JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Yuying Wang,Xiutao Yang,Guopeng Zhu,Haibin Niu,Shaoqing Zhang,Quanying Wang,Hongwen Yu
The accurate non-enzymatic electrochemical detection of glucose is constrained by sluggish charge transfer kinetics and non-optimized adsorption of reaction intermediates on single-phase transition metal oxide. Herein, we rationally design heterojunction Co 3 O 4 /NiMoO 4 hierarchical arrays, where a spontaneous built-in electric field (BEF) is formed at the p-n hereo-interface due to the precise work function difference in NiMoO 4 and Co 3 O 4 . This BEF directionally drives electrons from NiMoO 4 to Co 3 O 4 at 0.16 |e|, as confirmed by DFT charge density and Bader charge analysis, thereby accelerating glucose electrocatalytic oxidation kinetics. Moreover, the hierarchical structure of Co 3 O 4 nanoneedles grown on NiMoO 4 nanorods enhances the electrochemical active area and introduces dual catalytic sites of Co and Ni atoms, whose d-band centers are modulated to weaken excessive adsorption at Co sites while maintaining Ni activity. As a results, the assembled sensor achieves an ultrahigh sensitivity of 28,470 μA mM −1 cm −2 , a low detection limit of 0.396 μM and excellent recovery rates (94.6%–105.6%) in complex real samples. This work demonstrates that resolving the charge transfer and adsorption trade-off via BEF-engineered heterostructure offers a generalizable route for high-performance sensing. Download: Download high-res image (156KB) Download: Download full-size image
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 8
·522
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IF 5.4
Qiao Yuchun,Wu Yiying,He Jiahui,Chen Wen,Fan Jiaqi,Zhang Zhicong,Shen Jialu,Su Mengping,Wang Qidong,Li Shuai,Shen Yingjie,Shang Jizhen,Wang Hua
Glucose is a vital energy source, and its accurate monitoring is crucial for the diagnosis and management of metabolic diseases. Herein, we report a simple colorimetric sensing platform for glucose detection based on MnO 2 /Au-Ag nanozymes, glucose oxidase (GOx), and 3,3′,5,5′-tetramethylbenzidine (TMB). In this cascade system, GOx catalyzes the oxidation of glucose to generate H 2 O 2 , which is subsequently decomposed by MnO 2 /Au-Ag to produce reactive species that oxidize TMB, yielding a visible blue signal. The incorporation of Au-Ag nanoparticles provides additional catalytic sites and promotes interfacial electron transfer, thereby enhancing the catalytic performance of MnO 2 . The platform exhibits a linear response over 0.025-0.20 mM with a detection limit of 0.012 mM. It enables reliable glucose detection in artificial sweat and 80-fold diluted serum samples. In addition, portable nitrocellulose test strips were developed for visual and smartphone-assisted glucose detection. This strategy provides a simple and portable approach for low-concentration glucose analysis and offers potential for point-of-care applications after further validation. Graphical
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Nature Communications
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2026
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IF 18.1
Han Zilong,Lu Yuchen,Yang Hua,Mu Yan,Li Siming,Wang Jiahao,Yang Wei,Qu Shaoxing
Water in hydrogels has often been overlooked or deemed detrimental to the mechanical properties of hydrogels due to the plasticizing effect of water, which weakens interchain interactions and accelerates crack propagation. Here, we propose a slow-water strategy that imparts enhanced fracture resistance to hydrogels. By converting free water into slowly migrating intermediate water, we suppress excess chain mobility by reducing the free volume around polymer chains, thereby enhancing interchain interactions and substantially extending the load-transfer length. Notably, even with only 13% polymer content and without additional network design, the hydrogels achieve orders-of-magnitude improvements in fracture toughness and fatigue threshold solely through medium design, and these enhancements are demonstrated to be dominated by the intermediate water. The strategy demonstrates versatility, providing insights into the role of intermediate water in biological systems and enabling innovative approaches to reinforcing biomimetic materials under complex stress conditions.
