POLYMER BULLETIN
·
2023
·Vol. 80
·期 12
·12539-12556
·
IF 3.2
An Li,Chen Yinjie,Song Jing,Zhang Xinlin,Li Zhongxiao
A reactive quaternary ammonium salt containing double bonds, N -(2-(acryloyloxy)ethyl)- N -allyl- N , N -dimethyl-ammonium bromide (AEADAB), was synthesized by the reaction of 2-(dimethylamino)ethyl acrylate with allyl bromide. Acrylate-functional poly(acrylonitrile–styrene) (PAS) latex particles were prepared by a two-step method. First, the mini-emulsion polymerization of styrene and acrylonitrile in the presence of a reactive emulsifier (SE-10N) was employed to prepare the PAS particles. The PAS latex was then precipitated via ion-exchange reaction with AEADAB aqueous solution to obtain the AEADAB-modified acrylate-functional PAS latex particles. The PAS latex was also treated with tetrabutylammonium bromide (TBAB) aqueous solution to prepare the TBAB-modified latex particles. The modified latex particles could be re-dispersed in some organic solvents such as 2-butanone, acetone, 1,4-dioxane and tetrahydrofuran to form stable non-aqueous dispersions. In addition, a water-dispersible multi-acrylate polymer (M-PMVMA) was prepared by the reaction of poly(methylvinylether-alt-maleicanhydride (PMVMA) with methoxypolyethylene glycol and 2-hydroxyethyl acrylate. Coating solutions were prepared with the polymer particles, M-PMVMA, iodonium bis(4-methylphenyl)hexafluorophosphate, and a near-infrared (NIR) absorbing agent (IR830). The NIR radiation-sensitive coating was prepared by applying the coating solution onto the aluminum lithographic substrate. An infrared laser exposure and processing of the exposed coating formed a visible image on the substrate. The image quality and image adhesion to the substrate was investigated. Results showed that the NIR radiation-sensitive coating worked by heat-induced coalescence of the polymer particles and free radical crosslinking polymerization occurred during the exposure step. The coating derived from AEADAB-modified acrylate-functional PAS latex particles provided a better image quality compared with that derived from TBAB-modified PAS latex particles.
研究领域:
材料科学
·
化学工程
·
印刷技术
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Rixiang Su,Peiyuan Li,Ying Zhang,Yingbin Lv,Fangzhou Wen,Wei Su
The design and development of smart shape-adaptable wound dressings with superior antimicrobial ability remain a challenge in therapeutic and clinical application. Herein, polydopamine/tannic acid/chitosan/poloxamer 407/188 hydrogel (PTCPP) was prepared with the aim of developing an in situ -formed antibacterial wound dressing with temperature stimulation and near-infrared radiation (NIR) responsive ability. PTCPP possessed injectability, photothermal stability, sustained release properties and cytocompatibility. In vitro antibacterial results showed that the bactericidal rates of PTCPP against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) under NIR irradiation were 99.994 % and 99.91 %, respectively. In vivo experiments, PTCPP can adapt to shape of the wound, showing good adhesion, while promoting wound healing in bacterial infections. Therefore, PTCPP has potential application in the treatment of infectious wounds, and provides a strategic choice for developing antibacterial wound dressing combined with photothermal therapy.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2024
·
IF 4.4
Duoduo Zhang,Shiyue Bie,Mhd Anas Tomeh,Xinyu Zhang,Xiubo Zhao
Antimicrobial resistance (AMR) has emerged as a significant threat to human health. Antimicrobial peptides (AMPs) have proven to be an effective strategy against antibiotic-resistant bacteria, given their capacity to swiftly disrupt microorganism membranes and alter cell morphology. A common limitation, however, lies in the inherent toxicity of many AMPs and their vulnerability to protease degradation within the body. Photothermal therapy (PTT) stands out as a widely utilized approach in combating antibiotic-resistant bacterial infections, boasting high efficiency and non-invasive benefits. To enhance the stability and antibacterial efficacy of AMPs, a novel approach involving the combination of AMPs and PTT has been proposed. This study focuses on the encapsulation of At10 (an AMP designed by our group), and copper sulfide nanoparticles (CuS NPs) within zeolitic imidazolate framework-8 (ZIF-8) to form nanocomposites (At10/CuS@ZIF-8). The encapsulated CuS NPs exhibit notable photothermal properties upon exposure to near-infrared radiation. This induces the cleavage of ZIF-8, facilitating the release of At10, which effectively targets bacterial membranes to exert its antibacterial effects. Bacteria treated with At10/CuS@ZIF-8 under light radiation exhibited not only membrane folding and intracellular matrix outflow but also bacterial fracture. This synergistic antibacterial strategy, integrating the unique properties of AMPs, CuS NPs, and pH responsiveness of ZIF-8, holds promising potential for widespread application in the treatment of bacterial infections.
