ACS Applied Polymer Materials
·
2023
·
IF 5
Sijia Chen,Junyi Tang,Jiachun Feng
The development of high-performance hydrogels has received much attention, but the simple and cost-effective preparation of hydrogels with high mechanical strength and excellent swelling resistance remains a challenge. In this study, a facile and green strategy was proposed to construct a polyvinyl alcohol/chitosan-based (PVA/CS-based) hydrogel with high mechanical strength and superior swelling resistance. By introducing tannic acid (TA), a natural polyphenol, and forming hydrogen bonding cross-linking with the polymer chains through solvent regulation, as well as by ionic cross-linking and salting-out effects further induced through sodium citrate solution immersion, a strong and homogeneous multiple physical cross-linking network was formed, which endowed the resulting hydrogel with excellent mechanical and swelling resistance performance. For the hydrogel with PVA, CS, and TA in the mass ratio of 5:1:5, the tensile strength was up to 8.22 MPa, and the tensile strength retention was up to 96% of the original value after swelling equilibrium. In addition, our hydrogel can be attached in situ to various substrates and enabled wet adhesion. The easy scale-up and energy-saving features made our method highly promising for the preparation of high-performance hydrogels for many advanced applications.
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JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 4
·1325-1335
·
IF 3.9
Xiaoyan Fu,Shaofeng Yuan,Fangwei Yang,Hang Yu,Yunfei Xie,Yahui Guo,Weirong Yao
The binding of pesticide residues and fruit components may have a profound impact on pesticide dissipation and the functional characteristics of the corresponding components. Therefore, the interaction between boscalid and tannic acid (TA, a representative phenolic in fruit) was systematically investigated using spectroscopic, thermodynamic, and computational chemistry methods. A separable system was designed to obtain the boscalid–TA complex. Fourier transform infrared and 1 H-NMR spectroscopies indicated the formation of hydrogen bonds in the complex. Isothermal titration calorimetry showed that the complex bound spontaneously through hydrophobic interactions (Δ G < 0, Δ H > 0, Δ S > 0), with a binding constant of 6.0 × 10 5 M −1 at 298 K. The molecular docking results further confirmed the formation of hydrogen bonds and hydrophobic interactions in the complex at the molecular level, with a binding energy of −8.43 kcal mol −1 . In addition, the binding of boscalid to TA significantly decreased the antioxidant activity of TA. The binding of boscalid residue to TA was characterized at the molecular level, which significantly reduced the in vitro antioxidant properties of TA. Practical Application This study provides a reference for the molecular mechanisms of the interaction between pesticide residues and food matrices, as well as a basis for regulating bound-state pesticide residues in food.
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JOURNAL OF POLYMER RESEARCH
·
2022
·Vol. 30
·期 1
·1-11
·
IF 3.061
Qiao Yansha,Zhang Qian,Wang Qian,Li Yan,Wang Lu
Aiming at the serious complications elicited by the inflammatory response to the polypropylene (PP) hernia mesh, we decorated the PP mesh with the immunomodulatory chondroitin sulfate (CS, a sulfated glycosaminoglycan present in extracellular matrixes) in the form of chrysanthemum–like hierarchitectures through the oxidative co-deposition with tannic acid (TA, a natural polyphenol compound). The mass ratio (MR) of TA to CS was modulated to obtain a hybrid colloidal particle with the balanced intermolecular interactions as the precursor of the co-deposition coating (TC). The interactions also protected the phenolic hydroxyls of TA from excessive oxidation and facilitated TA deposition, ultimately strengthening the antioxidant ability of TC. Relying on the immunomodulatory and antioxidant properties, the PP mesh coated with TC exhibited excellent anti-inflammatory effects in vitro. Moreover, TC had good stability without any adverse influence on the original mesh properties (the pore structure and compliance), which holds a great potential in the biocompatible modification of implants.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Hankun Cao,Du Xiang,Xin Zhou,Pengpeng Yue,Yongkang Zou,Zibiao Zhong,Yongsheng Ma,Lizhe Wang,Shuangquan Wu,Qifa Ye
Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. Herein, we fabricated novel multifunctional chitin/PEGDE-tannic acid (CPT) hydrogels through chemical- and physical-crosslinking strategies, using chitin as the base material, polyethylene glycol diglycidyl ether (PEGDE) and tannic acid (TA) as crosslinking agents, and 90 % ethanol as the regenerative bath. CPT hydrogels maintained a stable three-dimensional porous structure with suitable water contents and excellent biocompatibility. The mechanical properties of hydrogels were greatly improved (tensile stress up to 5.43 ± 1.14 MPa). Moreover, CPT hydrogels had good antibacterial, antioxidant , and hemostatic activities and could substantially promote wound healing in a rat model of full-thickness skin defect by regulating inflammatory responses and promoting collagen deposition and blood vessel formation . Therefore, this work provides a useful strategy to fabricate novel multifunctional CPT hydrogels with excellent mechanical, antibacterial, antioxidant, hemostatic, and biocompatible properties. CPT hydrogels could be promising candidates for wound healing.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Guoxu He,Menghui Wan,Zhihua Wang,Yanbao Zhao,Lei Sun
Due to its minute droplet size and stability, separation of the emulsion is a non-negligible challenge. In this paper, polyvinylidene fluoride (PVDF) nanofibrous membranes were prepared via the electrospinning method. The nanofibrous membranes were subsequently surface-modified by ZnO nanoparticles , tannic acid (TA), and n-dodecyl mercaptan (DT), in order to reduce the nanofiber membranes' surface energy while increasing their surface roughness . Thus, superhydrophobic and antibacterial nanofibrous membranes have been fabricated for oil-water emulsion separation. The as-fabricated nanofibrous membranes have a water contact angle of 156.5°. The product has a porosity of up to 73.3% due to the high porosity of the electrospinning nanofibrous membranes. In addition, the tensile strength of the PVDF@ZnO@TA@DT nanofibrous membrane is up to 69.25 MPa. Due to these properties, oil droplets can pass through the membrane during the oil-water separation, while the water phase is blocked by the membrane. This results in a good selective permeability of the membrane. As a result, the separation efficiency of the PVDF@ZnO@TA@DT nanofibrous membranes reaches more than 99%, and the flow flux is 1008.88 L·m −2 ·h −1 . At the same time, antimicrobial testing demonstrates that the nanofibrous membranes have a bacteriostatic rate of over 98%. Combined with these properties, PVDF@ZnO@TA@DT electrospun nanofibrous membranes have great potential for efficient emulsion separation and deep purification of wastewater.
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Advanced Healthcare Materials
·
2023
·Vol. 12
·期 13
·2203306
·
IF 10
Xinchang Kang,Pengfei Guan,Cairong Xiao,Can Liu,Youjun Guan,Yeying Lin,Yu Tian,Kunyu Ren,Yanting Huang,Rumin Fu,Chengyun Ning,Lei Fan,Guoxin Tan,Lei Zhou
Photothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on-demand removability without additional nanomaterials-based photothermal agents have rarely been reported in the literature. In this work, an injectable intrinsic photothermal hydrogel bioadhesive with an on-demand removal trait is developed through dynamic cross-linking of gelatin (Gel), tannic acid (TA) quinone, and borax for closing skin incisions and accelerating methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing. The TA quinone containing polyphenol and quinone groups with multifunctional adhesiveness and intrinsic photothermal performance confer the hydrogel adhesive with near-infrared (NIR) responsive antibacterial activity. The cross-linking of pH-sensitive boronic ester (polyphenol−B) and Schiff base bonds endow the hydrogel with great self-healing capacity and on-demand removability. Moreover, the hydrogel possesses good biocompatibility, injectability, and hemostasis. The in vivo experiment in a rat cutaneous incision model and full-thickness MRSA-infected wound model indicate that the smart hydrogel can close wounds efficiently and treat infected ones, demonstrating its superiority in noninvasive treatment of cutaneous incisions and enhancing infected full-thickness wound healing.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2022
·
IF 11.357
Yuling Ren,Pengfei Qi,Yinhua Wan,Chulong Chen,Xiangrong Chen,Shichao Feng,Jianquan Luo