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Materials Today Bio
·
2026
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IF 11
Yongguo Xiang,Jiaojiao Kou,Huijie Cao,Yuhui Zhang,Hong Cheng,Tu Wang,Jialing Jiang,Shuren Pan,Juan Kang,Yuanfu Ding,Wenjuan Wan,Shijie Zheng,Man Li,Xiaobei Huang,Ke Hu
Ocular fundus diseases—including age-related macular degeneration and diabetic retinopathy—are leading causes of irreversible vision loss worldwide. Current macromolecular therapies require frequent intravitreal injections, which increase patient burden and complication risks. To address these limitations, we engineered a macrophage membrane-biomimetic nanovesicle encapsulating ranibizumab (designated M@R) for noninvasive ocular delivery and selective targeting of inflammatory lesions in the posterior segment. In vitro studies demonstrated that M@R retained potent cytokine-scavenging activity against key pro-inflammatory mediators, and the macrophage membrane coating significantly enhanced transcytosis-mediated transport of ranibizumab across ocular epithelial barriers. Ex vivo and in vivo studies confirmed that M@R is capable of noninvasive traversal of ocular barriers, achieving targeted delivery to inflammatory lesions within the fundus. In a laser-induced choroidal neovascularization (CNV) mouse model, topical ocular administration of M@R significantly reduced both the area and thickness of CNV, attributable to its dual anti-inflammatory and anti-VEGF activities. Although multiple dosing was required to achieve therapeutic efficacy comparable to that of a single intravitreal ranibizumab injection, M@R exhibited markedly improved safety profiles, with no observable local ocular toxicity or systemic adverse effects following repeated administration. Collectively, these findings establish macrophage membrane-coated nanovesicles as a promising platform for barrier-penetrating, inflammation-targeted delivery of biologics in the treatment of fundus diseases.
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Cunxian Lai,Wentian Zhang,Fangang Meng,Shanshan Zhao
Precise ion sieving by polyamide (PA) nanofiltration (NF) membranes relies on narrowly distributed subnanometer pores and tailored surface chemistry, yet simultaneously controlling both within a single interfacial polymerization (IP) process remains challenging. Here, we developed a density contrast-assisted sequential immersion strategy by preloading a porous substrate with a polyethyleneimine (PEI)/sucrose phase before piperazine (PIP) immersion. The preloaded phase regulated PIP storage and interfacial supply, enabling rapid PIP-dominated film formation and diffusion-limited growth, while limited PEI near the initial interface may participate in reaction before interfacial sealing. This reaction-diffusion process produced a thinner selective layer with an MWCO of approximately 190 Da, a narrowed pore-size distribution, and modified chemical and electrostatic characteristics. The resulting sequential immersion membrane (SIM-PA) achieved a Li + /Mg 2+ selectivity of 28.7 at a Mg 2+ /Li + mass ratio of 100:1 and maintained stable separation under moderately elevated salinity. Transport analysis suggested that the enhanced Mg 2+ /Li + discrimination mainly originated from strengthened steric and dielectric exclusion during ion partitioning and diffusion. Integrated with multistage NF and evaporation-precipitation, SIM-PA enabled lithium recovery from both simulated salt-lake brine and spent lithium-ion battery discharge wastewater. This work establishes density contrast-assisted sequential monomer loading as a practical route to NF membranes with narrow pore-size distributions for lithium recovery from complex saline streams.