研究领域:
生物医学工程
·
纳米技术
·
微生物学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale Advances
·
2021
·Vol. 3
·期 12
·3481-3490
·
IF 4.553
Xueyi Guo,Sheng Liu,Weijia Wang,Chongyao Li,Ying Yang,Qinghua Tian,Yong Liu
Recombination centers generated from structural and interfacial defects in nanoheterostructures (NHs) prevent effective photo-induced charge transfer and have blocked the advance of many photoresponsive applications. Strategies to construct high-quality interfaces in NHs are emerging but are limited in the release of interfacial strain and the integrality of the sublattice. Herein, we synthesize single-particulate Cu1.94S–ZnS NHs with a continuous sublattice using a nanoscale cation exchange reaction (CE). Under near-infrared (NIR) radiation (λ = 1500 nm), femtosecond open-aperture (OA) Z-scan measurements are applied to investigate the nonlinear optical features of samples and verify the existence of plasma-induced charge transfer in the Cu1.94S–ZnS NHs system. The resulting charge transfer time (τCT) of ∼0.091 picoseconds (ps) was confirmed by the femtosecond time-resolved pump–probe technique. Such an ultrafast charge transfer process has been rarely reported in semiconductor–semiconductor NHs. The results suggest that CE can be used as a promising tool to construct well-ordered interfacial structures, which are significant for the performance enhancement of NHs for photon utilization.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
光子学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Yongjun Luo,Xiaoping Zhu,Jun Qian,Yiyi Yu,Jing Li,Zhiyong He,Suyan Duan,Honglei Guo,Xiangchun Shen,Qianqian Guo
Overuse of antibiotics has led to an increased threat of drug-resistant pathogens and sustained chronic infections, suggesting an urgent need for effective strategies against drug-resistant bacterial infections. Herein, we developed au gold nanorods coated with pH-responsive polymers (GNR-DPArPEGMA) for photothermal therapy against multidrug-resistant bacteria. The size and zeta potential of GNR-DPArPEGMA was 78 nm and −37.96 mV, respectively. In subacidic conditions, the nanocomposite surface was positively (14.18 mV) charged, leading to better bacterial adhesion and antibacterial efficiency. The nanocomposites showed augmented in vitro photothermal efficiency up to 70 °C under 808 nm irradiation for 3 min, which further demonstrated an enhanced photothermal bacteria-killing efficiency. The in vivo assays showed that GNR-DPArPEGMA irradiated with near-infrared radiation could treat a drug-resistant Staphylococcus aureus-caused subcutaneous abscess and drug-resistant Pseudomonas aeruginosa-caused pneumonia while reducing the number of bacteria and attenuating inflammation in the infected sites. These results indicate that the nanocomposites could be used as a potential photothermal agent to combat drug-resistant bacterial infections in the future.
研究领域:
纳米技术
·
生物医学工程
·
微生物学
·
治疗学
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Yannan Cheng,Yuanfang Huo,Yongle Yu,Ping duan,Xianzhen Dong,Zirui Yu,Qiang Cheng,Honglian Dai,Zhenyu Pan
Managing bone defects remains a formidable clinical hurdle, primarily attributed to the inadequate orchestration of vascular reconstruction and osteogenic differentiation in both spatial and temporal dimensions. This challenge persists due to the constrained availability of autogenous grafts and the limited regenerative capacity of allogeneic or synthetic bone substitutes, thus necessitating continual exploration and innovation in the realm of functional and bioactive bone graft materials. While synthetic scaffolds have emerged as promising carriers for bone grafts, their efficacy is curtailed by deficiencies in vascularization and osteoinductive potential. Nitric oxide (NO) plays a key role in revascularization and bone tissue regeneration, yet studies related to the use of NO for the treatment of bone defects remain scarce. Herein, we present a pioneering approach leveraging a photothermal-responsive system to augment NO release. This system comprises macromolecular mPEG-P nanoparticles encapsulating indocyanine green (ICG) (NO-NPs@ICG) and a mPEG-PA-PP injectable thermosensitive hydrogel carrier. By harnessing the synergistic photothermal effects of near-infrared radiation and ICG, the system achieves sustained NO release, thereby activating the soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signaling pathway both in vitro and in vivo. This orchestrated cascade culminates in the facilitation of angiogenesis and osteogenesis, thus expediting the reparative processes in bone defects. In a nutshell, the NO release-responsive system elucidated in this study presents a pioneering avenue for refining the bone tissue microenvironment and fostering enhanced bone regeneration.