A nanofiltration (NF) membrane with high salt permeation and high retention of small organics is appealing for the treatment of high-salinity organic wastewater. However, the conventional negatively charged NF membranes commonly show high retention of divalent anions (e.g., SO42–), and the reported positively charged NF membranes normally suffer super low selectivity for small organics/Na2SO4 and high fouling potential. In this work, we propose a novel “etching–swelling–planting” strategy assisted by interfacial polymerization and mussel-inspired catecholamine chemistry to prepare a mix-charged NF membrane. By X-ray photoelectron spectroscopy depth profiling and pore size distribution analysis, it was found that such a strategy could not only deepen the positive charge distribution but also narrow the pore size. Molecular dynamics confirm that the planted polyethyleneimine chains play an important role to relay SO42– ions to facilitate their transport across the membrane, thus reversing the retention of Na2SO4 and glucose (43 vs 71%). Meanwhile, due to the high surface hydrophilicity and smoothness as well as the preservation of abundant negatively charged groups (−OH and −COOH) inside the separation layer, the obtained membrane exhibited excellent antifouling performance, even for the coking wastewater. This study advances the importance of vertical charge distribution of NF membranes in separation selectivity and antifouling performance.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Shichao Zhang,Yong Li,Xinxin Li,Jingjing Gu,Hongwei Shao,Qiang Huang,Peng Cui,Yahua Liu,Jin Ran,Cen-Feng Fu
Two dimensional (2D) TaS 2 laminates have highly regular and ordered transfer mass channels, thus being promising acid recovery membrane candidates for diffusion dialysis (DD) applications to discern H + and metallic ions. However, it remains a daunting task to get access to high-performance 2D acid recycling membranes made from single TaS 2 nanosheets . Here, we report manipulation of the chemical environments of TaS 2 channels to develop excellent acid recycling 2D membranes. As demonstration projects, positively charged poly(diallyldimethylammonium chloride) (PDDA) and poly(4-vinylpyridine) (P4VP) in acid solution were chosen as polycation intercalators to modify the TaS 2 2D channels. Under the DD mode, the TaS 2 membrane exhibits a H + dialysis coefficient (U H + ) of 3.72 × 10 −3 m h −1 and separation factor (S) of 9 towards the simulated acid pickle. In contrast, the U H + and S value of the PDDA@TaS 2 membrane improve to 12.7 × 10 −3 m h −1 and 34.4 respectively. Those of the P4VP@TaS 2 membrane increase to 12.5 × 10 −3 m h −1 and 29.1 respectively. The reported acid recovery properties of PDDA@TaS 2 and P4VP@TaS 2 membranes exceed the commercial DF-120 acid recovery membranes. The experiment and simulation results reveal that the synergistical enhancements of U H + and S originate from the incorporating polycations in PDDA@TaS 2 and P4VP@TaS 2 composite channels.
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ENVIRONMENTAL ENGINEERING SCIENCE
·
2022
·Vol. 39
·期 12
·907-917
·
IF 2.172
Peng Wan,Xuanning Yang,Qinhua Feng,Shuyu Shi,Baolin Deng,Lina Zhang
Efficient separation of oil droplets from oil/water emulsions is necessary for many energy and food industrial processes and for industrial wastewater treatment. Membrane microfiltration has been explored to address this issue because it is simple to operate and low in cost. However, filtration of oil droplets with a size around or less than 1 μm is still a major challenge. Furthermore, the fabrication process for polymeric membranes often uses hazardous organic solvents and petroleum-derived and nonbiodegradable raw materials, which pose additional environmental health and safety risk. In this study, we examined the use of chitosan-based membranes to efficiently remove oil droplets with an average diameter of ∼1 μm. The membranes were fabricated based on the rapid dissolution of chitosan in an alkaline/urea solvent system at a low temperature, thus avoiding the use of any toxic organic solvent. The chitosan membranes were further modified by dopamine and tannic acid (TA). The as-prepared membrane was characterized in terms of surface morphology, pore size distribution, and mechanical strength. The membrane performance was evaluated on a custom-designed crossflow filtration system. The results showed that the modified chitosan membrane with dopamine and TA had a water flux of 230.9 LMH at 1bar transmembrane pressure and oil droplet rejection of 99%. This water flux represented an increase of more than 10 times when compared with the original chitosan membrane without modification. The study also demonstrated excellent antifouling properties of the modified membrane that could achieve near 100% water flux recovery.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Shuoshuo Yang,Guoqi Ni,Mengyang Xia,Hailing Li,Zhonghong Gao