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npj Science of Food
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2026
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IF 9.7
Mao Yuezhong,Qi Xiangcao,Liu Chenchen,Wang Yun,Bai Jinxia,Ke Lijing,Tian Shiyi
Reducing sugar content while maintaining palatability remains challenging, particularly when functional ingredients introduce bitterness. However, sweet-bitter interactions are rarely quantified at detection and discrimination thresholds. In this study, we applied a threshold-based psychophysical approach to characterise the bidirectional modulation between sucrose and three bitterants: iso-α-acid, epigallocatechin gallate, and quinine hydrochloride. Absolute and difference thresholds were determined under reciprocal background concentrations, concentration-difference strength functions were established, and a computable bidirectional interaction model was developed using quinine hydrochloride as a representative bitter compound. The absolute thresholds were 0.173% w/v for sucrose, 0.00018% w/v for iso-α-acid, 0.0093% w/v for epigallocatechin gallate, and 0.00025% w/v for quinine hydrochloride, indicating the following bitterness potency order: iso-α-acid > quinine hydrochloride > epigallocatechin gallate. The Weber fraction was 18.43% for sucrose and 11.09%, 21.40%, and 21.24% for iso-α-acid, epigallocatechin gallate, and quinine hydrochloride, respectively. Under sucrose backgrounds ranging from 1% to 8%, bitter absolute thresholds increased by 188.9% for iso-α-acid, 201.1% for epigallocatechin gallate, and 28.0% for quinine hydrochloride, while the corresponding Weber fractions increased by 148.9%, 51.2%, and 45.0%, respectively. Conversely, bitter backgrounds increased the sucrose absolute threshold by 74.1% to 116.2%. Despite these threshold shifts, the concentration–difference strength functions remained consistent with Weber–Fechner behaviour, with R 2 values greater than 0.97. These findings provide a quantitative, compound-specific framework for preserving perceived sweetness and mitigating bitterness in sugar-reduced food formulations.
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Energy & Environmental Materials
·
2026
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IF 13.8
Lingni Yang,Wei Li,Chunran Wu,Qing Zhang,Fenglin Wang,Xingyu Chen,Haijun Mao,Zhuofeng Liu,Hu Ye,Yujiu Zhou,Fujia Chen,Weijun Zhang
Dielectric capacitors are pivotal components in advanced electronic systems, yet their practical applications are hindered by the low volumetric energy density of commercial dielectric materials. Herein, a facile and scalable densification strategy is proposed to fabricate high-performance all-organic composite films by incorporating sucrose, a cost-effective and hydroxyl-rich disaccharide, into a poly(vinylidene fluoride-co-hexafluoropropylene) [P(VDF-HFP)] matrix. Benefitting from its abundant hydrogen-bonding sites, sucrose forms robust hydrogen-bonded crosslinking networks with P(VDF-HFP) chains. Those networks untangle and rearrange molecular chains, prompting the transformation from the non-polar α phase to the polar β / γ phases, while simultaneously elevating crystallinity and constricting amorphous chain spacing to diminish free volume for film densification. By integrating density functional theory calculations, molecular dynamics simulations, and comprehensive experimental characterizations, this study elucidates a novel “Hydrogen-bond Crosslinking-Densification” synergistic regulation mechanism at the molecular and mesoscopic scales. Consequently, the optimized P(VDF-HFP) composite film with 0.8 wt% sucrose achieves a significant breakdown strength of 627.84 MV m −1 and an ultrahigh discharged energy density of 31.86 J cm −3 , exhibiting a competitive discharged energy density among all-organic counterparts. This work bridges the gap between molecular-scale interactions and macroscopic dielectric performance via free volume theory, offering a scalable and cost-effective pathway for designing high-performance dielectric materials.