研究领域:
生物材料
·
组织工程
·
再生医学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 20
·14456-14468
·
IF 2.993
Dou Qianqian,Wong Ka Wai,Li Yang,Ng Ka Ming
The localized surface plasmon resonance (LSPR) behavior of indium-doped ZnO (IZO) nanocrystals synthesized in different solvents was studied. 1-octadecanol, oleic acid, oleyl alcohol, oleyl amine and 1-octadecene were used as solvent(s) and co-solvent(s) in the pyrolysis synthesis of indium-doped ZnO (IZO) nanoparticles. The results showed that the nanocrystals from a solvent system consisting of 1-octadecene, 1-octadecanol, and oleic acid exhibited enhanced LSPR near-infrared radiation absorption without sacrificing transparency in the visible region. The indium-rich core verified using ICP and XPS analysis was shown to be critical for the enhancement. The reaction mechanism of solvents on the generation of indium-rich core was elucidated through a systematic study of the reaction parameters. The interaction between the activating agent, inhibiting agent and solvent, and their effect on tuning the reactivity of dopant and host precursors were important for the formation of a nanostructure with a dopant-rich core. The solvent effect was also found in the synthesis of gallium-doped ZnO and confirmed to be a general phenomenon in the preparation of doped ZnO nanoparticles.
研究领域:
材料科学
·
纳米技术
·
光学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2016
·
IF 2.267
Guanru Chang,Shikuo Li,Fangzhi Huang,Xiuzhen Zhang,Yuhua Shen,Anjian Xie
To combine localized drug release with multimodal therapy for malignant tumor, a composite hydrogel as an integrative drug delivery system was facilely prepared. The system contains spinach extract (SE), reduced graphene oxide (rGO) and gold nanocages (AuNCs). SE conduces to the formation of hydrogel, and also serves as a green material for improving the biocompatibility of hydrogel, and a natural photosensitizer for killing tumor cells under laser radiation (660 nm). AuNCs show obvious photothermy and can enhance the generation of cytotoxic singlet oxygen ( 1 O 2 ). The composite hydrogel shell on tumor cells exhibits several competitive advantages including enhanced antitumor effect by retaining the high concentration of drugs around cancer cell, excellent PDT/PTT compatibility as well as high loading and controllable release of fluorouracil (5-FU) for synergetic multimodal treatment. The survival rate of HeLa cells incubated with 5-FU loaded hydrogel under NIR radiation for 10 min sharply decreases to 1.2%, indicating remarkably improved antitumor effects. These results demonstrate that the hydrogel is an excellent delivery carrier for localizable, NIR-responsive and combined PTT/PDT/Chemo synergetic antitumor.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
癌症研究
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yu Zhang,Weichen Sun,Zhe Cui,Yong Wang,Wenjuan Li,Chengyan Zhou,Mingtao Run,Shuai Guo,Jianglei Qin
Designing hydrogel dressing with intrinsic antibacterial property to promote skin injury recovery remains a significant challenge. In this research, poly(aspartic hydrazide) with grafted betaine (PAHB) was designed and reacted with oxidized dextran (OD) to fabricate biodegradable PAHB/OD hydrogel and its application as wound dressing was systematically investigated. The PAHB/OD hydrogels exhibited fast gelation, strong tissue adhesion, preferable mechanical properties and biocompatibility. The grafted betaine endowed the hydrogel with antibacterial property and antibacterial rate enhanced through photothermal performance of composited CuS nanoparticles under near infrared (NIR) radiation. The CuS composited PAHB/OD hydrogel (CuS/hydrogel) with microporous morphology was used as burn wound dressing with loaded anti-inflammatory drug diclofenac sodium (DS) in mouse model. The results showed the DS loaded CuS/hydrogel (CuS@DS/hydrogel) promoted the tissue regeneration and suppressed the inflammatory response. The histological analysis and immunohistochemical expression confirmed the CuS@DS/hydrogel promote angiogenesis of the burn wound by regulating the expression of inflammatory cytokines (IL-6 and CD68) and vascular endothelial growth factor (VEGF). Overall, the CuS@DS/hydrogel hydrogel is a promising candidate as wound dressing due to its tissue adhesive, antioxidant, antibacterial and anti-inflammatory activities.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Fenghua Wang,Jiahua Sun,Hui Shi,Jie Zhou,Xiaoke Ma,Xiaolu Song,Xianhao Su,Lei Liu
