Nanoscale
·
2015
·Vol. 7
·期 33
·13918-13923
·
IF 7.394
Wenlong Gao,Mei Liu,Limei Liu,Hui Zhang,Bin Dong,Christopher Y. Li
Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications.
研究领域:
材料科学
·
化学工程
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2022
·Vol. 18
·期 50
·2205286
·
IF 15.153
Xiaohu Chen,Xiyang Zeng,Kun Luo,Tao Chen,Ting Zhang,Guilong Yan,Li Wang
Stimuli-responsive materials can transform from temporary to permanent shapes by specific external triggers. However, the damage might inevitably occur to them when exposed to complex environments, causing a significant reduction in their lifetime and quality. In this study, recyclable remotely controlled shape-changing polyurethane composite with self-healing compacity is developed from polyethylene glycol, polytetrahydrofuran diol using isophorone diisocyanate as crosslinker. After the incorporation of magnetite nanoparticles (MNPs), remote heating could be generated by near-infrared irradiation and alternating magnetic fields. The results show that MNPs are uniformly distributed in the smart networks, resulting in tunable temperature changes of the polymer composite material under various direct/indirect triggering in bending experiments, presenting different shape recovery rates. Moreover, to enhance the self-healing capability, a disulfide bond is introduced into the polymer networks, and the results show that highly efficient and rapid healing could be achieved from tensile tests, scanning electron microscopy as well as optical microscopy. Additionally, the synergistic effect of transesterification and the dynamic exchange of disulfide bonds brin the networks reproducibility for recycling use. The obtained material is promising to be an alternative material for soft robots and smart sensors.
研究领域:
材料科学
·
智能材料
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 39
·18081-18089
·
IF 6.97
Ran Xiong,Wenting Zhang,Yifan Zhang,Ye Zhang,Yimin Chen,Yuan He,Haiming Fan
Remote modulation of nanoscale biochemical processes in a living system using magnetic stimulation is appealing but is restricted by the lack of a highly efficient nanomediator which can deliver timely and effective response to biological molecules under an external magnetic field. Herein, we report the development of a novel nanocatalyst based on a ferrimagnetic vortex-domain nanoring (FVIO)–enzyme hybrid that enables real-time modulation of enzymatic catalysis under an alternating magnetic field (AMF). The role of the FVIO is to provide localized heating immediately upon exposure to an AMF, which efficiently and selectively promotes the activity of conjugated enzymes on the surface. The reaction rate of the as-fabricated FVIO–β-Gal hybrid was shown to be boosted up to 180% of its initial value by localized heat generated under an AMF of 550 Oe in less than 2 s and without heating up the bulk solution. Moreover, the degree of activity acceleration was shown to be tunable by increasing the strength of the AMF. The concept of remote magnetic stimulation of enzymatic reactions has been further applied to other enzymes (e.g. FVIO–KPC and FVIO–GOx), demonstrating the general applicability of this strategy. Since almost all metabolic processes in cells rely on enzymatic catalysis to sustain life, the FVIO–enzyme system developed in this work provides a valuable nanoplatform for spatiotemporally manipulating biochemical reactions, which might pave the way for future remote manipulation of living organisms.