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Next Materials
·
2026
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IF 4.7
Zhichun Si,Xinhua Zhou,Haofeng Wu,Chunguang Wei,Feiyu Kang
Zinc anodes suffer from dendrite growth and side reactions, limiting Coulombic efficiency (CE) and cycling stability. Constructing a stable solid electrolyte interphase (SEI) is critical, yet the electrolyte structure–SEI relationship remains unclear. Here, we introduce tetraethylene glycol dimethyl ether (TEGDME) into aqueous Zn(OTf) 2 electrolyte. Unlike conventional additives, TEGDME does not enter the primary Zn(H₂O)₆²⁺ solvation shell but alters the secondary solvation shell, disrupting hydrogen bonding and facilitating solvent−separated ion pairs (SSIPs, e.g., Zn 2 + –H 2 O–OTf⁻). This creates an “organic–inorganic hybrid” solvation structure, leading to a gradient hybrid SEI with a ZnF₂−rich outer layer and an inner layer enriched in organic species, ZnS, and ZnCO 3 . This SEI enables dendrite−free Zn deposition and suppresses side reactions. Consequently, the Zn||Cu cell achieves 99.76% CE, the Zn||Zn symmetric cell cycles for 2400 h, and the Zn||VOH full cell retains 80% capacity after 1100 cycles, far outperforming the unmodified electrolyte.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Xinming Wang,Weichang Xie,Zichen Wang,Haonan Zhang,Jia Li,Xingjian Gao,Dingjie Zhou,Huaiyu Jiang,Shixing Huang,Qiang Zhao,Xiaofeng Ye
Repairing anisotropic tissues such as the myocardium requires implanted cells to organize into highly ordered structures. However, achieving controlled cell alignment remains a major challenge for current cell delivery patches. Here, we develop a magnetically aligned, fiber-reinforced extracellular matrix (ECM) patch that directs anisotropic cell organization and supports stem cell implantation. Poly-lactic acid fibers containing Fe 3 O 4 are fabricated via electrospinning and controlled hydrolysis, and are aligned uniaxially within ECM hydrogels using an external magnetic field prior to gelation. The resulting ECM–fiber patches exhibit enhanced mechanical strength and reliably guide the alignment of cardiomyocytes, fibroblasts, and endothelial cells. A beating patch is also created by seeding human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). In a nude mouse myocardial infarction (MI) model, implantation of iPSC-CMs@ECM–fiber patches preserves cardiac function, reduces apoptosis, limits fibrosis, and enhances vascularization. Implanted iPSC-CMs demonstrate high viability and low immunogenicity. Molecular profiling reveals transient modulation of early inflammatory responses post-MI, probably mediated through IL-17, IL-3, and IL-1β pathways. Overall, the ECM–fiber patch provides a versatile platform for delivering highly organized cells for in vivo tissue repair.
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Small Methods
·
2026
·
IF 8.7
Dalong Ma,Meichen Wen,Zhipeng Wang,Jintao He,Wenbin You,Guozhen Zhu,Limin Wu,Renchao Che
Magnetic alloy/carbon composites are promising microwave absorbers due to abundant interfaces and multiple loss mechanisms. However, reducing carbon content while maintaining uniform magnetic component distribution remains challenging. We report a spray-drying strategy to address this. By tuning nitrate precursor ratios and optimizing thermal treatment, we synthesize low-carbon alloy/oxide microspheres with uniformly distributed alloy phases. Limiting carbon content improves impedance matching, while selective nitrate precipitation creates a magnetic alloy architecture that suppresses nanoparticle agglomeration and enhances interfacial polarization. For this multiscale synergistic polarization is achieved: highly conductive Cu maximizes conduction loss, insulating Al 2 O 3 buffers impedance, and Mn provides abundant polarization centers. The resulting microspheres exhibit tunable, exceptional performance. The attenuation-dominated FeCuMn system achieves −48.2 dB minimum reflection loss at 1.5 mm thickness. The impedance-matched FeCuAl system delivers an ultra-broad effective absorption bandwidth (EAB) of 5.12 GHz. Additionally, the FeAlMn system demonstrates superior polarization miniaturization for optimal absorption at extremely thin matching thicknesses. This work provides a practical strategy for designing electromagnetic composite structures with tunable component distribution.