Oxidative stress is associated with most traumatic or pathological bone defects, and seriously affects the effect of implantation. The construction of antioxidative and osteogenic coatings is of great significance to accelerate the bone regeneration of implants. In this study, baicalein (BAI), a nature flavonoid drug, was loaded in bovine serum albumin (BSA) by desolvent method to prepare BAI-BSA composite protein, and tannic acid (TA)/BAI-BSA coatings were further built via layer by layer self-assembly technology. BAI-BSA possesses good biocompatibility that showed no cytotoxicity to osteoblasts and erythrocytes, and helps to enhance the activity of alkaline phosphatase (ALP) and promote the formation of osteogenic mineralized calcium nodules. After assembled with TA, BAI-BSA coating significantly promoted cell adhesion and in vitro osteogenic mineralization of MC3T3-E1. Moreover, BAI drug loading improved the antioxidative function of BSA coatings effectively. The scavenging rates of (TA/BAI-BSA-10) 4 for ABTS +• and DPPH • free radicals were 69.6 ± 16.1 % and 53.4 ± 2.4 %, respectively. At cellular level, the TA/BAI-BSA coating effectively inhibited the impact of oxidative stress on the oxidative damage of osteoblasts. The drug-loaded protein coatings possess both great antioxidative and osteogenic functions, which have important potential in the field of bone repair.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Shue Jin,Renli Yang,Chen Hu,Shiqi Xiao,Yi Zuo,Yi Man,Yubao Li,Jidong Li
The regeneration of oral tissues is a challenging clinical problem because of the complex microbial and biological stress environments. Electrospun fibrous scaffolds have attracted significant interest as effective barrier membranes for guided bone regeneration (GBR); however, no mature strategy yet exists for the surface modification of fibers to provide versatility to satisfy clinical requirements. This study demonstrated a practical biosafety strategy: the combined use of plant polyphenols and LL-37 peptides to modify the fiber surface to endow the fibrous scaffold with antimicrobial activity, immunoregulation, and vascularized bone regeneration. We confirmed that the LL-37 peptides interacted with tannic acid (TA) through noncovalent bonds through experiments and molecular docking simulation analysis. In vitro experiments showed that the TA coating imparted strong antibacterial properties to the fibrous scaffold, but it also caused cytotoxicity. The grafting of LL-37 peptide promoted the spreading, migration, and osteogenic differentiation of mesenchymal stem cells and was also conducive to the M2 polarization of RAW264.7 cells. In vivo experiments further verified that the LL-37 peptide-grafted fibrous scaffold significantly enhanced angiogenesis, anti-inflammatory effects, and type-H vascularized bone regeneration. Overall, the fibrous scaffold modified by the LL-37 peptide through TA grafting has significant potential for GBR applications.
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Leqi Wu,Sui Wang,Jie Mao,Zhiyong Guo,Yufang Hu
In this study, a conductive double network cross-linked hydrogel with anti-swelling and shape memory was successfully prepared by [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), polyvinyl alcohol (PVA), and tannic acid (TA). The hydrogel is formed by SBMA radical polymerization to form the first layer of the network and PVA freeze-thawing to form the second layer of the network. The conversion of -SO 3 - on the SBMA structure to -SO3H in the presence of TA and the electrostatic repulsion between -N + (CH 3 ) 3 reduces the osmotic pressure and achieves an anti-swelling effect. The prepared hydrogels have good mechanical properties tensile strength of 1.4 MPa, elongation at break of 287.52 %, and compressive strength of 2.36 MPa at 80 % strain. The structure of SBMA forms ion channels with stable conductivity, simulating the realization of underwater monitoring movements. In addition, the hydrogel can recover its original shape in a few seconds at 60 °C and has a 99 % inactivation rate against E. coli and S. aureus within 24 h, which can provide new ideas for the biomedical field.
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