimers and their potential ability to form unimolecular nanoparticles with enhanced stability to survive the high dilution-associated deformation and subsequently premature drug release in the body fluids and blood during circulation. Clearly, the star structure exerts a significant effect on their bioproperties and potential applications. In this study, three star-shaped amphiphilic copolymers with the same polymer compositions but different star structures were synthesized to investigate the effect of star architecture on their properties as well as potential applications as drug carriers. Three different branched alcohols, 2-(hydroxymethyl) propane-1,3-diol, pentaerythritol and dipentaerythritol with 3, 4, and 6 respective hydroxyl groups were chosen as the starting core to generate the target star-shaped amphiphilic block copolymers composed of hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(oligoethyleneglycol methacrylate) (POEGMA) with 3, 4, and 6 corresponding star arms by a combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Dynamic light scattering (DLS) measurements and pyrene fluorescence probe technique confirmed the capability of the resultant star-shaped amphiphilic copolymers to form unimolecular micelles with average diameters smaller than 50 nm in an aqueous phase. A comparison of the drug loading capacity revealed that the micelles of 4-star-PCL–POEGMA (4s-PCL–POEGMA) exhibited the highest drug loading content (DLC) of all the three formulations. More importantly, in vitro doxorubicin (DOX) release study showed unique pH-mediated drug release behaviors, i.e., dramatically accelerated release at pH 6.0 but a much slower profile at pH 7.4, from these generally recognized “pH-insensitive” 4-arm star-shaped micelles. An acid-triggered degradation and an acid–base titration were performed to further reveal that such interesting pH-responsive drug release behaviors were attributed primarily to the hydrophilic corona of OEG brushes. This study is believed to provide a new insight into the structure–bioproperties relationship of star-shaped polymers, thus should be useful for the future design and development of novel star-shaped polymers for controlled drug delivery.
研究领域:
高分子药剂学
·
纳米医学
·
药物控释
·
生物材料
·
药剂学
·
肿瘤治疗
·
纳米载体
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）