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JOURNAL OF HAZARDOUS MATERIALS
·
2026
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IF 10.6
Hao Hu,Yuxin Sun,Ruomiao Yang,Qian Hu,Bryan W. Brooks,Huizhen Li,Jing You
The tire-derived contaminant N -(1,3-dimethylbutyl)- N ′-phenyl- p -phenylenediamine quinone (6PPD-Q) is widespread in aquatic ecosystems and poses significant ecological risk. As a chiral compound, its enantiomers may exhibit differential toxicity, yet the underlying mechanisms remain limited. Here, we found that (+)-6PPD-Q was 2.4-fold more toxic to rainbow trout than (-)-6PPD-Q ( p < 0.05). In addition, in vitro metabolism assays using liver S9 fraction showed that (+)-6PPD-Q was metabolized 2.5-fold faster than (-)-6PPD-Q. Semi-quantitative nontarget analysis revealed that hydroxylated metabolites dominated the phase I metabolism. We identified metabolites with 3.5- and 1.5-fold lower toxicity than (+)-6PPD-Q and (-)-6PPD-Q, respectively, indicating that metabolism primarily serves as a detoxification pathway and does not explain enantioselective toxicity in vivo . To resolve this discrepancy, we systemically characterized the in vivo enantioselective toxicokinetics of 6PPD-Q enantiomers for the first time. (+)-6PPD-Q exhibited a significantly higher uptake rate and slower elimination rate, leading to 4–9-fold greater bioaccumulation. This predominant accumulation outweighed faster metabolism than (-)-6PPD-Q, resulting in substantially higher internal concentrations and ultimately greater toxicity of (+)-6PPD-Q. Neglecting enantiomer-specific bioaccumulation and elimination could substantially underestimate risks of chiral pollutants such as 6PPD-Q in aquatic systems. Our findings demonstrate that enantioselective toxicity of 6PPD-Q is governed by whole toxicokinetics rather than metabolism alone, highlighting the necessity of incorporating enantioselective toxicokinetic analysis into ecological risk assessment of chiral contaminants.
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MICROCHEMICAL JOURNAL
·
2026
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IF 5.2
Jingjing Liu,Shikun Liu,Weijia Li,Hongwei Yu,Dongfu Xu,Tianhui Huang,Yan Zhang,Jiale Kuang
In the study of taste perception, researchers aim to achieve the goal of simulating the human tongue’s sensory process through machines, and reproducing taste functions in vitro. Based on the principle of astringency perception, a tongue-mimicking gel sensor was designed based on the principle of astringency perception, replicating its composition, content, and cross-linked structure. This design enables the sensor’s internal signal variations to closely reproduce the key molecular dynamic processes of the salivary pellicle, thereby achieving in vitro simulation of polyphenol-induced astringency. However, conventional tongue-mimicking gel sensor analyses rely solely on conductivity signals, which are insufficiently comprehensive and insufficient to capture the complex dynamics of the sensing process. To address this limitation, in-depth research into the reaction kinetics within the tongue-mimicking gel sensor is essential for a more precise interpretation of oral astringency perception mechanisms. Consequently, developing feature processing methods capable of analyzing dynamic changes – such as molecular recognition and signal conversion within the system – has emerged as a critical scientific challenge requiring important resolution. Therefore, the present study employs electrochemical impedance spectroscopy (EIS) combined with signal transduction analysis within the tongue-mimicking gel sensor to establish an equivalent circuit model. This model enables stage-by-stage interpretation of the reaction kinetics through the variations in component parameters. Through systematic analysis of how these parameters change with astringent compound concentrations and investigation of their correlation with the sensor’s conductivity, the magnitude of the constant phase element parameter Q (CPE-Q) was extracted as the most significant feature. The variations in CPE-Q reflect its crucial role in both signal transduction and astringency sensing, making it a key parameter for characterizing the sensor’s dynamic response mechanism. This newly developed feature selection method for the tongue-mimicking gel sensor utilizes the CPE-Q parameter to comprehensively capture the dynamic information involved in astringency recognition. By effectively overcoming the informational limitations inherent in traditional conductivity-based measurements, this approach achieves a significant improvement in prediction accuracy. Furthermore, based on this advancement, the study establishes a theoretical model that enables systematic analysis of the molecular dynamics underlying astringency recognition within the sensor system. This model bridges biomimetic sensing signals with physiological taste mechanisms, thereby providing a novel platform and perspective for mechanistic research and application development in related fields.
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