研究领域:
纳米技术
·
生物化学
·
分子生物学
·
催化
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2023
·Vol. 10
·期 10
·2205343
·
IF 15.1
Xiaohui Ma,Xiaotong Wu,Shitai Cao,Yinfeng Zhao,Yong Lin,Yurui Xu,Xinghai Ning,Desheng Kong
Surgery represents a primary clinical treatment of solid tumors. The high risk of local relapse typically requires frequent hospital visits for postoperative adjuvant therapy. Here, device designs and system integration of a stretchable electronic device for wearable cancer treatment are presented. The soft electronic patch harnesses compliant materials to achieve conformal and stable attachment to the surgical wound. A composite nanotextile dressing is laminated to the electronic patch to allow the on-demand release of anticancer drugs under electro-thermal actuation. An additional flexible circuit and a compact battery complete an untethered wearable system to execute remote therapeutic commands from a smartphone. The successful implementation of combined chemothermotherapy to inhibit tumor recurrence demonstrates the promising potential of stretchable electronics for advanced wearable therapies without interfering with daily activities.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
·
电子学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2018
·
IF 9.89
Ziyang Cao,Yinchu Ma,Chunyang Sun,Zidong Lu,Zeyu Yao,Junxia Wang,Dongdong Li,Youyong Yuan,Xianzhu Yang
Drug delivery systems with remotely controlled drug release capability are rather attractive options for cancer therapy. Herein, a reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize remotely controlled drug release by light-activated size shrinkage. The TK-PPE@NPCe6/DOX encapsulating chlorin e6 (Ce6) and doxorubicin (DOX) was self-assembled from an innovative ROS-sensitive polymer TK-PPE with the assistance of an amphiphilic copolymer poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL). Under the 660 nm red light irradiation, ROS generated by the encapsulated Ce6 were capable of cleaving the TK linker in situ, which resulted in the rapid degradation of the TK-PPE@NPCe6/DOX core. Consequently, the size of TK-PPE@NPCe6/DOX shrank from 154 ± 4 nm to 72 ± 3 nm, and such size shrinkage affected further triggered rapid DOX release. As evidenced by both in vitro and in vivo experiments, such ROS-sensitive polymeric nanocarriers with light-induced size shrinkage capability offer remarkable therapeutic effects in cancer treatment. This concept provides new avenues for the development of light-activated drug delivery systems for remotely controlled drug release in vivo.
研究领域:
生物材料学
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Intelligent Systems
·
2023
·
IF 7.4
Pengfei Lou,Linlin Tian,Miao Yao,Jun Nie,Yong He
Remote stimuli-responsive movable soft robots without the need for complex 3D deformation processes and specific working environments is an unsolved problem and urgent need. In this work, under the inspiration of mother nature, a novel strategy of simple combination of the bionic bristles structure and the photothermal-driven reversible shape change liquid crystal polymer (LCP) actuator is proposed to work out this difficulty. The combination structure is designed as unique three parts with two bionic bristle units at the two ends and one LCP unit in the center with a soft connection between them. After matching the driving force and the resistance, the prepared soft robot can realize the earthworm-like unidirectionally crawl on the paper surface upon near-infrared light irradiation through the contracting and stretching of LCP with a maximum average speed of 4.4 mm min −1 . What's more, the crawling speed of the soft robot can be regulated by varying the irradiation distance of near-infrared light or the length of the actuators. This strategy realizes the type of remote wireless control soft robot and has potential application ability in other soft robots with various demands.
研究领域:
软体机器人
·
材料科学
·
生物力学
·
光电技术
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yanxia Yang,Yingzi Li,Xin Xia,Shengkai Li,Shen Wang,Liang Zhang,Yuqi Cheng,Long Chen,Qian Dong,Zhuo Chen
Developing acid-tolerant magnetothermal nanoplatform with robust drug loading capacity for remote controlled drug release is challenging in the harsh acid environment of stomach. Herein, a nanopomegranate-type magnetothermal controllable drug release platform (FeCo@G@MSN), consisted of magnetothermal convertor (graphene-isolated FeCo nanocrystal core, FeCo@G) and drug reservoir (mesoporous silica, MSN), with acid-tolerant hierarchical structure was developed. Benefiting from the acid tolerance of graphene and MSN, FeCo@G@MSN was stable in 1 M hydrochloric acid for more than 12 h. The nanopomegranate-type hierarchical structure endowed FeCo@G@MSN with high saturation magnetization (114.9 emu/g) to generate a magnetothermal effect and large specific surface area (293.7 m 2 /g) to provide ample space for drug loading. As a proof of concept, a heat-triggered nitric oxide (NO) precursor was loaded, and NO were controlled released by breaking of S-NO bonds through localized heat derived from magnetothermal effect of FeCo@G, resulting in an inhibition effect towards Helicobacter pylori . A chemotherapeutic drug (doxorubicin, DOX) was also loaded and controlled released by breaking of hydrogen bonds between silica and DOX under remote an alternating magnetic field, thus exhibiting an inhibition effect towards gastric cancer cells. This work provides an efficient strategy to exploit magnetothermal controlled drug release platform and offers inspiration for the treatment of gastric diseases.