Hemostasis and anti-infection are crucial for emergency treatment of severe trauma. Developing functional biomaterial with efficient hemostasis, antibacterial activity and wound healing is of great social significance and clinical value to fast stop bleeding and save lives, but it is still challenged. Here we designed a series of multifunctionalized SA/PDA cryogels by using two-step cross-linking of dopamine and sodium alginate. The resulting interpenetrating network structure had good swelling ratio, excellent mechanical and shape memory properties. Compared with cotton gauze and gelatin sponge, the cryogels exhibited excellent activation of coagulation cascade, more blood cells and platelet adhesion . Due to the action of polydopamine, the cryogel also showed good antioxidant activity and photothermal antibacterial ability assisted by near-infrared radiation, as well as better wound healing performance than gelatin sponge and Tegaderm™ film. Moreover, in the tests of mouse tail docking model, rat femoral artery hemostasis model and non-compressible rabbit liver defect model, the treatment by SA/PDA cryogels presented less blood loss and shorter hemostasis time than cotton gauze and gelatin sponge. Therefore, SA/PDA cryogels with simple preparation process, low cost, and good biocompatibility would be applied in the variety of great clinical applications in bleeding control, anti-infection and wound healing, etc.
研究领域:
生物材料
·
止血
·
抗菌材料
·
伤口愈合
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Li Sun,Tao Li,Binglin Li,Yingshu Guo
A bispecific thermosensitive system was created to deliver drugs and aid T cells in identifying cancer cells for enhancing the tumor-killing effect. Among various nanocarriers, gold nanocages (AuNCs) were selected as the photothermal agents for photothermal therapy (PTT) due to their distinctive hollow and void structures, which make them ideal carriers throughout the therapy. To achieve controlled drug release under near-infrared radiation, lauric acid (LA) was chosen as the “gatekeeper”, responding to a temperature stimulus. Bispecific aptamers with surface modifications were utilized to increase the intracellular drug content while triggering the immune system to eliminate the cancer cells. The homologous targeting ability of AuNCs/LA/ doxorubicin (DOX)/Apt resulted in a high tumor site aggregation. PTT-induced in situ tumor heat elimination and increased tumor cell immunogenicity upon exposure to laser irradiation. Consequently, the smart nano platform not only destroyed the tumor cells through PTT and chemotherapy but also formed a T cell–cancer cell complex at the tumor site, causing the immune cells to precisely identify the tumor and achieve in situ activation of the immune response at the tumor site. The proposed strategy was a classic “cocktail therapy”.
研究领域:
纳米技术
·
癌症治疗
·
药物递送系统
·
光热疗法
·
免疫疗法
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
ShengZhe Zhou,Xueliang Zhang,Wei Ni,Yu He,Ming Li,Caixia Wang,Yubing Bai,Hao Zhang,Min Yao
Bacterial infections and excessive inflammation present substantial challenges for clinical wound healing. Hydrogels with mild photothermal (PTT) effects have emerged as promising agents owing to their dual actions: positive effects on cells and negative effects on bacteria. Here, an injectable self-healing hydrogel of oxidized konjac glucomannan/arginine-modified chitosan (OKGM/CS-Arg, OC) integrated with protocatechualdehyde-@Fe (PF) nanoparticles capable of effectively absorbing near-infrared radiation is synthesized successfully. The OC/PF hydrogels exhibit excellent mechanical properties, biocompatibility, and antioxidant activity. Moreover, in synergy with PTT, OC/PF demonstrates potent antibacterial effects while concurrently stimulating cell migration and new blood vessel formation. In methicillin-resistant Staphylococcus aureus -infected full-thickness mouse wounds, the OC/PF hydrogel displays remarkable antibacterial and anti-inflammatory activities, and accelerates wound healing by regulating the wound immune microenvironment and promoting M2 macrophage polarization. Consequently, the OC/PF hydrogel represents a novel therapeutic approach for treating multidrug-resistant bacterial infections and offers a technologically advanced solution for managing infectious wounds in clinical settings.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
伤口愈合
·
传染病学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）