研究领域:
纳米技术
·
药物递送系统
·
磁性材料
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Shuo Zhang,Liuqi Ji,Siyuan Wang,Yunduo Yi,Dakai Wang,Changchao Zhang,Bo Li,Shichao Niu,Junqiu Zhang,Zhiwu Han,Luquan Ren
Flexible pressure sensors with high sensitivity and a broad pressure range are critical to practical applications such as smart healthcare, human-machine interfaces, and remote precision control. However, under high pressure, the deformation of microscale sensing structures in flexible materials becomes saturated, sharply reducing sensitivity and limiting accurate monitoring across a broad pressure range. Inspired by human fingertips, a bioinspired multiscale heterogeneous gradient sensing strategy was designed to realize an ionic capacitive pressure sensor combining high sensitivity with a wide pressure detection. The sensor exhibits a maximum sensitivity of 622.8 kPa −1 , while maintaining a stable sensitivity of 74.4 kPa −1 even under high pressure up to 350 kPa. Moreover, the sensor demonstrates a fast response time of 38 ms and excellent stability over 20,000 cycles. As proof of concept, the bioinspired sensor was successfully applied to wearable physiological signal monitoring, robotic object recognition, and remote unmanned aerial vehicle control, highlighting its potential to integrate high sensitivity with a broad operating range.
研究领域:
生物医学工程
·
柔性电子学
·
传感技术
·
人机交互
·
康复工程
·
智能医疗
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Jingjing Zhang,Yong Mei Chen,Sihui Yang,Yang Yang,Andleeb Rani,Xuwu Sun,Yuan He
Solar vapor evaporators in saline hold enormous potentials in resource sustainability, seawater desalination, as well as renewable energy harvesting. Nanocomposite hydrogels with the property of photothermal conversion have emerged as candidates for solar-driven steam generation devices, but are limited by remote control and low mechanical properties in a saline environment. Here, we developed a remote-controlled, saline tolerant, and tough-yet-strong solar vapor evaporator based on multifunctional Fe 3 O 4 nanoparticles reinforced gel-nacre. The Fe 3 O 4 nanoparticles play triple roles of acting as nano-crosslinks, photothermal converters, and untethered manipulation, coupling gel-nacre matrix with a shrinking tendency in saline that contributes to synergistic mechanical reinforcement. Such integrated magnetic nanocomposite hydrogel exhibits tough-yet-strong mechanical properties (19.58 MPa ultimate strength, 300 % failure strain, self-recoverability under 500 %, and fatigue-resistance), addressing the challenges of remote operation system and high strength requirement for practical applications. Moreover, good photothermal conversion performances (1.26 kg m −2 h −1 evaporation rate and 92.84 % evaporation efficiency) could be achieved with remotely controlled motion or adjustable position simultaneously under an external magnetic field. The intelligent solar vapor evaporation system based on multifunctional magnetic Fe 3 O 4 @gel-nacre nanocomposite provides new opportunities for flexible energy-transducing devices with untethered manipulation in saline environment.
研究领域:
材料科学
·
纳米技术
·
可再生能源
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Meng Meng,Bosen Chai,Haifeng Qiu,Yan Liu,Liguo Weng,Deqiang Lian,Konghua Yang,Chunbao Liu
Surface wettability switching is of great importance in both theoretical studies and practical applications. The surface wettability switching of thermally responsive shape memory polymer (SMP) by altering temperature has been widely discussed. However, meeting diverse application requirements by selectively switching the local wettability of thermally responsive SMP surfaces remains a significant challenge. Here, we prepared a photocontrolled wettability-switchable SMP surface by doping graphene oxide into a thermally responsive SMP, utilizing a template method. By leveraging the excellent photothermal conversion properties of graphene oxide and the thermal-responsive shape memory properties of SMP, the surface can reversibly change the surface morphology through loading deformation and near-infrared light irradiation. This enables achieving reversible switching of wettability between a superhydrophobic low-adhesion state and a hydrophobic high-adhesion state. The flexibility of near-infrared light irradiation allows for localized wettability switching on the surface by varying the position of light irradiation. Furthermore, we demonstrate the application of this photocontrolled SMP surface for droplet capture and remote, contactless selective release. This showcases the versatility of this surface for various application needs and highlights its immense potential in droplet-based microreactions, bioassays, chemical synthesis, and other applications.
研究领域:
材料科学
·
表面工程
·
光学控制
·
微流体技术
·
智能材料
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Shiwei Feng,Xuelin Peng,Jingjing Cui,Ruiqi Feng,Yongding Sun,Yunlong Guo,Zhe Lu,Weizi Gao,Fukang Liu,Chen Liang,Guang Hu,Biao Zhang
Photo-triggered shape morphing structures can be found in myriads of areas. Utilizing light as a switch can effectively control and regulate the precise deformation of structures. However, the integration of photo-switching functions in shape-morphing structures with complex geometries remains a challenge. Here, photoswitchable digital light processing based 4D printing high-resolution and highly complex geometries, based on UV curable WO 2.9 nanoparticle doped shape memory polymer nanocomposites is reported, which are highly deformable (stretchability up to ≈1000% at rubbery state) and fatigue resistant (repeatedly loaded >1200 times at ambient temperature). The presence of just trace WO 2.9 nanoparticles (<0.20 wt.‰) contributes to the controlled photothermal property of nanocomposite via selective absorption of light, which enables reversibly photoswitchable (>50 times), spatial and remote control of 4D printing shape morphing structures. These findings offer a promising approach to expanding the applications of photo-triggered shape-morphing structures.
研究领域:
材料科学
·
纳米技术
·
3D/4D打印
·
智能材料
✓ 已验证
产品关联
DOI
高影响因子
Science Robotics
·
2017
·Vol. 2
·期 12
·
IF 0
Xiaohui Yan,Qi Zhou,Melissa Vincent,Yan Deng,Jiangfan Yu,Jianbin Xu,Tiantian Xu,Tao Tang,Liming Bian,Yi-Xiang J. Wang,Kostas Kostarelos,Li Zhang
Magnetic microrobots and nanorobots can be remotely controlled to propel in complex biological fluids with high precision by using magnetic fields. Their potential for controlled navigation in hard-to-reach cavities of the human body makes them promising miniaturized robotic tools to diagnose and treat diseases in a minimally invasive manner. However, critical issues, such as motion tracking, biocompatibility, biodegradation, and diagnostic/therapeutic effects, need to be resolved to allow preclinical in vivo development and clinical trials. We report biohybrid magnetic robots endowed with multifunctional capabilities by integrating desired structural and functional attributes from a biological matrix and an engineered coating. Helical microswimmers were fabricated from Spirulina microalgae via a facile dip-coating process in magnetite (Fe3O4) suspensions, superparamagnetic, and equipped with robust navigation capability in various biofluids. The innate properties of the microalgae allowed in vivo fluorescence imaging and remote diagnostic sensing without the need for any surface modification. Furthermore, in vivo magnetic resonance imaging tracked a swarm of microswimmers inside rodent stomachs, a deep organ where fluorescence-based imaging ceased to work because of its penetration limitation. Meanwhile, the microswimmers were able to degrade and exhibited selective cytotoxicity to cancer cell lines, subject to the thickness of the Fe3O4 coating, which could be tailored via the dip-coating process. The biohybrid microrobots reported herein represent a microrobotic platform that could be further developed for in vivo imaging–guided therapy and a proof of concept for the engineering of multifunctional microrobotic and nanorobotic devices.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
机器人技术
·
医学成像
✓ 已验证
产品关联
DOI
PubMed
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